Q9HMF0 - HALSA - GREMLIN Contacts

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Q9HMF0 - Pab N-terminal acetyltransferase

UniProt:	Q9HMF0	Sequences: MSAVGDKPNRDVCRGVTAVQRGDPDVWVRQATRADLLAIVRIEQSVFSHPWPYAAFERQLDTAGFLVAAEQSGLDSVAGYVVGDTIPGHGRPLGHIKDIAVRSTRQGDGIGRLLLSRGVAALAGQGAHTVKLEVRESNEVARHLYEEFGFEYIRRLPEYYADGEDAGVMAVRLADRDGF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	179 (143)
Sequences:	9619 (7348)
Seq/√Len:	614.4

ECOLI - RIMI YJGM MNAT PHNO YPEA YEDL YAFP
BACSU - RIMI YYAR PAIA YQJY YHFO YWNH YTMI YBFA YUAI YESJ YSNE YHDJ YDGE YYCN YVBK
HALSA - Q9HMF0 Q9HSL3 Q9HMI8 Q9HQD2
SULSO - Y209 Q7LXZ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
45_S	102_R	2.960	1.00
119_V	150_F	2.839	1.00
112_R	147_E	2.660	1.00
119_V	171_V	2.619	1.00
112_R	148_F	2.571	1.00
129_T	170_A	2.530	1.00
29_R	35_D	2.520	1.00
81_V	118_G	2.520	1.00
29_R	70_E	2.457	1.00
152_Y	155_R	2.223	1.00
116_S	148_F	2.118	1.00
152_Y	167_G	2.066	1.00
78_A	105_R	2.056	1.00
119_V	130_V	2.055	1.00
31_A	39_I	1.994	1.00
153_I	170_A	1.956	1.00
146_E	152_Y	1.893	1.00
37_L	53_Y	1.889	1.00
117_R	120_A	1.779	1.00
142_R	146_E	1.769	1.00
137_S	164_E	1.753	1.00
83_G	118_G	1.741	1.00
143_H	146_E	1.733	1.00
106_Q	140_V	1.715	1.00
79_G	101_V	1.704	1.00
155_R	165_D	1.692	1.00
136_E	165_D	1.687	1.00
115_L	148_F	1.571	1.00
121_A	124_G	1.568	1.00
132_L	145_Y	1.549	1.00
40_V	44_Q	1.537	1.00
45_S	103_S	1.532	1.00
94_G	122_L	1.507	1.00
136_E	167_G	1.495	1.00
29_R	71_Q	1.493	1.00
101_V	110_I	1.492	1.00
105_R	108_D	1.492	1.00
46_V	100_A	1.484	1.00
69_A	110_I	1.372	1.00
38_A	41_R	1.365	1.00
53_Y	57_E	1.333	1.00
121_A	125_Q	1.292	1.00
136_E	155_R	1.290	1.00
153_I	168_V	1.257	1.00
141_A	145_Y	1.234	1.00
38_A	77_V	1.215	1.00
76_S	104_T	1.180	1.00
112_R	116_S	1.169	1.00
123_A	171_V	1.163	1.00
107_G	140_V	1.147	1.00
33_R	57_E	1.141	1.00
135_R	164_E	1.136	1.00
68_A	77_V	1.119	1.00
142_R	152_Y	1.118	1.00
76_S	102_R	1.115	1.00
83_G	122_L	1.112	1.00
40_V	53_Y	1.107	1.00
67_V	117_R	1.105	1.00
139_E	142_R	1.092	1.00
71_Q	74_L	1.084	1.00
133_E	166_A	1.080	1.00
152_Y	169_M	1.068	1.00
85_T	127_A	1.062	1.00
55_A	59_Q	1.054	1.00
157_P	165_D	1.051	1.00
86_I	91_R	1.050	1.00
139_E	143_H	1.039	1.00
28_V	113_L	1.038	1.00
28_V	117_R	1.034	1.00
71_Q	78_A	1.031	1.00
81_V	96_I	1.025	1.00
43_E	56_F	1.017	1.00
47_F	100_A	1.007	1.00
131_K	170_A	1.005	1.00
81_V	114_L	1.005	1.00
92_P	128_H	0.995	1.00
70_E	75_D	0.994	1.00
117_R	121_A	0.993	1.00
41_R	45_S	0.988	1.00
134_V	141_A	0.985	1.00
70_E	110_I	0.976	1.00
129_T	172_R	0.969	1.00
57_E	61_D	0.967	1.00
93_L	131_K	0.966	1.00
122_L	130_V	0.965	1.00
56_F	59_Q	0.959	1.00
31_A	68_A	0.957	1.00
155_R	167_G	0.953	1.00
38_A	76_S	0.951	1.00
52_P	55_A	0.942	1.00
46_V	106_Q	0.938	1.00
109_G	112_R	0.936	1.00
159_Y	166_A	0.934	1.00
33_R	61_D	0.932	1.00
134_V	138_N	0.930	1.00
144_L	148_F	0.926	1.00
42_I	102_R	0.917	1.00
120_A	124_G	0.915	1.00
45_S	104_T	0.910	1.00
43_E	80_Y	0.908	1.00
93_L	129_T	0.891	1.00
113_L	116_S	0.889	1.00
58_R	62_T	0.877	1.00
42_I	46_V	0.868	1.00
142_R	167_G	0.864	1.00
102_R	105_R	0.854	1.00
130_V	150_F	0.854	1.00
42_I	77_V	0.829	1.00
66_L	82_V	0.828	1.00
43_E	98_D	0.812	1.00
41_R	102_R	0.798	1.00
59_Q	82_V	0.796	1.00
36_L	40_V	0.794	1.00
95_H	131_K	0.782	1.00
138_N	141_A	0.780	1.00
151_E	170_A	0.780	1.00
31_A	35_D	0.778	1.00
78_A	110_I	0.772	1.00
26_V	110_I	0.763	1.00
146_E	169_M	0.759	1.00
76_S	105_R	0.756	1.00
37_L	41_R	0.752	1.00
30_Q	121_A	0.745	1.00
151_E	172_R	0.743	1.00
82_V	97_K	0.740	1.00
71_Q	105_R	0.740	1.00
85_T	125_Q	0.739	1.00
35_D	70_E	0.737	1.00
160_Y	166_A	0.735	1.00
63_A	70_E	0.730	1.00
132_L	141_A	0.728	1.00
84_D	97_K	0.726	1.00
43_E	47_F	0.723	1.00
146_E	151_E	0.716	1.00
81_V	99_I	0.712	1.00
131_K	153_I	0.711	1.00
66_L	69_A	0.707	1.00
122_L	127_A	0.705	1.00
94_G	127_A	0.704	1.00
31_A	66_L	0.703	1.00
54_A	58_R	0.702	1.00
142_R	169_M	0.690	1.00
32_T	35_D	0.686	1.00
129_T	153_I	0.679	1.00
107_G	143_H	0.667	1.00
82_V	98_D	0.666	1.00
133_E	156_L	0.661	1.00
80_Y	100_A	0.659	1.00
69_A	114_L	0.658	1.00
41_R	76_S	0.654	1.00
58_R	61_D	0.653	1.00
116_S	120_A	0.649	1.00
119_V	123_A	0.648	1.00
139_E	146_E	0.648	1.00
96_I	115_L	0.642	1.00
115_L	150_F	0.641	1.00
136_E	164_E	0.641	1.00
63_A	68_A	0.637	1.00
29_R	32_T	0.636	1.00
115_L	144_L	0.629	1.00
80_Y	98_D	0.628	1.00
40_V	56_F	0.627	1.00
51_W	55_A	0.623	1.00
101_V	111_G	0.619	1.00
51_W	56_F	0.618	1.00
156_L	168_V	0.617	1.00
54_A	57_E	0.613	1.00
65_F	125_Q	0.611	1.00
27_W	70_E	0.607	1.00
119_V	148_F	0.607	1.00
134_V	145_Y	0.607	1.00
113_L	117_R	0.606	1.00
46_V	103_S	0.598	1.00
65_F	121_A	0.592	1.00
38_A	42_I	0.588	1.00
38_A	102_R	0.585	1.00
51_W	59_Q	0.582	1.00
103_S	106_Q	0.581	1.00
140_V	143_H	0.575	1.00
39_I	80_Y	0.571	1.00
36_L	60_L	0.571	1.00
92_P	127_A	0.571	1.00
63_A	69_A	0.570	1.00
26_V	113_L	0.569	1.00
141_A	144_L	0.565	1.00
110_I	113_L	0.563	1.00
83_G	94_G	0.556	1.00
28_V	114_L	0.554	1.00
69_A	77_V	0.553	1.00
70_E	77_V	0.551	1.00
65_F	69_A	0.544	0.99
67_V	82_V	0.544	0.99
56_F	80_Y	0.543	0.99
93_L	156_L	0.540	0.99
36_L	57_E	0.533	0.99
56_F	60_L	0.528	0.99
99_I	115_L	0.527	0.99
69_A	79_G	0.526	0.99
59_Q	62_T	0.525	0.99
47_F	80_Y	0.524	0.99
107_G	111_G	0.523	0.99
26_V	69_A	0.522	0.99
42_I	100_A	0.521	0.99
89_H	92_P	0.521	0.99
86_I	93_L	0.521	0.99
101_V	114_L	0.516	0.99
56_F	82_V	0.515	0.99
55_A	58_R	0.514	0.99
33_R	36_L	0.514	0.99
84_D	95_H	0.509	0.99
31_A	36_L	0.506	0.99
158_E	165_D	0.503	0.99
63_A	66_L	0.502	0.99
90_G	93_L	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ob0A	1	0.8771	99.9	0.368	Contact Map
4kvxA	1	0.8212	99.9	0.372	Contact Map
2reeA	1	0.8436	99.9	0.392	Contact Map
2r7hA	2	0.8212	99.9	0.396	Contact Map
4pv6C	3	0.8603	99.9	0.402	Contact Map
3kkwA	1	0.8603	99.9	0.407	Contact Map
4r3lA	1	0.8212	99.9	0.408	Contact Map
2cntA	1	0.8268	99.9	0.408	Contact Map
3dr6A	2	0.8547	99.9	0.412	Contact Map
1mk4A	2	0.8156	99.9	0.413	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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