Q9HMF9 - HALSA - GREMLIN Contacts

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Q9HMF9 - Uncharacterized protein

UniProt:	Q9HMF9	Sequences: MARRRQILAGGASLIAASLAGCTSSQSPTDDGSTTQTDAGSDSYTVTVEPNPPHTFESVPETYAAIPSVWMDIGMALGIQPSATASLGRAPLKFYDALPDVAFHKAEIEQLASDSESGYDKENFYAADCDVHLIDPRMLKFYANWTDDDIAAIESSAGPFMGSSIRFASSSAVGDGPFYDLYEAFEKAAEIFQRRARFEAWQSIKADLMDTISDGLPPESDRPTVAAIWRGVRPDTGQFRIAPLDPDQNNTLTYRRLGMQDAFAGAVPDGPIGYEELLDVDPDYIGAVGGLTSQTHAEFVDTVVEPFEANPNGQQLTAVENGNLVRTGGQFMGPIVDLFSTEALAKMVYPDAFGSWPGSPTEIPASERLFDRQRVADAINGVGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	384 (305)
Sequences:	9146 (7570)
Seq/√Len:	433.4

ECOLI - FECB FEPB FHUD BTUF
BACSU - YVRC YFMC YFIY YCLQ YXEB YHFQ FHUD FEUA
HALSA - Q9HMF9 Q9HPB0 Q9HMG8 BTUFA
SULSO - Q97ZU2 Q980Z0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
186_E	199_E	4.369	1.00
281_D	317_T	4.208	1.00
189_A	198_F	4.117	1.00
182_Y	206_A	3.766	1.00
317_T	321_N	3.621	1.00
194_R	197_R	3.608	1.00
190_E	195_R	3.355	1.00
210_D	214_D	2.993	1.00
203_S	207_D	2.901	1.00
186_E	202_Q	2.889	1.00
199_E	203_S	2.876	1.00
65_A	71_M	2.816	1.00
123_N	126_A	2.810	1.00
197_R	200_A	2.806	1.00
208_L	342_E	2.698	1.00
308_E	322_G	2.500	1.00
206_A	210_D	2.412	1.00
207_D	211_T	2.378	1.00
254_Y	259_M	2.369	1.00
276_E	279_D	2.316	1.00
283_D	317_T	2.301	1.00
305_E	309_A	2.281	1.00
211_T	215_G	2.277	1.00
63_Y	192_F	2.223	1.00
64_A	124_F	2.178	1.00
224_T	260_Q	2.134	1.00
74_G	192_F	2.126	1.00
44_Y	48_V	2.060	1.00
62_T	84_T	2.031	1.00
304_V	308_E	1.998	1.00
47_T	53_P	1.984	1.00
284_Y	323_N	1.927	1.00
200_A	204_I	1.920	1.00
317_T	320_E	1.903	1.00
45_T	48_V	1.891	1.00
150_I	154_E	1.804	1.00
301_D	305_E	1.800	1.00
133_L	188_A	1.783	1.00
284_Y	325_V	1.759	1.00
49_E	53_P	1.748	1.00
315_Q	320_E	1.734	1.00
180_D	183_E	1.728	1.00
119_Y	124_F	1.707	1.00
79_I	192_F	1.705	1.00
210_D	213_S	1.694	1.00
196_A	200_A	1.667	1.00
316_L	319_V	1.648	1.00
151_A	155_S	1.641	1.00
183_E	186_E	1.631	1.00
79_I	194_R	1.629	1.00
45_T	53_P	1.627	1.00
214_D	217_P	1.623	1.00
224_T	283_D	1.605	1.00
14_L	17_A	1.593	1.00
52_P	154_E	1.583	1.00
225_V	259_M	1.580	1.00
64_A	127_A	1.574	1.00
48_V	52_P	1.548	1.00
203_S	206_A	1.546	1.00
276_E	280_V	1.543	1.00
251_T	255_R	1.529	1.00
109_E	123_N	1.521	1.00
274_Y	310_N	1.508	1.00
211_T	214_D	1.490	1.00
195_R	199_E	1.468	1.00
73_I	185_F	1.457	1.00
45_T	55_T	1.456	1.00
15_I	18_S	1.448	1.00
122_E	275_E	1.442	1.00
305_E	308_E	1.436	1.00
223_P	284_Y	1.425	1.00
285_I	318_A	1.425	1.00
259_M	348_V	1.423	1.00
197_R	201_W	1.422	1.00
147_D	151_A	1.412	1.00
62_T	128_D	1.412	1.00
284_Y	348_V	1.401	1.00
207_D	210_D	1.398	1.00
208_L	211_T	1.395	1.00
209_M	341_T	1.387	1.00
204_I	208_L	1.387	1.00
120_D	123_N	1.375	1.00
131_V	161_M	1.344	1.00
196_A	199_E	1.340	1.00
152_A	155_S	1.339	1.00
204_I	207_D	1.329	1.00
94_F	98_L	1.309	1.00
84_T	127_A	1.304	1.00
223_P	323_N	1.302	1.00
182_Y	202_Q	1.280	1.00
61_E	130_D	1.273	1.00
76_A	201_W	1.264	1.00
85_A	127_A	1.262	1.00
187_K	190_E	1.257	1.00
13_S	17_A	1.256	1.00
161_M	187_K	1.254	1.00
74_G	79_I	1.249	1.00
134_I	162_G	1.248	1.00
313_G	319_V	1.241	1.00
161_M	191_I	1.238	1.00
56_F	59_V	1.235	1.00
61_E	82_S	1.222	1.00
63_Y	131_V	1.215	1.00
201_W	204_I	1.213	1.00
325_V	347_M	1.207	1.00
121_K	152_A	1.194	1.00
151_A	154_E	1.186	1.00
209_M	213_S	1.181	1.00
48_V	51_N	1.181	1.00
56_F	159_P	1.176	1.00
302_T	305_E	1.175	1.00
213_S	217_P	1.171	1.00
186_E	206_A	1.165	1.00
183_E	187_K	1.159	1.00
265_G	280_V	1.148	1.00
262_A	280_V	1.141	1.00
344_L	348_V	1.141	1.00
176_G	179_Y	1.135	1.00
146_T	149_D	1.132	1.00
212_I	345_A	1.125	1.00
211_T	342_E	1.119	1.00
44_Y	190_E	1.109	1.00
202_Q	206_A	1.105	1.00
260_Q	264_A	1.105	1.00
311_P	314_Q	1.102	1.00
64_A	85_A	1.100	1.00
65_A	74_G	1.096	1.00
63_Y	74_G	1.095	1.00
333_G	336_V	1.094	1.00
212_I	341_T	1.093	1.00
58_S	61_E	1.093	1.00
56_F	60_P	1.081	1.00
222_R	260_Q	1.069	1.00
103_F	106_A	1.067	1.00
246_P	255_R	1.066	1.00
152_A	156_S	1.066	1.00
317_T	323_N	1.061	1.00
11_G	15_I	1.061	1.00
15_I	19_L	1.054	1.00
334_P	337_D	1.047	1.00
313_G	316_L	1.038	1.00
12_A	16_A	1.036	1.00
186_E	190_E	1.034	1.00
94_F	97_A	1.033	1.00
185_F	198_F	1.033	1.00
340_S	343_A	1.031	1.00
131_V	191_I	1.019	1.00
226_A	229_W	1.018	1.00
262_A	265_G	1.017	1.00
342_E	346_K	1.014	1.00
205_K	209_M	1.009	1.00
226_A	282_P	1.002	1.00
199_E	202_Q	1.000	1.00
302_T	306_P	0.993	1.00
125_Y	156_S	0.990	1.00
253_T	341_T	0.988	1.00
149_D	152_A	0.987	1.00
263_F	280_V	0.976	1.00
95_Y	98_L	0.976	1.00
77_L	194_R	0.968	1.00
257_L	348_V	0.968	1.00
125_Y	158_G	0.965	1.00
59_V	194_R	0.951	1.00
83_A	108_I	0.950	1.00
277_L	316_L	0.948	1.00
16_A	20_A	0.948	1.00
208_L	338_L	0.948	1.00
86_S	108_I	0.943	1.00
200_A	203_S	0.939	1.00
225_V	254_Y	0.939	1.00
105_K	108_I	0.934	1.00
213_S	256_R	0.931	1.00
308_E	324_L	0.926	1.00
87_L	90_A	0.918	1.00
154_E	160_F	0.916	1.00
93_K	97_A	0.911	1.00
64_A	111_L	0.910	1.00
319_V	324_L	0.907	1.00
335_I	338_L	0.904	1.00
44_Y	59_V	0.902	1.00
51_N	54_H	0.901	1.00
227_A	254_Y	0.900	1.00
226_A	230_R	0.900	1.00
228_I	231_G	0.897	1.00
133_L	191_I	0.897	1.00
60_P	131_V	0.890	1.00
228_I	310_N	0.890	1.00
184_A	187_K	0.885	1.00
287_A	326_R	0.884	1.00
303_V	306_P	0.882	1.00
343_A	346_K	0.882	1.00
74_G	133_L	0.881	1.00
73_I	188_A	0.880	1.00
43_S	55_T	0.878	1.00
339_F	343_A	0.876	1.00
219_E	222_R	0.876	1.00
216_L	345_A	0.875	1.00
337_D	340_S	0.873	1.00
182_Y	209_M	0.870	1.00
263_F	276_E	0.868	1.00
252_L	256_R	0.867	1.00
12_A	15_I	0.866	1.00
263_F	266_A	0.863	1.00
343_A	347_M	0.860	1.00
59_V	193_Q	0.857	1.00
334_P	338_L	0.854	1.00
132_H	158_G	0.854	1.00
252_L	255_R	0.853	1.00
46_V	161_M	0.851	1.00
228_I	285_I	0.838	1.00
205_K	256_R	0.838	1.00
92_L	95_Y	0.837	1.00
132_H	157_A	0.837	1.00
66_I	132_H	0.835	1.00
93_K	96_D	0.834	1.00
278_L	316_L	0.834	1.00
226_A	277_L	0.830	1.00
163_S	187_K	0.827	1.00
286_G	344_L	0.820	1.00
49_E	52_P	0.817	1.00
272_I	277_L	0.813	1.00
188_A	192_F	0.812	1.00
74_G	83_A	0.812	1.00
79_I	82_S	0.811	1.00
17_A	20_A	0.808	1.00
219_E	223_P	0.807	1.00
198_F	202_Q	0.802	1.00
129_C	132_H	0.799	1.00
16_A	19_L	0.797	1.00
208_L	212_I	0.796	1.00
64_A	84_T	0.791	1.00
22_C	25_S	0.786	1.00
304_V	326_R	0.782	1.00
13_S	16_A	0.779	1.00
272_I	280_V	0.777	1.00
240_R	271_P	0.777	1.00
189_A	202_Q	0.776	1.00
11_G	14_L	0.771	1.00
237_G	242_A	0.766	1.00
50_P	162_G	0.762	1.00
306_P	309_A	0.760	1.00
65_A	83_A	0.759	1.00
60_P	130_D	0.758	1.00
76_A	185_F	0.755	1.00
56_F	191_I	0.754	1.00
106_A	109_E	0.754	1.00
261_D	265_G	0.753	1.00
44_Y	49_E	0.748	1.00
278_L	312_N	0.746	1.00
334_P	340_S	0.745	1.00
274_Y	313_G	0.738	1.00
278_L	315_Q	0.737	1.00
46_V	49_E	0.735	1.00
88_G	91_P	0.734	1.00
48_V	54_H	0.730	1.00
44_Y	57_E	0.725	1.00
216_L	219_E	0.722	1.00
10_G	14_L	0.720	1.00
73_I	76_A	0.718	1.00
63_Y	82_S	0.717	1.00
257_L	341_T	0.717	1.00
20_A	23_T	0.716	1.00
11_G	18_S	0.714	1.00
209_M	338_L	0.714	1.00
43_S	48_V	0.711	1.00
109_E	127_A	0.708	1.00
80_Q	83_A	0.708	1.00
132_H	153_I	0.707	1.00
82_S	192_F	0.705	1.00
18_S	21_G	0.705	1.00
72_D	333_G	0.704	1.00
251_T	264_A	0.704	1.00
48_V	53_P	0.703	1.00
136_P	164_S	0.702	1.00
187_K	191_I	0.701	1.00
36_Q	39_A	0.701	1.00
259_M	284_Y	0.701	1.00
245_D	251_T	0.699	1.00
83_A	86_S	0.698	1.00
237_G	240_R	0.698	1.00
54_H	161_M	0.698	1.00
247_D	251_T	0.696	1.00
188_A	191_I	0.696	1.00
113_S	118_G	0.694	1.00
60_P	63_Y	0.694	1.00
225_V	229_W	0.694	1.00
22_C	26_Q	0.693	1.00
285_I	313_G	0.690	1.00
64_A	129_C	0.690	1.00
282_P	285_I	0.687	1.00
237_G	241_I	0.687	1.00
77_L	201_W	0.686	1.00
91_P	94_F	0.684	1.00
150_I	160_F	0.683	1.00
225_V	228_I	0.682	1.00
248_Q	251_T	0.681	1.00
44_Y	56_F	0.680	1.00
64_A	132_H	0.678	1.00
57_E	159_P	0.677	1.00
182_Y	186_E	0.676	1.00
336_V	339_F	0.675	1.00
7_I	10_G	0.671	1.00
185_F	201_W	0.670	1.00
109_E	112_A	0.669	1.00
27_S	30_D	0.668	1.00
85_A	111_L	0.667	1.00
113_S	117_S	0.667	1.00
212_I	215_G	0.667	1.00
227_A	250_N	0.666	1.00
328_G	331_F	0.665	1.00
12_A	18_S	0.664	1.00
70_W	163_S	0.664	1.00
333_G	337_D	0.663	1.00
44_Y	58_S	0.663	1.00
104_H	107_E	0.662	1.00
44_Y	60_P	0.660	1.00
78_G	81_P	0.657	1.00
179_Y	183_E	0.657	1.00
74_G	188_A	0.657	1.00
273_G	276_E	0.656	0.99
222_R	226_A	0.651	0.99
82_S	194_R	0.647	0.99
56_F	131_V	0.647	0.99
260_Q	265_G	0.645	0.99
253_T	344_L	0.643	0.99
75_M	80_Q	0.640	0.99
89_R	92_L	0.640	0.99
181_L	205_K	0.639	0.99
212_I	257_L	0.639	0.99
239_F	242_A	0.637	0.99
316_L	320_E	0.635	0.99
8_L	18_S	0.635	0.99
14_L	18_S	0.631	0.99
337_D	341_T	0.629	0.99
154_E	159_P	0.629	0.99
40_G	43_S	0.626	0.99
215_G	218_P	0.623	0.99
60_P	192_F	0.622	0.99
80_Q	107_E	0.622	0.99
77_L	198_F	0.620	0.99
336_V	340_S	0.618	0.99
77_L	189_A	0.617	0.99
201_W	205_K	0.616	0.99
72_D	335_I	0.615	0.99
67_P	135_D	0.615	0.99
157_A	160_F	0.614	0.99
134_I	160_F	0.613	0.99
286_G	325_V	0.613	0.99
212_I	338_L	0.613	0.99
215_G	345_A	0.610	0.99
225_V	286_G	0.609	0.99
238_Q	271_P	0.608	0.99
66_I	111_L	0.607	0.99
148_D	151_A	0.606	0.99
340_S	344_L	0.606	0.99
124_F	132_H	0.606	0.99
205_K	208_L	0.604	0.99
314_Q	319_V	0.604	0.99
186_E	189_A	0.602	0.99
62_T	130_D	0.602	0.99
65_A	70_W	0.601	0.99
52_P	150_I	0.599	0.99
246_P	251_T	0.599	0.99
102_A	106_A	0.597	0.99
328_G	343_A	0.595	0.99
54_H	154_E	0.593	0.99
246_P	266_A	0.592	0.99
121_K	124_F	0.590	0.99
111_L	127_A	0.589	0.99
192_F	195_R	0.588	0.99
89_R	110_Q	0.587	0.99
42_D	193_Q	0.586	0.99
287_A	324_L	0.586	0.99
338_L	342_E	0.586	0.99
209_M	256_R	0.581	0.99
212_I	216_L	0.576	0.99
37_T	40_G	0.575	0.99
223_P	283_D	0.575	0.99
335_I	339_F	0.574	0.99
123_N	127_A	0.574	0.99
227_A	288_V	0.574	0.99
54_H	159_P	0.572	0.99
303_V	307_F	0.571	0.99
14_L	20_A	0.568	0.99
77_L	192_F	0.568	0.99
19_L	22_C	0.567	0.99
84_T	129_C	0.565	0.98
208_L	339_F	0.564	0.98
47_T	55_T	0.563	0.98
179_Y	182_Y	0.563	0.98
278_L	282_P	0.560	0.98
202_Q	205_K	0.560	0.98
80_Q	104_H	0.560	0.98
290_G	329_G	0.559	0.98
186_E	195_R	0.557	0.98
307_F	310_N	0.556	0.98
56_F	161_M	0.555	0.98
26_Q	29_T	0.555	0.98
11_G	17_A	0.554	0.98
50_P	154_E	0.554	0.98
153_I	160_F	0.550	0.98
72_D	336_V	0.549	0.98
238_Q	241_I	0.549	0.98
75_M	83_A	0.549	0.98
286_G	348_V	0.549	0.98
90_A	93_K	0.549	0.98
185_F	202_Q	0.548	0.98
44_Y	47_T	0.547	0.98
89_R	93_K	0.545	0.98
249_N	252_L	0.543	0.98
132_H	160_F	0.542	0.98
66_I	134_I	0.539	0.98
9_A	13_S	0.538	0.98
182_Y	205_K	0.536	0.98
88_G	110_Q	0.536	0.98
310_N	313_G	0.535	0.98
241_I	244_L	0.534	0.98
70_W	133_L	0.533	0.98
310_N	314_Q	0.532	0.98
163_S	188_A	0.532	0.98
213_S	257_L	0.531	0.98
98_L	103_F	0.531	0.98
45_T	49_E	0.531	0.98
105_K	109_E	0.531	0.98
333_G	338_L	0.531	0.98
92_L	98_L	0.530	0.98
213_S	216_L	0.530	0.98
284_Y	347_M	0.530	0.98
121_K	153_I	0.529	0.98
341_T	345_A	0.528	0.98
224_T	262_A	0.528	0.98
124_F	127_A	0.528	0.98
46_V	56_F	0.527	0.98
226_A	231_G	0.523	0.98
49_E	187_K	0.523	0.98
245_D	248_Q	0.523	0.98
35_T	39_A	0.523	0.98
25_S	28_P	0.522	0.98
214_D	218_P	0.521	0.97
307_F	319_V	0.519	0.97
66_I	119_Y	0.518	0.97
250_N	254_Y	0.516	0.97
332_M	337_D	0.516	0.97
124_F	153_I	0.515	0.97
71_M	90_A	0.514	0.97
342_E	345_A	0.513	0.97
85_A	112_A	0.512	0.97
209_M	212_I	0.511	0.97
77_L	197_R	0.509	0.97
126_A	279_D	0.509	0.97
59_V	82_S	0.508	0.97
222_R	228_I	0.502	0.97
91_P	95_Y	0.502	0.97
122_E	273_G	0.502	0.97
109_E	126_A	0.502	0.97
312_N	315_Q	0.502	0.97
283_D	316_L	0.500	0.97
62_T	129_C	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ovkA	1	0.8073	100	0.31	Contact Map
4hn9A	1	0.7969	100	0.314	Contact Map
4mo9A	1	0.849	100	0.318	Contact Map
4n01A	1	0.7552	100	0.324	Contact Map
4pagA	2	0.7891	100	0.331	Contact Map
3pshA	1	0.8021	100	0.335	Contact Map
4inoA	1	0.7786	100	0.353	Contact Map
2etvA	2	0.7734	100	0.36	Contact Map
4mlzA	1	0.7708	100	0.364	Contact Map
4ljsA	1	0.8047	100	0.395	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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