GREMLIN Database
Q9HMF1 - Aconitase
UniProt: Q9HMF1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 661 (638)
Sequences: 3542 (1514)
Seq/√Len: 60.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_D264_D6.4011.00
160_R259_V6.2761.00
229_R232_D5.0231.00
195_T257_E5.0181.00
551_P577_I4.3041.00
266_E282_R4.2431.00
480_L516_I3.9771.00
342_T346_M3.8981.00
333_S355_A3.7141.00
185_K256_D3.7141.00
421_D425_P3.6191.00
613_F625_A3.5001.00
69_Q72_F3.4391.00
165_L174_V3.3621.00
617_V621_W3.2401.00
269_I284_V3.1821.00
326_A358_G3.1731.00
536_E562_Q3.1681.00
408_E411_D3.1081.00
162_E259_V3.0851.00
534_A561_A3.0731.00
560_L625_A3.0701.00
33_L100_C3.0201.00
166_P169_A2.9921.00
346_M351_N2.9201.00
344_E347_A2.8531.00
280_P283_E2.7671.00
131_L221_S2.7351.00
313_E344_E2.7251.00
266_E280_P2.7231.00
157_V256_D2.7181.00
611_E625_A2.6931.00
537_N540_Q2.6701.00
235_A240_E2.5941.00
517_D521_A2.5521.00
228_D232_D2.4951.00
181_R258_I2.4861.00
158_N195_T2.4741.00
612_E622_E2.4501.00
190_K256_D2.4401.00
235_A241_D2.4021.00
413_R416_S2.4011.00
517_D520_F2.3771.00
615_V623_A2.3461.00
522_E526_A2.3421.00
614_T622_E2.3161.00
591_E595_D2.3081.00
283_E286_G2.2991.00
629_A637_L2.2971.00
371_S388_E2.2971.00
593_G597_E2.2841.00
12_D15_V2.2411.00
181_R260_V2.1961.00
617_V620_D2.1701.00
269_I395_C2.1581.00
177_E180_R2.1571.00
562_Q586_T2.1411.00
639_A648_Q2.1261.00
155_E190_K2.1231.00
164_E201_S2.0821.00
514_S519_T2.0691.00
610_Q624_T2.0621.00
612_E624_T2.0501.00
284_V409_I2.0491.00
289_V374_L2.0331.00
326_A353_S2.0311.00
180_R278_V1.9791.00
155_E256_D1.9741.00
372_V409_I1.9721.00
57_E113_K1.9611.00
109_A125_P1.9421.00
507_R510_E1.9271.00
343_A347_A1.9231.00
160_R197_P1.9041.00
180_R184_V1.9021.00
51_M457_K1.8991.00
374_L403_S1.8971.00
435_G439_A1.8921.00
478_T481_K1.8791.00
214_G222_S1.8571.00
615_V621_W1.8461.00
593_G596_V1.8431.00
586_T589_R1.8391.00
521_A524_A1.8361.00
613_F623_A1.8331.00
531_V558_S1.8281.00
109_A130_Q1.8271.00
591_E597_E1.8241.00
177_E181_R1.8181.00
478_T597_E1.8171.00
292_V404_A1.8020.99
600_D603_A1.7960.99
293_M358_G1.7960.99
353_S358_G1.7830.99
274_M277_N1.7800.99
592_Q597_E1.7800.99
536_E584_E1.7730.99
159_V181_R1.7590.99
157_V255_A1.7440.99
200_E247_Q1.7430.99
481_K587_Y1.7420.99
600_D614_T1.7250.99
593_G598_V1.7170.99
204_V229_R1.7140.99
591_E594_D1.7120.99
408_E412_P1.7040.99
522_E525_K1.6960.99
177_E268_L1.6930.99
219_A222_S1.6920.99
260_V264_D1.6860.99
308_A398_E1.6820.99
376_T400_A1.6790.99
592_Q595_D1.6620.99
581_N626_T1.6590.99
533_V560_L1.6560.99
284_V403_S1.6540.99
287_Q393_Y1.6380.99
337_A342_T1.6310.99
160_R195_T1.6240.99
481_K588_A1.6230.99
520_F524_A1.6150.99
342_T352_F1.6120.99
569_K633_E1.6110.99
157_V190_K1.6050.99
323_M350_V1.6030.99
231_E235_A1.6020.99
581_N628_D1.5970.99
54_V144_M1.5830.99
217_L222_S1.5800.99
268_L278_V1.5760.99
629_A634_R1.5700.99
289_V403_S1.5590.99
514_S518_D1.5520.98
105_K208_T1.5460.98
441_D445_I1.5390.98
592_Q596_V1.5380.98
200_E228_D1.5380.98
591_E598_V1.5280.98
164_E197_P1.5260.98
438_G441_D1.5190.98
157_V185_K1.5180.98
514_S522_E1.5100.98
520_F523_R1.5080.98
475_R597_E1.5060.98
276_D485_N1.4980.98
26_G150_Y1.4960.98
294_V308_A1.4920.98
578_L637_L1.4770.98
306_L341_W1.4650.98
80_F84_A1.4520.98
592_Q598_V1.4520.98
605_A608_D1.4510.98
79_R449_E1.4500.98
517_D523_R1.4480.98
473_D600_D1.4480.98
361_I494_A1.4440.98
589_R621_W1.4350.97
533_V582_I1.4340.97
75_T79_R1.4340.97
476_G598_V1.4320.97
160_R251_D1.4110.97
159_V178_L1.3980.97
166_P266_E1.3960.97
515_R518_D1.3920.97
334_E337_A1.3920.97
165_L169_A1.3910.97
214_G217_L1.3850.97
631_E635_R1.3810.97
308_A437_Y1.3790.97
635_R638_A1.3750.97
639_A645_L1.3720.97
37_T494_A1.3600.96
69_Q73_K1.3550.96
499_L505_I1.3520.96
311_M401_T1.3480.96
203_S229_R1.3410.96
353_S359_A1.3410.96
441_D444_I1.3350.96
214_G219_A1.3290.96
109_A128_L1.3220.96
34_S100_C1.3190.96
601_D604_A1.3160.96
616_R619_D1.3130.96
533_V587_Y1.3100.96
312_L402_A1.3030.95
232_D235_A1.3030.95
343_A346_M1.3020.95
177_E260_V1.3010.95
167_E434_S1.2930.95
10_L19_L1.2870.95
223_I226_T1.2840.95
530_G556_V1.2790.95
402_A415_L1.2790.95
508_L550_C1.2770.95
477_E595_D1.2700.95
310_K313_E1.2700.95
585_E589_R1.2670.95
594_D597_E1.2630.95
422_L425_P1.2600.95
169_A267_P1.2600.95
558_S598_V1.2560.94
160_R257_E1.2550.94
482_M486_I1.2530.94
306_L325_V1.2530.94
457_K466_V1.2510.94
474_V531_V1.2490.94
155_E255_A1.2480.94
481_K533_V1.2470.94
531_V560_L1.2400.94
159_V260_V1.2390.94
116_L149_Y1.2390.94
515_R520_F1.2370.94
241_D245_D1.2320.94
110_A246_L1.2310.94
477_E528_D1.2240.94
260_V265_L1.2180.94
606_V609_G1.2170.93
82_R86_G1.2160.93
26_G632_R1.2160.93
533_V615_V1.2150.93
55_Q90_A1.2110.93
552_M557_E1.2050.93
158_N257_E1.2040.93
123_P222_S1.2030.93
183_S276_D1.2010.93
156_V191_V1.1980.93
374_L395_C1.1960.93
207_R227_D1.1940.93
591_E596_V1.1900.93
457_K462_S1.1880.93
368_A371_S1.1860.93
519_T523_R1.1860.93
276_D540_Q1.1830.92
478_T533_V1.1820.92
532_L556_V1.1770.92
285_A411_D1.1770.92
151_V630_S1.1750.92
70_F73_K1.1740.92
52_D87_T1.1730.92
166_P263_S1.1730.92
199_V225_P1.1670.92
38_T361_I1.1650.92
479_L556_V1.1650.92
595_D598_V1.1650.92
498_I502_R1.1600.92
346_M352_F1.1600.92
147_G649_R1.1600.92
269_I409_I1.1590.92
476_G616_R1.1580.92
131_L383_G1.1560.92
439_A443_D1.1560.92
59_A144_M1.1490.91
35_Q38_T1.1470.91
127_G211_T1.1430.91
205_P236_R1.1380.91
560_L623_A1.1330.91
37_T40_T1.1320.91
562_Q587_Y1.1310.91
540_Q551_P1.1300.91
473_D601_D1.1300.91
518_D521_A1.1290.91
211_T222_S1.1240.90
307_P440_G1.1220.90
34_S42_V1.1160.90
337_A346_M1.1140.90
38_T543_S1.1090.90
84_A455_L1.1060.90
162_E197_P1.1060.90
240_E243_F1.1050.90
290_E389_D1.1010.90
162_E263_S1.1000.89
372_V393_Y1.0980.89
16_E19_L1.0870.89
506_E510_E1.0870.89
506_E509_S1.0820.89
600_D604_A1.0800.89
312_L348_A1.0790.89
333_S337_A1.0720.88
113_K130_Q1.0620.88
128_L234_L1.0610.88
284_V372_V1.0590.88
487_T490_H1.0590.88
630_S633_E1.0560.87
277_N485_N1.0560.87
449_E452_D1.0550.87
499_L502_R1.0550.87
485_N537_N1.0540.87
424_A430_G1.0540.87
289_V372_V1.0480.87
568_H572_L1.0470.87
519_T522_E1.0460.87
288_E320_H1.0410.87
524_A527_A1.0380.87
500_K509_S1.0380.87
367_P370_D1.0370.86
164_E263_S1.0360.86
266_E283_E1.0320.86
9_I223_I1.0300.86
421_D424_A1.0280.86
31_Q104_H1.0270.86
517_D524_A1.0260.86
561_A581_N1.0240.86
478_T596_V1.0210.86
405_I429_M1.0140.85
16_E21_P1.0130.85
601_D605_A1.0110.85
616_R620_D1.0080.85
195_T259_V1.0070.85
594_D598_V1.0030.85
583_D586_T1.0030.85
476_G531_V1.0000.84
594_D618_N0.9980.84
323_M401_T0.9980.84
247_Q250_A0.9960.84
285_A417_D0.9910.84
538_Y568_H0.9900.84
102_N300_G0.9890.84
598_V616_R0.9880.84
203_S303_E0.9820.83
598_V611_E0.9800.83
607_A634_R0.9790.83
288_E408_E0.9780.83
302_Y339_E0.9730.83
54_V90_A0.9710.83
226_T231_E0.9690.83
232_D236_R0.9620.82
467_K639_A0.9620.82
281_V415_L0.9590.82
293_M377_F0.9580.82
473_D602_V0.9550.82
211_T223_I0.9520.81
338_R446_T0.9510.81
180_R268_L0.9470.81
292_V400_A0.9460.81
167_E435_G0.9450.81
177_E265_L0.9420.81
83_S455_L0.9420.81
424_A429_M0.9410.81
223_I252_A0.9410.81
599_V602_V0.9370.80
194_Y222_S0.9350.80
562_Q588_A0.9330.80
317_V320_H0.9330.80
501_F507_R0.9300.80
468_D648_Q0.9270.80
597_E600_D0.9260.80
110_A242_E0.9230.79
468_D639_A0.9170.79
512_T550_C0.9170.79
159_V194_Y0.9150.79
197_P201_S0.9140.79
312_L323_M0.9130.79
531_V597_E0.9130.79
610_Q626_T0.9120.78
142_V147_G0.9120.78
288_E411_D0.9110.78
593_G599_V0.9100.78
531_V551_P0.9090.78
125_P132_A0.9060.78
592_Q617_V0.9050.78
150_Y632_R0.9040.78
558_S625_A0.9030.78
10_L15_V0.9030.78
214_G540_Q0.9010.78
339_E440_G0.9010.78
591_E599_V0.8990.77
125_P129_G0.8970.77
298_T378_N0.8960.77
417_D420_G0.8950.77
68_Y143_A0.8940.77
627_L634_R0.8940.77
438_G442_T0.8900.77
110_A113_K0.8890.77
403_S408_E0.8840.76
285_A413_R0.8800.76
27_I114_T0.8770.76
192_L217_L0.8760.76
416_S419_L0.8760.76
231_E240_E0.8750.76
475_R598_V0.8690.75
56_T59_A0.8650.75
115_L125_P0.8630.75
582_I586_T0.8610.74
514_S521_A0.8590.74
597_E614_T0.8570.74
475_R616_R0.8560.74
10_L153_M0.8550.74
48_A458_G0.8540.74
163_G263_S0.8540.74
178_L192_L0.8510.74
457_K460_N0.8500.73
242_E245_D0.8500.73
350_V404_A0.8470.73
445_I448_E0.8460.73
492_I512_T0.8440.73
284_V287_Q0.8420.73
516_I519_T0.8410.73
440_G444_I0.8370.72
324_I353_S0.8370.72
482_M534_A0.8360.72
506_E553_F0.8350.72
375_R392_V0.8330.72
267_P281_V0.8330.72
84_A88_Y0.8330.72
147_G646_T0.8310.72
585_E588_A0.8300.72
516_I520_F0.8290.72
442_T445_I0.8280.71
464_V494_A0.8280.71
30_D111_P0.8270.71
306_L339_E0.8250.71
500_K505_I0.8240.71
211_T214_G0.8220.71
514_S520_F0.8210.71
402_A429_M0.8190.71
249_D252_A0.8190.71
281_V399_V0.8190.71
217_L223_I0.8180.71
17_G21_P0.8180.71
42_V115_L0.8170.70
425_P430_G0.8150.70
427_F431_T0.8150.70
444_I448_E0.8090.70
102_N106_E0.8080.70
194_Y214_G0.8070.69
19_L22_G0.8050.69
178_L260_V0.8040.69
383_G386_G0.8030.69
174_V210_I0.8010.69
580_L625_A0.8000.69
80_F455_L0.7990.69
61_Q85_A0.7990.69
211_T219_A0.7970.69
161_L178_L0.7950.68
165_L201_S0.7940.68
395_C400_A0.7940.68
501_F511_F0.7920.68
126_G211_T0.7920.68
105_K125_P0.7900.68
21_P155_E0.7890.68
477_E593_G0.7890.68
405_I419_L0.7870.68
367_P371_S0.7840.67
175_I210_I0.7830.67
614_T617_V0.7790.67
533_V597_E0.7780.67
71_D388_E0.7760.66
421_D426_G0.7750.66
573_F637_L0.7740.66
252_A383_G0.7730.66
333_S342_T0.7720.66
615_V619_D0.7670.66
282_R414_D0.7670.66
125_P222_S0.7670.66
292_V350_V0.7640.65
194_Y437_Y0.7610.65
322_E365_H0.7610.65
592_Q599_V0.7600.65
476_G529_S0.7580.65
317_V323_M0.7580.65
234_L240_E0.7580.65
597_E616_R0.7560.64
412_P417_D0.7550.64
339_E342_T0.7540.64
10_L13_H0.7540.64
369_S389_D0.7530.64
159_V265_L0.7530.64
84_A197_P0.7520.64
294_V323_M0.7510.64
142_V646_T0.7500.64
271_E279_V0.7500.64
29_I55_Q0.7490.64
533_V621_W0.7490.64
440_G443_D0.7480.64
422_L426_G0.7480.64
34_S118_S0.7470.64
307_P441_D0.7460.63
43_W61_Q0.7440.63
482_M516_I0.7410.63
287_Q409_I0.7400.63
171_A174_V0.7370.62
613_F624_T0.7360.62
131_L199_V0.7340.62
71_D393_Y0.7330.62
74_N78_H0.7330.62
178_L536_E0.7320.62
10_L131_L0.7310.62
32_T116_L0.7300.62
285_A414_D0.7300.62
609_G631_E0.7290.62
209_T301_A0.7290.62
615_V634_R0.7290.62
564_F581_N0.7280.62
551_P554_L0.7280.62
226_T243_F0.7280.62
97_N330_K0.7280.62
475_R596_V0.7280.62
615_V618_N0.7250.61
366_V370_D0.7240.61
584_E589_R0.7230.61
325_V345_M0.7230.61
597_E601_D0.7220.61
499_L629_A0.7220.61
590_I618_N0.7220.61
506_E515_R0.7200.61
14_L17_G0.7170.60
29_I114_T0.7150.60
13_H30_D0.7120.60
342_T351_N0.7120.60
311_M315_R0.7120.60
290_E386_G0.7110.60
306_L336_L0.7100.60
443_D446_T0.7090.59
595_D599_V0.7090.59
293_M324_I0.7080.59
202_L206_E0.7070.59
46_F88_Y0.7070.59
322_E351_N0.7060.59
38_T44_L0.7060.59
269_I279_V0.7050.59
114_T221_S0.7040.59
42_V143_A0.7030.59
84_A175_I0.7030.59
170_T398_E0.7030.59
162_E264_D0.7020.59
178_L265_L0.7020.59
79_R456_I0.7000.58
38_T502_R0.7000.58
200_E225_P0.6990.58
586_T590_I0.6990.58
370_D388_E0.6990.58
183_S215_T0.6980.58
211_T221_S0.6980.58
11_D15_V0.6970.58
157_V192_L0.6950.58
175_I194_Y0.6950.58
199_V202_L0.6950.58
523_R527_A0.6950.58
123_P132_A0.6940.58
24_E152_E0.6930.58
386_G393_Y0.6920.58
322_E350_V0.6920.58
603_A607_A0.6910.58
43_W90_A0.6910.58
147_G632_R0.6910.58
474_V557_E0.6880.57
472_A603_A0.6880.57
289_V409_I0.6870.57
636_T645_L0.6850.57
206_E303_E0.6830.57
84_A100_C0.6820.57
408_E417_D0.6810.56
308_A345_M0.6810.56
281_V284_V0.6800.56
38_T494_A0.6800.56
529_S557_E0.6790.56
27_I100_C0.6790.56
611_E617_V0.6770.56
62_Y65_H0.6770.56
444_I450_S0.6770.56
515_R527_A0.6770.56
178_L181_R0.6750.56
604_A609_G0.6750.56
174_V263_S0.6750.56
231_E244_V0.6740.56
465_P469_P0.6730.56
522_E606_V0.6730.56
164_E198_G0.6730.56
236_R444_I0.6730.56
332_A335_M0.6720.55
516_I523_R0.6720.55
325_V350_V0.6720.55
33_L117_G0.6710.55
53_E450_S0.6700.55
159_V318_S0.6700.55
42_V46_F0.6700.55
478_T590_I0.6690.55
152_E630_S0.6690.55
128_L204_V0.6690.55
208_T301_A0.6680.55
49_L361_I0.6670.55
634_R638_A0.6670.55
53_E89_G0.6650.55
516_I521_A0.6650.55
182_L258_I0.6650.55
440_G445_I0.6640.55
67_T356_T0.6630.54
494_A543_S0.6600.54
81_L494_A0.6600.54
645_L649_R0.6580.54
469_P532_L0.6580.54
162_E261_D0.6570.54
179_L561_A0.6570.54
165_L265_L0.6570.54
478_T615_V0.6570.54
208_T328_G0.6570.54
179_L217_L0.6570.54
169_A434_S0.6560.54
91_Y103_V0.6550.54
318_S405_I0.6550.54
585_E590_I0.6550.54
305_V345_M0.6540.53
205_P332_A0.6530.53
605_A611_E0.6520.53
128_L254_Y0.6520.53
326_A345_M0.6520.53
197_P200_E0.6520.53
182_L192_L0.6510.53
142_V642_K0.6500.53
628_D637_L0.6500.53
394_L561_A0.6500.53
84_A630_S0.6500.53
199_V250_A0.6480.53
19_L153_M0.6480.53
288_E349_G0.6480.53
474_V529_S0.6480.53
337_A343_A0.6480.53
494_A498_I0.6470.53
573_F633_E0.6440.52
102_N105_K0.6440.52
102_N332_A0.6430.52
370_D389_D0.6430.52
603_A611_E0.6420.52
181_R265_L0.6410.52
443_D560_L0.6400.52
184_V537_N0.6400.52
421_D427_F0.6400.52
533_V586_T0.6390.52
201_S416_S0.6380.52
289_V404_A0.6370.51
338_R444_I0.6350.51
35_Q100_C0.6350.51
485_N540_Q0.6350.51
40_T81_L0.6340.51
291_Q324_I0.6340.51
419_L429_M0.6340.51
467_K552_M0.6330.51
228_D243_F0.6330.51
155_E608_D0.6330.51
62_Y93_S0.6330.51
605_A634_R0.6310.51
298_T328_G0.6300.51
37_T508_L0.6300.51
84_A151_V0.6300.51
125_P130_Q0.6290.51
498_I508_L0.6290.51
185_K257_E0.6290.51
159_V192_L0.6280.50
612_E618_N0.6270.50
395_C399_V0.6270.50
27_I33_L0.6270.50
204_V208_T0.6260.50
24_E33_L0.6260.50
477_E530_G0.6260.50
210_I471_G0.6260.50
532_L559_V0.6260.50
610_Q615_V0.6250.50
35_Q363_I0.6250.50
231_E313_E0.6240.50
382_E490_H0.6240.50
143_A632_R0.6240.50
562_Q581_N0.6240.50
476_G597_E0.6210.50
109_A234_L0.6200.50
622_E626_T0.6190.49
460_N463_S0.6180.49
464_V467_K0.6170.49
291_Q389_D0.6160.49
439_A442_T0.6140.49
405_I432_S0.6140.49
562_Q583_D0.6140.49
60_A96_G0.6130.49
371_S393_Y0.6130.49
521_A525_K0.6110.49
347_A351_N0.6110.49
199_V224_F0.6110.49
512_T552_M0.6110.49
78_H91_Y0.6110.49
613_F616_R0.6110.49
124_T300_G0.6100.48
251_D257_E0.6090.48
11_D14_L0.6090.48
235_A244_V0.6080.48
80_F143_A0.6080.48
326_A354_E0.6070.48
195_T340_G0.6070.48
562_Q584_E0.6070.48
254_Y564_F0.6070.48
123_P211_T0.6060.48
127_G255_A0.6060.48
613_F622_E0.6050.48
424_A427_F0.6050.48
188_V220_T0.6040.48
369_S418_D0.6040.48
40_T44_L0.6040.48
607_A627_L0.6040.48
222_S540_Q0.6030.48
613_F617_V0.6010.47
241_D426_G0.6010.47
60_A108_F0.6010.47
62_Y66_Q0.6010.47
385_S486_I0.6000.47
129_G207_R0.5990.47
33_L390_D0.5990.47
266_E415_L0.5980.47
157_V211_T0.5980.47
198_G201_S0.5970.47
348_A405_I0.5970.47
608_D626_T0.5960.47
371_S533_V0.5960.47
317_V404_A0.5950.47
46_F145_G0.5940.47
177_E264_D0.5930.47
187_G565_A0.5930.47
511_F560_L0.5920.46
48_A51_M0.5900.46
310_K341_W0.5900.46
627_L637_L0.5890.46
371_S386_G0.5880.46
105_K204_V0.5880.46
175_I215_T0.5880.46
599_V603_A0.5870.46
96_G175_I0.5860.46
406_A412_P0.5860.46
313_E347_A0.5860.46
84_A210_I0.5850.46
498_I575_F0.5840.46
35_Q361_I0.5830.45
78_H540_Q0.5830.45
159_V180_R0.5830.45
226_T230_T0.5830.45
247_Q614_T0.5830.45
79_R371_S0.5820.45
518_D524_A0.5820.45
376_T395_C0.5820.45
228_D573_F0.5820.45
478_T587_Y0.5820.45
301_A328_G0.5810.45
532_L583_D0.5800.45
41_M45_Q0.5790.45
274_M537_N0.5770.45
300_G305_V0.5760.45
35_Q114_T0.5760.45
161_L202_L0.5740.44
274_M485_N0.5740.44
35_Q194_Y0.5740.44
62_Y100_C0.5730.44
32_T143_A0.5730.44
478_T558_S0.5730.44
164_E618_N0.5720.44
20_Q155_E0.5710.44
24_E49_L0.5710.44
393_Y445_I0.5700.44
435_G438_G0.5700.44
155_E635_R0.5690.44
187_G215_T0.5690.44
97_N103_V0.5690.44
202_L284_V0.5690.44
273_S353_S0.5680.44
37_T100_C0.5680.44
594_D617_V0.5680.44
43_W84_A0.5660.44
606_V610_Q0.5650.43
269_I287_Q0.5650.43
412_P418_D0.5650.43
62_Y104_H0.5640.43
600_D605_A0.5640.43
135_A140_I0.5630.43
406_A414_D0.5620.43
100_C297_C0.5620.43
191_V221_S0.5620.43
279_V287_Q0.5620.43
161_L201_S0.5610.43
171_A206_E0.5600.43
602_V605_A0.5600.43
245_D583_D0.5600.43
32_T59_A0.5600.43
335_M339_E0.5590.43
324_I336_L0.5590.43
107_N331_Q0.5580.43
100_C109_A0.5580.43
449_E456_I0.5580.43
473_D603_A0.5570.43
373_S472_A0.5570.43
542_S571_N0.5560.42
285_A408_E0.5560.42
245_D475_R0.5560.42
80_F505_I0.5550.42
79_R290_E0.5550.42
307_P445_I0.5550.42
197_P248_A0.5550.42
269_I426_G0.5550.42
514_S534_A0.5540.42
215_T568_H0.5540.42
10_L14_L0.5540.42
520_F525_K0.5540.42
533_V613_F0.5530.42
306_L373_S0.5530.42
560_L624_T0.5530.42
601_D606_V0.5520.42
415_L430_G0.5510.42
471_G534_A0.5510.42
616_R622_E0.5500.42
59_A386_G0.5500.42
34_S59_A0.5500.42
429_M432_S0.5490.42
621_W624_T0.5490.42
57_E87_T0.5490.42
96_G354_E0.5490.42
243_F246_L0.5490.42
197_P249_D0.5480.42
143_A392_V0.5480.42
477_E529_S0.5480.42
419_L432_S0.5480.42
558_S599_V0.5480.42
61_Q81_L0.5460.41
336_L342_T0.5460.41
97_N221_S0.5450.41
242_E442_T0.5440.41
478_T531_V0.5440.41
602_V638_A0.5420.41
104_H113_K0.5420.41
12_D16_E0.5420.41
236_R243_F0.5420.41
450_S456_I0.5420.41
28_E254_Y0.5420.41
68_Y540_Q0.5410.41
276_D537_N0.5410.41
53_E286_G0.5400.41
361_I543_S0.5400.41
131_L153_M0.5400.41
247_Q251_D0.5400.41
434_S437_Y0.5390.41
99_I102_N0.5390.41
280_P445_I0.5390.41
151_V175_I0.5380.40
317_V348_A0.5380.40
61_Q65_H0.5380.40
199_V478_T0.5370.40
42_V455_L0.5370.40
338_R606_V0.5370.40
612_E649_R0.5360.40
324_I365_H0.5360.40
521_A526_A0.5360.40
427_F430_G0.5360.40
180_R255_A0.5350.40
597_E623_A0.5350.40
166_P201_S0.5350.40
284_V374_L0.5350.40
341_W344_E0.5350.40
24_E630_S0.5350.40
175_I217_L0.5350.40
45_Q575_F0.5340.40
17_G631_E0.5340.40
596_V599_V0.5330.40
395_C619_D0.5330.40
24_E150_Y0.5320.40
471_G474_V0.5320.40
149_Y308_A0.5310.40
470_L648_Q0.5310.40
185_K486_I0.5310.40
204_V230_T0.5310.40
91_Y108_F0.5310.40
57_E143_A0.5310.40
35_Q491_I0.5310.40
390_D577_I0.5300.40
609_G613_F0.5300.40
150_Y645_L0.5300.40
86_G605_A0.5300.40
363_I500_K0.5290.40
10_L25_I0.5290.40
326_A356_T0.5290.40
434_S438_G0.5290.40
29_I135_A0.5280.39
76_D80_F0.5280.39
279_V393_Y0.5280.39
131_L228_D0.5270.39
166_P264_D0.5260.39
481_K623_A0.5250.39
182_L297_C0.5250.39
87_T451_I0.5250.39
480_L533_V0.5250.39
426_G429_M0.5250.39
162_E174_V0.5240.39
296_S299_N0.5230.39
599_V604_A0.5230.39
19_L28_E0.5220.39
166_P286_G0.5220.39
200_E250_A0.5220.39
80_F149_Y0.5210.39
455_L459_P0.5210.39
9_I12_D0.5210.39
465_P506_E0.5210.39
169_A419_L0.5210.39
315_R421_D0.5210.39
27_I149_Y0.5200.39
159_V257_E0.5200.39
412_P415_L0.5200.39
279_V283_E0.5200.39
265_L289_V0.5200.39
78_H85_A0.5190.38
302_Y335_M0.5190.38
318_S321_T0.5190.38
60_A65_H0.5190.38
169_A415_L0.5180.38
538_Y551_P0.5180.38
150_Y205_P0.5180.38
326_A378_N0.5180.38
471_G637_L0.5170.38
226_T254_Y0.5170.38
460_N644_S0.5170.38
174_V198_G0.5160.38
416_S420_G0.5160.38
312_L418_D0.5150.38
366_V369_S0.5150.38
521_A553_F0.5150.38
270_A330_K0.5150.38
228_D248_A0.5140.38
78_H276_D0.5140.38
34_S61_Q0.5140.38
306_L310_K0.5140.38
46_F388_E0.5140.38
162_E257_E0.5130.38
105_K219_A0.5120.38
283_E415_L0.5110.38
40_T63_C0.5110.38
533_V591_E0.5100.38
228_D231_E0.5100.38
617_V634_R0.5100.38
474_V558_S0.5090.37
605_A609_G0.5090.37
12_D17_G0.5090.37
246_L252_A0.5090.37
249_D253_E0.5080.37
394_L577_I0.5080.37
444_I449_E0.5080.37
525_K528_D0.5070.37
263_S280_P0.5070.37
280_P609_G0.5060.37
437_Y445_I0.5060.37
477_E596_V0.5060.37
424_A431_T0.5060.37
286_G624_T0.5050.37
418_D426_G0.5030.37
282_R285_A0.5030.37
35_Q39_G0.5020.37
284_V408_E0.5010.37
481_K629_A0.5010.37
353_S378_N0.5010.37
573_F579_P0.5010.37
448_E606_V0.5010.37
263_S605_A0.5000.36
457_K463_S0.5000.36
583_D596_V0.5000.36
426_G430_G0.5000.36
510_E522_E0.5000.36
197_P242_E0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3yA 1 0.9758 100 0.185 Contact Map
1c96A 1 0.9743 100 0.194 Contact Map
4kp1A 1 0.6263 100 0.415 Contact Map
4kp2A 2 0.6157 100 0.42 Contact Map
1l5jA 1 0.6702 100 0.494 Contact Map
3vbaA 2 0.2557 100 0.825 Contact Map
2pkpA 2 0.2526 100 0.828 Contact Map
1v7lA 6 0.2466 100 0.831 Contact Map
3q3wA 1 0.2481 100 0.842 Contact Map
2hcuA 1 0.2481 100 0.844 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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