GREMLIN Database
Q9HME7 - Iron-dependent repressor homolog
UniProt: Q9HME7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (117)
Sequences: 2570 (1743)
Seq/√Len: 161.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_E76_R2.8131.00
89_S103_L2.6821.00
99_T108_S2.5941.00
15_T82_R2.5701.00
10_D54_R2.3791.00
9_A43_T2.3791.00
80_W116_R2.3101.00
58_D66_T2.2681.00
30_T44_V2.2491.00
17_I57_V2.2201.00
11_N105_G1.9721.00
114_A117_E1.9121.00
90_A97_A1.9031.00
77_T109_A1.8271.00
48_F57_V1.7851.00
21_G72_E1.7561.00
116_R121_H1.6821.00
46_E50_D1.6661.00
52_A59_Y1.6601.00
43_T47_R1.6181.00
87_H91_D1.5611.00
19_I79_A1.5571.00
70_R73_R1.5461.00
56_L70_R1.5431.00
107_L112_A1.5241.00
88_F93_L1.5241.00
69_D72_E1.5121.00
15_T101_D1.4941.00
86_H90_A1.4881.00
85_A107_L1.4831.00
23_V36_E1.4371.00
21_G28_A1.4341.00
102_E106_A1.4271.00
16_A36_E1.4251.00
39_V44_V1.4211.00
11_N104_G1.3591.00
17_I28_A1.3581.00
92_E118_H1.3531.00
117_E121_H1.3011.00
59_Y62_Y1.2961.00
33_V48_F1.2791.00
16_A33_V1.2511.00
7_S10_D1.2501.00
101_D105_G1.2501.00
32_A35_A1.2411.00
48_F65_A1.2251.00
95_L111_A1.2131.00
10_D47_R1.1461.00
45_T59_Y1.1451.00
8_R12_R1.1431.00
119_I122_P1.1291.00
33_V65_A1.1231.00
93_L114_A1.1191.00
12_R105_G1.1111.00
41_P47_R1.1091.00
95_L99_T1.1031.00
19_I36_E1.0971.00
101_D104_G1.0931.00
30_T48_F1.0901.00
57_V65_A1.0880.99
15_T104_G1.0760.99
99_T111_A1.0620.99
82_R104_G1.0510.99
16_A37_L1.0210.99
88_F92_E1.0110.99
31_G41_P0.9850.99
96_P110_D0.9780.99
88_F118_H0.9660.99
14_L18_F0.9640.99
73_R77_T0.9520.99
11_N78_L0.9510.99
30_T41_P0.9500.99
80_W84_L0.9490.99
12_R101_D0.9140.98
77_T81_K0.9090.98
110_D114_A0.9060.98
18_F79_A0.8940.98
88_F115_L0.8810.98
27_R64_G0.8810.98
47_R50_D0.8810.98
109_A113_A0.8800.98
49_R52_A0.8500.97
12_R104_G0.8440.97
14_L74_I0.8330.97
17_I44_V0.8320.97
78_L81_K0.8220.97
21_G26_C0.8210.97
74_I77_T0.8140.96
37_L47_R0.8070.96
55_D70_R0.8050.96
49_R53_A0.7970.96
30_T45_T0.7890.96
7_S62_Y0.7800.95
81_K109_A0.7740.95
58_D68_T0.7670.95
40_S45_T0.7620.95
12_R15_T0.7620.95
88_F119_I0.7600.95
83_C86_H0.7500.94
40_S46_E0.7450.94
18_F75_A0.7440.94
82_R86_H0.7420.94
87_H115_L0.7280.93
10_D49_R0.7240.93
33_V44_V0.7210.93
94_D114_A0.7180.93
82_R101_D0.7170.93
19_I78_L0.7160.93
85_A111_A0.7140.93
25_D32_A0.7080.92
69_D73_R0.7010.92
25_D62_Y0.6960.92
48_F59_Y0.6940.92
100_A106_A0.6930.92
108_S111_A0.6870.91
15_T19_I0.6760.91
20_V28_A0.6750.90
22_T83_C0.6740.90
11_N15_T0.6740.90
70_R74_I0.6720.90
37_L41_P0.6700.90
18_F22_T0.6690.90
86_H97_A0.6670.90
81_K112_A0.6660.90
107_L111_A0.6660.90
82_R105_G0.6500.89
10_D15_T0.6450.88
93_L118_H0.6430.88
9_A12_R0.6340.88
9_A47_R0.6290.87
46_E49_R0.6280.87
85_A115_L0.6270.87
15_T105_G0.6260.87
30_T59_Y0.6240.87
44_V48_F0.6240.87
16_A19_I0.6180.86
99_T114_A0.6150.86
18_F72_E0.6060.85
18_F76_R0.6020.85
29_E64_G0.5960.84
30_T64_G0.5950.84
21_G27_R0.5890.83
31_G63_Q0.5880.83
27_R66_T0.5870.83
99_T106_A0.5820.83
99_T107_L0.5820.83
113_A116_R0.5770.82
79_A83_C0.5770.82
99_T110_D0.5690.81
54_R70_R0.5670.81
28_A33_V0.5650.81
39_V42_S0.5620.81
31_G46_E0.5600.80
103_L106_A0.5570.80
39_V43_T0.5570.80
8_R28_A0.5560.80
85_A103_L0.5490.79
51_L56_L0.5480.79
87_H122_P0.5420.78
87_H123_C0.5390.78
60_E66_T0.5340.77
52_A63_Q0.5280.76
33_V37_L0.5250.76
23_V26_C0.5220.75
84_L115_L0.5190.75
83_C122_P0.5160.75
10_D78_L0.5160.75
7_S39_V0.5080.74
20_V32_A0.5070.73
17_I33_V0.5070.73
39_V47_R0.5060.73
15_T79_A0.5040.73
39_V46_E0.5040.73
10_D50_D0.5030.73
12_R16_A0.5020.73
99_T102_E0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fx7A 4 0.9655 99.9 0.497 Contact Map
4o5vA 2 0.9448 99.9 0.505 Contact Map
2qq9A 2 0.9103 99.9 0.507 Contact Map
3hrsA 2 0.9379 99.9 0.519 Contact Map
1on2A 2 0.9034 99.7 0.619 Contact Map
2x4hA 3 0.8759 99.7 0.621 Contact Map
2h09A 2 0.8138 99.7 0.642 Contact Map
2p8tA 1 0.8138 99.6 0.654 Contact Map
2fxaA 4 0.8759 99.1 0.743 Contact Map
3u2rA 4 0.7034 99 0.755 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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