Q9HMF8 - HALSA - GREMLIN Contacts

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Q9HMF8 - Uncharacterized protein

UniProt:	Q9HMF8	Sequences: MNDTTDACTAPHDDCGIAGETLETVAFLARSEHRLGVLALLDGTARTRSDLEAHTDATRVTLSRVLNDLTERSLIEHDPSSNAYTLTQFGALVYRDFDRLLGTVAVGQALPSVINRLPVDWFDFDLQCLAGSEHVGTEQADPLAAARVVAGAVGAADSCRSLLGTFISLPMYTFGEAVRKGTAPSVTVIADAEVAATMTEDAALRERWEAIEAGTDRTTYYRIGERVPCSVDLIDGETVFLTVNRHQDAGFDVLRSTHPDVVAWAHATIESMQAGAVPLSQAARADD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	287 (249)
Sequences:	535 (466)
Seq/√Len:	29.5

HALSA - Q9HMF8 Q9HRH9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
187_T	273_Q	4.145	1.00
220_Y	273_Q	4.003	1.00
125_D	128_C	3.683	1.00
69_L	74_L	3.266	1.00
41_L	86_L	3.206	1.00
27_F	72_R	2.503	0.99
52_E	59_R	2.465	0.99
233_L	269_I	2.407	0.99
164_G	230_S	2.388	0.99
125_D	267_A	2.365	0.99
233_L	242_T	2.337	0.99
65_V	69_L	2.181	0.98
58_T	162_L	2.162	0.98
76_E	85_T	2.153	0.98
187_T	269_I	2.135	0.98
76_E	87_T	2.115	0.98
48_R	63_S	2.057	0.97
59_R	62_L	2.032	0.97
51_L	67_N	2.014	0.97
181_G	216_D	1.999	0.97
41_L	75_I	1.996	0.97
48_R	66_L	1.994	0.97
164_G	188_V	1.985	0.97
135_V	148_V	1.843	0.95
173_T	209_E	1.838	0.95
62_L	121_W	1.801	0.94
181_G	263_A	1.770	0.94
172_Y	176_E	1.768	0.94
34_R	38_L	1.734	0.93
84_Y	264_W	1.729	0.93
60_V	65_V	1.713	0.93
160_R	266_H	1.711	0.93
132_S	154_G	1.702	0.92
238_T	265_A	1.692	0.92
100_L	168_S	1.675	0.92
133_E	246_H	1.671	0.92
55_T	65_V	1.662	0.92
233_L	265_A	1.661	0.91
196_A	219_T	1.659	0.91
78_D	85_T	1.636	0.91
149_V	170_P	1.631	0.91
61_T	64_R	1.630	0.91
131_G	258_H	1.620	0.90
160_R	187_T	1.617	0.90
50_D	145_A	1.607	0.90
79_P	83_A	1.580	0.89
123_D	269_I	1.574	0.89
113_V	117_L	1.531	0.88
220_Y	276_A	1.530	0.88
40_L	46_R	1.515	0.87
117_L	123_D	1.507	0.87
234_I	269_I	1.504	0.87
87_T	156_A	1.504	0.87
198_M	220_Y	1.453	0.85
87_T	142_P	1.441	0.84
65_V	68_D	1.434	0.84
112_S	193_E	1.426	0.84
205_R	213_A	1.406	0.83
46_R	50_D	1.385	0.82
87_T	154_G	1.377	0.81
230_S	242_T	1.375	0.81
137_T	145_A	1.363	0.81
33_H	55_T	1.360	0.81
246_H	274_A	1.360	0.81
156_A	234_I	1.357	0.80
42_D	98_D	1.350	0.80
162_L	206_E	1.340	0.80
73_S	235_D	1.336	0.79
96_D	168_S	1.333	0.79
102_G	130_A	1.333	0.79
117_L	242_T	1.323	0.79
149_V	161_S	1.311	0.78
158_S	235_D	1.309	0.78
268_T	272_M	1.299	0.77
49_S	52_E	1.299	0.77
24_T	74_L	1.274	0.76
129_L	247_Q	1.270	0.76
191_D	269_I	1.269	0.76
25_V	101_L	1.259	0.75
35_L	74_L	1.252	0.75
44_T	210_A	1.242	0.74
240_F	243_V	1.238	0.74
26_A	30_R	1.237	0.74
194_V	231_V	1.229	0.73
244_N	248_D	1.220	0.73
118_P	142_P	1.217	0.73
254_L	264_W	1.216	0.73
134_H	180_K	1.209	0.72
63_S	86_L	1.207	0.72
181_G	246_H	1.201	0.72
42_D	86_L	1.195	0.71
193_E	251_F	1.194	0.71
148_V	255_R	1.190	0.71
47_T	50_D	1.188	0.71
169_L	215_T	1.186	0.71
60_V	64_R	1.180	0.70
86_L	161_S	1.170	0.70
131_G	217_R	1.168	0.69
91_A	162_L	1.162	0.69
75_I	116_R	1.155	0.69
48_R	106_V	1.143	0.68
162_L	272_M	1.137	0.67
37_V	76_E	1.127	0.67
132_S	187_T	1.121	0.66
64_R	142_P	1.118	0.66
106_V	166_F	1.112	0.66
43_G	108_Q	1.111	0.66
257_T	276_A	1.110	0.65
93_V	104_V	1.109	0.65
174_F	177_A	1.104	0.65
181_G	236_G	1.101	0.65
31_S	72_R	1.100	0.65
154_G	176_E	1.100	0.65
55_T	108_Q	1.088	0.64
48_R	113_V	1.079	0.63
95_R	278_P	1.078	0.63
29_A	69_L	1.074	0.63
144_A	217_R	1.059	0.62
260_D	274_A	1.053	0.61
53_A	80_S	1.049	0.61
68_D	276_A	1.038	0.60
107_G	112_S	1.036	0.60
92_L	115_N	1.033	0.60
240_F	280_S	1.031	0.60
43_G	136_G	1.028	0.59
153_V	277_V	1.016	0.58
122_F	126_L	1.013	0.58
74_L	255_R	1.013	0.58
58_T	150_A	1.011	0.58
120_D	174_F	1.011	0.58
140_A	255_R	1.008	0.58
126_L	254_L	1.002	0.57
45_A	187_T	0.995	0.57
211_I	217_R	0.994	0.57
75_I	266_H	0.981	0.56
33_H	66_L	0.981	0.56
32_E	35_L	0.975	0.55
122_F	125_D	0.975	0.55
75_I	102_G	0.969	0.55
159_C	229_C	0.966	0.55
29_A	66_L	0.964	0.54
95_R	274_A	0.964	0.54
44_T	102_G	0.962	0.54
205_R	279_L	0.962	0.54
31_S	34_R	0.961	0.54
143_L	168_S	0.961	0.54
122_F	243_V	0.960	0.54
33_H	74_L	0.959	0.54
240_F	244_N	0.955	0.54
73_S	91_A	0.947	0.53
153_V	189_I	0.940	0.53
51_L	98_D	0.935	0.52
109_A	279_L	0.934	0.52
149_V	168_S	0.932	0.52
102_G	198_M	0.929	0.52
66_L	107_G	0.927	0.52
190_A	207_R	0.919	0.51
61_T	65_V	0.914	0.51
232_D	253_V	0.911	0.50
66_L	168_S	0.909	0.50
175_G	210_A	0.907	0.50
259_P	263_A	0.906	0.50
161_S	219_T	0.905	0.50
61_T	142_P	0.904	0.50
134_H	204_L	0.904	0.50
242_T	269_I	0.899	0.49
25_V	29_A	0.899	0.49
178_V	214_G	0.895	0.49
151_G	200_E	0.894	0.49
192_A	203_A	0.889	0.49
139_Q	227_V	0.888	0.48
156_A	237_E	0.884	0.48
133_E	157_D	0.877	0.48
176_E	181_G	0.873	0.47
163_L	232_D	0.873	0.47
214_G	217_R	0.871	0.47
154_G	212_E	0.867	0.47
161_S	165_T	0.866	0.47
174_F	255_R	0.866	0.47
162_L	234_I	0.863	0.46
86_L	113_V	0.861	0.46
159_C	219_T	0.858	0.46
31_S	114_I	0.854	0.46
166_F	197_T	0.853	0.46
53_A	91_A	0.853	0.46
273_Q	276_A	0.852	0.46
28_L	64_R	0.847	0.45
31_S	256_S	0.841	0.45
43_G	205_R	0.839	0.45
34_R	60_V	0.835	0.44
59_R	114_I	0.833	0.44
208_W	279_L	0.832	0.44
38_L	264_W	0.828	0.44
52_E	254_L	0.827	0.44
44_T	127_Q	0.823	0.43
41_L	44_T	0.816	0.43
66_L	149_V	0.815	0.43
52_E	242_T	0.814	0.43
37_V	140_A	0.813	0.43
259_P	266_H	0.805	0.42
88_Q	159_C	0.803	0.42
59_R	63_S	0.802	0.42
151_G	178_V	0.796	0.41
31_S	37_V	0.790	0.41
228_P	238_T	0.789	0.41
98_D	269_I	0.789	0.41
98_D	157_D	0.788	0.41
89_F	192_A	0.788	0.41
134_H	143_L	0.786	0.41
32_E	198_M	0.785	0.40
37_V	57_A	0.783	0.40
210_A	231_V	0.783	0.40
52_E	57_A	0.781	0.40
71_E	199_T	0.775	0.40
48_R	110_L	0.774	0.40
113_V	165_T	0.768	0.39
162_L	212_E	0.759	0.39
178_V	251_F	0.755	0.38
31_S	63_S	0.755	0.38
59_R	94_Y	0.754	0.38
59_R	228_P	0.754	0.38
34_R	276_A	0.752	0.38
45_A	85_T	0.750	0.38
243_V	250_G	0.750	0.38
229_C	258_H	0.749	0.38
199_T	208_W	0.748	0.38
110_L	134_H	0.743	0.37
44_T	157_D	0.743	0.37
28_L	221_Y	0.742	0.37
37_V	44_T	0.741	0.37
70_T	178_V	0.738	0.37
256_S	261_V	0.738	0.37
87_T	270_E	0.735	0.37
25_V	31_S	0.732	0.37
75_I	180_K	0.732	0.37
187_T	218_T	0.731	0.36
45_A	83_A	0.730	0.36
71_E	224_G	0.729	0.36
192_A	256_S	0.727	0.36
155_A	272_M	0.725	0.36
89_F	143_L	0.722	0.36
102_G	113_V	0.721	0.36
50_D	98_D	0.721	0.36
108_Q	155_A	0.715	0.35
58_T	65_V	0.709	0.35
31_S	235_D	0.709	0.35
28_L	74_L	0.708	0.35
123_D	158_S	0.708	0.35
141_D	167_I	0.708	0.35
153_V	227_V	0.707	0.35
86_L	189_I	0.707	0.35
180_K	206_E	0.706	0.35
167_I	220_Y	0.703	0.34
97_F	100_L	0.701	0.34
91_A	269_I	0.699	0.34
71_E	155_A	0.699	0.34
235_D	270_E	0.697	0.34
93_V	278_P	0.694	0.34
66_L	84_Y	0.693	0.34
40_L	99_R	0.691	0.34
43_G	85_T	0.691	0.34
213_A	276_A	0.689	0.33
63_S	66_L	0.687	0.33
63_S	69_L	0.684	0.33
132_S	254_L	0.683	0.33
196_A	200_E	0.680	0.33
167_I	188_V	0.676	0.33
132_S	256_S	0.673	0.32
87_T	267_A	0.672	0.32
269_I	273_Q	0.672	0.32
58_T	272_M	0.672	0.32
59_R	242_T	0.670	0.32
189_I	252_D	0.669	0.32
57_A	114_I	0.667	0.32
44_T	269_I	0.667	0.32
32_E	200_E	0.666	0.32
218_T	278_P	0.660	0.31
213_A	266_H	0.658	0.31
161_S	196_A	0.655	0.31
187_T	231_V	0.653	0.31
46_R	270_E	0.650	0.31
209_E	277_V	0.650	0.31
55_T	63_S	0.649	0.31
75_I	157_D	0.649	0.31
180_K	200_E	0.648	0.31
79_P	214_G	0.647	0.31
68_D	72_R	0.641	0.30
170_P	188_V	0.637	0.30
27_F	68_D	0.632	0.30
77_H	84_Y	0.632	0.30
149_V	232_D	0.630	0.29
92_L	95_R	0.629	0.29
143_L	167_I	0.623	0.29
43_G	138_E	0.620	0.29
110_L	256_S	0.618	0.29
27_F	70_T	0.617	0.29
27_F	55_T	0.615	0.28
100_L	107_G	0.614	0.28
193_E	267_A	0.612	0.28
57_A	65_V	0.612	0.28
189_I	274_A	0.610	0.28
32_E	225_E	0.609	0.28
55_T	69_L	0.609	0.28
61_T	122_F	0.607	0.28
169_L	265_A	0.605	0.28
42_D	266_H	0.602	0.28
131_G	147_R	0.602	0.28
187_T	220_Y	0.601	0.28
86_L	168_S	0.600	0.28
228_P	276_A	0.595	0.27
87_T	105_A	0.592	0.27
248_D	265_A	0.591	0.27
169_L	172_Y	0.591	0.27
104_V	206_E	0.590	0.27
171_M	198_M	0.588	0.27
56_D	270_E	0.584	0.27
47_T	87_T	0.582	0.26
195_A	198_M	0.577	0.26
176_E	258_H	0.576	0.26
26_A	64_R	0.576	0.26
32_E	36_G	0.576	0.26
78_D	267_A	0.575	0.26
78_D	159_C	0.573	0.26
97_F	195_A	0.567	0.25
137_T	144_A	0.565	0.25
141_D	147_R	0.564	0.25
223_I	227_V	0.564	0.25
31_S	67_N	0.562	0.25
158_S	183_A	0.562	0.25
72_R	215_T	0.561	0.25
195_A	208_W	0.561	0.25
117_L	142_P	0.558	0.25
213_A	280_S	0.554	0.25
165_T	253_V	0.549	0.24
119_V	122_F	0.548	0.24
225_E	240_F	0.542	0.24
80_S	139_Q	0.538	0.24
69_L	114_I	0.534	0.24
37_V	65_V	0.534	0.24
125_D	129_L	0.534	0.24
191_D	237_E	0.533	0.23
39_A	98_D	0.530	0.23
29_A	33_H	0.529	0.23
137_T	178_V	0.528	0.23
163_L	231_V	0.528	0.23
25_V	133_E	0.527	0.23
38_L	41_L	0.527	0.23
24_T	55_T	0.526	0.23
163_L	196_A	0.526	0.23
47_T	97_F	0.523	0.23
27_F	252_D	0.523	0.23
69_L	269_I	0.522	0.23
76_E	175_G	0.520	0.23
73_S	119_V	0.519	0.23
71_E	260_D	0.519	0.23
49_S	165_T	0.517	0.23
40_L	229_C	0.517	0.23
85_T	159_C	0.516	0.23
189_I	270_E	0.515	0.22
24_T	108_Q	0.515	0.22
32_E	67_N	0.515	0.22
102_G	176_E	0.513	0.22
86_L	135_V	0.512	0.22
176_E	214_G	0.511	0.22
64_R	146_A	0.511	0.22
105_A	157_D	0.509	0.22
159_C	169_L	0.508	0.22
77_H	212_E	0.508	0.22
27_F	33_H	0.508	0.22
45_A	213_A	0.508	0.22
154_G	207_R	0.507	0.22
44_T	136_G	0.507	0.22
75_I	264_W	0.503	0.22
37_V	188_V	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qphA	2	0.8084	99.3	0.796	Contact Map
3df8A	2	0.3449	98.9	0.83	Contact Map
4k2eA	2	0.3206	98.8	0.837	Contact Map
1yyvA	2	0.3659	98.8	0.837	Contact Map
2f2eA	4	0.4704	98.7	0.841	Contact Map
2fswA	2	0.338	98.7	0.842	Contact Map
1u2wA	2	0.3554	98.7	0.843	Contact Map
1z7uA	2	0.3554	98.6	0.844	Contact Map
1y0uA	2	0.3031	98.6	0.844	Contact Map
3f6oA	2	0.324	98.6	0.846	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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