GREMLIN Database
Q9HMF5 - Uncharacterized protein
UniProt: Q9HMF5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 153 (148)
Sequences: 106 (90)
Seq/√Len: 7.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_I36_S3.0040.85
96_D135_T2.9900.85
4_V8_H2.6010.76
6_S41_A2.5430.74
4_V15_A2.3300.67
129_L132_S2.2290.63
56_S75_L2.2000.62
33_I143_G2.1870.62
7_A146_D2.0560.57
117_P125_V2.0460.56
81_D91_I1.9840.54
125_V137_V1.9540.53
115_W121_L1.9290.52
2_A49_N1.9160.51
3_S15_A1.7890.46
27_T36_S1.7770.46
100_Q108_V1.7620.45
48_A81_D1.7310.44
32_I41_A1.7080.43
117_P123_V1.7030.43
86_S121_L1.6920.42
3_S7_A1.6590.41
22_L120_L1.6510.41
8_H115_W1.6390.40
3_S20_A1.6190.40
33_I45_A1.5810.38
7_A26_L1.5580.37
84_P115_W1.5340.36
4_V11_L1.5290.36
30_A115_W1.5170.36
47_H58_P1.5030.35
90_D111_N1.4830.35
18_F67_D1.4470.33
100_Q137_V1.4430.33
29_S41_A1.4390.33
110_A113_D1.4180.32
54_V77_K1.3720.31
8_H121_L1.3610.30
96_D133_T1.3600.30
67_D139_V1.3470.30
22_L51_A1.3380.30
36_S56_S1.3350.29
8_H26_L1.3240.29
3_S77_K1.3230.29
52_F115_W1.3020.28
5_S11_L1.2980.28
26_L33_I1.2950.28
99_Y134_E1.2890.28
1_M16_I1.2860.28
55_V135_T1.2840.28
29_S32_I1.2550.27
36_S73_T1.2390.26
92_T99_Y1.2350.26
46_A103_A1.2330.26
40_A109_S1.2120.26
91_I148_F1.1980.25
74_I137_V1.1930.25
3_S18_F1.1910.25
30_A86_S1.1720.24
55_V143_G1.1680.24
3_S8_H1.1670.24
45_A79_T1.1610.24
71_T132_S1.1430.24
33_I54_V1.1420.24
44_D75_L1.1370.23
8_H52_F1.1270.23
109_S123_V1.1120.23
7_A149_T1.1020.22
79_T135_T1.0980.22
77_K116_R1.0950.22
87_D91_I1.0920.22
18_F23_A1.0810.22
7_A97_G1.0770.22
55_V77_K1.0760.22
39_D122_R1.0600.21
35_D132_S1.0540.21
17_L33_I1.0530.21
124_E128_D1.0280.20
81_D95_V1.0210.20
30_A121_L1.0200.20
86_S134_E1.0170.20
58_P143_G1.0140.20
66_N84_P1.0070.20
92_T125_V1.0050.20
15_A19_S1.0050.20
8_H146_D0.9930.20
104_S126_T0.9920.20
40_A119_T0.9790.19
101_T108_V0.9780.19
60_A136_R0.9630.19
35_D96_D0.9560.19
132_S141_T0.9460.18
56_S134_E0.9430.18
111_N148_F0.9380.18
38_N51_A0.9350.18
17_L143_G0.9350.18
129_L133_T0.9350.18
39_D85_L0.9320.18
72_L117_P0.9290.18
86_S115_W0.9230.18
129_L148_F0.9220.18
16_I116_R0.9130.18
36_S48_A0.9120.18
88_P91_I0.9030.17
79_T144_H0.9000.17
42_D52_F0.8940.17
66_N148_F0.8930.17
49_N68_T0.8910.17
135_T138_V0.8850.17
2_A36_S0.8840.17
56_S99_Y0.8840.17
5_S27_T0.8750.17
117_P145_R0.8720.17
30_A99_Y0.8710.17
116_R129_L0.8600.16
60_A123_V0.8450.16
45_A124_E0.8290.16
95_V143_G0.8280.16
68_T73_T0.8250.16
98_E106_A0.8240.16
77_K117_P0.8240.16
73_T120_L0.8200.16
100_Q127_V0.8180.16
49_N144_H0.8160.16
4_V145_R0.8030.15
9_L140_D0.8020.15
87_D95_V0.8020.15
56_S146_D0.7890.15
68_T74_I0.7890.15
45_A112_A0.7780.15
20_A53_S0.7720.15
116_R136_R0.7610.14
100_Q111_N0.7570.14
53_S79_T0.7530.14
63_S75_L0.7530.14
5_S72_L0.7480.14
15_A132_S0.7390.14
48_A122_R0.7360.14
59_G75_L0.7350.14
40_A99_Y0.7320.14
30_A56_S0.7300.14
43_T71_T0.7280.14
25_A38_N0.7200.14
20_A34_G0.7160.14
54_V63_S0.7100.13
44_D51_A0.7090.13
87_D93_V0.7080.13
30_A84_P0.7060.13
33_I137_V0.7030.13
12_F80_G0.6980.13
12_F78_N0.6980.13
41_A96_D0.6970.13
22_L73_T0.6960.13
56_S86_S0.6960.13
96_D140_D0.6950.13
54_V143_G0.6880.13
10_V17_L0.6870.13
34_G118_G0.6870.13
42_D144_H0.6870.13
91_I113_D0.6790.13
74_I91_I0.6780.13
24_G37_V0.6700.13
39_D139_V0.6670.13
52_F139_V0.6600.13
3_S89_R0.6590.13
28_D36_S0.6550.12
20_A24_G0.6530.12
15_A125_V0.6530.12
124_E131_P0.6460.12
30_A134_E0.6430.12
74_I105_T0.6420.12
90_D139_V0.6410.12
93_V139_V0.6360.12
44_D56_S0.6340.12
124_E133_T0.6260.12
70_D93_V0.6230.12
21_A68_T0.6230.12
146_D149_T0.6220.12
19_S30_A0.6210.12
37_V85_L0.6180.12
95_V131_P0.6170.12
74_I107_V0.6100.12
88_P145_R0.6050.12
24_G34_G0.6020.12
76_V82_S0.6010.12
3_S112_A0.5910.11
91_I121_L0.5910.11
39_D43_T0.5850.11
128_D140_D0.5850.11
8_H36_S0.5830.11
96_D143_G0.5830.11
29_S47_H0.5790.11
115_W146_D0.5720.11
98_E114_T0.5720.11
77_K143_G0.5670.11
84_P121_L0.5610.11
28_D101_T0.5530.11
72_L107_V0.5490.11
1_M11_L0.5480.11
94_L129_L0.5480.11
9_L22_L0.5440.11
5_S14_A0.5420.11
70_D127_V0.5400.11
94_L147_H0.5380.11
119_T123_V0.5350.11
9_L60_A0.5350.11
24_G139_V0.5320.11
24_G148_F0.5320.11
125_V138_V0.5310.10
10_V54_V0.5270.10
21_A102_P0.5260.10
103_A112_A0.5230.10
84_P103_A0.5230.10
55_V75_L0.5220.10
66_N105_T0.5210.10
83_T102_P0.5170.10
40_A64_V0.5140.10
41_A125_V0.5120.10
136_R145_R0.5120.10
107_V148_F0.5020.10
29_S98_E0.5000.10
27_T48_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l0dA 1 0.6209 95.6 0.889 Contact Map
3iduA 1 0.6863 91.3 0.907 Contact Map
2kutA 1 0.6013 90.3 0.909 Contact Map
3isyA 1 0.6536 78.8 0.922 Contact Map
2e6jA 1 0.6732 76.6 0.924 Contact Map
2w9xA 2 0.549 48.3 0.937 Contact Map
2x3cA 2 0.5817 36.4 0.941 Contact Map
2qsvA 1 0.6078 33.3 0.942 Contact Map
2w87A 1 0.7582 30.1 0.944 Contact Map
2r39A 1 0.6144 26.9 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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