GREMLIN Database
Q9HMF7 - TRK potassium uptake system protein
UniProt: Q9HMF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 515 (405)
Sequences: 5222 (3913)
Seq/√Len: 194.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
368_A374_V4.1621.00
439_G489_N3.6551.00
121_N483_K3.4561.00
216_I230_I3.3241.00
262_V327_L3.2361.00
120_L484_G3.0981.00
219_L261_T3.0851.00
215_A264_I2.8881.00
157_W212_T2.7921.00
222_A254_S2.5391.00
369_A379_L2.4621.00
343_T351_V2.4461.00
245_R251_A2.3911.00
247_G251_A2.3711.00
218_L260_A2.3641.00
87_A119_P2.3481.00
452_P455_Y2.3321.00
156_E235_T2.3021.00
222_A256_A2.2971.00
318_S321_A2.2731.00
123_V487_I2.2471.00
153_S231_N2.2471.00
447_L482_A2.2071.00
266_I299_F2.1931.00
294_W383_I2.1661.00
305_V359_F2.1261.00
220_L226_P2.1241.00
149_H227_W2.1011.00
146_R150_W2.0911.00
303_A327_L2.0901.00
91_V119_P2.0831.00
235_T339_F2.0131.00
120_L487_I2.0111.00
333_A360_A2.0111.00
127_I487_I1.9941.00
222_A260_A1.9841.00
306_L356_P1.9801.00
232_H243_A1.9721.00
117_L143_D1.9461.00
216_I226_P1.9411.00
258_E325_I1.9371.00
302_G363_G1.9121.00
87_A91_V1.9041.00
258_E324_R1.8801.00
269_S295_V1.8751.00
262_V331_V1.8641.00
222_A257_I1.8541.00
269_S335_S1.8451.00
147_A151_W1.8071.00
120_L480_A1.7991.00
83_G127_I1.7871.00
139_T142_G1.7771.00
307_S311_F1.7621.00
256_A260_A1.7601.00
249_I261_T1.7581.00
220_L229_A1.7521.00
184_Y187_E1.7311.00
266_I331_V1.7201.00
118_H121_N1.7161.00
237_I268_G1.7031.00
302_G330_F1.7001.00
361_C461_M1.6861.00
218_L256_A1.6781.00
320_A324_R1.6781.00
459_D474_T1.6701.00
440_V457_L1.6621.00
136_T140_T1.6561.00
255_P324_R1.6311.00
258_E341_T1.6161.00
259_Y263_P1.6031.00
462_S467_V1.5801.00
253_N325_I1.5791.00
436_L461_M1.5721.00
183_L187_E1.5711.00
140_T143_D1.5631.00
76_A491_W1.5481.00
307_S326_G1.5441.00
447_L479_P1.5421.00
259_Y324_R1.5401.00
202_Q206_R1.5341.00
297_A301_V1.5121.00
384_T413_L1.5101.00
385_L429_F1.5101.00
265_M337_T1.4951.00
390_A394_R1.4921.00
216_I233_G1.4891.00
336_N467_V1.4881.00
377_I382_V1.4881.00
117_L144_L1.4641.00
309_L356_P1.4621.00
455_Y471_A1.4531.00
236_G261_T1.4381.00
90_F155_T1.4341.00
128_S242_F1.4311.00
265_M332_S1.4291.00
245_R252_Y1.4251.00
299_F331_V1.4201.00
259_Y320_A1.4141.00
219_L257_I1.4131.00
292_T296_V1.4101.00
330_F333_A1.4091.00
447_L481_L1.3961.00
439_G485_M1.3911.00
444_L447_L1.3911.00
125_E137_M1.3871.00
289_D409_G1.3871.00
451_H473_I1.3851.00
120_L483_K1.3811.00
313_T316_Y1.3771.00
141_E246_A1.3741.00
149_H153_S1.3711.00
228_D245_R1.3711.00
218_L222_A1.3691.00
314_G317_D1.3641.00
366_T379_L1.3621.00
231_N244_V1.3591.00
470_D474_T1.3591.00
301_V305_V1.3551.00
284_R288_A1.3541.00
156_E240_G1.3521.00
263_P267_A1.3511.00
119_P123_V1.3451.00
484_G488_I1.3451.00
436_L464_Q1.3441.00
127_I491_W1.3421.00
224_M257_I1.3381.00
311_F322_S1.3331.00
259_Y327_L1.3251.00
484_G487_I1.3241.00
329_Q341_T1.3121.00
224_M228_D1.3121.00
344_I360_A1.2991.00
306_L360_A1.2921.00
123_V484_G1.2881.00
294_W379_L1.2861.00
362_L366_T1.2801.00
361_C457_L1.2761.00
443_L485_M1.2711.00
117_L138_A1.2691.00
303_A326_G1.2661.00
405_S412_K1.2621.00
259_Y323_F1.2581.00
236_G339_F1.2521.00
319_L323_F1.2471.00
198_I202_Q1.2461.00
226_P230_I1.2461.00
277_L285_N1.2451.00
215_A233_G1.2411.00
220_L225_P1.2371.00
451_H456_V1.2371.00
232_H244_V1.2291.00
357_T471_A1.2271.00
300_A303_A1.2271.00
146_R227_W1.2211.00
129_G242_F1.2201.00
140_T246_A1.2161.00
298_W379_L1.2151.00
488_I492_V1.2131.00
432_W464_Q1.2071.00
366_T382_V1.2071.00
473_I477_G1.2051.00
126_T155_T1.2011.00
307_S322_S1.1981.00
255_P258_E1.1951.00
313_T317_D1.1891.00
247_G250_G1.1881.00
121_N137_M1.1831.00
211_L267_A1.1781.00
439_G460_V1.1771.00
344_I352_W1.1741.00
139_T246_A1.1681.00
236_G264_I1.1671.00
440_V460_V1.1641.00
144_L152_R1.1581.00
266_I296_V1.1561.00
325_I329_Q1.1461.00
115_V145_P1.1381.00
250_G340_G1.1381.00
478_M486_L1.1341.00
384_T418_A1.1261.00
460_V489_N1.1261.00
153_S230_I1.1251.00
325_I342_T1.1211.00
258_E262_V1.1131.00
123_V127_I1.1121.00
303_A323_F1.1111.00
303_A330_F1.1051.00
118_H480_A1.1041.00
444_L482_A1.1031.00
298_W302_G1.0991.00
184_Y188_A1.0981.00
321_A325_I1.0941.00
211_L275_H1.0861.00
183_L186_S1.0861.00
361_C458_F1.0811.00
443_L481_L1.0801.00
94_A147_A1.0791.00
86_G155_T1.0761.00
365_L436_L1.0751.00
153_S227_W1.0731.00
305_V355_G1.0721.00
150_W154_L1.0651.00
86_G126_T1.0641.00
344_I471_A1.0611.00
370_A380_I1.0561.00
250_G343_T1.0531.00
436_L440_V1.0521.00
262_V303_A1.0421.00
353_Q356_P1.0341.00
265_M331_V1.0321.00
259_Y262_V1.0291.00
217_A221_L1.0281.00
293_R409_G1.0281.00
303_A307_S1.0271.00
91_V122_A1.0251.00
80_A491_W1.0221.00
180_S187_E1.0181.00
253_N258_E1.0181.00
215_A261_T1.0171.00
255_P259_Y1.0171.00
290_L383_I1.0121.00
206_R210_G1.0091.00
309_L355_G1.0071.00
478_M482_A1.0051.00
153_S234_M1.0041.00
306_L330_F0.9991.00
93_V148_L0.9941.00
266_I295_V0.9891.00
78_A163_V0.9870.99
479_P482_A0.9850.99
294_W386_I0.9820.99
415_E419_Q0.9800.99
140_T144_L0.9800.99
146_R149_H0.9800.99
82_V130_F0.9790.99
243_A246_A0.9760.99
225_P229_A0.9730.99
290_L387_K0.9720.99
254_S257_I0.9720.99
325_I341_T0.9710.99
73_V77_T0.9700.99
357_T455_Y0.9700.99
212_T233_G0.9690.99
215_A260_A0.9660.99
138_A144_L0.9660.99
255_P320_A0.9650.99
161_V205_W0.9620.99
428_V432_W0.9610.99
290_L409_G0.9600.99
219_L236_G0.9580.99
243_A248_S0.9580.99
298_W366_T0.9560.99
215_A219_L0.9520.99
460_V486_L0.9490.99
150_W227_W0.9460.99
129_G152_R0.9460.99
274_V292_T0.9430.99
87_A123_V0.9430.99
463_A486_L0.9420.99
137_M140_T0.9390.99
221_L256_A0.9360.99
302_G359_F0.9340.99
355_G441_A0.9290.99
215_A236_G0.9270.99
443_L447_L0.9150.99
307_S323_F0.9150.99
345_G351_V0.9140.99
345_G357_T0.9140.99
83_G130_F0.9140.99
125_E140_T0.9100.99
142_G246_A0.9060.99
388_G426_T0.9030.99
386_I390_A0.9020.99
180_S184_Y0.8980.99
364_M467_V0.8970.99
140_T152_R0.8920.99
219_L260_A0.8920.99
296_V300_A0.8900.99
270_I292_T0.8890.99
267_A275_H0.8820.99
462_S470_D0.8760.99
481_L485_M0.8740.99
299_F327_L0.8700.99
240_G336_N0.8690.99
459_D470_D0.8670.99
244_V252_Y0.8670.99
232_H245_R0.8660.99
179_G184_Y0.8630.99
354_T454_E0.8630.99
77_T81_V0.8620.99
333_A469_L0.8540.99
311_F319_L0.8520.99
182_T196_S0.8520.99
429_F433_L0.8470.98
127_I500_I0.8460.98
125_E152_R0.8460.98
90_F148_L0.8460.98
435_F492_V0.8440.98
84_V119_P0.8400.98
392_Q419_Q0.8360.98
290_L294_W0.8360.98
213_L217_A0.8350.98
370_A379_L0.8340.98
153_S235_T0.8330.98
387_K408_I0.8300.98
217_A220_L0.8260.98
440_V453_L0.8260.98
207_L211_L0.8220.98
329_Q360_A0.8210.98
394_R404_R0.8210.98
219_L249_I0.8210.98
464_Q489_N0.8200.98
249_I257_I0.8200.98
225_P228_D0.8160.98
135_L462_S0.8140.98
211_L237_I0.8100.98
345_G471_A0.8090.98
320_A323_F0.8090.98
482_A486_L0.8080.98
156_E238_A0.8070.98
391_W406_L0.8050.98
387_K406_L0.8040.98
330_F363_G0.7990.98
262_V266_I0.7980.98
203_E276_Y0.7980.98
275_H286_V0.7940.98
88_L92_L0.7930.98
225_P252_Y0.7910.98
180_S183_L0.7910.98
461_M465_S0.7870.97
153_S156_E0.7830.97
216_I220_L0.7830.97
130_F155_T0.7820.97
364_M462_S0.7790.97
83_G123_V0.7770.97
239_T335_S0.7770.97
432_W436_L0.7740.97
299_F303_A0.7740.97
182_T185_E0.7730.97
196_S199_T0.7720.97
119_P484_G0.7710.97
310_L326_G0.7710.97
359_F441_A0.7690.97
277_L288_A0.7660.97
91_V116_F0.7650.97
183_L188_A0.7610.97
166_L205_W0.7600.97
329_Q344_I0.7570.97
125_E136_T0.7550.97
305_V309_L0.7540.97
385_L389_T0.7510.97
185_E188_A0.7470.97
352_W356_P0.7440.96
288_A292_T0.7400.96
136_T152_R0.7370.96
120_L486_L0.7360.96
178_S198_I0.7360.96
178_S182_T0.7360.96
361_C454_E0.7350.96
199_T202_Q0.7340.96
431_L498_I0.7330.96
228_D232_H0.7320.96
231_N235_T0.7230.96
497_I501_A0.7230.96
249_I252_Y0.7170.96
365_L432_W0.7140.96
440_V461_M0.7140.96
210_G214_G0.7110.95
76_A500_I0.7110.95
440_V456_V0.7100.95
156_E234_M0.7090.95
458_F469_L0.7080.95
477_G480_A0.7040.95
342_T352_W0.7040.95
269_S368_A0.7010.95
145_P148_L0.6990.95
292_T295_V0.6980.95
474_T478_M0.6940.95
84_V87_A0.6940.95
327_L331_V0.6930.95
135_L463_A0.6870.95
435_F489_N0.6870.95
208_F238_A0.6860.95
239_T373_T0.6860.95
232_H261_T0.6840.94
391_W415_E0.6810.94
340_G343_T0.6800.94
435_F439_G0.6790.94
89_P151_W0.6790.94
215_A218_L0.6770.94
92_L147_A0.6770.94
273_P371_G0.6760.94
319_L322_S0.6750.94
142_G245_R0.6740.94
389_T431_L0.6730.94
274_V289_D0.6730.94
434_A438_I0.6710.94
358_L453_L0.6670.94
223_G227_W0.6670.94
239_T337_T0.6660.94
122_A126_T0.6650.94
69_P73_V0.6650.94
293_R297_A0.6640.94
291_Q369_A0.6640.94
329_Q332_S0.6630.93
389_T427_L0.6620.93
239_T268_G0.6610.93
249_I258_E0.6590.93
200_T372_S0.6580.93
492_V500_I0.6570.93
456_V473_I0.6560.93
212_T216_I0.6550.93
430_V434_A0.6530.93
71_A74_T0.6520.93
258_E329_Q0.6520.93
282_D285_N0.6510.93
232_H339_F0.6500.93
207_L275_H0.6500.93
385_L426_T0.6480.93
226_P229_A0.6470.93
454_E471_A0.6460.93
91_V118_H0.6450.93
275_H279_F0.6450.93
270_I275_H0.6450.93
340_G469_L0.6440.92
333_A363_G0.6430.92
180_S186_S0.6430.92
156_E339_F0.6420.92
483_K487_I0.6420.92
233_G264_I0.6410.92
315_Q351_V0.6410.92
248_S467_V0.6400.92
205_W209_V0.6390.92
458_F470_D0.6390.92
135_L469_L0.6390.92
117_L145_P0.6360.92
333_A344_I0.6340.92
453_L456_V0.6330.92
256_A259_Y0.6330.92
84_V123_V0.6330.92
444_L486_L0.6320.92
387_K390_A0.6290.92
177_S180_S0.6260.91
72_M502_V0.6240.91
141_E149_H0.6220.91
250_G253_N0.6200.91
457_L461_M0.6180.91
328_F339_F0.6160.91
157_W208_F0.6150.91
271_A291_Q0.6140.91
358_L362_L0.6120.90
227_W231_N0.6110.90
135_L470_D0.6110.90
287_Y291_Q0.6110.90
136_T141_E0.6100.90
455_Y473_I0.6090.90
91_V117_L0.6090.90
124_F137_M0.6090.90
462_S474_T0.6090.90
222_A252_Y0.6080.90
295_V299_F0.6080.90
451_H478_M0.6080.90
210_G213_L0.6080.90
432_W465_S0.6030.90
211_L268_G0.6020.90
464_Q497_I0.6020.90
480_A483_K0.6010.90
332_S469_L0.6000.90
361_C471_A0.5990.89
444_L460_V0.5990.89
344_I476_P0.5980.89
212_T234_M0.5980.89
354_T357_T0.5970.89
458_F462_S0.5960.89
208_F212_T0.5950.89
294_W298_W0.5950.89
213_L216_I0.5920.89
132_G336_N0.5920.89
270_I295_V0.5920.89
368_A379_L0.5910.89
118_H122_A0.5910.89
249_I328_F0.5900.89
284_R287_Y0.5900.89
377_I429_F0.5900.89
221_L229_A0.5890.89
228_D244_V0.5850.88
69_P77_T0.5850.88
250_G341_T0.5840.88
181_Y186_S0.5840.88
138_A143_D0.5840.88
179_G187_E0.5820.88
480_A484_G0.5820.88
246_A251_A0.5820.88
234_M238_A0.5810.88
317_D326_G0.5800.88
83_G491_W0.5790.88
345_G473_I0.5770.88
361_C365_L0.5730.87
91_V145_P0.5730.87
300_A304_A0.5730.87
316_Y325_I0.5720.87
135_L459_D0.5720.87
456_V460_V0.5710.87
435_F464_Q0.5700.87
336_N375_S0.5690.87
132_G239_T0.5680.87
323_F327_L0.5660.87
143_D146_R0.5660.87
88_L91_V0.5660.87
137_M483_K0.5660.87
459_D469_L0.5660.87
455_Y478_M0.5650.87
332_S337_T0.5640.87
135_L474_T0.5630.86
194_H200_T0.5630.86
212_T237_I0.5630.86
384_T388_G0.5620.86
117_L121_N0.5610.86
204_I494_R0.5610.86
364_M465_S0.5600.86
389_T430_V0.5590.86
362_L437_A0.5590.86
67_K70_D0.5580.86
131_T375_S0.5550.86
164_I478_M0.5540.86
385_L430_V0.5540.86
315_Q342_T0.5540.86
459_D462_S0.5540.86
266_I292_T0.5530.85
459_D486_L0.5520.85
219_L339_F0.5500.85
306_L326_G0.5480.85
307_S319_L0.5480.85
431_L435_F0.5480.85
286_V289_D0.5470.85
150_W153_S0.5470.85
94_A116_F0.5460.85
304_A308_A0.5450.85
283_L287_Y0.5450.85
281_G284_R0.5440.85
171_L503_L0.5430.84
436_L457_L0.5420.84
266_I327_L0.5420.84
128_S133_T0.5420.84
278_L286_V0.5420.84
506_A510_H0.5410.84
136_T235_T0.5410.84
451_H455_Y0.5400.84
329_Q352_W0.5390.84
161_V204_I0.5390.84
131_T238_A0.5370.84
138_A141_E0.5370.84
249_I341_T0.5360.84
336_N464_Q0.5350.84
418_A421_E0.5340.83
276_Y280_T0.5330.83
138_A152_R0.5330.83
230_I233_G0.5330.83
248_S341_T0.5320.83
309_L353_Q0.5310.83
243_A247_G0.5310.83
182_T198_I0.5300.83
90_F126_T0.5300.83
393_I505_S0.5290.83
373_T378_K0.5290.83
299_F330_F0.5280.83
73_V76_A0.5260.82
298_W363_G0.5260.82
308_A312_Y0.5250.82
147_A150_W0.5240.82
427_L431_L0.5220.82
470_D476_P0.5220.82
444_L463_A0.5210.82
316_Y342_T0.5200.82
330_F360_A0.5200.82
459_D463_A0.5200.82
235_T467_V0.5190.82
116_F137_M0.5160.81
436_L460_V0.5160.81
331_V462_S0.5160.81
216_I234_M0.5160.81
300_A319_L0.5150.81
157_W234_M0.5150.81
150_W231_N0.5150.81
136_T340_G0.5140.81
265_M299_F0.5140.81
290_L408_I0.5130.81
131_T371_G0.5120.81
265_M330_F0.5100.81
477_G481_L0.5090.80
221_L226_P0.5090.80
136_T246_A0.5090.80
287_Y292_T0.5090.80
143_D246_A0.5080.80
174_G179_G0.5080.80
396_V407_R0.5070.80
122_A144_L0.5070.80
340_G476_P0.5050.80
182_T188_A0.5050.80
86_G269_S0.5040.80
232_H249_I0.5040.80
210_G263_P0.5030.80
307_S310_L0.5020.80
261_T339_F0.5020.80
473_I476_P0.5010.79
437_A441_A0.5010.79
358_L440_V0.5010.79
163_V192_K0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjzA 2 0.8951 100 0.154 Contact Map
4j7cI 2 0.7825 100 0.337 Contact Map
3ukmA 2 0.4466 96.5 0.944 Contact Map
4twkA 2 0.4641 93.6 0.954 Contact Map
4wfeA 2 0.3942 91 0.957 Contact Map
4bw5A 2 0.468 90.5 0.958 Contact Map
2ih3C 4 0.1728 87.8 0.96 Contact Map
3vouA 4 0.2602 87.3 0.96 Contact Map
4h33A 3 0.167 86.2 0.961 Contact Map
3effK 4 0.2272 85.3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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