GREMLIN Database
Q9HMF2 - Halolysin
UniProt: Q9HMF2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 525 (458)
Sequences: 5865 (4559)
Seq/√Len: 213.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
308_A316_A5.1721.00
151_I205_A4.9301.00
307_S328_A4.5221.00
111_N238_A4.3791.00
229_L235_G4.2401.00
359_V399_A4.2061.00
285_A353_T4.1211.00
359_V397_V3.8111.00
200_H351_M3.7921.00
338_W344_E3.6731.00
145_G220_N3.5791.00
383_V398_D3.4581.00
281_L304_L3.3851.00
308_A318_Y3.1191.00
154_V228_A3.0211.00
316_A332_T2.9891.00
298_A305_A2.9481.00
147_A220_N2.9371.00
338_W346_I2.7791.00
117_Q285_A2.7651.00
152_G252_A2.6451.00
318_Y332_T2.6251.00
203_G336_S2.6131.00
313_E396_R2.5971.00
153_V205_A2.5921.00
193_N196_I2.5661.00
256_N353_T2.4091.00
202_A225_A2.3881.00
356_V397_V2.3641.00
207_A337_T2.3301.00
381_T402_A2.3071.00
353_T357_A2.2961.00
170_D174_S2.2771.00
308_A332_T2.2721.00
327_L397_V2.2231.00
114_L237_T2.2111.00
370_S373_E2.2111.00
200_H336_S2.1871.00
281_L360_A2.1341.00
285_A352_A2.1301.00
248_A280_A2.1281.00
206_A221_S2.0961.00
203_G337_T2.0571.00
185_G188_Y2.0181.00
92_R95_F1.9971.00
224_I252_A1.9971.00
204_I355_V1.9841.00
315_L328_A1.9791.00
366_Q369_L1.9541.00
398_D401_N1.9341.00
417_G420_D1.9271.00
228_A259_L1.9171.00
43_E111_N1.8721.00
204_I351_M1.8701.00
284_A303_V1.8671.00
240_I259_L1.8381.00
369_L377_H1.8301.00
200_H204_I1.8231.00
150_T222_S1.8171.00
364_L374_L1.8131.00
256_N357_A1.8061.00
226_G243_A1.7811.00
151_I361_G1.7771.00
201_V256_N1.7771.00
310_D332_T1.7691.00
400_A404_N1.7651.00
327_L378_L1.7301.00
154_V243_A1.7281.00
170_D175_N1.7171.00
335_L345_S1.7151.00
375_R379_K1.7141.00
158_V223_V1.6991.00
273_T302_G1.6891.00
135_N398_D1.6671.00
359_V378_L1.6541.00
151_I221_S1.6521.00
336_S351_M1.6441.00
139_A403_V1.6391.00
206_A223_V1.6321.00
309_L328_A1.6281.00
149_V364_L1.6041.00
218_I358_G1.6031.00
283_V353_T1.6011.00
244_I275_A1.6001.00
228_A243_A1.5991.00
376_N380_A1.5771.00
330_P334_V1.5541.00
174_S177_G1.5531.00
266_N270_N1.5531.00
254_V281_L1.5381.00
248_A275_A1.5321.00
307_S325_I1.5241.00
47_G106_K1.5231.00
179_D184_D1.5171.00
116_A229_L1.5101.00
124_R127_D1.5041.00
428_G432_G1.4971.00
417_G421_S1.4911.00
236_S239_D1.4871.00
150_T224_I1.4671.00
153_V201_V1.4621.00
244_I257_L1.4571.00
315_L319_S1.4531.00
363_T402_A1.4461.00
275_A282_V1.4351.00
177_G180_F1.4231.00
200_H346_I1.4081.00
152_G247_A1.4071.00
283_V357_A1.4041.00
360_A374_L1.3921.00
144_T365_A1.3891.00
306_V327_L1.3861.00
283_V356_V1.3801.00
180_F183_D1.3731.00
346_I351_M1.3581.00
226_G246_W1.3531.00
253_D364_L1.3521.00
184_D187_P1.3441.00
273_T301_G1.3311.00
417_G422_T1.3301.00
416_G420_D1.3301.00
272_V303_V1.3291.00
194_E231_E1.3101.00
148_G222_S1.3061.00
149_V361_G1.3021.00
159_K339_T1.2791.00
153_V202_A1.2701.00
255_I275_A1.2701.00
309_L396_R1.2661.00
363_T369_L1.2641.00
176_G180_F1.2631.00
179_D182_D1.2601.00
219_G361_G1.2571.00
174_S178_R1.2571.00
281_L371_N1.2531.00
360_A363_T1.2501.00
363_T374_L1.2431.00
451_V455_L1.2391.00
418_G421_S1.2371.00
49_S106_K1.2331.00
456_D459_G1.2271.00
165_L337_T1.2211.00
112_V237_T1.2201.00
164_D337_T1.2191.00
291_S321_Y1.2191.00
146_D219_G1.2161.00
451_V454_E1.2041.00
158_V225_A1.2021.00
318_Y347_S1.1941.00
379_K394_A1.1911.00
468_N501_S1.1901.00
109_E267_T1.1861.00
455_L459_G1.1851.00
109_E265_T1.1841.00
105_I108_V1.1681.00
134_V218_I1.1591.00
179_D187_P1.1521.00
156_Q195_E1.1511.00
96_V100_E1.1511.00
152_G224_I1.1491.00
286_A305_A1.1471.00
99_L105_I1.1361.00
142_T400_A1.1311.00
158_V165_L1.1271.00
258_S354_P1.1241.00
218_I355_V1.1211.00
76_L84_P1.1181.00
281_L374_L1.1171.00
49_S104_T1.1071.00
168_N208_E1.1071.00
161_D192_L1.1031.00
290_G320_N1.0971.00
383_V396_R1.0961.00
329_A356_V1.0911.00
315_L391_Q1.0861.00
300_Y303_V1.0861.00
156_Q193_N1.0821.00
451_V463_F1.0801.00
226_G250_E1.0781.00
266_N269_Q1.0771.00
181_V184_D1.0771.00
241_A271_A1.0751.00
241_A267_T1.0701.00
96_V108_V1.0691.00
213_N218_I1.0681.00
247_A255_I1.0661.00
145_G365_A1.0591.00
76_L82_G1.0571.00
426_V432_G1.0551.00
190_D193_N1.0491.00
116_A156_Q1.0471.00
426_V430_L1.0451.00
421_S427_S1.0421.00
306_V356_V1.0401.00
418_G422_T1.0401.00
180_F185_G1.0381.00
381_T405_T1.0371.00
205_A358_G1.0301.00
273_T277_N1.0271.00
182_D185_G1.0271.00
201_V354_P1.0261.00
256_N283_V1.0201.00
240_I257_L1.0161.00
269_Q273_T1.0151.00
270_N274_Y1.0141.00
133_Q313_E1.0121.00
202_A223_V1.0071.00
111_N114_L1.0011.00
52_E56_Q1.0001.00
196_I346_I0.9961.00
445_Y448_P0.9891.00
47_G107_Y0.9871.00
159_K342_D0.9861.00
382_A395_G0.9841.00
271_A275_A0.9801.00
321_Y391_Q0.9791.00
369_L373_E0.9781.00
364_L369_L0.9741.00
74_E242_D0.9701.00
113_E236_S0.9661.00
498_P502_V0.9641.00
496_D500_T0.9641.00
283_V360_A0.9631.00
308_A347_S0.9631.00
117_Q260_G0.9601.00
315_L321_Y0.9581.00
179_D183_D0.9571.00
148_G219_G0.9531.00
207_A215_V0.9521.00
215_V218_I0.9521.00
254_V357_A0.9491.00
475_P478_S0.9481.00
493_I498_P0.9481.00
439_W443_Y0.9471.00
276_A281_L0.9451.00
48_V83_L0.9441.00
286_A307_S0.9441.00
455_L458_P0.9430.99
97_D100_E0.9400.99
273_T300_Y0.9380.99
170_D176_G0.9350.99
213_N216_T0.9340.99
309_L313_E0.9340.99
143_T146_D0.9300.99
328_A352_A0.9280.99
175_N178_R0.9270.99
159_K192_L0.9270.99
184_D188_Y0.9270.99
154_V257_L0.9260.99
183_D186_D0.9250.99
364_L367_W0.9230.99
244_I272_V0.9200.99
269_Q300_Y0.9190.99
257_L284_A0.9170.99
254_V360_A0.9150.99
289_D320_N0.9150.99
139_A142_T0.9120.99
142_T404_N0.9080.99
487_T491_E0.9070.99
304_L375_R0.9070.99
332_T347_S0.9050.99
98_R101_S0.9050.99
491_E496_D0.9000.99
366_Q377_H0.9000.99
274_Y277_N0.8980.99
214_G218_I0.8980.99
180_F187_P0.8870.99
422_T427_S0.8860.99
362_L399_A0.8830.99
176_G179_D0.8810.99
372_A376_N0.8800.99
255_I282_V0.8790.99
178_R182_D0.8760.99
491_E498_P0.8730.99
443_Y446_S0.8720.99
451_V457_G0.8710.99
245_T249_N0.8700.99
245_T274_Y0.8690.99
489_S493_I0.8690.99
284_A298_A0.8660.99
180_F184_D0.8660.99
327_L356_V0.8660.99
498_P501_S0.8650.99
174_S188_Y0.8640.99
218_I359_V0.8610.99
136_A140_W0.8570.99
229_L239_D0.8570.99
248_A274_Y0.8550.99
125_F128_Q0.8520.99
488_G491_E0.8510.99
162_H343_Y0.8500.99
244_I271_A0.8490.99
247_A252_A0.8490.99
44_Y48_V0.8480.99
182_D187_P0.8470.99
356_V378_L0.8460.99
134_V355_V0.8420.99
53_D56_Q0.8390.99
267_T270_N0.8380.99
466_Y501_S0.8370.99
493_I500_T0.8370.99
183_D187_P0.8370.99
165_L169_I0.8300.99
502_V505_N0.8300.99
276_A375_R0.8300.99
196_I338_W0.8290.99
477_T480_Y0.8290.99
67_E70_G0.8280.99
181_V186_D0.8280.99
167_G208_E0.8270.99
164_D209_V0.8270.99
333_N347_S0.8260.99
259_L284_A0.8250.99
290_G315_L0.8250.99
492_S496_D0.8240.99
326_D329_A0.8230.99
138_E141_D0.8200.99
133_Q309_L0.8200.99
493_I496_D0.8180.99
174_S181_V0.8140.99
458_P461_A0.8130.99
493_I497_N0.8130.99
381_T401_N0.8130.99
296_Y299_A0.8120.98
178_R181_V0.8120.98
451_V458_P0.8110.98
65_G69_V0.8070.98
72_V75_R0.8070.98
429_S432_G0.8060.98
422_T426_V0.8060.98
244_I255_I0.8060.98
377_H406_D0.8010.98
176_G224_I0.8000.98
316_A347_S0.7990.98
60_E64_Q0.7990.98
164_D343_Y0.7980.98
140_W216_T0.7980.98
56_Q59_V0.7970.98
174_S186_D0.7960.98
135_N400_A0.7950.98
497_N500_T0.7940.98
490_Q493_I0.7940.98
178_R187_P0.7940.98
179_D185_G0.7920.98
170_D177_G0.7900.98
439_W445_Y0.7860.98
360_A378_L0.7850.98
478_S482_F0.7830.98
246_W249_N0.7820.98
494_T498_P0.7800.98
181_V185_G0.7790.98
197_H288_N0.7790.98
182_D186_D0.7780.98
257_L282_V0.7780.98
286_A325_I0.7780.98
246_W250_E0.7780.98
351_M354_P0.7770.98
176_G187_P0.7760.98
419_G422_T0.7750.98
226_G247_A0.7750.98
469_T473_A0.7730.98
426_V429_S0.7710.98
153_V225_A0.7710.98
209_V216_T0.7690.98
295_S320_N0.7690.98
179_D227_R0.7620.98
351_M355_V0.7620.98
423_S426_V0.7600.98
175_N180_F0.7590.98
476_T480_Y0.7580.98
170_D224_I0.7550.98
79_A82_G0.7550.98
399_A403_V0.7550.98
53_D57_Q0.7540.98
229_L259_L0.7540.98
325_I328_A0.7530.98
165_L203_G0.7530.98
326_D331_G0.7520.98
494_T497_N0.7510.97
310_D314_S0.7470.97
135_N138_E0.7460.97
111_N236_S0.7450.97
377_H405_T0.7440.97
122_D125_F0.7440.97
74_E84_P0.7430.97
200_H334_V0.7410.97
160_Y169_I0.7410.97
330_P355_V0.7400.97
180_F246_W0.7390.97
140_W362_L0.7360.97
421_S426_V0.7350.97
276_A282_V0.7320.97
176_G182_D0.7310.97
491_E501_S0.7310.97
175_N179_D0.7290.97
488_G496_D0.7270.97
237_T268_M0.7270.97
178_R185_G0.7240.97
228_A257_L0.7230.97
227_R231_E0.7210.97
255_I280_A0.7210.97
281_L364_L0.7190.97
146_D221_S0.7160.97
416_G419_G0.7160.97
326_D330_P0.7160.97
76_L80_V0.7150.97
204_I336_S0.7150.97
51_V54_D0.7150.97
498_P504_L0.7140.97
420_D430_L0.7120.97
454_E457_G0.7110.97
43_E46_V0.7110.97
441_F445_Y0.7070.96
44_Y108_V0.7070.96
420_D423_S0.7070.96
400_A403_V0.7060.96
138_E142_T0.7050.96
438_C443_Y0.7040.96
502_V506_V0.7040.96
422_T425_S0.7040.96
170_D222_S0.7040.96
95_F98_R0.7030.96
300_Y305_A0.7010.96
461_A469_T0.7010.96
423_S432_G0.7000.96
489_S505_N0.6980.96
131_D134_V0.6970.96
288_N350_S0.6950.96
489_S497_N0.6950.96
455_L465_L0.6950.96
442_S445_Y0.6950.96
385_I396_R0.6940.96
138_E400_A0.6930.96
166_D169_I0.6930.96
416_G421_S0.6910.96
276_A372_A0.6880.96
336_S339_T0.6870.96
40_D43_E0.6860.96
180_F226_G0.6860.96
457_G461_A0.6860.96
73_Q84_P0.6860.96
100_E108_V0.6850.96
160_Y192_L0.6850.96
42_S110_Q0.6810.96
137_P141_D0.6810.96
114_L240_I0.6800.96
285_A295_S0.6790.95
430_L434_G0.6780.95
487_T494_T0.6770.95
174_S183_D0.6770.95
420_D424_S0.6760.95
419_G425_S0.6760.95
164_D207_A0.6750.95
247_A275_A0.6740.95
488_G493_I0.6700.95
180_F188_Y0.6700.95
116_A235_G0.6700.95
417_G427_S0.6690.95
326_D379_K0.6690.95
294_V324_K0.6660.95
334_V355_V0.6650.95
455_L461_A0.6630.95
228_A240_I0.6620.95
488_G492_S0.6600.95
150_T252_A0.6600.95
489_S498_P0.6600.95
453_I461_A0.6580.95
155_D197_H0.6570.95
112_V265_T0.6560.95
69_V72_V0.6550.95
156_Q196_I0.6530.94
152_G226_G0.6520.94
493_I502_V0.6510.94
162_H203_G0.6500.94
441_F448_P0.6480.94
492_S498_P0.6480.94
205_A221_S0.6470.94
177_G182_D0.6460.94
451_V456_D0.6430.94
305_A324_K0.6420.94
123_P128_Q0.6420.94
488_G495_I0.6420.94
489_S496_D0.6410.94
158_V202_A0.6400.94
311_P333_N0.6400.94
284_A300_Y0.6380.94
350_S354_P0.6380.94
155_D198_G0.6380.94
476_T479_S0.6380.94
444_E447_N0.6370.94
57_Q61_Q0.6320.93
154_V226_G0.6320.93
327_L359_V0.6310.93
320_N325_I0.6310.93
417_G426_V0.6280.93
227_R230_S0.6270.93
242_D245_T0.6250.93
490_Q495_I0.6240.93
140_W143_T0.6240.93
493_I499_D0.6240.93
464_D491_E0.6240.93
251_G280_A0.6220.93
308_A331_G0.6210.93
325_I393_G0.6190.93
254_V364_L0.6190.93
324_K327_L0.6190.93
495_I499_D0.6180.93
488_G498_P0.6180.93
422_T430_L0.6140.92
352_A355_V0.6140.92
252_A280_A0.6140.92
175_N182_D0.6140.92
462_D466_Y0.6130.92
389_D392_Q0.6130.92
262_G289_D0.6130.92
391_Q395_G0.6120.92
197_H350_S0.6110.92
373_E408_G0.6100.92
120_P123_P0.6100.92
495_I498_P0.6100.92
230_S233_G0.6100.92
120_P125_F0.6090.92
174_S180_F0.6080.92
449_S452_V0.6050.92
247_A251_G0.6050.92
423_S427_S0.6050.92
175_N222_S0.6040.92
149_V365_A0.6030.92
294_V299_A0.6020.92
177_G184_D0.6010.92
176_G181_V0.6010.92
304_L356_V0.6000.92
235_G239_D0.5990.91
57_Q60_E0.5960.91
131_D136_A0.5950.91
54_D57_Q0.5940.91
182_D188_Y0.5940.91
293_S296_Y0.5930.91
82_G85_A0.5930.91
54_D58_H0.5920.91
491_E497_N0.5910.91
279_G371_N0.5910.91
462_D465_L0.5910.91
170_D178_R0.5900.91
476_T485_W0.5890.91
137_P140_W0.5870.91
149_V254_V0.5870.91
67_E72_V0.5870.91
501_S504_L0.5860.91
152_G255_I0.5860.91
194_E230_S0.5860.91
498_P506_V0.5850.91
441_F444_E0.5850.91
333_N345_S0.5830.90
492_S497_N0.5830.90
420_D427_S0.5810.90
304_L360_A0.5810.90
55_P58_H0.5810.90
260_G297_P0.5810.90
255_I259_L0.5800.90
377_H381_T0.5800.90
418_G426_V0.5800.90
194_E227_R0.5790.90
309_L385_I0.5790.90
174_S184_D0.5780.90
501_S506_V0.5760.90
174_S185_G0.5760.90
486_T494_T0.5750.90
364_L371_N0.5750.90
70_G74_E0.5740.90
395_G398_D0.5720.90
382_A394_A0.5720.90
130_A133_Q0.5710.89
146_D365_A0.5710.89
56_Q60_E0.5710.89
457_G463_F0.5680.89
84_P238_A0.5680.89
237_T265_T0.5670.89
247_A282_V0.5660.89
428_G434_G0.5660.89
165_L202_A0.5660.89
460_N463_F0.5650.89
92_R96_V0.5640.89
497_N502_V0.5630.89
176_G185_G0.5630.89
443_Y447_N0.5630.89
465_L478_S0.5600.89
210_N214_G0.5580.88
482_F485_W0.5580.88
151_I206_A0.5570.88
178_R186_D0.5570.88
363_T399_A0.5560.88
384_D389_D0.5560.88
421_S431_R0.5560.88
471_T475_P0.5560.88
480_Y483_R0.5560.88
495_I500_T0.5550.88
496_D499_D0.5550.88
435_D438_C0.5510.88
472_N476_T0.5510.88
480_Y506_V0.5510.88
432_G436_S0.5510.88
177_G181_V0.5500.88
481_E484_S0.5500.88
177_G187_P0.5490.88
58_H62_Y0.5490.88
139_A400_A0.5480.87
205_A256_N0.5480.87
101_S104_T0.5470.87
204_I346_I0.5470.87
52_E60_E0.5460.87
93_K97_D0.5450.87
439_W444_E0.5450.87
81_V85_A0.5440.87
237_T240_I0.5430.87
230_S239_D0.5430.87
453_I463_F0.5410.87
399_A402_A0.5410.87
290_G321_Y0.5410.87
42_S46_V0.5390.87
428_G431_R0.5380.87
473_A476_T0.5370.86
52_E55_P0.5350.86
121_N124_R0.5330.86
336_S352_A0.5330.86
276_A371_N0.5330.86
145_G148_G0.5330.86
170_D185_G0.5330.86
215_V220_N0.5330.86
47_G50_N0.5320.86
452_V455_L0.5310.86
118_L121_N0.5300.86
427_S431_R0.5270.85
156_Q227_R0.5270.85
254_V374_L0.5270.85
135_N383_V0.5270.85
500_T504_L0.5270.85
78_T81_V0.5260.85
331_G351_M0.5260.85
177_G183_D0.5260.85
170_D186_D0.5250.85
416_G422_T0.5250.85
149_V152_G0.5240.85
420_D426_V0.5230.85
130_A355_V0.5230.85
494_T499_D0.5230.85
159_K340_A0.5220.85
471_T476_T0.5210.85
491_E505_N0.5210.85
59_V64_Q0.5200.85
99_L102_R0.5200.85
417_G429_S0.5190.85
377_H380_A0.5180.84
469_T504_L0.5170.84
54_D61_Q0.5160.84
216_T219_G0.5160.84
215_V337_T0.5150.84
107_Y270_N0.5130.84
424_S432_G0.5130.84
496_D501_S0.5120.84
424_S428_G0.5120.84
467_A506_V0.5110.84
244_I282_V0.5100.83
148_G221_S0.5100.83
159_K338_W0.5090.83
193_N227_R0.5090.83
421_S425_S0.5080.83
149_V362_L0.5080.83
421_S429_S0.5080.83
200_H338_W0.5080.83
237_T261_G0.5080.83
175_N181_V0.5080.83
423_S428_G0.5070.83
425_S428_G0.5070.83
432_G435_D0.5060.83
272_V284_A0.5060.83
492_S495_I0.5060.83
382_A393_G0.5050.83
140_W145_G0.5040.83
491_E494_T0.5030.83
220_N365_A0.5020.83
240_I268_M0.5010.82
174_S187_P0.5010.82
241_A268_M0.5010.82
54_D60_E0.5010.82
317_S347_S0.5000.82
460_N465_L0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3afgA 1 0.8895 100 0.326 Contact Map
3whiA 2 0.661 100 0.346 Contact Map
3wiuA 2 0.6648 100 0.37 Contact Map
1r6vA 1 0.8762 100 0.372 Contact Map
2id4A 1 0.7752 100 0.388 Contact Map
4tr2A 2 0.6762 100 0.399 Contact Map
3t41A 1 0.659 100 0.405 Contact Map
1wmdA 1 0.7105 100 0.41 Contact Map
4rydA 4 0.7638 100 0.415 Contact Map
1dbiA 1 0.5124 100 0.416 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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