GREMLIN Database
Q9HMF9 - Uncharacterized protein
UniProt: Q9HMF9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 384 (305)
Sequences: 9146 (7570)
Seq/√Len: 433.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_E199_E4.3691.00
281_D317_T4.2081.00
189_A198_F4.1171.00
182_Y206_A3.7661.00
317_T321_N3.6211.00
194_R197_R3.6081.00
190_E195_R3.3551.00
210_D214_D2.9931.00
203_S207_D2.9011.00
186_E202_Q2.8891.00
199_E203_S2.8761.00
65_A71_M2.8161.00
123_N126_A2.8101.00
197_R200_A2.8061.00
208_L342_E2.6981.00
308_E322_G2.5001.00
206_A210_D2.4121.00
207_D211_T2.3781.00
254_Y259_M2.3691.00
276_E279_D2.3161.00
283_D317_T2.3011.00
305_E309_A2.2811.00
211_T215_G2.2771.00
63_Y192_F2.2231.00
64_A124_F2.1781.00
224_T260_Q2.1341.00
74_G192_F2.1261.00
44_Y48_V2.0601.00
62_T84_T2.0311.00
304_V308_E1.9981.00
47_T53_P1.9841.00
284_Y323_N1.9271.00
200_A204_I1.9201.00
317_T320_E1.9031.00
45_T48_V1.8911.00
150_I154_E1.8041.00
301_D305_E1.8001.00
133_L188_A1.7831.00
284_Y325_V1.7591.00
49_E53_P1.7481.00
315_Q320_E1.7341.00
180_D183_E1.7281.00
119_Y124_F1.7071.00
79_I192_F1.7051.00
210_D213_S1.6941.00
196_A200_A1.6671.00
316_L319_V1.6481.00
151_A155_S1.6411.00
183_E186_E1.6311.00
79_I194_R1.6291.00
45_T53_P1.6271.00
214_D217_P1.6231.00
224_T283_D1.6051.00
14_L17_A1.5931.00
52_P154_E1.5831.00
225_V259_M1.5801.00
64_A127_A1.5741.00
48_V52_P1.5481.00
203_S206_A1.5461.00
276_E280_V1.5431.00
251_T255_R1.5291.00
109_E123_N1.5211.00
274_Y310_N1.5081.00
211_T214_D1.4901.00
195_R199_E1.4681.00
73_I185_F1.4571.00
45_T55_T1.4561.00
15_I18_S1.4481.00
122_E275_E1.4421.00
305_E308_E1.4361.00
223_P284_Y1.4251.00
285_I318_A1.4251.00
259_M348_V1.4231.00
197_R201_W1.4221.00
147_D151_A1.4121.00
62_T128_D1.4121.00
284_Y348_V1.4011.00
207_D210_D1.3981.00
208_L211_T1.3951.00
209_M341_T1.3871.00
204_I208_L1.3871.00
120_D123_N1.3751.00
131_V161_M1.3441.00
196_A199_E1.3401.00
152_A155_S1.3391.00
204_I207_D1.3291.00
94_F98_L1.3091.00
84_T127_A1.3041.00
223_P323_N1.3021.00
182_Y202_Q1.2801.00
61_E130_D1.2731.00
76_A201_W1.2641.00
85_A127_A1.2621.00
187_K190_E1.2571.00
13_S17_A1.2561.00
161_M187_K1.2541.00
74_G79_I1.2491.00
134_I162_G1.2481.00
313_G319_V1.2411.00
161_M191_I1.2381.00
56_F59_V1.2351.00
61_E82_S1.2221.00
63_Y131_V1.2151.00
201_W204_I1.2131.00
325_V347_M1.2071.00
121_K152_A1.1941.00
151_A154_E1.1861.00
209_M213_S1.1811.00
48_V51_N1.1811.00
56_F159_P1.1761.00
302_T305_E1.1751.00
213_S217_P1.1711.00
186_E206_A1.1651.00
183_E187_K1.1591.00
265_G280_V1.1481.00
262_A280_V1.1411.00
344_L348_V1.1411.00
176_G179_Y1.1351.00
146_T149_D1.1321.00
212_I345_A1.1251.00
211_T342_E1.1191.00
44_Y190_E1.1091.00
202_Q206_A1.1051.00
260_Q264_A1.1051.00
311_P314_Q1.1021.00
64_A85_A1.1001.00
65_A74_G1.0961.00
63_Y74_G1.0951.00
333_G336_V1.0941.00
212_I341_T1.0931.00
58_S61_E1.0931.00
56_F60_P1.0811.00
222_R260_Q1.0691.00
103_F106_A1.0671.00
246_P255_R1.0661.00
152_A156_S1.0661.00
317_T323_N1.0611.00
11_G15_I1.0611.00
15_I19_L1.0541.00
334_P337_D1.0471.00
313_G316_L1.0381.00
12_A16_A1.0361.00
186_E190_E1.0341.00
94_F97_A1.0331.00
185_F198_F1.0331.00
340_S343_A1.0311.00
131_V191_I1.0191.00
226_A229_W1.0181.00
262_A265_G1.0171.00
342_E346_K1.0141.00
205_K209_M1.0091.00
226_A282_P1.0021.00
199_E202_Q1.0001.00
302_T306_P0.9931.00
125_Y156_S0.9901.00
253_T341_T0.9881.00
149_D152_A0.9871.00
263_F280_V0.9761.00
95_Y98_L0.9761.00
77_L194_R0.9681.00
257_L348_V0.9681.00
125_Y158_G0.9651.00
59_V194_R0.9511.00
83_A108_I0.9501.00
277_L316_L0.9481.00
16_A20_A0.9481.00
208_L338_L0.9481.00
86_S108_I0.9431.00
200_A203_S0.9391.00
225_V254_Y0.9391.00
105_K108_I0.9341.00
213_S256_R0.9311.00
308_E324_L0.9261.00
87_L90_A0.9181.00
154_E160_F0.9161.00
93_K97_A0.9111.00
64_A111_L0.9101.00
319_V324_L0.9071.00
335_I338_L0.9041.00
44_Y59_V0.9021.00
51_N54_H0.9011.00
227_A254_Y0.9001.00
226_A230_R0.9001.00
228_I231_G0.8971.00
133_L191_I0.8971.00
60_P131_V0.8901.00
228_I310_N0.8901.00
184_A187_K0.8851.00
287_A326_R0.8841.00
303_V306_P0.8821.00
343_A346_K0.8821.00
74_G133_L0.8811.00
73_I188_A0.8801.00
43_S55_T0.8781.00
339_F343_A0.8761.00
219_E222_R0.8761.00
216_L345_A0.8751.00
337_D340_S0.8731.00
182_Y209_M0.8701.00
263_F276_E0.8681.00
252_L256_R0.8671.00
12_A15_I0.8661.00
263_F266_A0.8631.00
343_A347_M0.8601.00
59_V193_Q0.8571.00
334_P338_L0.8541.00
132_H158_G0.8541.00
252_L255_R0.8531.00
46_V161_M0.8511.00
228_I285_I0.8381.00
205_K256_R0.8381.00
92_L95_Y0.8371.00
132_H157_A0.8371.00
66_I132_H0.8351.00
93_K96_D0.8341.00
278_L316_L0.8341.00
226_A277_L0.8301.00
163_S187_K0.8271.00
286_G344_L0.8201.00
49_E52_P0.8171.00
272_I277_L0.8131.00
188_A192_F0.8121.00
74_G83_A0.8121.00
79_I82_S0.8111.00
17_A20_A0.8081.00
219_E223_P0.8071.00
198_F202_Q0.8021.00
129_C132_H0.7991.00
16_A19_L0.7971.00
208_L212_I0.7961.00
64_A84_T0.7911.00
22_C25_S0.7861.00
304_V326_R0.7821.00
13_S16_A0.7791.00
272_I280_V0.7771.00
240_R271_P0.7771.00
189_A202_Q0.7761.00
11_G14_L0.7711.00
237_G242_A0.7661.00
50_P162_G0.7621.00
306_P309_A0.7601.00
65_A83_A0.7591.00
60_P130_D0.7581.00
76_A185_F0.7551.00
56_F191_I0.7541.00
106_A109_E0.7541.00
261_D265_G0.7531.00
44_Y49_E0.7481.00
278_L312_N0.7461.00
334_P340_S0.7451.00
274_Y313_G0.7381.00
278_L315_Q0.7371.00
46_V49_E0.7351.00
88_G91_P0.7341.00
48_V54_H0.7301.00
44_Y57_E0.7251.00
216_L219_E0.7221.00
10_G14_L0.7201.00
73_I76_A0.7181.00
63_Y82_S0.7171.00
257_L341_T0.7171.00
20_A23_T0.7161.00
11_G18_S0.7141.00
209_M338_L0.7141.00
43_S48_V0.7111.00
109_E127_A0.7081.00
80_Q83_A0.7081.00
132_H153_I0.7071.00
82_S192_F0.7051.00
18_S21_G0.7051.00
72_D333_G0.7041.00
251_T264_A0.7041.00
48_V53_P0.7031.00
136_P164_S0.7021.00
187_K191_I0.7011.00
36_Q39_A0.7011.00
259_M284_Y0.7011.00
245_D251_T0.6991.00
83_A86_S0.6981.00
237_G240_R0.6981.00
54_H161_M0.6981.00
247_D251_T0.6961.00
188_A191_I0.6961.00
113_S118_G0.6941.00
60_P63_Y0.6941.00
225_V229_W0.6941.00
22_C26_Q0.6931.00
285_I313_G0.6901.00
64_A129_C0.6901.00
282_P285_I0.6871.00
237_G241_I0.6871.00
77_L201_W0.6861.00
91_P94_F0.6841.00
150_I160_F0.6831.00
225_V228_I0.6821.00
248_Q251_T0.6811.00
44_Y56_F0.6801.00
64_A132_H0.6781.00
57_E159_P0.6771.00
182_Y186_E0.6761.00
336_V339_F0.6751.00
7_I10_G0.6711.00
185_F201_W0.6701.00
109_E112_A0.6691.00
27_S30_D0.6681.00
85_A111_L0.6671.00
113_S117_S0.6671.00
212_I215_G0.6671.00
227_A250_N0.6661.00
328_G331_F0.6651.00
12_A18_S0.6641.00
70_W163_S0.6641.00
333_G337_D0.6631.00
44_Y58_S0.6631.00
104_H107_E0.6621.00
44_Y60_P0.6601.00
78_G81_P0.6571.00
179_Y183_E0.6571.00
74_G188_A0.6571.00
273_G276_E0.6560.99
222_R226_A0.6510.99
82_S194_R0.6470.99
56_F131_V0.6470.99
260_Q265_G0.6450.99
253_T344_L0.6430.99
75_M80_Q0.6400.99
89_R92_L0.6400.99
181_L205_K0.6390.99
212_I257_L0.6390.99
239_F242_A0.6370.99
316_L320_E0.6350.99
8_L18_S0.6350.99
14_L18_S0.6310.99
337_D341_T0.6290.99
154_E159_P0.6290.99
40_G43_S0.6260.99
215_G218_P0.6230.99
60_P192_F0.6220.99
80_Q107_E0.6220.99
77_L198_F0.6200.99
336_V340_S0.6180.99
77_L189_A0.6170.99
201_W205_K0.6160.99
72_D335_I0.6150.99
67_P135_D0.6150.99
157_A160_F0.6140.99
134_I160_F0.6130.99
286_G325_V0.6130.99
212_I338_L0.6130.99
215_G345_A0.6100.99
225_V286_G0.6090.99
238_Q271_P0.6080.99
66_I111_L0.6070.99
148_D151_A0.6060.99
340_S344_L0.6060.99
124_F132_H0.6060.99
205_K208_L0.6040.99
314_Q319_V0.6040.99
186_E189_A0.6020.99
62_T130_D0.6020.99
65_A70_W0.6010.99
52_P150_I0.5990.99
246_P251_T0.5990.99
102_A106_A0.5970.99
328_G343_A0.5950.99
54_H154_E0.5930.99
246_P266_A0.5920.99
121_K124_F0.5900.99
111_L127_A0.5890.99
192_F195_R0.5880.99
89_R110_Q0.5870.99
42_D193_Q0.5860.99
287_A324_L0.5860.99
338_L342_E0.5860.99
209_M256_R0.5810.99
212_I216_L0.5760.99
37_T40_G0.5750.99
223_P283_D0.5750.99
335_I339_F0.5740.99
123_N127_A0.5740.99
227_A288_V0.5740.99
54_H159_P0.5720.99
303_V307_F0.5710.99
14_L20_A0.5680.99
77_L192_F0.5680.99
19_L22_C0.5670.99
84_T129_C0.5650.98
208_L339_F0.5640.98
47_T55_T0.5630.98
179_Y182_Y0.5630.98
278_L282_P0.5600.98
202_Q205_K0.5600.98
80_Q104_H0.5600.98
290_G329_G0.5590.98
186_E195_R0.5570.98
307_F310_N0.5560.98
56_F161_M0.5550.98
26_Q29_T0.5550.98
11_G17_A0.5540.98
50_P154_E0.5540.98
153_I160_F0.5500.98
72_D336_V0.5490.98
238_Q241_I0.5490.98
75_M83_A0.5490.98
286_G348_V0.5490.98
90_A93_K0.5490.98
185_F202_Q0.5480.98
44_Y47_T0.5470.98
89_R93_K0.5450.98
249_N252_L0.5430.98
132_H160_F0.5420.98
66_I134_I0.5390.98
9_A13_S0.5380.98
182_Y205_K0.5360.98
88_G110_Q0.5360.98
310_N313_G0.5350.98
241_I244_L0.5340.98
70_W133_L0.5330.98
310_N314_Q0.5320.98
163_S188_A0.5320.98
213_S257_L0.5310.98
98_L103_F0.5310.98
45_T49_E0.5310.98
105_K109_E0.5310.98
333_G338_L0.5310.98
92_L98_L0.5300.98
213_S216_L0.5300.98
284_Y347_M0.5300.98
121_K153_I0.5290.98
341_T345_A0.5280.98
224_T262_A0.5280.98
124_F127_A0.5280.98
46_V56_F0.5270.98
226_A231_G0.5230.98
49_E187_K0.5230.98
245_D248_Q0.5230.98
35_T39_A0.5230.98
25_S28_P0.5220.98
214_D218_P0.5210.97
307_F319_V0.5190.97
66_I119_Y0.5180.97
250_N254_Y0.5160.97
332_M337_D0.5160.97
124_F153_I0.5150.97
71_M90_A0.5140.97
342_E345_A0.5130.97
85_A112_A0.5120.97
209_M212_I0.5110.97
77_L197_R0.5090.97
126_A279_D0.5090.97
59_V82_S0.5080.97
222_R228_I0.5020.97
91_P95_Y0.5020.97
122_E273_G0.5020.97
109_E126_A0.5020.97
312_N315_Q0.5020.97
283_D316_L0.5000.97
62_T129_C0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ovkA 1 0.8073 100 0.31 Contact Map
4hn9A 1 0.7969 100 0.314 Contact Map
4mo9A 1 0.849 100 0.318 Contact Map
4n01A 1 0.7552 100 0.324 Contact Map
4pagA 2 0.7891 100 0.331 Contact Map
3pshA 1 0.8021 100 0.335 Contact Map
4inoA 1 0.7786 100 0.353 Contact Map
2etvA 2 0.7734 100 0.36 Contact Map
4mlzA 1 0.7708 100 0.364 Contact Map
4ljsA 1 0.8047 100 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.