GREMLIN Database
Q9HME6 - Uncharacterized protein
UniProt: Q9HME6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (166)
Sequences: 5792 (4122)
Seq/√Len: 319.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V72_L2.9961.00
6_P27_E2.8071.00
100_V104_R2.5841.00
117_T141_E2.4041.00
108_R114_E2.3611.00
54_D162_P2.3091.00
11_R23_Y2.2991.00
167_L187_D2.2831.00
15_E20_D2.2181.00
70_M159_E2.2181.00
166_A183_L2.2091.00
54_D160_R2.1981.00
168_T172_T2.1681.00
9_E25_R2.1011.00
12_T15_E2.0821.00
98_S101_A2.0731.00
56_L160_R2.0671.00
120_L136_G2.0251.00
119_T141_E2.0211.00
123_E134_K2.0191.00
40_D132_R2.0131.00
59_D157_S2.0001.00
116_D142_D1.9661.00
25_R33_E1.9201.00
22_G40_D1.8441.00
104_R118_V1.8271.00
169_V174_P1.8191.00
77_V102_A1.8061.00
23_Y35_Q1.7701.00
59_D159_E1.7601.00
120_L123_E1.7471.00
47_V103_G1.7351.00
60_Q71_E1.7131.00
99_Y136_G1.7111.00
161_V169_V1.6801.00
16_T37_Y1.6391.00
27_E33_E1.6361.00
123_E136_G1.6151.00
116_D144_T1.6121.00
7_L63_P1.5861.00
162_P165_E1.5651.00
10_S22_G1.5611.00
114_E144_T1.5531.00
25_R35_Q1.5281.00
10_S24_D1.5041.00
48_V182_G1.4921.00
165_E168_T1.4811.00
101_A104_R1.4691.00
24_D63_P1.4621.00
125_W176_N1.4571.00
107_L115_A1.4471.00
8_V27_E1.4281.00
72_L182_G1.4241.00
97_E105_R1.4191.00
56_L113_F1.4081.00
100_V118_V1.4071.00
67_K176_N1.3681.00
117_T142_D1.3101.00
23_Y37_Y1.3041.00
102_A105_R1.2621.00
77_V99_Y1.2551.00
124_F181_E1.2551.00
108_R146_T1.2351.00
80_A97_E1.2351.00
104_R108_R1.2081.00
65_I125_W1.2031.00
73_V111_T1.1821.00
99_Y138_V1.1721.00
48_V186_A1.1601.00
161_V166_A1.1521.00
65_I69_C1.1481.00
108_R149_D1.1451.00
113_F145_A1.1371.00
49_A107_L1.1301.00
114_E146_T1.1221.00
56_L158_V1.1161.00
63_P66_R1.1151.00
168_T171_R1.0981.00
8_V33_E1.0921.00
124_F137_I1.0721.00
12_T20_D1.0691.00
127_A133_H1.0561.00
12_T22_G1.0541.00
120_L138_V1.0501.00
51_D141_E1.0451.00
167_L171_R1.0361.00
11_R25_R1.0331.00
165_E169_V1.0171.00
43_P77_V1.0171.00
59_D68_Q1.0081.00
53_N163_V0.9811.00
170_A180_I0.9641.00
121_L139_F0.9571.00
115_A118_V0.9381.00
45_V103_G0.9221.00
44_A135_R0.9081.00
41_L133_H0.9081.00
69_C128_T0.9071.00
61_Y66_R0.8981.00
24_D38_W0.8921.00
97_E102_A0.8601.00
62_R71_E0.8581.00
103_G118_V0.8581.00
43_P134_K0.8501.00
48_V55_V0.8491.00
29_P155_F0.8471.00
46_V135_R0.8431.00
55_V183_L0.8431.00
50_V139_F0.8411.00
137_I182_G0.8401.00
181_E184_L0.8381.00
55_V72_L0.8311.00
100_V120_L0.8311.00
47_V140_A0.8311.00
125_W134_K0.8061.00
118_V138_V0.7941.00
150_L156_L0.7921.00
51_D142_D0.7901.00
170_A175_A0.7891.00
167_L183_L0.7891.00
104_R114_E0.7821.00
124_F180_I0.7751.00
13_E21_G0.7731.00
143_L146_T0.7721.00
50_V163_V0.7691.00
13_E23_Y0.7670.99
118_V140_A0.7670.99
149_D154_E0.7640.99
68_Q155_F0.7540.99
57_F159_E0.7540.99
43_P136_G0.7540.99
39_A130_V0.7510.99
57_F161_V0.7470.99
38_W63_P0.7450.99
169_V172_T0.7430.99
150_L153_N0.7370.99
80_A105_R0.7370.99
20_D40_D0.7290.99
57_F70_M0.7270.99
115_A140_A0.7260.99
142_D146_T0.7260.99
50_V53_N0.7230.99
119_T139_F0.7220.99
124_F178_A0.7220.99
151_D154_E0.7210.99
46_V137_I0.7210.99
73_V107_L0.7160.99
70_M161_V0.7020.99
108_R147_D0.7010.99
147_D150_L0.7010.99
126_T130_V0.6990.99
127_A131_L0.6930.99
48_V72_L0.6910.99
19_Y39_A0.6860.99
21_G39_A0.6860.99
50_V55_V0.6850.99
45_V99_Y0.6700.99
9_E12_T0.6650.99
148_R151_D0.6620.99
57_F166_A0.6600.98
53_N164_A0.6590.98
58_V156_L0.6570.98
122_E181_E0.6550.98
123_E176_N0.6450.98
100_V138_V0.6450.98
74_A129_G0.6440.98
17_T23_Y0.6440.98
50_V141_E0.6360.98
49_A139_F0.6340.98
27_E31_G0.6330.98
7_L66_R0.6310.98
134_K176_N0.6250.98
162_P167_L0.6240.98
166_A170_A0.6230.98
7_L24_D0.6200.98
49_A58_V0.6190.98
59_D70_M0.6190.98
55_V186_A0.6170.98
80_A102_A0.6160.98
72_L183_L0.6160.98
30_D155_F0.6150.98
150_L154_E0.6150.98
28_Q34_K0.6140.98
148_R154_E0.6100.98
14_Y21_G0.6080.97
55_V163_V0.6080.97
163_V167_L0.6060.97
51_D144_T0.6000.97
11_R35_Q0.5990.97
49_A72_L0.5960.97
126_T178_A0.5950.97
42_P76_I0.5930.97
51_D54_D0.5900.97
26_V63_P0.5850.97
169_V175_A0.5800.97
49_A115_A0.5760.96
12_T40_D0.5720.96
46_V74_A0.5700.96
117_T120_L0.5690.96
126_T131_L0.5680.96
69_C125_W0.5660.96
147_D154_E0.5650.96
34_K153_N0.5650.96
55_V166_A0.5650.96
70_M169_V0.5590.96
161_V165_E0.5570.96
43_P76_I0.5560.96
148_R158_V0.5560.96
52_D160_R0.5560.96
26_V34_K0.5550.96
163_V187_D0.5550.96
159_E169_V0.5540.96
41_L130_V0.5530.96
170_A183_L0.5490.95
122_E185_L0.5490.95
103_G138_V0.5480.95
77_V136_G0.5470.95
164_A167_L0.5470.95
54_D165_E0.5470.95
165_E174_P0.5470.95
16_T36_Y0.5460.95
104_R115_A0.5460.95
166_A175_A0.5440.95
47_V73_V0.5440.95
103_G107_L0.5400.95
38_W64_T0.5380.95
19_Y22_G0.5380.95
62_R129_G0.5380.95
24_D66_R0.5350.95
50_V186_A0.5320.95
122_E173_P0.5320.95
115_A142_D0.5320.95
41_L131_L0.5300.94
180_I184_L0.5280.94
7_L10_S0.5220.94
16_T23_Y0.5220.94
100_V117_T0.5180.94
28_Q32_T0.5170.94
78_E102_A0.5150.94
10_S40_D0.5140.94
115_A143_L0.5110.93
18_W41_L0.5110.93
119_T122_E0.5110.93
30_D153_N0.5090.93
44_A76_I0.5060.93
9_E33_E0.5050.93
179_T183_L0.5020.93
47_V118_V0.5010.93
13_E37_Y0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g0sA 2 0.9115 100 0.364 Contact Map
2dscA 2 0.8958 100 0.38 Contact Map
1vhzA 2 0.9167 100 0.383 Contact Map
1mk1A 2 0.8281 100 0.422 Contact Map
3o6zA 2 0.8958 100 0.435 Contact Map
2yvpA 2 0.8958 100 0.474 Contact Map
1v8yA 2 0.7708 100 0.483 Contact Map
3q91A 2 0.6562 99.9 0.529 Contact Map
2w4eA 2 0.6823 99.9 0.597 Contact Map
2fvvA 1 0.6927 99.8 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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