GREMLIN Database
ENGB - Probable GTP-binding protein EngB
UniProt: Q9HME0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 206 (164)
Sequences: 25687 (16650)
Seq/√Len: 1300.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_A179_K3.2521.00
188_A191_S2.8781.00
172_I188_A2.8641.00
97_V138_A2.6941.00
170_D188_A2.4211.00
48_H57_M2.3811.00
102_G139_V2.3301.00
24_T176_T2.2651.00
188_A192_H2.2621.00
142_M173_A2.2081.00
100_L137_V2.1251.00
11_E57_M2.0811.00
13_V93_I2.0321.00
54_E190_N2.0171.00
28_A182_I1.8371.00
95_V136_V1.8201.00
27_R36_T1.8091.00
139_V173_A1.7971.00
97_V189_V1.7591.00
25_L99_V1.7521.00
154_D158_R1.7281.00
136_V188_A1.6861.00
14_L97_V1.6861.00
99_V140_N1.6831.00
156_A160_G1.6801.00
138_A185_L1.5791.00
26_M34_V1.5721.00
87_E127_L1.5581.00
153_N156_A1.5531.00
10_D193_F1.5311.00
50_D55_D1.5241.00
48_H59_T1.5051.00
25_L185_L1.4671.00
34_V47_N1.4561.00
81_E84_R1.4511.00
138_A174_P1.4451.00
14_L26_M1.4291.00
101_D104_A1.3651.00
98_L125_Y1.3531.00
123_E126_Y1.3311.00
117_E121_V1.3301.00
17_R121_V1.3181.00
136_V172_I1.3031.00
119_P123_E1.3021.00
151_R154_D1.2871.00
153_N157_D1.2691.00
56_F190_N1.2651.00
141_K144_K1.2531.00
139_V171_V1.2521.00
95_V192_H1.2501.00
97_V136_V1.2451.00
127_L131_L1.2431.00
140_N176_T1.2401.00
181_R184_A1.2401.00
152_L156_A1.2321.00
103_K144_K1.2271.00
52_A190_N1.2161.00
120_H123_E1.2101.00
9_S57_M1.2021.00
12_V189_V1.1951.00
123_E127_L1.1941.00
151_R155_I1.1911.00
46_P59_T1.1831.00
137_V171_V1.1681.00
54_E194_D1.1531.00
187_D191_S1.1491.00
98_L135_P1.1431.00
182_I186_E1.1421.00
122_V126_Y1.1301.00
184_A187_D1.1181.00
170_D192_H1.1171.00
18_S40_P1.1021.00
84_R88_S1.0931.00
155_I159_L1.0921.00
183_A187_D1.0831.00
25_L29_V1.0831.00
152_L155_I1.0811.00
23_S34_V1.0771.00
81_E85_Y1.0761.00
126_Y130_E1.0611.00
76_E79_K1.0611.00
127_L130_E1.0401.00
29_V186_E1.0381.00
186_E189_V1.0381.00
186_E190_N1.0351.00
184_A188_A1.0311.00
83_V87_E1.0291.00
154_D157_D1.0221.00
134_Q192_H1.0201.00
37_G42_V1.0161.00
19_N38_Q1.0121.00
97_V185_L1.0121.00
126_Y129_E1.0111.00
118_I121_V1.0071.00
128_L135_P0.9731.00
12_V95_V0.9721.00
103_K116_D0.9711.00
65_G79_K0.9691.00
185_L189_V0.9621.00
9_S55_D0.9451.00
51_W190_N0.9401.00
46_P89_H0.9391.00
121_V124_L0.9391.00
121_V125_Y0.9361.00
119_P122_V0.9341.00
51_W187_D0.9291.00
190_N194_D0.9281.00
77_A80_T0.9251.00
152_L173_A0.9191.00
136_V192_H0.9191.00
79_K82_V0.9121.00
27_R34_V0.9121.00
25_L174_P0.9111.00
117_E122_V0.9081.00
157_D161_L0.9031.00
79_K83_V0.8961.00
116_D121_V0.8921.00
29_V58_L0.8911.00
91_D131_L0.8881.00
11_E59_T0.8881.00
125_Y128_L0.8871.00
174_P185_L0.8841.00
25_L138_A0.8781.00
124_L128_L0.8741.00
35_P42_V0.8731.00
85_Y88_S0.8611.00
178_K181_R0.8561.00
101_D140_N0.8561.00
125_Y129_E0.8551.00
12_V58_L0.8541.00
120_H124_L0.8471.00
50_D53_S0.8301.00
102_G145_V0.8261.00
124_L127_L0.8221.00
83_V86_V0.8211.00
15_V96_G0.8161.00
17_R120_H0.8091.00
78_I82_V0.8071.00
100_L139_V0.8041.00
93_I96_G0.8021.00
157_D160_G0.7981.00
158_R161_L0.7961.00
174_P182_I0.7951.00
170_D191_S0.7921.00
13_V61_L0.7901.00
149_D153_N0.7871.00
15_V90_A0.7851.00
102_G142_M0.7801.00
12_V56_F0.7681.00
88_S91_D0.7641.00
25_L176_T0.7611.00
62_P82_V0.7601.00
142_M180_D0.7551.00
11_E94_M0.7531.00
64_F86_V0.7521.00
179_K182_I0.7461.00
52_A187_D0.7411.00
172_I184_A0.7311.00
128_L131_L0.7301.00
122_V158_R0.7291.00
98_L137_V0.7291.00
51_W56_F0.7201.00
150_E154_D0.7151.00
25_L182_I0.7141.00
183_A186_E0.7111.00
28_A176_T0.7091.00
170_D173_A0.7031.00
104_A118_I0.7001.00
121_V127_L0.6821.00
146_D149_D0.6821.00
98_L128_L0.6801.00
80_T84_R0.6791.00
161_L169_Q0.6771.00
101_D141_K0.6751.00
65_G86_V0.6731.00
104_A116_D0.6721.00
138_A172_I0.6701.00
50_D54_E0.6651.00
14_L34_V0.6651.00
96_G133_V0.6631.00
11_E92_N0.6631.00
28_A177_A0.6621.00
116_D119_P0.6621.00
74_H79_K0.6601.00
14_L25_L0.6601.00
17_R104_A0.6581.00
48_H92_N0.6561.00
51_W186_E0.6551.00
78_I81_E0.6531.00
125_Y135_P0.6501.00
135_P169_Q0.6481.00
24_T36_T0.6471.00
82_V86_V0.6411.00
74_H77_A0.6411.00
121_V128_L0.6391.00
95_V189_V0.6391.00
149_D152_L0.6381.00
187_D190_N0.6381.00
76_E80_T0.6321.00
26_M30_T0.6251.00
30_T49_F0.6221.00
172_I181_R0.6221.00
51_W183_A0.6201.00
77_A81_E0.6171.00
95_V134_Q0.6131.00
75_E79_K0.6131.00
20_V101_D0.6121.00
80_T83_V0.6071.00
85_Y89_H0.6061.00
24_T174_P0.6041.00
121_V131_L0.6001.00
62_P86_V0.5961.00
117_E120_H0.5951.00
152_L159_L0.5911.00
90_A93_I0.5831.00
136_V170_D0.5831.00
41_G65_G0.5821.00
146_D173_A0.5751.00
89_H92_N0.5731.00
104_A117_E0.5721.00
192_H195_A0.5711.00
64_F124_L0.5701.00
46_P85_Y0.5651.00
156_A173_A0.5651.00
34_V37_G0.5601.00
28_A174_P0.5561.00
17_R118_I0.5521.00
86_V89_H0.5501.00
121_V129_E0.5471.00
59_T89_H0.5431.00
30_T34_V0.5411.00
155_I160_G0.5351.00
10_D56_F0.5341.00
116_D120_H0.5341.00
99_V174_P0.5331.00
43_T46_P0.5311.00
83_V127_L0.5291.00
75_E78_I0.5281.00
11_E48_H0.5221.00
137_V168_W0.5201.00
84_R87_E0.5161.00
24_T27_R0.5111.00
160_G168_W0.5071.00
44_R74_H0.5061.00
35_P39_K0.5041.00
20_V23_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mkyA 1 0.8495 100 0.311 Contact Map
4dcuA 1 0.8981 100 0.334 Contact Map
1egaA 2 0.8738 100 0.344 Contact Map
3j8gX 1 0.8932 100 0.351 Contact Map
1xzpA 4 0.8689 100 0.367 Contact Map
3ievA 1 0.8835 100 0.367 Contact Map
3geeA 2 0.6845 100 0.374 Contact Map
3j65o 1 0.8932 100 0.375 Contact Map
3gehA 2 0.7621 99.9 0.38 Contact Map
1wf3A 1 0.8592 99.9 0.382 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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