GREMLIN Database
Q9HMF8 - Uncharacterized protein
UniProt: Q9HMF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (249)
Sequences: 535 (466)
Seq/√Len: 29.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_T273_Q4.1451.00
220_Y273_Q4.0031.00
125_D128_C3.6831.00
69_L74_L3.2661.00
41_L86_L3.2061.00
27_F72_R2.5030.99
52_E59_R2.4650.99
233_L269_I2.4070.99
164_G230_S2.3880.99
125_D267_A2.3650.99
233_L242_T2.3370.99
65_V69_L2.1810.98
58_T162_L2.1620.98
76_E85_T2.1530.98
187_T269_I2.1350.98
76_E87_T2.1150.98
48_R63_S2.0570.97
59_R62_L2.0320.97
51_L67_N2.0140.97
181_G216_D1.9990.97
41_L75_I1.9960.97
48_R66_L1.9940.97
164_G188_V1.9850.97
135_V148_V1.8430.95
173_T209_E1.8380.95
62_L121_W1.8010.94
181_G263_A1.7700.94
172_Y176_E1.7680.94
34_R38_L1.7340.93
84_Y264_W1.7290.93
60_V65_V1.7130.93
160_R266_H1.7110.93
132_S154_G1.7020.92
238_T265_A1.6920.92
100_L168_S1.6750.92
133_E246_H1.6710.92
55_T65_V1.6620.92
233_L265_A1.6610.91
196_A219_T1.6590.91
78_D85_T1.6360.91
149_V170_P1.6310.91
61_T64_R1.6300.91
131_G258_H1.6200.90
160_R187_T1.6170.90
50_D145_A1.6070.90
79_P83_A1.5800.89
123_D269_I1.5740.89
113_V117_L1.5310.88
220_Y276_A1.5300.88
40_L46_R1.5150.87
117_L123_D1.5070.87
234_I269_I1.5040.87
87_T156_A1.5040.87
198_M220_Y1.4530.85
87_T142_P1.4410.84
65_V68_D1.4340.84
112_S193_E1.4260.84
205_R213_A1.4060.83
46_R50_D1.3850.82
87_T154_G1.3770.81
230_S242_T1.3750.81
137_T145_A1.3630.81
33_H55_T1.3600.81
246_H274_A1.3600.81
156_A234_I1.3570.80
42_D98_D1.3500.80
162_L206_E1.3400.80
73_S235_D1.3360.79
96_D168_S1.3330.79
102_G130_A1.3330.79
117_L242_T1.3230.79
149_V161_S1.3110.78
158_S235_D1.3090.78
268_T272_M1.2990.77
49_S52_E1.2990.77
24_T74_L1.2740.76
129_L247_Q1.2700.76
191_D269_I1.2690.76
25_V101_L1.2590.75
35_L74_L1.2520.75
44_T210_A1.2420.74
240_F243_V1.2380.74
26_A30_R1.2370.74
194_V231_V1.2290.73
244_N248_D1.2200.73
118_P142_P1.2170.73
254_L264_W1.2160.73
134_H180_K1.2090.72
63_S86_L1.2070.72
181_G246_H1.2010.72
42_D86_L1.1950.71
193_E251_F1.1940.71
148_V255_R1.1900.71
47_T50_D1.1880.71
169_L215_T1.1860.71
60_V64_R1.1800.70
86_L161_S1.1700.70
131_G217_R1.1680.69
91_A162_L1.1620.69
75_I116_R1.1550.69
48_R106_V1.1430.68
162_L272_M1.1370.67
37_V76_E1.1270.67
132_S187_T1.1210.66
64_R142_P1.1180.66
106_V166_F1.1120.66
43_G108_Q1.1110.66
257_T276_A1.1100.65
93_V104_V1.1090.65
174_F177_A1.1040.65
181_G236_G1.1010.65
31_S72_R1.1000.65
154_G176_E1.1000.65
55_T108_Q1.0880.64
48_R113_V1.0790.63
95_R278_P1.0780.63
29_A69_L1.0740.63
144_A217_R1.0590.62
260_D274_A1.0530.61
53_A80_S1.0490.61
68_D276_A1.0380.60
107_G112_S1.0360.60
92_L115_N1.0330.60
240_F280_S1.0310.60
43_G136_G1.0280.59
153_V277_V1.0160.58
122_F126_L1.0130.58
74_L255_R1.0130.58
58_T150_A1.0110.58
120_D174_F1.0110.58
140_A255_R1.0080.58
126_L254_L1.0020.57
45_A187_T0.9950.57
211_I217_R0.9940.57
75_I266_H0.9810.56
33_H66_L0.9810.56
32_E35_L0.9750.55
122_F125_D0.9750.55
75_I102_G0.9690.55
159_C229_C0.9660.55
29_A66_L0.9640.54
95_R274_A0.9640.54
44_T102_G0.9620.54
205_R279_L0.9620.54
31_S34_R0.9610.54
143_L168_S0.9610.54
122_F243_V0.9600.54
33_H74_L0.9590.54
240_F244_N0.9550.54
73_S91_A0.9470.53
153_V189_I0.9400.53
51_L98_D0.9350.52
109_A279_L0.9340.52
149_V168_S0.9320.52
102_G198_M0.9290.52
66_L107_G0.9270.52
190_A207_R0.9190.51
61_T65_V0.9140.51
232_D253_V0.9110.50
66_L168_S0.9090.50
175_G210_A0.9070.50
259_P263_A0.9060.50
161_S219_T0.9050.50
61_T142_P0.9040.50
134_H204_L0.9040.50
242_T269_I0.8990.49
25_V29_A0.8990.49
178_V214_G0.8950.49
151_G200_E0.8940.49
192_A203_A0.8890.49
139_Q227_V0.8880.48
156_A237_E0.8840.48
133_E157_D0.8770.48
176_E181_G0.8730.47
163_L232_D0.8730.47
214_G217_R0.8710.47
154_G212_E0.8670.47
161_S165_T0.8660.47
174_F255_R0.8660.47
162_L234_I0.8630.46
86_L113_V0.8610.46
159_C219_T0.8580.46
31_S114_I0.8540.46
166_F197_T0.8530.46
53_A91_A0.8530.46
273_Q276_A0.8520.46
28_L64_R0.8470.45
31_S256_S0.8410.45
43_G205_R0.8390.45
34_R60_V0.8350.44
59_R114_I0.8330.44
208_W279_L0.8320.44
38_L264_W0.8280.44
52_E254_L0.8270.44
44_T127_Q0.8230.43
41_L44_T0.8160.43
66_L149_V0.8150.43
52_E242_T0.8140.43
37_V140_A0.8130.43
259_P266_H0.8050.42
88_Q159_C0.8030.42
59_R63_S0.8020.42
151_G178_V0.7960.41
31_S37_V0.7900.41
228_P238_T0.7890.41
98_D269_I0.7890.41
98_D157_D0.7880.41
89_F192_A0.7880.41
134_H143_L0.7860.41
32_E198_M0.7850.40
37_V57_A0.7830.40
210_A231_V0.7830.40
52_E57_A0.7810.40
71_E199_T0.7750.40
48_R110_L0.7740.40
113_V165_T0.7680.39
162_L212_E0.7590.39
178_V251_F0.7550.38
31_S63_S0.7550.38
59_R94_Y0.7540.38
59_R228_P0.7540.38
34_R276_A0.7520.38
45_A85_T0.7500.38
243_V250_G0.7500.38
229_C258_H0.7490.38
199_T208_W0.7480.38
110_L134_H0.7430.37
44_T157_D0.7430.37
28_L221_Y0.7420.37
37_V44_T0.7410.37
70_T178_V0.7380.37
256_S261_V0.7380.37
87_T270_E0.7350.37
25_V31_S0.7320.37
75_I180_K0.7320.37
187_T218_T0.7310.36
45_A83_A0.7300.36
71_E224_G0.7290.36
192_A256_S0.7270.36
155_A272_M0.7250.36
89_F143_L0.7220.36
102_G113_V0.7210.36
50_D98_D0.7210.36
108_Q155_A0.7150.35
58_T65_V0.7090.35
31_S235_D0.7090.35
28_L74_L0.7080.35
123_D158_S0.7080.35
141_D167_I0.7080.35
153_V227_V0.7070.35
86_L189_I0.7070.35
180_K206_E0.7060.35
167_I220_Y0.7030.34
97_F100_L0.7010.34
91_A269_I0.6990.34
71_E155_A0.6990.34
235_D270_E0.6970.34
93_V278_P0.6940.34
66_L84_Y0.6930.34
40_L99_R0.6910.34
43_G85_T0.6910.34
213_A276_A0.6890.33
63_S66_L0.6870.33
63_S69_L0.6840.33
132_S254_L0.6830.33
196_A200_E0.6800.33
167_I188_V0.6760.33
132_S256_S0.6730.32
87_T267_A0.6720.32
269_I273_Q0.6720.32
58_T272_M0.6720.32
59_R242_T0.6700.32
189_I252_D0.6690.32
57_A114_I0.6670.32
44_T269_I0.6670.32
32_E200_E0.6660.32
218_T278_P0.6600.31
213_A266_H0.6580.31
161_S196_A0.6550.31
187_T231_V0.6530.31
46_R270_E0.6500.31
209_E277_V0.6500.31
55_T63_S0.6490.31
75_I157_D0.6490.31
180_K200_E0.6480.31
79_P214_G0.6470.31
68_D72_R0.6410.30
170_P188_V0.6370.30
27_F68_D0.6320.30
77_H84_Y0.6320.30
149_V232_D0.6300.29
92_L95_R0.6290.29
143_L167_I0.6230.29
43_G138_E0.6200.29
110_L256_S0.6180.29
27_F70_T0.6170.29
27_F55_T0.6150.28
100_L107_G0.6140.28
193_E267_A0.6120.28
57_A65_V0.6120.28
189_I274_A0.6100.28
32_E225_E0.6090.28
55_T69_L0.6090.28
61_T122_F0.6070.28
169_L265_A0.6050.28
42_D266_H0.6020.28
131_G147_R0.6020.28
187_T220_Y0.6010.28
86_L168_S0.6000.28
228_P276_A0.5950.27
87_T105_A0.5920.27
248_D265_A0.5910.27
169_L172_Y0.5910.27
104_V206_E0.5900.27
171_M198_M0.5880.27
56_D270_E0.5840.27
47_T87_T0.5820.26
195_A198_M0.5770.26
176_E258_H0.5760.26
26_A64_R0.5760.26
32_E36_G0.5760.26
78_D267_A0.5750.26
78_D159_C0.5730.26
97_F195_A0.5670.25
137_T144_A0.5650.25
141_D147_R0.5640.25
223_I227_V0.5640.25
31_S67_N0.5620.25
158_S183_A0.5620.25
72_R215_T0.5610.25
195_A208_W0.5610.25
117_L142_P0.5580.25
213_A280_S0.5540.25
165_T253_V0.5490.24
119_V122_F0.5480.24
225_E240_F0.5420.24
80_S139_Q0.5380.24
69_L114_I0.5340.24
37_V65_V0.5340.24
125_D129_L0.5340.24
191_D237_E0.5330.23
39_A98_D0.5300.23
29_A33_H0.5290.23
137_T178_V0.5280.23
163_L231_V0.5280.23
25_V133_E0.5270.23
38_L41_L0.5270.23
24_T55_T0.5260.23
163_L196_A0.5260.23
47_T97_F0.5230.23
27_F252_D0.5230.23
69_L269_I0.5220.23
76_E175_G0.5200.23
73_S119_V0.5190.23
71_E260_D0.5190.23
49_S165_T0.5170.23
40_L229_C0.5170.23
85_T159_C0.5160.23
189_I270_E0.5150.22
24_T108_Q0.5150.22
32_E67_N0.5150.22
102_G176_E0.5130.22
86_L135_V0.5120.22
176_E214_G0.5110.22
64_R146_A0.5110.22
105_A157_D0.5090.22
159_C169_L0.5080.22
77_H212_E0.5080.22
27_F33_H0.5080.22
45_A213_A0.5080.22
154_G207_R0.5070.22
44_T136_G0.5070.22
75_I264_W0.5030.22
37_V188_V0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qphA 2 0.8084 99.3 0.796 Contact Map
3df8A 2 0.3449 98.9 0.83 Contact Map
4k2eA 2 0.3206 98.8 0.837 Contact Map
1yyvA 2 0.3659 98.8 0.837 Contact Map
2f2eA 4 0.4704 98.7 0.841 Contact Map
2fswA 2 0.338 98.7 0.842 Contact Map
1u2wA 2 0.3554 98.7 0.843 Contact Map
1z7uA 2 0.3554 98.6 0.844 Contact Map
1y0uA 2 0.3031 98.6 0.844 Contact Map
3f6oA 2 0.324 98.6 0.846 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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