Q9HMF5 - HALSA - GREMLIN Contacts

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Q9HMF5 - Uncharacterized protein

UniProt:	Q9HMF5	Sequences: MASVSSAHLVLFIAAILFSAALAGALTDSATIIGDSVNDAADTDAAHANTAFSVVSDPGAPNSVYNDTTDTLTILVKNTGDSTPLSDPRDITVLVDGEYQTPASTAVVSANADTWRPGTLLRVEVTVDLAPSTETRVVVDTNGHRDHFTFTTS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	153 (148)
Sequences:	106 (90)
Seq/√Len:	7.4

HALSA - Q9HMF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_I	36_S	3.004	0.85
96_D	135_T	2.990	0.85
4_V	8_H	2.601	0.76
6_S	41_A	2.543	0.74
4_V	15_A	2.330	0.67
129_L	132_S	2.229	0.63
56_S	75_L	2.200	0.62
33_I	143_G	2.187	0.62
7_A	146_D	2.056	0.57
117_P	125_V	2.046	0.56
81_D	91_I	1.984	0.54
125_V	137_V	1.954	0.53
115_W	121_L	1.929	0.52
2_A	49_N	1.916	0.51
3_S	15_A	1.789	0.46
27_T	36_S	1.777	0.46
100_Q	108_V	1.762	0.45
48_A	81_D	1.731	0.44
32_I	41_A	1.708	0.43
117_P	123_V	1.703	0.43
86_S	121_L	1.692	0.42
3_S	7_A	1.659	0.41
22_L	120_L	1.651	0.41
8_H	115_W	1.639	0.40
3_S	20_A	1.619	0.40
33_I	45_A	1.581	0.38
7_A	26_L	1.558	0.37
84_P	115_W	1.534	0.36
4_V	11_L	1.529	0.36
30_A	115_W	1.517	0.36
47_H	58_P	1.503	0.35
90_D	111_N	1.483	0.35
18_F	67_D	1.447	0.33
100_Q	137_V	1.443	0.33
29_S	41_A	1.439	0.33
110_A	113_D	1.418	0.32
54_V	77_K	1.372	0.31
8_H	121_L	1.361	0.30
96_D	133_T	1.360	0.30
67_D	139_V	1.347	0.30
22_L	51_A	1.338	0.30
36_S	56_S	1.335	0.29
8_H	26_L	1.324	0.29
3_S	77_K	1.323	0.29
52_F	115_W	1.302	0.28
5_S	11_L	1.298	0.28
26_L	33_I	1.295	0.28
99_Y	134_E	1.289	0.28
1_M	16_I	1.286	0.28
55_V	135_T	1.284	0.28
29_S	32_I	1.255	0.27
36_S	73_T	1.239	0.26
92_T	99_Y	1.235	0.26
46_A	103_A	1.233	0.26
40_A	109_S	1.212	0.26
91_I	148_F	1.198	0.25
74_I	137_V	1.193	0.25
3_S	18_F	1.191	0.25
30_A	86_S	1.172	0.24
55_V	143_G	1.168	0.24
3_S	8_H	1.167	0.24
45_A	79_T	1.161	0.24
71_T	132_S	1.143	0.24
33_I	54_V	1.142	0.24
44_D	75_L	1.137	0.23
8_H	52_F	1.127	0.23
109_S	123_V	1.112	0.23
7_A	149_T	1.102	0.22
79_T	135_T	1.098	0.22
77_K	116_R	1.095	0.22
87_D	91_I	1.092	0.22
18_F	23_A	1.081	0.22
7_A	97_G	1.077	0.22
55_V	77_K	1.076	0.22
39_D	122_R	1.060	0.21
35_D	132_S	1.054	0.21
17_L	33_I	1.053	0.21
124_E	128_D	1.028	0.20
81_D	95_V	1.021	0.20
30_A	121_L	1.020	0.20
86_S	134_E	1.017	0.20
58_P	143_G	1.014	0.20
66_N	84_P	1.007	0.20
92_T	125_V	1.005	0.20
15_A	19_S	1.005	0.20
8_H	146_D	0.993	0.20
104_S	126_T	0.992	0.20
40_A	119_T	0.979	0.19
101_T	108_V	0.978	0.19
60_A	136_R	0.963	0.19
35_D	96_D	0.956	0.19
132_S	141_T	0.946	0.18
56_S	134_E	0.943	0.18
111_N	148_F	0.938	0.18
38_N	51_A	0.935	0.18
17_L	143_G	0.935	0.18
129_L	133_T	0.935	0.18
39_D	85_L	0.932	0.18
72_L	117_P	0.929	0.18
86_S	115_W	0.923	0.18
129_L	148_F	0.922	0.18
16_I	116_R	0.913	0.18
36_S	48_A	0.912	0.18
88_P	91_I	0.903	0.17
79_T	144_H	0.900	0.17
42_D	52_F	0.894	0.17
66_N	148_F	0.893	0.17
49_N	68_T	0.891	0.17
135_T	138_V	0.885	0.17
2_A	36_S	0.884	0.17
56_S	99_Y	0.884	0.17
5_S	27_T	0.875	0.17
117_P	145_R	0.872	0.17
30_A	99_Y	0.871	0.17
116_R	129_L	0.860	0.16
60_A	123_V	0.845	0.16
45_A	124_E	0.829	0.16
95_V	143_G	0.828	0.16
68_T	73_T	0.825	0.16
98_E	106_A	0.824	0.16
77_K	117_P	0.824	0.16
73_T	120_L	0.820	0.16
100_Q	127_V	0.818	0.16
49_N	144_H	0.816	0.16
4_V	145_R	0.803	0.15
9_L	140_D	0.802	0.15
87_D	95_V	0.802	0.15
56_S	146_D	0.789	0.15
68_T	74_I	0.789	0.15
45_A	112_A	0.778	0.15
20_A	53_S	0.772	0.15
116_R	136_R	0.761	0.14
100_Q	111_N	0.757	0.14
53_S	79_T	0.753	0.14
63_S	75_L	0.753	0.14
5_S	72_L	0.748	0.14
15_A	132_S	0.739	0.14
48_A	122_R	0.736	0.14
59_G	75_L	0.735	0.14
40_A	99_Y	0.732	0.14
30_A	56_S	0.730	0.14
43_T	71_T	0.728	0.14
25_A	38_N	0.720	0.14
20_A	34_G	0.716	0.14
54_V	63_S	0.710	0.13
44_D	51_A	0.709	0.13
87_D	93_V	0.708	0.13
30_A	84_P	0.706	0.13
33_I	137_V	0.703	0.13
12_F	80_G	0.698	0.13
12_F	78_N	0.698	0.13
41_A	96_D	0.697	0.13
22_L	73_T	0.696	0.13
56_S	86_S	0.696	0.13
96_D	140_D	0.695	0.13
54_V	143_G	0.688	0.13
10_V	17_L	0.687	0.13
34_G	118_G	0.687	0.13
42_D	144_H	0.687	0.13
91_I	113_D	0.679	0.13
74_I	91_I	0.678	0.13
24_G	37_V	0.670	0.13
39_D	139_V	0.667	0.13
52_F	139_V	0.660	0.13
3_S	89_R	0.659	0.13
28_D	36_S	0.655	0.12
20_A	24_G	0.653	0.12
15_A	125_V	0.653	0.12
124_E	131_P	0.646	0.12
30_A	134_E	0.643	0.12
74_I	105_T	0.642	0.12
90_D	139_V	0.641	0.12
93_V	139_V	0.636	0.12
44_D	56_S	0.634	0.12
124_E	133_T	0.626	0.12
70_D	93_V	0.623	0.12
21_A	68_T	0.623	0.12
146_D	149_T	0.622	0.12
19_S	30_A	0.621	0.12
37_V	85_L	0.618	0.12
95_V	131_P	0.617	0.12
74_I	107_V	0.610	0.12
88_P	145_R	0.605	0.12
24_G	34_G	0.602	0.12
76_V	82_S	0.601	0.12
3_S	112_A	0.591	0.11
91_I	121_L	0.591	0.11
39_D	43_T	0.585	0.11
128_D	140_D	0.585	0.11
8_H	36_S	0.583	0.11
96_D	143_G	0.583	0.11
29_S	47_H	0.579	0.11
115_W	146_D	0.572	0.11
98_E	114_T	0.572	0.11
77_K	143_G	0.567	0.11
84_P	121_L	0.561	0.11
28_D	101_T	0.553	0.11
72_L	107_V	0.549	0.11
1_M	11_L	0.548	0.11
94_L	129_L	0.548	0.11
9_L	22_L	0.544	0.11
5_S	14_A	0.542	0.11
70_D	127_V	0.540	0.11
94_L	147_H	0.538	0.11
119_T	123_V	0.535	0.11
9_L	60_A	0.535	0.11
24_G	139_V	0.532	0.11
24_G	148_F	0.532	0.11
125_V	138_V	0.531	0.10
10_V	54_V	0.527	0.10
21_A	102_P	0.526	0.10
103_A	112_A	0.523	0.10
84_P	103_A	0.523	0.10
55_V	75_L	0.522	0.10
66_N	105_T	0.521	0.10
83_T	102_P	0.517	0.10
40_A	64_V	0.514	0.10
41_A	125_V	0.512	0.10
136_R	145_R	0.512	0.10
107_V	148_F	0.502	0.10
29_S	98_E	0.500	0.10
27_T	48_A	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2l0dA	1	0.6209	95.6	0.889	Contact Map
3iduA	1	0.6863	91.3	0.907	Contact Map
2kutA	1	0.6013	90.3	0.909	Contact Map
3isyA	1	0.6536	78.8	0.922	Contact Map
2e6jA	1	0.6732	76.6	0.924	Contact Map
2w9xA	2	0.549	48.3	0.937	Contact Map
2x3cA	2	0.5817	36.4	0.941	Contact Map
2qsvA	1	0.6078	33.3	0.942	Contact Map
2w87A	1	0.7582	30.1	0.944	Contact Map
2r39A	1	0.6144	26.9	0.945	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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