GREMLIN Database
Q9HME4 - Uncharacterized protein
UniProt: Q9HME4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (102)
Sequences: 10483 (7656)
Seq/√Len: 758.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_R89_E3.1201.00
27_P31_A2.9151.00
11_A103_E2.8091.00
5_L9_D2.2821.00
20_R57_D2.2631.00
95_I105_S2.1771.00
9_D13_V2.0701.00
6_S9_D2.0611.00
33_G99_P2.0491.00
30_F34_H1.8951.00
27_P40_N1.8821.00
97_G101_D1.8751.00
7_A97_G1.8541.00
58_R87_Q1.7351.00
61_T76_I1.6471.00
29_A68_S1.6181.00
7_A101_D1.5881.00
10_L21_I1.5701.00
54_A57_D1.5471.00
47_P51_D1.5221.00
13_V58_R1.4761.00
10_L91_L1.4601.00
33_G107_D1.4431.00
13_V16_D1.4101.00
73_A90_S1.4101.00
49_R52_Q1.3671.00
46_L50_V1.3621.00
7_A103_E1.3431.00
73_A88_V1.3381.00
24_I72_A1.3261.00
10_L60_V1.2971.00
55_G82_V1.2861.00
69_S90_S1.2821.00
22_V53_L1.2611.00
13_V19_L1.2461.00
7_A91_L1.1971.00
20_R39_E1.1951.00
31_A109_A1.1851.00
6_S92_G1.1741.00
41_I49_R1.1631.00
62_V95_I1.1611.00
95_I99_P1.1551.00
35_I62_V1.1261.00
25_R64_P1.1091.00
93_C97_G1.1071.00
5_L10_L1.0901.00
45_E49_R1.0701.00
21_I62_V1.0681.00
19_L60_V1.0671.00
96_D100_G1.0631.00
11_A15_D1.0571.00
61_T73_A1.0461.00
26_T29_A1.0071.00
35_I38_S1.0011.00
45_E48_Q0.9971.00
59_V76_I0.9901.00
61_T72_A0.9841.00
82_V86_T0.9411.00
61_T88_V0.9411.00
53_L59_V0.9391.00
63_C66_G0.9321.00
34_H62_V0.9301.00
29_A64_P0.9271.00
21_I35_I0.9191.00
96_D99_P0.9181.00
64_P96_D0.9171.00
25_R95_I0.9141.00
65_H96_D0.9041.00
8_D12_A0.8921.00
73_A78_S0.8911.00
4_E92_G0.8801.00
63_C69_S0.8801.00
50_V76_I0.8771.00
38_S62_V0.8681.00
36_P106_S0.8601.00
76_I88_V0.8601.00
75_L80_E0.8511.00
60_V91_L0.8371.00
10_L19_L0.8361.00
7_A11_A0.8331.00
8_D103_E0.8231.00
5_L89_E0.8151.00
24_I61_T0.8151.00
91_L98_W0.8141.00
48_Q52_Q0.8091.00
33_G105_S0.8061.00
10_L14_L0.8051.00
65_H68_S0.8021.00
74_R79_Y0.7951.00
97_G100_G0.7911.00
30_F38_S0.7911.00
36_P98_W0.7901.00
31_A108_T0.7901.00
91_L94_G0.7781.00
8_D101_D0.7741.00
10_L13_V0.7721.00
30_F40_N0.7701.00
33_G95_I0.7651.00
91_L97_G0.7591.00
46_L49_R0.7531.00
19_L58_R0.7421.00
35_I98_W0.7401.00
63_C68_S0.7201.00
46_L80_E0.7181.00
28_P31_A0.7081.00
20_R54_A0.7001.00
98_W103_E0.6891.00
29_A32_R0.6871.00
78_S86_T0.6791.00
70_K90_S0.6761.00
99_P105_S0.6751.00
76_I82_V0.6681.00
20_R59_V0.6581.00
82_V87_Q0.6491.00
43_F71_Q0.6451.00
9_D12_A0.6421.00
11_A14_L0.6421.00
5_L60_V0.6311.00
22_V61_T0.6181.00
22_V39_E0.6171.00
18_A58_R0.6161.00
82_V88_V0.6151.00
78_S88_V0.6091.00
64_P67_K0.6061.00
75_L79_Y0.6051.00
11_A104_Q0.6021.00
79_Y82_V0.6011.00
43_F72_A0.5951.00
34_H106_S0.5931.00
59_V82_V0.5851.00
46_L75_L0.5701.00
34_H40_N0.5681.00
43_F75_L0.5651.00
25_R40_N0.5651.00
71_Q74_R0.5631.00
13_V17_D0.5581.00
13_V89_E0.5541.00
44_Q47_P0.5471.00
13_V60_V0.5431.00
27_P42_P0.5401.00
41_I72_A0.5321.00
59_V88_V0.5311.00
81_G86_T0.5311.00
24_I43_F0.5261.00
14_L37_G0.5251.00
74_R78_S0.5231.00
50_V53_L0.5211.00
99_P103_E0.5141.00
10_L35_I0.5131.00
12_A16_D0.5081.00
15_D37_G0.5031.00
20_R58_R0.5011.00
64_P68_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yt8A 1 0.9667 99.9 0.215 Contact Map
3tp9A 2 0.8583 99.9 0.242 Contact Map
3ilmA 2 0.875 99.9 0.243 Contact Map
1e0cA 1 0.9583 99.9 0.245 Contact Map
2wlrA 1 0.9667 99.9 0.254 Contact Map
3hzuA 2 0.9583 99.9 0.256 Contact Map
1uarA 1 0.9583 99.9 0.259 Contact Map
2hhgA 2 0.85 99.9 0.267 Contact Map
1rhsA 1 0.9583 99.9 0.267 Contact Map
1okgA 1 0.9417 99.9 0.268 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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