Q9HMG0 - HALSA - GREMLIN Contacts

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Q9HMG0 - Ferrichrome ABC transporter permease protein

UniProt:	Q9HMG0	Sequences: MTANTDASATRRLATLAAGSLLVVLAATLLQVSFGAYPIPIADAWHTVFDPEIWSSAGVWRAFLLGGQLPEWLSRRQVVVWNIRLPRILVGTLVGANLAVSGAIFQIVTRNELASPYILGVSNGAGMVVLLTLTLFSGLLPVMPLLAALGGAVAFLIVYAIAWKNGTNPVRLVLAGVVVSTVFGSVQRALFFFIDNLGVVMSAQTWLSGSLLGTDWAQVRIALPFTVLSLALAFLVTNELDVLLLGEETAESLGMPVEKVRFGVAGIAILSTAAAIAVAGLIGFVGLIVPHMVRNIVGNNTRDLLAGCVVLGPALLVGADVGARLALDPVQLPVGIITGLVGGPYFLYLMRRTENLGDI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	359 (319)
Sequences:	13816 (9793)
Seq/√Len:	548.3

ECOLI - FEPG FECC FEPD BTUC FECD FHUB
BACSU - FHUB FHUG YVRB YFME YFHA YFMD FEUB YFIZ FEUC YCLN YCLO
HALSA - Q9HMG0 Q9HMG7 BTUCA
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
241_D	300_N	4.859	1.00
96_A	309_V	3.749	1.00
27_A	318_G	3.618	1.00
132_T	146_L	3.610	1.00
104_I	233_A	3.544	1.00
28_T	88_I	3.445	1.00
256_P	259_K	3.249	1.00
97_N	226_T	3.192	1.00
92_T	313_P	3.085	1.00
104_I	264_V	3.076	1.00
91_G	211_L	2.962	1.00
293_V	311_L	2.850	1.00
90_V	214_T	2.677	1.00
43_D	76_R	2.615	1.00
97_N	275_A	2.577	1.00
97_N	271_S	2.564	1.00
28_T	92_T	2.507	1.00
100_V	309_V	2.453	1.00
43_D	46_H	2.435	1.00
127_M	186_V	2.379	1.00
247_E	261_R	2.358	1.00
23_V	314_A	2.344	1.00
94_V	275_A	2.286	1.00
24_V	314_A	2.284	1.00
100_V	230_L	2.257	1.00
103_A	308_C	2.182	1.00
33_S	41_I	2.181	1.00
127_M	183_F	2.152	1.00
297_V	307_G	2.121	1.00
94_V	279_A	2.078	1.00
87_R	320_D	2.076	1.00
241_D	301_T	2.028	1.00
92_T	317_V	2.017	1.00
73_L	76_R	2.015	1.00
24_V	92_T	2.010	1.00
225_F	274_A	1.995	1.00
93_L	223_L	1.967	1.00
31_Q	88_I	1.966	1.00
40_P	43_D	1.949	1.00
107_I	301_T	1.895	1.00
239_E	260_V	1.893	1.00
131_L	135_L	1.860	1.00
27_A	314_A	1.858	1.00
105_F	268_A	1.800	1.00
51_P	77_Q	1.797	1.00
130_L	187_Q	1.770	1.00
242_V	255_M	1.767	1.00
236_V	239_E	1.759	1.00
214_T	218_Q	1.754	1.00
42_A	46_H	1.700	1.00
17_A	307_G	1.673	1.00
232_L	267_I	1.662	1.00
229_S	271_S	1.633	1.00
74_S	77_Q	1.578	1.00
24_V	310_V	1.574	1.00
151_G	273_A	1.556	1.00
285_V	316_L	1.556	1.00
322_G	326_A	1.555	1.00
236_V	263_G	1.545	1.00
129_V	147_A	1.544	1.00
259_K	263_G	1.518	1.00
323_A	334_V	1.517	1.00
77_Q	81_W	1.512	1.00
89_L	219_V	1.511	1.00
30_L	33_S	1.502	1.00
27_A	317_V	1.499	1.00
229_S	270_L	1.496	1.00
103_A	304_L	1.478	1.00
30_L	34_F	1.444	1.00
16_L	307_G	1.437	1.00
128_V	146_L	1.437	1.00
47_T	81_W	1.432	1.00
45_W	49_F	1.423	1.00
220_R	224_P	1.421	1.00
20_S	310_V	1.418	1.00
215_D	218_Q	1.416	1.00
322_G	337_I	1.407	1.00
236_V	260_V	1.404	1.00
101_S	271_S	1.396	1.00
211_L	316_L	1.386	1.00
303_D	306_A	1.384	1.00
293_V	304_L	1.377	1.00
155_F	269_I	1.361	1.00
20_S	307_G	1.352	1.00
229_S	267_I	1.344	1.00
126_G	187_Q	1.341	1.00
90_V	278_V	1.335	1.00
31_Q	321_V	1.313	1.00
220_R	223_L	1.308	1.00
128_V	150_G	1.304	1.00
289_V	315_L	1.297	1.00
122_S	272_T	1.297	1.00
182_V	343_G	1.282	1.00
154_A	183_F	1.280	1.00
293_V	307_G	1.270	1.00
99_A	289_V	1.269	1.00
236_V	264_V	1.243	1.00
232_L	236_V	1.242	1.00
93_L	219_V	1.240	1.00
224_P	228_L	1.218	1.00
20_S	311_L	1.206	1.00
108_V	264_V	1.193	1.00
324_R	331_Q	1.185	1.00
103_A	301_T	1.182	1.00
17_A	303_D	1.181	1.00
126_G	207_L	1.167	1.00
289_V	311_L	1.159	1.00
50_D	72_W	1.158	1.00
301_T	304_L	1.158	1.00
259_K	262_F	1.153	1.00
251_E	258_E	1.152	1.00
279_A	282_I	1.151	1.00
260_V	263_G	1.140	1.00
37_Y	79_V	1.140	1.00
103_A	305_L	1.131	1.00
146_L	150_G	1.128	1.00
78_V	82_N	1.125	1.00
249_T	252_S	1.125	1.00
38_P	41_I	1.124	1.00
47_T	72_W	1.123	1.00
258_E	261_R	1.120	1.00
246_G	250_A	1.117	1.00
24_V	313_P	1.117	1.00
156_L	160_A	1.115	1.00
130_L	203_A	1.105	1.00
96_A	99_A	1.104	1.00
158_V	179_V	1.100	1.00
47_T	77_Q	1.098	1.00
90_V	219_V	1.095	1.00
222_A	278_V	1.092	1.00
127_M	131_L	1.091	1.00
32_V	88_I	1.080	1.00
124_G	150_G	1.076	1.00
148_A	270_L	1.075	1.00
51_P	81_W	1.071	1.00
134_T	190_L	1.071	1.00
75_R	78_V	1.065	1.00
93_L	222_A	1.061	1.00
34_F	325_L	1.060	1.00
20_S	314_A	1.060	1.00
320_D	324_R	1.058	1.00
91_G	316_L	1.055	1.00
124_G	154_A	1.055	1.00
89_L	216_W	1.050	1.00
91_G	317_V	1.049	1.00
72_W	77_Q	1.048	1.00
282_I	316_L	1.045	1.00
163_W	258_E	1.035	1.00
81_W	85_L	1.035	1.00
28_T	317_V	1.033	1.00
96_A	313_P	1.028	1.00
232_L	263_G	1.026	1.00
153_V	157_I	1.023	1.00
242_V	253_L	1.022	1.00
339_G	344_P	1.022	1.00
15_T	18_A	1.019	1.00
322_G	325_L	1.016	1.00
233_A	267_I	1.011	1.00
47_T	80_V	1.008	1.00
306_A	309_V	1.003	1.00
314_A	318_G	1.000	1.00
44_A	80_V	0.999	1.00
222_A	226_T	0.999	1.00
231_A	235_L	0.990	1.00
131_L	190_L	0.989	1.00
27_A	321_V	0.989	1.00
22_L	26_A	0.987	1.00
258_E	262_F	0.987	1.00
228_L	231_A	0.975	1.00
51_P	72_W	0.974	1.00
88_I	321_V	0.974	1.00
14_A	17_A	0.968	1.00
145_L	149_L	0.967	1.00
297_V	303_D	0.963	1.00
29_L	33_S	0.963	1.00
123_N	183_F	0.961	1.00
180_S	184_G	0.959	1.00
221_I	224_P	0.957	1.00
229_S	274_A	0.943	1.00
47_T	51_P	0.938	1.00
122_S	281_L	0.937	1.00
275_A	279_A	0.934	1.00
33_S	44_A	0.933	1.00
134_T	194_I	0.932	1.00
289_V	293_V	0.925	1.00
216_W	219_V	0.923	1.00
189_A	193_F	0.917	1.00
304_L	308_C	0.916	1.00
127_M	187_Q	0.915	1.00
21_L	25_L	0.914	1.00
248_E	251_E	0.911	1.00
240_L	264_V	0.910	1.00
47_T	76_R	0.906	1.00
323_A	337_I	0.904	1.00
255_M	260_V	0.900	1.00
46_H	50_D	0.894	1.00
260_V	264_V	0.892	1.00
46_H	49_F	0.891	1.00
224_P	227_V	0.891	1.00
303_D	307_G	0.885	1.00
127_M	190_L	0.881	1.00
345_Y	348_Y	0.876	1.00
77_Q	82_N	0.876	1.00
29_L	41_I	0.871	1.00
323_A	333_P	0.871	1.00
327_L	330_V	0.870	1.00
132_T	143_M	0.865	1.00
129_V	143_M	0.864	1.00
296_I	311_L	0.863	1.00
15_T	19_G	0.862	1.00
102_G	290_P	0.859	1.00
14_A	18_A	0.856	1.00
93_L	226_T	0.853	1.00
121_V	151_G	0.849	1.00
301_T	306_A	0.849	1.00
46_H	51_P	0.847	1.00
117_Y	122_S	0.845	1.00
159_Y	258_E	0.844	1.00
35_G	84_R	0.839	1.00
318_G	322_G	0.838	1.00
241_D	302_R	0.836	1.00
16_L	19_G	0.833	1.00
44_A	47_T	0.833	1.00
16_L	20_S	0.829	1.00
97_N	101_S	0.828	1.00
96_A	230_L	0.828	1.00
87_R	324_R	0.826	1.00
294_R	304_L	0.823	1.00
87_R	331_Q	0.820	1.00
39_I	80_V	0.818	1.00
300_N	303_D	0.818	1.00
325_L	328_D	0.818	1.00
326_A	329_P	0.815	1.00
101_S	268_A	0.815	1.00
237_T	302_R	0.809	1.00
133_L	143_M	0.808	1.00
233_A	264_V	0.807	1.00
232_L	235_L	0.806	1.00
203_A	207_L	0.804	1.00
247_E	251_E	0.804	1.00
344_P	348_Y	0.803	1.00
88_I	317_V	0.801	1.00
148_A	152_A	0.798	1.00
25_L	29_L	0.798	1.00
123_N	126_G	0.792	1.00
21_L	310_V	0.783	1.00
143_M	146_L	0.782	1.00
109_T	173_V	0.780	1.00
72_W	76_R	0.779	1.00
201_M	204_Q	0.777	1.00
316_L	338_T	0.774	1.00
236_V	267_I	0.772	1.00
105_F	119_L	0.769	1.00
225_F	229_S	0.769	1.00
340_L	344_P	0.767	1.00
99_A	103_A	0.765	1.00
131_L	136_F	0.763	1.00
196_N	202_S	0.762	1.00
262_F	266_G	0.760	1.00
39_I	76_R	0.757	1.00
293_V	297_V	0.757	1.00
257_V	261_R	0.757	1.00
151_G	269_I	0.754	1.00
227_V	231_A	0.753	1.00
293_V	296_I	0.751	1.00
99_A	309_V	0.751	1.00
25_L	28_T	0.751	1.00
247_E	257_V	0.750	1.00
285_V	338_T	0.745	1.00
159_Y	262_F	0.745	1.00
24_V	28_T	0.745	1.00
125_A	151_G	0.744	1.00
85_L	216_W	0.742	1.00
115_S	118_I	0.739	1.00
194_I	199_V	0.737	1.00
163_W	167_T	0.736	1.00
163_W	166_G	0.734	1.00
96_A	226_T	0.729	1.00
265_A	269_I	0.728	1.00
250_A	257_V	0.727	1.00
218_Q	278_V	0.725	1.00
26_A	29_L	0.721	1.00
33_S	38_P	0.720	1.00
310_V	314_A	0.716	1.00
24_V	317_V	0.715	1.00
222_A	274_A	0.714	1.00
152_A	273_A	0.713	1.00
130_L	191_F	0.712	1.00
100_V	305_L	0.711	1.00
150_G	154_A	0.710	1.00
217_A	220_R	0.710	1.00
274_A	278_V	0.708	1.00
315_L	319_A	0.705	1.00
327_L	332_L	0.705	1.00
50_D	77_Q	0.701	1.00
320_D	331_Q	0.699	1.00
100_V	233_A	0.699	1.00
37_Y	40_P	0.698	1.00
154_A	158_V	0.698	1.00
155_F	265_A	0.695	1.00
226_T	275_A	0.695	1.00
89_L	93_L	0.694	1.00
31_Q	324_R	0.693	1.00
241_D	306_A	0.693	1.00
131_L	186_V	0.692	1.00
126_G	281_L	0.690	1.00
124_G	183_F	0.683	1.00
292_M	311_L	0.681	1.00
94_V	211_L	0.677	1.00
37_Y	41_I	0.675	1.00
107_I	244_L	0.675	1.00
234_F	237_T	0.674	1.00
39_I	47_T	0.672	1.00
90_V	222_A	0.669	1.00
282_I	334_V	0.668	1.00
194_I	200_V	0.663	1.00
251_E	257_V	0.663	1.00
143_M	147_A	0.661	1.00
74_S	78_V	0.661	1.00
348_Y	352_R	0.657	1.00
204_Q	207_L	0.656	1.00
133_L	202_S	0.656	1.00
32_V	85_L	0.656	1.00
34_F	38_P	0.656	1.00
235_L	239_E	0.655	1.00
121_V	155_F	0.653	1.00
313_P	317_V	0.653	1.00
98_L	285_V	0.651	1.00
274_A	277_A	0.651	1.00
101_S	272_T	0.650	1.00
223_L	227_V	0.647	1.00
158_V	162_A	0.646	1.00
196_N	201_M	0.645	1.00
85_L	89_L	0.643	1.00
295_N	349_L	0.642	1.00
41_I	44_A	0.640	1.00
78_V	83_I	0.639	1.00
225_F	270_L	0.637	1.00
239_E	255_M	0.637	1.00
40_P	76_R	0.636	1.00
78_V	81_W	0.634	1.00
229_S	233_A	0.634	1.00
152_A	269_I	0.632	1.00
160_A	163_W	0.632	1.00
32_V	80_V	0.631	1.00
319_A	337_I	0.631	1.00
16_L	296_I	0.631	1.00
162_A	175_A	0.631	1.00
243_L	257_V	0.631	1.00
115_S	286_G	0.628	1.00
290_P	308_C	0.626	1.00
41_I	45_W	0.622	1.00
20_S	24_V	0.620	1.00
292_M	295_N	0.620	1.00
216_W	220_R	0.619	1.00
309_V	313_P	0.618	1.00
241_D	244_L	0.618	1.00
272_T	276_I	0.618	1.00
44_A	48_V	0.618	1.00
273_A	277_A	0.616	1.00
323_A	331_Q	0.615	1.00
175_A	178_V	0.613	1.00
99_A	312_G	0.613	1.00
128_V	132_T	0.611	1.00
96_A	100_V	0.606	1.00
191_F	204_Q	0.605	1.00
315_L	341_V	0.604	1.00
161_I	175_A	0.603	1.00
302_R	306_A	0.603	1.00
230_L	234_F	0.602	1.00
122_S	125_A	0.601	1.00
29_L	45_W	0.601	1.00
91_G	334_V	0.600	1.00
316_L	334_V	0.600	1.00
104_I	267_I	0.599	1.00
109_T	112_E	0.599	1.00
149_L	153_V	0.596	1.00
26_A	30_L	0.595	1.00
28_T	32_V	0.594	1.00
133_L	203_A	0.593	1.00
105_F	114_A	0.586	1.00
43_D	50_D	0.586	1.00
188_R	206_W	0.584	1.00
222_A	225_F	0.584	1.00
42_A	45_W	0.584	1.00
191_F	207_L	0.583	1.00
73_L	77_Q	0.581	0.99
318_G	321_V	0.581	0.99
188_R	192_F	0.576	0.99
149_L	152_A	0.576	0.99
24_V	88_I	0.576	0.99
196_N	200_V	0.575	0.99
168_N	171_R	0.574	0.99
43_D	72_W	0.574	0.99
135_L	138_G	0.572	0.99
288_I	346_F	0.572	0.99
323_A	326_A	0.571	0.99
292_M	315_L	0.571	0.99
239_E	242_V	0.570	0.99
351_R	354_E	0.570	0.99
125_A	147_A	0.569	0.99
105_F	121_V	0.567	0.99
195_D	199_V	0.566	0.99
292_M	345_Y	0.565	0.99
123_N	184_G	0.564	0.99
287_L	349_L	0.561	0.99
211_L	334_V	0.560	0.99
33_S	45_W	0.560	0.99
287_L	290_P	0.556	0.99
30_L	321_V	0.553	0.99
170_V	173_V	0.553	0.99
211_L	279_A	0.552	0.99
154_A	179_V	0.552	0.99
121_V	158_V	0.552	0.99
293_V	308_C	0.552	0.99
123_N	180_S	0.551	0.99
317_V	321_V	0.550	0.99
298_G	306_A	0.549	0.99
114_A	121_V	0.549	0.99
240_L	301_T	0.548	0.99
268_A	273_A	0.546	0.99
199_V	202_S	0.545	0.99
157_I	160_A	0.543	0.99
129_V	146_L	0.541	0.99
153_V	156_L	0.541	0.99
132_T	136_F	0.540	0.99
121_V	210_S	0.540	0.99
288_I	345_Y	0.539	0.99
185_S	288_I	0.539	0.99
263_G	267_I	0.537	0.99
152_A	266_G	0.536	0.99
221_I	274_A	0.536	0.99
184_G	188_R	0.535	0.99
155_F	159_Y	0.534	0.99
235_L	238_N	0.534	0.99
285_V	315_L	0.534	0.99
34_F	321_V	0.534	0.99
288_I	292_M	0.532	0.99
80_V	85_L	0.532	0.99
159_Y	163_W	0.530	0.99
27_A	30_L	0.530	0.99
19_G	22_L	0.529	0.99
184_G	207_L	0.528	0.99
241_D	304_L	0.527	0.99
18_A	22_L	0.527	0.99
228_L	232_L	0.527	0.99
19_G	23_V	0.525	0.99
16_L	297_V	0.525	0.99
136_F	139_L	0.523	0.99
264_V	268_A	0.523	0.99
44_A	49_F	0.521	0.99
167_T	171_R	0.520	0.99
192_F	336_I	0.520	0.99
43_D	47_T	0.520	0.99
226_T	230_L	0.520	0.99
256_P	263_G	0.519	0.99
269_I	273_A	0.519	0.99
115_S	338_T	0.518	0.99
219_V	222_A	0.517	0.99
162_A	172_L	0.516	0.99
219_V	223_L	0.515	0.99
321_V	325_L	0.515	0.99
36_A	329_P	0.514	0.99
90_V	94_V	0.514	0.99
17_A	21_L	0.514	0.99
230_L	233_A	0.513	0.99
323_A	332_L	0.513	0.99
103_A	293_V	0.513	0.99
306_A	310_V	0.512	0.99
200_V	203_A	0.510	0.99
175_A	179_V	0.506	0.99
217_A	221_I	0.506	0.99
221_I	225_F	0.506	0.99
115_S	281_L	0.506	0.99
46_H	72_W	0.503	0.99
289_V	319_A	0.502	0.99
226_T	231_A	0.502	0.99
233_A	305_L	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nq2A	2	0.8607	100	0.206	Contact Map
4g1uA	2	0.8217	100	0.209	Contact Map
2qi9A	2	0.8942	100	0.212	Contact Map
2m8rA	1	0.1031	36.6	0.962	Contact Map
4huqS	1	0.4345	18.7	0.967	Contact Map
2m20A	2	0.078	13.9	0.969	Contact Map
3rceA	1	0.727	8.6	0.972	Contact Map
3rlbA	1	0.4735	7.5	0.972	Contact Map
2l2tA	2	0.1086	6.6	0.973	Contact Map
2l9uA	2	0.0864	5.8	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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