GREMLIN Database
DUT - Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
UniProt: Q9HMF3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (144)
Sequences: 1799 (807)
Seq/√Len: 67.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_T115_T5.5631.00
28_T79_A3.9831.00
27_L137_A3.8941.00
110_W118_G3.3311.00
87_N143_T3.1981.00
12_V25_V3.1511.00
79_A133_G2.8131.00
103_C128_I2.5651.00
19_Q28_T2.1921.00
91_F142_A2.1171.00
90_G141_L2.0881.00
15_V25_V2.0071.00
30_D77_Q1.9801.00
81_T115_T1.9641.00
23_N112_A1.9151.00
84_I90_G1.9001.00
15_V20_I1.8561.00
115_T156_H1.8011.00
30_D133_G1.8001.00
84_I88_H1.7251.00
36_T75_I1.6000.99
114_Y157_E1.5960.99
77_Q117_R1.5920.99
27_L139_L1.5860.99
96_S100_R1.5770.99
66_T129_T1.5590.99
56_P63_T1.5300.99
111_D154_Y1.5030.99
70_Q127_E1.4880.99
16_A19_Q1.4870.99
70_Q73_T1.4800.99
117_R159_T1.4780.99
110_W139_L1.4290.98
66_T131_A1.3990.98
108_A111_D1.3980.98
68_T129_T1.3830.98
86_E149_T1.3670.98
74_Y124_V1.3520.97
79_A132_R1.3440.97
121_L157_E1.3050.97
91_F109_V1.2900.97
75_I119_E1.2710.96
94_P99_M1.2310.96
95_R135_R1.2310.96
41_I44_D1.2200.95
90_G139_L1.2150.95
78_Y120_G1.2040.95
98_L134_A1.1980.95
14_P80_E1.1900.95
46_K49_G1.1820.94
76_L94_P1.1700.94
107_S111_D1.1680.94
32_V77_Q1.1440.93
35_Q102_S1.1360.93
26_D95_R1.1230.93
94_P106_H1.1170.93
120_G124_V1.1170.93
111_D114_Y1.1150.93
37_E50_D1.1110.92
68_T139_L1.0840.91
104_M123_E1.0740.91
20_I25_V1.0720.91
105_L137_A1.0690.91
11_H83_T1.0680.91
21_Q138_Q1.0550.90
29_V76_L1.0550.90
71_P127_E1.0430.90
50_D53_P1.0400.90
71_P103_C1.0400.90
76_L136_V1.0180.89
90_G110_W1.0030.88
27_L78_Y1.0030.88
21_Q26_D0.9930.87
133_G158_R0.9850.87
93_Y106_H0.9780.87
96_S138_Q0.9690.86
95_R98_L0.9580.85
85_P116_G0.9330.84
76_L122_F0.9290.84
117_R158_R0.9250.83
24_G107_S0.9240.83
26_D140_V0.9180.83
87_N115_T0.9150.83
27_L82_I0.9100.82
19_Q135_R0.9080.82
24_G108_A0.9050.82
73_T135_R0.9050.82
69_I122_F0.9030.82
42_D45_G0.8990.82
48_I53_P0.8880.81
104_M125_H0.8840.80
99_M121_L0.8770.80
16_A28_T0.8740.80
24_G109_V0.8710.79
95_R153_S0.8690.79
103_C124_V0.8670.79
85_P88_H0.8660.79
65_T68_T0.8460.77
56_P127_E0.8440.77
86_E113_G0.8400.77
53_P56_P0.8330.76
23_N124_V0.8260.76
29_V130_I0.8240.76
122_F130_I0.8100.74
92_V110_W0.8010.73
97_S138_Q0.8000.73
150_Y154_Y0.7930.73
114_Y118_G0.7920.73
13_E16_A0.7910.73
93_Y114_Y0.7840.72
65_T132_R0.7810.72
26_D135_R0.7720.71
100_R138_Q0.7710.71
22_P138_Q0.7640.70
109_V114_Y0.7590.69
37_E41_I0.7580.69
13_E17_D0.7570.69
127_E137_A0.7530.69
89_V109_V0.7530.69
91_F140_V0.7520.69
18_D83_T0.7520.69
62_S66_T0.7490.68
99_M106_H0.7430.68
108_A114_Y0.7210.65
33_L132_R0.7160.65
17_D139_L0.7120.64
86_E141_L0.7070.64
78_Y99_M0.7060.64
16_A158_R0.7050.64
20_I130_I0.7040.64
49_G56_P0.7020.63
113_G144_G0.6910.62
46_K51_R0.6870.62
93_Y121_L0.6850.61
13_E18_D0.6830.61
81_T117_R0.6820.61
94_P157_E0.6780.61
37_E52_S0.6740.60
111_D116_G0.6640.59
89_V140_V0.6630.59
93_Y157_E0.6620.59
24_G140_V0.6610.59
88_H141_L0.6610.59
102_S137_A0.6530.58
84_I141_L0.6530.58
34_E77_Q0.6510.58
24_G152_G0.6510.58
83_T86_E0.6500.57
23_N131_A0.6450.57
46_K52_S0.6440.57
64_D67_V0.6420.57
130_I144_G0.6390.56
37_E40_R0.6370.56
151_D158_R0.6360.56
17_D20_I0.6360.56
75_I94_P0.6350.56
109_V142_A0.6300.55
35_Q73_T0.6290.55
47_T51_R0.6210.54
86_E148_N0.6200.54
52_S143_T0.6180.54
96_S99_M0.6170.54
47_T52_S0.6140.53
95_R138_Q0.6090.53
124_V141_L0.6090.53
78_Y136_V0.6050.52
31_A158_R0.5980.51
140_V144_G0.5950.51
114_Y140_V0.5950.51
95_R100_R0.5930.51
31_A143_T0.5920.51
103_C122_F0.5880.50
13_E52_S0.5860.50
129_T132_R0.5780.49
107_S110_W0.5770.49
69_I137_A0.5730.48
68_T73_T0.5700.48
44_D112_A0.5680.48
27_L116_G0.5670.48
38_P126_H0.5620.47
120_G137_A0.5610.47
82_I139_L0.5610.47
103_C109_V0.5580.47
89_V125_H0.5570.46
78_Y121_L0.5510.46
32_V37_E0.5470.45
33_L66_T0.5380.44
67_V74_Y0.5380.44
31_A52_S0.5380.44
15_V19_Q0.5370.44
21_Q78_Y0.5350.44
93_Y99_M0.5330.44
64_D132_R0.5310.43
75_I120_G0.5290.43
67_V92_V0.5270.43
34_E136_V0.5260.43
49_G53_P0.5220.42
112_A144_G0.5220.42
103_C123_E0.5200.42
51_R55_T0.5200.42
52_S56_P0.5200.42
77_Q118_G0.5180.42
93_Y140_V0.5150.42
31_A53_P0.5150.42
47_T85_P0.5140.41
16_A120_G0.5130.41
29_V74_Y0.5110.41
27_L143_T0.5100.41
24_G99_M0.5080.41
66_T130_I0.5060.41
54_V64_D0.5040.40
50_D73_T0.5030.40
26_D33_L0.5020.40
27_L136_V0.5020.40
75_I103_C0.5010.40
94_P118_G0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pkhA 5 0.903 100 0.29 Contact Map
1xs1A 5 1 100 0.3 Contact Map
2qxxA 3 0.9879 100 0.309 Contact Map
4xjcA 3 0.9697 100 0.313 Contact Map
2yzjA 3 0.903 100 0.318 Contact Map
4dhkA 5 0.8727 100 0.331 Contact Map
3km3A 4 0.8364 100 0.334 Contact Map
2r9qA 4 0.8848 100 0.381 Contact Map
3lqwA 3 0.7273 99.9 0.585 Contact Map
1dunA 3 0.697 99.8 0.6 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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