GREMLIN Database
Q9HMG0 - Ferrichrome ABC transporter permease protein
UniProt: Q9HMG0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 359 (319)
Sequences: 13816 (9793)
Seq/√Len: 548.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
241_D300_N4.8591.00
96_A309_V3.7491.00
27_A318_G3.6181.00
132_T146_L3.6101.00
104_I233_A3.5441.00
28_T88_I3.4451.00
256_P259_K3.2491.00
97_N226_T3.1921.00
92_T313_P3.0851.00
104_I264_V3.0761.00
91_G211_L2.9621.00
293_V311_L2.8501.00
90_V214_T2.6771.00
43_D76_R2.6151.00
97_N275_A2.5771.00
97_N271_S2.5641.00
28_T92_T2.5071.00
100_V309_V2.4531.00
43_D46_H2.4351.00
127_M186_V2.3791.00
247_E261_R2.3581.00
23_V314_A2.3441.00
94_V275_A2.2861.00
24_V314_A2.2841.00
100_V230_L2.2571.00
103_A308_C2.1821.00
33_S41_I2.1811.00
127_M183_F2.1521.00
297_V307_G2.1211.00
94_V279_A2.0781.00
87_R320_D2.0761.00
241_D301_T2.0281.00
92_T317_V2.0171.00
73_L76_R2.0151.00
24_V92_T2.0101.00
225_F274_A1.9951.00
93_L223_L1.9671.00
31_Q88_I1.9661.00
40_P43_D1.9491.00
107_I301_T1.8951.00
239_E260_V1.8931.00
131_L135_L1.8601.00
27_A314_A1.8581.00
105_F268_A1.8001.00
51_P77_Q1.7971.00
130_L187_Q1.7701.00
242_V255_M1.7671.00
236_V239_E1.7591.00
214_T218_Q1.7541.00
42_A46_H1.7001.00
17_A307_G1.6731.00
232_L267_I1.6621.00
229_S271_S1.6331.00
74_S77_Q1.5781.00
24_V310_V1.5741.00
151_G273_A1.5561.00
285_V316_L1.5561.00
322_G326_A1.5551.00
236_V263_G1.5451.00
129_V147_A1.5441.00
259_K263_G1.5181.00
323_A334_V1.5171.00
77_Q81_W1.5121.00
89_L219_V1.5111.00
30_L33_S1.5021.00
27_A317_V1.4991.00
229_S270_L1.4961.00
103_A304_L1.4781.00
30_L34_F1.4441.00
16_L307_G1.4371.00
128_V146_L1.4371.00
47_T81_W1.4321.00
45_W49_F1.4231.00
220_R224_P1.4211.00
20_S310_V1.4181.00
215_D218_Q1.4161.00
322_G337_I1.4071.00
236_V260_V1.4041.00
101_S271_S1.3961.00
211_L316_L1.3861.00
303_D306_A1.3841.00
293_V304_L1.3771.00
155_F269_I1.3611.00
20_S307_G1.3521.00
229_S267_I1.3441.00
126_G187_Q1.3411.00
90_V278_V1.3351.00
31_Q321_V1.3131.00
220_R223_L1.3081.00
128_V150_G1.3041.00
289_V315_L1.2971.00
122_S272_T1.2971.00
182_V343_G1.2821.00
154_A183_F1.2801.00
293_V307_G1.2701.00
99_A289_V1.2691.00
236_V264_V1.2431.00
232_L236_V1.2421.00
93_L219_V1.2401.00
224_P228_L1.2181.00
20_S311_L1.2061.00
108_V264_V1.1931.00
324_R331_Q1.1851.00
103_A301_T1.1821.00
17_A303_D1.1811.00
126_G207_L1.1671.00
289_V311_L1.1591.00
50_D72_W1.1581.00
301_T304_L1.1581.00
259_K262_F1.1531.00
251_E258_E1.1521.00
279_A282_I1.1511.00
260_V263_G1.1401.00
37_Y79_V1.1401.00
103_A305_L1.1311.00
146_L150_G1.1281.00
78_V82_N1.1251.00
249_T252_S1.1251.00
38_P41_I1.1241.00
47_T72_W1.1231.00
258_E261_R1.1201.00
246_G250_A1.1171.00
24_V313_P1.1171.00
156_L160_A1.1151.00
130_L203_A1.1051.00
96_A99_A1.1041.00
158_V179_V1.1001.00
47_T77_Q1.0981.00
90_V219_V1.0951.00
222_A278_V1.0921.00
127_M131_L1.0911.00
32_V88_I1.0801.00
124_G150_G1.0761.00
148_A270_L1.0751.00
51_P81_W1.0711.00
134_T190_L1.0711.00
75_R78_V1.0651.00
93_L222_A1.0611.00
34_F325_L1.0601.00
20_S314_A1.0601.00
320_D324_R1.0581.00
91_G316_L1.0551.00
124_G154_A1.0551.00
89_L216_W1.0501.00
91_G317_V1.0491.00
72_W77_Q1.0481.00
282_I316_L1.0451.00
163_W258_E1.0351.00
81_W85_L1.0351.00
28_T317_V1.0331.00
96_A313_P1.0281.00
232_L263_G1.0261.00
153_V157_I1.0231.00
242_V253_L1.0221.00
339_G344_P1.0221.00
15_T18_A1.0191.00
322_G325_L1.0161.00
233_A267_I1.0111.00
47_T80_V1.0081.00
306_A309_V1.0031.00
314_A318_G1.0001.00
44_A80_V0.9991.00
222_A226_T0.9991.00
231_A235_L0.9901.00
131_L190_L0.9891.00
27_A321_V0.9891.00
22_L26_A0.9871.00
258_E262_F0.9871.00
228_L231_A0.9751.00
51_P72_W0.9741.00
88_I321_V0.9741.00
14_A17_A0.9681.00
145_L149_L0.9671.00
297_V303_D0.9631.00
29_L33_S0.9631.00
123_N183_F0.9611.00
180_S184_G0.9591.00
221_I224_P0.9571.00
229_S274_A0.9431.00
47_T51_P0.9381.00
122_S281_L0.9371.00
275_A279_A0.9341.00
33_S44_A0.9331.00
134_T194_I0.9321.00
289_V293_V0.9251.00
216_W219_V0.9231.00
189_A193_F0.9171.00
304_L308_C0.9161.00
127_M187_Q0.9151.00
21_L25_L0.9141.00
248_E251_E0.9111.00
240_L264_V0.9101.00
47_T76_R0.9061.00
323_A337_I0.9041.00
255_M260_V0.9001.00
46_H50_D0.8941.00
260_V264_V0.8921.00
46_H49_F0.8911.00
224_P227_V0.8911.00
303_D307_G0.8851.00
127_M190_L0.8811.00
345_Y348_Y0.8761.00
77_Q82_N0.8761.00
29_L41_I0.8711.00
323_A333_P0.8711.00
327_L330_V0.8701.00
132_T143_M0.8651.00
129_V143_M0.8641.00
296_I311_L0.8631.00
15_T19_G0.8621.00
102_G290_P0.8591.00
14_A18_A0.8561.00
93_L226_T0.8531.00
121_V151_G0.8491.00
301_T306_A0.8491.00
46_H51_P0.8471.00
117_Y122_S0.8451.00
159_Y258_E0.8441.00
35_G84_R0.8391.00
318_G322_G0.8381.00
241_D302_R0.8361.00
16_L19_G0.8331.00
44_A47_T0.8331.00
16_L20_S0.8291.00
97_N101_S0.8281.00
96_A230_L0.8281.00
87_R324_R0.8261.00
294_R304_L0.8231.00
87_R331_Q0.8201.00
39_I80_V0.8181.00
300_N303_D0.8181.00
325_L328_D0.8181.00
326_A329_P0.8151.00
101_S268_A0.8151.00
237_T302_R0.8091.00
133_L143_M0.8081.00
233_A264_V0.8071.00
232_L235_L0.8061.00
203_A207_L0.8041.00
247_E251_E0.8041.00
344_P348_Y0.8031.00
88_I317_V0.8011.00
148_A152_A0.7981.00
25_L29_L0.7981.00
123_N126_G0.7921.00
21_L310_V0.7831.00
143_M146_L0.7821.00
109_T173_V0.7801.00
72_W76_R0.7791.00
201_M204_Q0.7771.00
316_L338_T0.7741.00
236_V267_I0.7721.00
105_F119_L0.7691.00
225_F229_S0.7691.00
340_L344_P0.7671.00
99_A103_A0.7651.00
131_L136_F0.7631.00
196_N202_S0.7621.00
262_F266_G0.7601.00
39_I76_R0.7571.00
293_V297_V0.7571.00
257_V261_R0.7571.00
151_G269_I0.7541.00
227_V231_A0.7531.00
293_V296_I0.7511.00
99_A309_V0.7511.00
25_L28_T0.7511.00
247_E257_V0.7501.00
285_V338_T0.7451.00
159_Y262_F0.7451.00
24_V28_T0.7451.00
125_A151_G0.7441.00
85_L216_W0.7421.00
115_S118_I0.7391.00
194_I199_V0.7371.00
163_W167_T0.7361.00
163_W166_G0.7341.00
96_A226_T0.7291.00
265_A269_I0.7281.00
250_A257_V0.7271.00
218_Q278_V0.7251.00
26_A29_L0.7211.00
33_S38_P0.7201.00
310_V314_A0.7161.00
24_V317_V0.7151.00
222_A274_A0.7141.00
152_A273_A0.7131.00
130_L191_F0.7121.00
100_V305_L0.7111.00
150_G154_A0.7101.00
217_A220_R0.7101.00
274_A278_V0.7081.00
315_L319_A0.7051.00
327_L332_L0.7051.00
50_D77_Q0.7011.00
320_D331_Q0.6991.00
100_V233_A0.6991.00
37_Y40_P0.6981.00
154_A158_V0.6981.00
155_F265_A0.6951.00
226_T275_A0.6951.00
89_L93_L0.6941.00
31_Q324_R0.6931.00
241_D306_A0.6931.00
131_L186_V0.6921.00
126_G281_L0.6901.00
124_G183_F0.6831.00
292_M311_L0.6811.00
94_V211_L0.6771.00
37_Y41_I0.6751.00
107_I244_L0.6751.00
234_F237_T0.6741.00
39_I47_T0.6721.00
90_V222_A0.6691.00
282_I334_V0.6681.00
194_I200_V0.6631.00
251_E257_V0.6631.00
143_M147_A0.6611.00
74_S78_V0.6611.00
348_Y352_R0.6571.00
204_Q207_L0.6561.00
133_L202_S0.6561.00
32_V85_L0.6561.00
34_F38_P0.6561.00
235_L239_E0.6551.00
121_V155_F0.6531.00
313_P317_V0.6531.00
98_L285_V0.6511.00
274_A277_A0.6511.00
101_S272_T0.6501.00
223_L227_V0.6471.00
158_V162_A0.6461.00
196_N201_M0.6451.00
85_L89_L0.6431.00
295_N349_L0.6421.00
41_I44_A0.6401.00
78_V83_I0.6391.00
225_F270_L0.6371.00
239_E255_M0.6371.00
40_P76_R0.6361.00
78_V81_W0.6341.00
229_S233_A0.6341.00
152_A269_I0.6321.00
160_A163_W0.6321.00
32_V80_V0.6311.00
319_A337_I0.6311.00
16_L296_I0.6311.00
162_A175_A0.6311.00
243_L257_V0.6311.00
115_S286_G0.6281.00
290_P308_C0.6261.00
41_I45_W0.6221.00
20_S24_V0.6201.00
292_M295_N0.6201.00
216_W220_R0.6191.00
309_V313_P0.6181.00
241_D244_L0.6181.00
272_T276_I0.6181.00
44_A48_V0.6181.00
273_A277_A0.6161.00
323_A331_Q0.6151.00
175_A178_V0.6131.00
99_A312_G0.6131.00
128_V132_T0.6111.00
96_A100_V0.6061.00
191_F204_Q0.6051.00
315_L341_V0.6041.00
161_I175_A0.6031.00
302_R306_A0.6031.00
230_L234_F0.6021.00
122_S125_A0.6011.00
29_L45_W0.6011.00
91_G334_V0.6001.00
316_L334_V0.6001.00
104_I267_I0.5991.00
109_T112_E0.5991.00
149_L153_V0.5961.00
26_A30_L0.5951.00
28_T32_V0.5941.00
133_L203_A0.5931.00
105_F114_A0.5861.00
43_D50_D0.5861.00
188_R206_W0.5841.00
222_A225_F0.5841.00
42_A45_W0.5841.00
191_F207_L0.5831.00
73_L77_Q0.5810.99
318_G321_V0.5810.99
188_R192_F0.5760.99
149_L152_A0.5760.99
24_V88_I0.5760.99
196_N200_V0.5750.99
168_N171_R0.5740.99
43_D72_W0.5740.99
135_L138_G0.5720.99
288_I346_F0.5720.99
323_A326_A0.5710.99
292_M315_L0.5710.99
239_E242_V0.5700.99
351_R354_E0.5700.99
125_A147_A0.5690.99
105_F121_V0.5670.99
195_D199_V0.5660.99
292_M345_Y0.5650.99
123_N184_G0.5640.99
287_L349_L0.5610.99
211_L334_V0.5600.99
33_S45_W0.5600.99
287_L290_P0.5560.99
30_L321_V0.5530.99
170_V173_V0.5530.99
211_L279_A0.5520.99
154_A179_V0.5520.99
121_V158_V0.5520.99
293_V308_C0.5520.99
123_N180_S0.5510.99
317_V321_V0.5500.99
298_G306_A0.5490.99
114_A121_V0.5490.99
240_L301_T0.5480.99
268_A273_A0.5460.99
199_V202_S0.5450.99
157_I160_A0.5430.99
129_V146_L0.5410.99
153_V156_L0.5410.99
132_T136_F0.5400.99
121_V210_S0.5400.99
288_I345_Y0.5390.99
185_S288_I0.5390.99
263_G267_I0.5370.99
152_A266_G0.5360.99
221_I274_A0.5360.99
184_G188_R0.5350.99
155_F159_Y0.5340.99
235_L238_N0.5340.99
285_V315_L0.5340.99
34_F321_V0.5340.99
288_I292_M0.5320.99
80_V85_L0.5320.99
159_Y163_W0.5300.99
27_A30_L0.5300.99
19_G22_L0.5290.99
184_G207_L0.5280.99
241_D304_L0.5270.99
18_A22_L0.5270.99
228_L232_L0.5270.99
19_G23_V0.5250.99
16_L297_V0.5250.99
136_F139_L0.5230.99
264_V268_A0.5230.99
44_A49_F0.5210.99
167_T171_R0.5200.99
192_F336_I0.5200.99
43_D47_T0.5200.99
226_T230_L0.5200.99
256_P263_G0.5190.99
269_I273_A0.5190.99
115_S338_T0.5180.99
219_V222_A0.5170.99
162_A172_L0.5160.99
219_V223_L0.5150.99
321_V325_L0.5150.99
36_A329_P0.5140.99
90_V94_V0.5140.99
17_A21_L0.5140.99
230_L233_A0.5130.99
323_A332_L0.5130.99
103_A293_V0.5130.99
306_A310_V0.5120.99
200_V203_A0.5100.99
175_A179_V0.5060.99
217_A221_I0.5060.99
221_I225_F0.5060.99
115_S281_L0.5060.99
46_H72_W0.5030.99
289_V319_A0.5020.99
226_T231_A0.5020.99
233_A305_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.8607 100 0.206 Contact Map
4g1uA 2 0.8217 100 0.209 Contact Map
2qi9A 2 0.8942 100 0.212 Contact Map
2m8rA 1 0.1031 36.6 0.962 Contact Map
4huqS 1 0.4345 18.7 0.967 Contact Map
2m20A 2 0.078 13.9 0.969 Contact Map
3rceA 1 0.727 8.6 0.972 Contact Map
3rlbA 1 0.4735 7.5 0.972 Contact Map
2l2tA 2 0.1086 6.6 0.973 Contact Map
2l9uA 2 0.0864 5.8 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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