Q9HME9 - HALSA - GREMLIN Contacts

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Q9HME9 - Uncharacterized protein

UniProt:	Q9HME9	Sequences: MGYLCPVCGVETADGEHLANHVAFTALTRGGDHEAWLDEHAPAWADSGPAELADTVVGHATETDAEPVSEAHTHDAPAGARASVDASAADSDDVLAEARELTAAMYAASADDNGDSENE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	119 (102)
Sequences:	107 (104)
Seq/√Len:	10.2

HALSA - Q9HME9 O51967

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_G	33_H	3.828	0.98
9_G	18_L	2.659	0.88
9_G	22_V	2.559	0.86
3_Y	15_G	2.356	0.81
5_C	8_C	2.323	0.80
16_E	23_A	2.296	0.79
88_A	92_D	2.142	0.74
4_L	19_A	2.136	0.73
5_C	21_H	2.082	0.71
8_C	21_H	2.082	0.71
14_D	26_A	1.993	0.68
29_R	33_H	1.904	0.64
100_E	104_A	1.729	0.56
4_L	24_F	1.670	0.54
46_D	54_D	1.652	0.53
23_A	31_G	1.641	0.52
7_V	37_L	1.631	0.52
6_P	24_F	1.545	0.48
96_A	103_A	1.521	0.47
13_A	17_H	1.509	0.46
99_R	104_A	1.490	0.45
73_T	76_A	1.476	0.45
50_A	57_V	1.427	0.42
19_A	22_V	1.402	0.41
19_A	27_L	1.387	0.41
33_H	46_D	1.361	0.40
8_C	25_T	1.352	0.39
5_C	25_T	1.352	0.39
17_H	24_F	1.324	0.38
59_H	94_V	1.291	0.36
6_P	10_V	1.286	0.36
3_Y	23_A	1.275	0.36
63_T	77_P	1.263	0.35
4_L	12_T	1.245	0.34
28_T	31_G	1.163	0.31
4_L	13_A	1.159	0.31
3_Y	16_E	1.155	0.31
11_E	20_N	1.151	0.31
14_D	19_A	1.150	0.31
7_V	24_F	1.119	0.29
8_C	12_T	1.114	0.29
5_C	12_T	1.114	0.29
9_G	19_A	1.088	0.28
29_R	53_A	1.080	0.28
28_T	34_E	1.058	0.27
18_L	25_T	1.058	0.27
20_N	23_A	1.041	0.26
7_V	16_E	1.038	0.26
42_P	58_G	1.036	0.26
7_V	18_L	1.032	0.26
10_V	13_A	1.027	0.26
32_D	55_T	1.020	0.26
14_D	38_D	1.019	0.26
17_H	38_D	1.015	0.26
93_D	102_T	1.000	0.25
95_L	103_A	0.997	0.25
17_H	31_G	0.983	0.24
80_A	83_S	0.967	0.24
70_E	96_A	0.966	0.24
101_L	104_A	0.954	0.23
64_D	81_R	0.945	0.23
51_E	92_D	0.942	0.23
47_S	57_V	0.935	0.23
23_A	42_P	0.917	0.22
21_H	25_T	0.903	0.22
20_N	83_S	0.901	0.22
18_L	26_A	0.896	0.22
24_F	40_H	0.896	0.22
71_A	79_G	0.881	0.21
67_P	81_R	0.875	0.21
33_H	36_W	0.870	0.21
70_E	85_D	0.869	0.21
14_D	18_L	0.868	0.21
15_G	19_A	0.865	0.21
12_T	19_A	0.862	0.21
64_D	72_H	0.852	0.20
22_V	73_T	0.839	0.20
68_V	72_H	0.838	0.20
50_A	82_A	0.838	0.20
90_D	93_D	0.837	0.20
29_R	82_A	0.831	0.20
7_V	14_D	0.829	0.20
5_C	18_L	0.828	0.20
8_C	18_L	0.828	0.20
25_T	90_D	0.814	0.19
3_Y	8_C	0.814	0.19
79_G	83_S	0.808	0.19
66_E	72_H	0.804	0.19
56_V	103_A	0.783	0.18
4_L	17_H	0.779	0.18
39_E	61_T	0.778	0.18
64_D	76_A	0.778	0.18
9_G	15_G	0.776	0.18
4_L	71_A	0.774	0.18
51_E	70_E	0.774	0.18
20_N	80_A	0.769	0.18
88_A	98_A	0.764	0.18
81_R	85_D	0.758	0.18
86_A	92_D	0.756	0.18
6_P	29_R	0.747	0.17
70_E	74_H	0.746	0.17
100_E	103_A	0.734	0.17
87_S	91_S	0.733	0.17
48_G	87_S	0.732	0.17
10_V	32_D	0.722	0.17
33_H	75_D	0.711	0.16
40_H	67_P	0.706	0.16
43_A	53_A	0.690	0.16
98_A	103_A	0.687	0.16
47_S	69_S	0.685	0.16
83_S	97_E	0.682	0.16
13_A	22_V	0.677	0.15
15_G	38_D	0.677	0.15
13_A	91_S	0.660	0.15
70_E	87_S	0.648	0.15
89_A	95_L	0.647	0.15
26_A	34_E	0.636	0.15
70_E	84_V	0.633	0.14
67_P	84_V	0.633	0.14
3_Y	25_T	0.630	0.14
68_V	79_G	0.616	0.14
73_T	83_S	0.613	0.14
35_A	59_H	0.599	0.14
74_H	84_V	0.598	0.14
99_R	102_T	0.595	0.14
66_E	86_A	0.591	0.14
10_V	46_D	0.586	0.13
93_D	97_E	0.580	0.13
56_V	69_S	0.579	0.13
41_A	99_R	0.573	0.13
67_P	79_G	0.565	0.13
38_D	87_S	0.563	0.13
11_E	99_R	0.561	0.13
97_E	100_E	0.560	0.13
9_G	13_A	0.556	0.13
7_V	10_V	0.553	0.13
59_H	101_L	0.553	0.13
47_S	82_A	0.546	0.13
43_A	91_S	0.543	0.13
12_T	21_H	0.542	0.12
36_W	46_D	0.534	0.12
53_A	70_E	0.533	0.12
6_P	11_E	0.525	0.12
6_P	17_H	0.524	0.12
58_G	78_A	0.524	0.12
4_L	86_A	0.522	0.12
4_L	10_V	0.519	0.12
35_A	62_E	0.516	0.12
62_E	74_H	0.516	0.12
62_E	68_V	0.515	0.12
32_D	38_D	0.511	0.12
15_G	60_A	0.510	0.12
3_Y	53_A	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1njqA	1	0.2857	98.7	0.564	Contact Map
2eoxA	1	0.2857	98.7	0.567	Contact Map
2eluA	1	0.2437	98.7	0.568	Contact Map
2el5A	1	0.2857	98.7	0.568	Contact Map
1x3cA	1	0.3782	98.7	0.568	Contact Map
2eouA	1	0.2857	98.7	0.568	Contact Map
2eonA	1	0.3025	98.7	0.569	Contact Map
2yu5A	1	0.2857	98.7	0.569	Contact Map
2ytdA	1	0.3025	98.7	0.57	Contact Map
2embA	1	0.2857	98.7	0.57	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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