Q9HME6 - HALSA - GREMLIN Contacts

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Q9HME6 - Uncharacterized protein

UniProt:	Q9HME6	Sequences: MSHDWPLVESRTEYETTWYDGGYDRVEQPDGTEKQYYWADLPPAVVVVAVDDNDVLFVDQYRPTIRKQCMELVAGIVEEATADATPTDAVAPHPTRESYVAAGRRELREETGFEADTVTLLEEFWTATGVLRHKRGIVFAEDLTATDRDLDDNEFLSVERVPVAEALTVARTPPANDATIEGLLLADADGHL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	192 (166)
Sequences:	5792 (4122)
Seq/√Len:	319.9

ECOLI - NUDE NUDK ADPP
BACSU - ADPP
HALSA - Q9HME6 Q9HNS9
SULSO - Q97WP3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_V	72_L	2.996	1.00
6_P	27_E	2.807	1.00
100_V	104_R	2.584	1.00
117_T	141_E	2.404	1.00
108_R	114_E	2.361	1.00
54_D	162_P	2.309	1.00
11_R	23_Y	2.299	1.00
167_L	187_D	2.283	1.00
15_E	20_D	2.218	1.00
70_M	159_E	2.218	1.00
166_A	183_L	2.209	1.00
54_D	160_R	2.198	1.00
168_T	172_T	2.168	1.00
9_E	25_R	2.101	1.00
12_T	15_E	2.082	1.00
98_S	101_A	2.073	1.00
56_L	160_R	2.067	1.00
120_L	136_G	2.025	1.00
119_T	141_E	2.021	1.00
123_E	134_K	2.019	1.00
40_D	132_R	2.013	1.00
59_D	157_S	2.000	1.00
116_D	142_D	1.966	1.00
25_R	33_E	1.920	1.00
22_G	40_D	1.844	1.00
104_R	118_V	1.827	1.00
169_V	174_P	1.819	1.00
77_V	102_A	1.806	1.00
23_Y	35_Q	1.770	1.00
59_D	159_E	1.760	1.00
120_L	123_E	1.747	1.00
47_V	103_G	1.735	1.00
60_Q	71_E	1.713	1.00
99_Y	136_G	1.711	1.00
161_V	169_V	1.680	1.00
16_T	37_Y	1.639	1.00
27_E	33_E	1.636	1.00
123_E	136_G	1.615	1.00
116_D	144_T	1.612	1.00
7_L	63_P	1.586	1.00
162_P	165_E	1.565	1.00
10_S	22_G	1.561	1.00
114_E	144_T	1.553	1.00
25_R	35_Q	1.528	1.00
10_S	24_D	1.504	1.00
48_V	182_G	1.492	1.00
165_E	168_T	1.481	1.00
101_A	104_R	1.469	1.00
24_D	63_P	1.462	1.00
125_W	176_N	1.457	1.00
107_L	115_A	1.447	1.00
8_V	27_E	1.428	1.00
72_L	182_G	1.424	1.00
97_E	105_R	1.419	1.00
56_L	113_F	1.408	1.00
100_V	118_V	1.407	1.00
67_K	176_N	1.368	1.00
117_T	142_D	1.310	1.00
23_Y	37_Y	1.304	1.00
102_A	105_R	1.262	1.00
77_V	99_Y	1.255	1.00
124_F	181_E	1.255	1.00
108_R	146_T	1.235	1.00
80_A	97_E	1.235	1.00
104_R	108_R	1.208	1.00
65_I	125_W	1.203	1.00
73_V	111_T	1.182	1.00
99_Y	138_V	1.172	1.00
48_V	186_A	1.160	1.00
161_V	166_A	1.152	1.00
65_I	69_C	1.148	1.00
108_R	149_D	1.145	1.00
113_F	145_A	1.137	1.00
49_A	107_L	1.130	1.00
114_E	146_T	1.122	1.00
56_L	158_V	1.116	1.00
63_P	66_R	1.115	1.00
168_T	171_R	1.098	1.00
8_V	33_E	1.092	1.00
124_F	137_I	1.072	1.00
12_T	20_D	1.069	1.00
127_A	133_H	1.056	1.00
12_T	22_G	1.054	1.00
120_L	138_V	1.050	1.00
51_D	141_E	1.045	1.00
167_L	171_R	1.036	1.00
11_R	25_R	1.033	1.00
165_E	169_V	1.017	1.00
43_P	77_V	1.017	1.00
59_D	68_Q	1.008	1.00
53_N	163_V	0.981	1.00
170_A	180_I	0.964	1.00
121_L	139_F	0.957	1.00
115_A	118_V	0.938	1.00
45_V	103_G	0.922	1.00
44_A	135_R	0.908	1.00
41_L	133_H	0.908	1.00
69_C	128_T	0.907	1.00
61_Y	66_R	0.898	1.00
24_D	38_W	0.892	1.00
97_E	102_A	0.860	1.00
62_R	71_E	0.858	1.00
103_G	118_V	0.858	1.00
43_P	134_K	0.850	1.00
48_V	55_V	0.849	1.00
29_P	155_F	0.847	1.00
46_V	135_R	0.843	1.00
55_V	183_L	0.843	1.00
50_V	139_F	0.841	1.00
137_I	182_G	0.840	1.00
181_E	184_L	0.838	1.00
55_V	72_L	0.831	1.00
100_V	120_L	0.831	1.00
47_V	140_A	0.831	1.00
125_W	134_K	0.806	1.00
118_V	138_V	0.794	1.00
150_L	156_L	0.792	1.00
51_D	142_D	0.790	1.00
170_A	175_A	0.789	1.00
167_L	183_L	0.789	1.00
104_R	114_E	0.782	1.00
124_F	180_I	0.775	1.00
13_E	21_G	0.773	1.00
143_L	146_T	0.772	1.00
50_V	163_V	0.769	1.00
13_E	23_Y	0.767	0.99
118_V	140_A	0.767	0.99
149_D	154_E	0.764	0.99
68_Q	155_F	0.754	0.99
57_F	159_E	0.754	0.99
43_P	136_G	0.754	0.99
39_A	130_V	0.751	0.99
57_F	161_V	0.747	0.99
38_W	63_P	0.745	0.99
169_V	172_T	0.743	0.99
150_L	153_N	0.737	0.99
80_A	105_R	0.737	0.99
20_D	40_D	0.729	0.99
57_F	70_M	0.727	0.99
115_A	140_A	0.726	0.99
142_D	146_T	0.726	0.99
50_V	53_N	0.723	0.99
119_T	139_F	0.722	0.99
124_F	178_A	0.722	0.99
151_D	154_E	0.721	0.99
46_V	137_I	0.721	0.99
73_V	107_L	0.716	0.99
70_M	161_V	0.702	0.99
108_R	147_D	0.701	0.99
147_D	150_L	0.701	0.99
126_T	130_V	0.699	0.99
127_A	131_L	0.693	0.99
48_V	72_L	0.691	0.99
19_Y	39_A	0.686	0.99
21_G	39_A	0.686	0.99
50_V	55_V	0.685	0.99
45_V	99_Y	0.670	0.99
9_E	12_T	0.665	0.99
148_R	151_D	0.662	0.99
57_F	166_A	0.660	0.98
53_N	164_A	0.659	0.98
58_V	156_L	0.657	0.98
122_E	181_E	0.655	0.98
123_E	176_N	0.645	0.98
100_V	138_V	0.645	0.98
74_A	129_G	0.644	0.98
17_T	23_Y	0.644	0.98
50_V	141_E	0.636	0.98
49_A	139_F	0.634	0.98
27_E	31_G	0.633	0.98
7_L	66_R	0.631	0.98
134_K	176_N	0.625	0.98
162_P	167_L	0.624	0.98
166_A	170_A	0.623	0.98
7_L	24_D	0.620	0.98
49_A	58_V	0.619	0.98
59_D	70_M	0.619	0.98
55_V	186_A	0.617	0.98
80_A	102_A	0.616	0.98
72_L	183_L	0.616	0.98
30_D	155_F	0.615	0.98
150_L	154_E	0.615	0.98
28_Q	34_K	0.614	0.98
148_R	154_E	0.610	0.98
14_Y	21_G	0.608	0.97
55_V	163_V	0.608	0.97
163_V	167_L	0.606	0.97
51_D	144_T	0.600	0.97
11_R	35_Q	0.599	0.97
49_A	72_L	0.596	0.97
126_T	178_A	0.595	0.97
42_P	76_I	0.593	0.97
51_D	54_D	0.590	0.97
26_V	63_P	0.585	0.97
169_V	175_A	0.580	0.97
49_A	115_A	0.576	0.96
12_T	40_D	0.572	0.96
46_V	74_A	0.570	0.96
117_T	120_L	0.569	0.96
126_T	131_L	0.568	0.96
69_C	125_W	0.566	0.96
147_D	154_E	0.565	0.96
34_K	153_N	0.565	0.96
55_V	166_A	0.565	0.96
70_M	169_V	0.559	0.96
161_V	165_E	0.557	0.96
43_P	76_I	0.556	0.96
148_R	158_V	0.556	0.96
52_D	160_R	0.556	0.96
26_V	34_K	0.555	0.96
163_V	187_D	0.555	0.96
159_E	169_V	0.554	0.96
41_L	130_V	0.553	0.96
170_A	183_L	0.549	0.95
122_E	185_L	0.549	0.95
103_G	138_V	0.548	0.95
77_V	136_G	0.547	0.95
164_A	167_L	0.547	0.95
54_D	165_E	0.547	0.95
165_E	174_P	0.547	0.95
16_T	36_Y	0.546	0.95
104_R	115_A	0.546	0.95
166_A	175_A	0.544	0.95
47_V	73_V	0.544	0.95
103_G	107_L	0.540	0.95
38_W	64_T	0.538	0.95
19_Y	22_G	0.538	0.95
62_R	129_G	0.538	0.95
24_D	66_R	0.535	0.95
50_V	186_A	0.532	0.95
122_E	173_P	0.532	0.95
115_A	142_D	0.532	0.95
41_L	131_L	0.530	0.94
180_I	184_L	0.528	0.94
7_L	10_S	0.522	0.94
16_T	23_Y	0.522	0.94
100_V	117_T	0.518	0.94
28_Q	32_T	0.517	0.94
78_E	102_A	0.515	0.94
10_S	40_D	0.514	0.94
115_A	143_L	0.511	0.93
18_W	41_L	0.511	0.93
119_T	122_E	0.511	0.93
30_D	153_N	0.509	0.93
44_A	76_I	0.506	0.93
9_E	33_E	0.505	0.93
179_T	183_L	0.502	0.93
47_V	118_V	0.501	0.93
13_E	37_Y	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1g0sA	2	0.9115	100	0.364	Contact Map
2dscA	2	0.8958	100	0.38	Contact Map
1vhzA	2	0.9167	100	0.383	Contact Map
1mk1A	2	0.8281	100	0.422	Contact Map
3o6zA	2	0.8958	100	0.435	Contact Map
2yvpA	2	0.8958	100	0.474	Contact Map
1v8yA	2	0.7708	100	0.483	Contact Map
3q91A	2	0.6562	99.9	0.529	Contact Map
2w4eA	2	0.6823	99.9	0.597	Contact Map
2fvvA	1	0.6927	99.8	0.623	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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