COFE - HALSA - GREMLIN Contacts

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COFE - Coenzyme F420:L-glutamate ligase

UniProt:	Q9HME1	Sequences: MHAFAVDGLPEIDAGDDLAALVAERADLTDGDVVCVASTVVSKAEGRTAALAEFTPGPRAEEIAARLADVTGEQKDPRFAQAVIEEATEVIMDAPFLLTETTCGHVGVNAGIDRSNTGGAELLLLPKRPAESAARIQAGLAADVGVVVTDTSGRPFRHGQRGVALGWAGLPAARDWRGETDRDGHELAVTVEAVVDELAATANLVSGEGDDGTPVVVVREFEFGDHDGSEQLFRAVDGDFVRQALRGWTFDGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	253 (225)
Sequences:	691 (441)
Seq/√Len:	29.4

HALSA - COFE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
81_Q	85_E	4.700	1.00
99_T	110_A	4.191	1.00
22_V	215_V	4.027	1.00
35_C	149_T	4.015	1.00
145_G	170_L	3.588	1.00
45_E	132_S	3.556	1.00
47_R	124_L	3.485	1.00
18_L	40_V	3.158	1.00
5_A	213_T	2.925	1.00
12_I	21_L	2.719	1.00
198_L	221_F	2.711	1.00
167_W	172_A	2.686	1.00
11_E	182_R	2.622	1.00
82_A	112_I	2.566	0.99
32_D	219_R	2.502	0.99
137_Q	168_A	2.460	0.99
14_A	48_T	2.403	0.99
23_A	140_L	2.384	0.99
12_I	44_A	2.361	0.99
19_A	139_G	2.186	0.98
88_T	100_E	2.171	0.98
18_L	136_I	2.152	0.98
162_G	203_N	2.123	0.98
193_A	232_L	2.094	0.98
9_L	12_I	2.093	0.98
17_D	139_G	2.056	0.97
131_E	135_R	2.032	0.97
36_V	136_I	2.029	0.97
203_N	208_E	2.008	0.97
3_A	216_V	2.000	0.97
30_D	143_D	1.976	0.97
50_A	53_E	1.901	0.96
151_T	160_Q	1.844	0.95
152_S	163_V	1.799	0.94
34_V	217_V	1.774	0.94
100_E	242_R	1.762	0.94
158_H	238_G	1.675	0.92
134_A	138_A	1.664	0.91
107_G	152_S	1.628	0.91
48_T	123_L	1.519	0.87
235_A	238_G	1.514	0.87
137_Q	169_G	1.514	0.87
9_L	22_V	1.508	0.87
128_R	131_E	1.496	0.86
6_V	12_I	1.449	0.85
175_D	191_V	1.449	0.85
34_V	198_L	1.443	0.84
5_A	215_V	1.441	0.84
205_V	216_V	1.441	0.84
108_V	241_V	1.440	0.84
162_G	208_E	1.417	0.83
4_F	219_R	1.398	0.82
198_L	218_V	1.395	0.82
105_H	110_A	1.361	0.81
21_L	44_A	1.360	0.80
7_D	213_T	1.346	0.80
151_T	197_E	1.320	0.78
140_L	144_V	1.315	0.78
160_Q	189_V	1.290	0.77
147_V	198_L	1.289	0.77
13_D	16_D	1.281	0.76
9_L	21_L	1.278	0.76
186_E	198_L	1.273	0.76
228_G	231_Q	1.270	0.76
162_G	182_R	1.267	0.75
81_Q	84_I	1.264	0.75
82_A	122_L	1.260	0.75
18_L	41_V	1.248	0.74
41_V	148_V	1.246	0.74
34_V	140_L	1.236	0.74
147_V	221_F	1.208	0.72
61_E	65_A	1.191	0.71
28_L	34_V	1.186	0.70
130_A	241_V	1.170	0.69
51_L	78_R	1.152	0.68
38_S	123_L	1.147	0.68
130_A	234_R	1.142	0.67
92_M	152_S	1.141	0.67
4_F	217_V	1.134	0.67
162_G	206_S	1.134	0.67
37_A	216_V	1.134	0.67
172_A	231_Q	1.131	0.67
77_P	216_V	1.120	0.66
101_T	105_H	1.119	0.66
171_P	194_V	1.115	0.66
130_A	166_G	1.114	0.66
60_A	64_A	1.113	0.65
101_T	172_A	1.112	0.65
35_C	218_V	1.104	0.65
117_T	123_L	1.103	0.65
182_R	208_E	1.079	0.63
98_L	108_V	1.057	0.61
36_V	135_R	1.054	0.61
112_I	122_L	1.039	0.60
47_R	127_K	1.039	0.60
84_I	91_I	1.036	0.60
5_A	103_C	1.030	0.59
47_R	132_S	1.021	0.59
131_E	141_A	1.020	0.59
153_G	234_R	1.018	0.58
6_V	213_T	1.017	0.58
160_Q	176_W	1.014	0.58
34_V	202_A	1.012	0.58
30_D	142_A	0.998	0.57
234_R	241_V	0.998	0.57
137_Q	145_G	0.995	0.57
3_A	201_T	0.985	0.56
66_R	146_V	0.985	0.56
114_R	122_L	0.983	0.56
39_T	156_F	0.980	0.56
39_T	124_L	0.964	0.54
176_W	179_E	0.963	0.54
197_E	208_E	0.961	0.54
60_A	81_Q	0.960	0.54
43_K	197_E	0.949	0.53
39_T	96_F	0.949	0.53
40_V	214_P	0.943	0.53
112_I	171_P	0.932	0.52
160_Q	208_E	0.929	0.52
43_K	154_R	0.926	0.51
187_L	190_T	0.925	0.51
236_V	242_R	0.914	0.50
135_R	139_G	0.902	0.49
146_V	217_V	0.899	0.49
167_W	170_L	0.896	0.49
4_F	29_T	0.896	0.49
38_S	117_T	0.895	0.49
145_G	223_F	0.893	0.49
156_F	241_V	0.891	0.49
166_G	234_R	0.890	0.48
35_C	198_L	0.885	0.48
89_E	236_V	0.884	0.48
170_L	221_F	0.884	0.48
88_T	102_T	0.880	0.48
167_W	195_V	0.878	0.48
141_A	144_V	0.872	0.47
208_E	211_D	0.872	0.47
38_S	109_N	0.868	0.47
108_V	156_F	0.868	0.47
111_G	169_G	0.863	0.46
180_T	187_L	0.861	0.46
42_S	201_T	0.859	0.46
153_G	166_G	0.856	0.46
5_A	205_V	0.851	0.45
41_V	213_T	0.844	0.45
63_I	136_I	0.836	0.44
157_R	168_A	0.833	0.44
63_I	170_L	0.812	0.42
20_A	24_E	0.811	0.42
17_D	20_A	0.807	0.42
11_E	183_D	0.806	0.42
18_L	44_A	0.803	0.42
130_A	153_G	0.801	0.42
105_H	152_S	0.799	0.41
177_R	191_V	0.799	0.41
24_E	33_V	0.799	0.41
49_A	147_V	0.798	0.41
88_T	99_T	0.796	0.41
60_A	84_I	0.791	0.41
176_W	209_G	0.786	0.40
26_A	144_V	0.783	0.40
23_A	139_G	0.780	0.40
79_F	122_L	0.780	0.40
153_G	156_F	0.779	0.40
180_T	186_E	0.775	0.40
3_A	168_A	0.772	0.39
152_S	208_E	0.772	0.39
11_E	162_G	0.770	0.39
151_T	208_E	0.770	0.39
200_A	203_N	0.761	0.39
173_A	232_L	0.760	0.38
158_H	231_Q	0.758	0.38
9_L	44_A	0.758	0.38
96_F	108_V	0.756	0.38
174_R	240_F	0.748	0.38
138_A	227_D	0.745	0.37
156_F	234_R	0.744	0.37
18_L	34_V	0.739	0.37
52_A	120_A	0.737	0.37
177_R	192_E	0.736	0.37
89_E	100_E	0.730	0.36
16_D	21_L	0.728	0.36
96_F	156_F	0.727	0.36
134_A	228_G	0.726	0.36
37_A	60_A	0.724	0.36
90_V	99_T	0.722	0.36
24_E	29_T	0.722	0.36
30_D	134_A	0.719	0.35
140_L	202_A	0.719	0.35
144_V	185_H	0.717	0.35
239_D	242_R	0.714	0.35
42_S	123_L	0.714	0.35
20_A	50_A	0.713	0.35
26_A	140_L	0.711	0.35
118_G	183_D	0.709	0.35
22_V	34_V	0.707	0.35
45_E	240_F	0.706	0.35
203_N	206_S	0.706	0.35
81_Q	90_V	0.706	0.35
108_V	234_R	0.706	0.35
206_S	216_V	0.706	0.35
125_L	166_G	0.705	0.34
89_E	189_V	0.703	0.34
165_L	240_F	0.702	0.34
100_E	155_P	0.702	0.34
130_A	220_E	0.701	0.34
38_S	124_L	0.700	0.34
98_L	105_H	0.691	0.33
151_T	234_R	0.690	0.33
173_A	191_V	0.687	0.33
172_A	229_S	0.685	0.33
163_V	167_W	0.682	0.33
77_P	84_I	0.681	0.33
34_V	164_A	0.681	0.33
38_S	162_G	0.680	0.33
29_T	219_R	0.679	0.33
35_C	143_D	0.677	0.32
92_M	241_V	0.675	0.32
166_G	241_V	0.674	0.32
100_E	106_V	0.672	0.32
174_R	186_E	0.666	0.32
53_E	135_R	0.664	0.32
112_I	124_L	0.663	0.32
28_L	215_V	0.660	0.31
92_M	97_L	0.659	0.31
154_R	234_R	0.659	0.31
14_A	179_E	0.658	0.31
22_V	180_T	0.653	0.31
202_A	206_S	0.653	0.31
108_V	130_A	0.651	0.31
51_L	112_I	0.649	0.31
29_T	118_G	0.648	0.31
53_E	117_T	0.646	0.30
45_E	135_R	0.644	0.30
230_E	233_F	0.642	0.30
50_A	91_I	0.641	0.30
33_V	122_L	0.640	0.30
8_G	15_G	0.633	0.30
10_P	51_L	0.632	0.29
37_A	55_T	0.631	0.29
130_A	167_W	0.630	0.29
8_G	25_R	0.629	0.29
106_V	169_G	0.626	0.29
34_V	240_F	0.624	0.29
105_H	208_E	0.617	0.28
149_T	199_A	0.617	0.28
76_D	80_A	0.613	0.28
165_L	228_G	0.611	0.28
23_A	26_A	0.610	0.28
152_S	193_A	0.610	0.28
59_R	62_E	0.608	0.28
203_N	241_V	0.608	0.28
116_N	181_D	0.605	0.28
5_A	136_I	0.605	0.28
79_F	91_I	0.604	0.28
14_A	28_L	0.599	0.27
6_V	9_L	0.599	0.27
134_A	168_A	0.599	0.27
28_L	144_V	0.598	0.27
173_A	189_V	0.597	0.27
106_V	154_R	0.596	0.27
33_V	137_Q	0.595	0.27
62_E	65_A	0.593	0.27
93_D	112_I	0.591	0.27
139_G	142_A	0.588	0.27
38_S	90_V	0.588	0.27
81_Q	91_I	0.587	0.27
21_L	175_D	0.585	0.26
234_R	239_D	0.578	0.26
96_F	240_F	0.576	0.26
100_E	236_V	0.576	0.26
39_T	98_L	0.573	0.26
197_E	239_D	0.573	0.26
62_E	66_R	0.573	0.26
116_N	190_T	0.571	0.26
33_V	145_G	0.569	0.26
46_G	120_A	0.566	0.25
197_E	203_N	0.565	0.25
80_A	97_L	0.565	0.25
34_V	213_T	0.564	0.25
6_V	27_D	0.564	0.25
79_F	83_V	0.563	0.25
115_S	181_D	0.562	0.25
16_D	148_V	0.562	0.25
190_T	208_E	0.560	0.25
153_G	241_V	0.560	0.25
11_E	147_V	0.560	0.25
45_E	215_V	0.560	0.25
43_K	156_F	0.559	0.25
92_M	108_V	0.559	0.25
30_D	144_V	0.558	0.25
7_D	10_P	0.553	0.25
98_L	101_T	0.551	0.24
155_P	163_V	0.550	0.24
79_F	82_A	0.549	0.24
92_M	156_F	0.545	0.24
43_K	106_V	0.543	0.24
182_R	203_N	0.542	0.24
30_D	190_T	0.540	0.24
50_A	121_E	0.539	0.24
101_T	203_N	0.539	0.24
34_V	180_T	0.537	0.24
173_A	202_A	0.537	0.24
52_A	225_D	0.537	0.24
40_V	240_F	0.536	0.24
193_A	226_H	0.535	0.24
104_G	154_R	0.534	0.23
4_F	33_V	0.533	0.23
122_L	142_A	0.533	0.23
129_P	229_S	0.531	0.23
133_A	148_V	0.530	0.23
98_L	215_V	0.528	0.23
60_A	97_L	0.527	0.23
155_P	201_T	0.526	0.23
98_L	192_E	0.526	0.23
36_V	217_V	0.525	0.23
39_T	108_V	0.525	0.23
106_V	153_G	0.524	0.23
7_D	20_A	0.523	0.23
17_D	136_I	0.519	0.23
81_Q	109_N	0.518	0.23
154_R	239_D	0.518	0.23
4_F	7_D	0.518	0.23
33_V	66_R	0.517	0.23
39_T	152_S	0.515	0.22
35_C	202_A	0.511	0.22
156_F	239_D	0.511	0.22
167_W	229_S	0.509	0.22
176_W	211_D	0.508	0.22
84_I	95_P	0.508	0.22
108_V	154_R	0.507	0.22
183_D	209_G	0.506	0.22
50_A	120_A	0.506	0.22
19_A	180_T	0.503	0.22
225_D	228_G	0.503	0.22
105_H	229_S	0.502	0.22
115_S	187_L	0.501	0.22
192_E	203_N	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2phnA	2	0.9605	100	0.22	Contact Map
4ig1A	1	0.8419	22.3	0.969	Contact Map
3g98A	1	0.3518	18.8	0.97	Contact Map
2o34A	1	0.8221	11.9	0.972	Contact Map
4ob9A	2	0.2885	11.1	0.973	Contact Map
1um0A	4	0.3953	10.6	0.973	Contact Map
1xe1A	2	0.1502	9.9	0.973	Contact Map
1r8oA	1	0.3043	9.4	0.974	Contact Map
3eiqA	1	0.5375	8.5	0.974	Contact Map
1sq1A	4	0.2332	8.1	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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