ENGB - HALSA - GREMLIN Contacts

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ENGB - Probable GTP-binding protein EngB

UniProt:	Q9HME0	Sequences: MFKDRPDRSDEVVLVGRSNVGKSTLMRAVTGHQVPTGQKPGVTRQPNHFDWASEDFMLTDLPGFGYMQGVEDGHEEAIKTEVVRYVESHADNIMVGVLVLDGKAAVDIIDRHSGGDEIPHVVELYYLLEELGVQPVVAVNKMDKVDDRDERLNDIADRLGLYPPWEQWQDVIAPITAKKDRIAALEDAVNSHFDAAKRDDLKQFFS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	206 (164)
Sequences:	25687 (16650)
Seq/√Len:	1300.2

ECOLI - DER ERA ENGB MNME YKFA YFJP HFLX FEOB OBG EFTU1 CRFC EFTU2 CYSN
BACSU - DER MNME ENGB ERA HFLX OBG YPBR EFTU IF2
HALSA - ENGB Q9HMD6 Q9HQ88 Q9HMC2 Y1111 IF2G Q9HRX2 IF2P Q9HP92
SULSO - Q7LXR6 HFLX IF2G IF2P Q7LXL0 EF1A

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
28_A	179_K	3.252	1.00
188_A	191_S	2.878	1.00
172_I	188_A	2.864	1.00
97_V	138_A	2.694	1.00
170_D	188_A	2.421	1.00
48_H	57_M	2.381	1.00
102_G	139_V	2.330	1.00
24_T	176_T	2.265	1.00
188_A	192_H	2.262	1.00
142_M	173_A	2.208	1.00
100_L	137_V	2.125	1.00
11_E	57_M	2.081	1.00
13_V	93_I	2.032	1.00
54_E	190_N	2.017	1.00
28_A	182_I	1.837	1.00
95_V	136_V	1.820	1.00
27_R	36_T	1.809	1.00
139_V	173_A	1.797	1.00
97_V	189_V	1.759	1.00
25_L	99_V	1.752	1.00
154_D	158_R	1.728	1.00
136_V	188_A	1.686	1.00
14_L	97_V	1.686	1.00
99_V	140_N	1.683	1.00
156_A	160_G	1.680	1.00
138_A	185_L	1.579	1.00
26_M	34_V	1.572	1.00
87_E	127_L	1.558	1.00
153_N	156_A	1.553	1.00
10_D	193_F	1.531	1.00
50_D	55_D	1.524	1.00
48_H	59_T	1.505	1.00
25_L	185_L	1.467	1.00
34_V	47_N	1.456	1.00
81_E	84_R	1.451	1.00
138_A	174_P	1.445	1.00
14_L	26_M	1.429	1.00
101_D	104_A	1.365	1.00
98_L	125_Y	1.353	1.00
123_E	126_Y	1.331	1.00
117_E	121_V	1.330	1.00
17_R	121_V	1.318	1.00
136_V	172_I	1.303	1.00
119_P	123_E	1.302	1.00
151_R	154_D	1.287	1.00
153_N	157_D	1.269	1.00
56_F	190_N	1.265	1.00
141_K	144_K	1.253	1.00
139_V	171_V	1.252	1.00
95_V	192_H	1.250	1.00
97_V	136_V	1.245	1.00
127_L	131_L	1.243	1.00
140_N	176_T	1.240	1.00
181_R	184_A	1.240	1.00
152_L	156_A	1.232	1.00
103_K	144_K	1.227	1.00
52_A	190_N	1.216	1.00
120_H	123_E	1.210	1.00
9_S	57_M	1.202	1.00
12_V	189_V	1.195	1.00
123_E	127_L	1.194	1.00
151_R	155_I	1.191	1.00
46_P	59_T	1.183	1.00
137_V	171_V	1.168	1.00
54_E	194_D	1.153	1.00
187_D	191_S	1.149	1.00
98_L	135_P	1.143	1.00
182_I	186_E	1.142	1.00
122_V	126_Y	1.130	1.00
184_A	187_D	1.118	1.00
170_D	192_H	1.117	1.00
18_S	40_P	1.102	1.00
84_R	88_S	1.093	1.00
155_I	159_L	1.092	1.00
183_A	187_D	1.083	1.00
25_L	29_V	1.083	1.00
152_L	155_I	1.081	1.00
23_S	34_V	1.077	1.00
81_E	85_Y	1.076	1.00
126_Y	130_E	1.061	1.00
76_E	79_K	1.061	1.00
127_L	130_E	1.040	1.00
29_V	186_E	1.038	1.00
186_E	189_V	1.038	1.00
186_E	190_N	1.035	1.00
184_A	188_A	1.031	1.00
83_V	87_E	1.029	1.00
154_D	157_D	1.022	1.00
134_Q	192_H	1.020	1.00
37_G	42_V	1.016	1.00
19_N	38_Q	1.012	1.00
97_V	185_L	1.012	1.00
126_Y	129_E	1.011	1.00
118_I	121_V	1.007	1.00
128_L	135_P	0.973	1.00
12_V	95_V	0.972	1.00
103_K	116_D	0.971	1.00
65_G	79_K	0.969	1.00
185_L	189_V	0.962	1.00
9_S	55_D	0.945	1.00
51_W	190_N	0.940	1.00
46_P	89_H	0.939	1.00
121_V	124_L	0.939	1.00
121_V	125_Y	0.936	1.00
119_P	122_V	0.934	1.00
51_W	187_D	0.929	1.00
190_N	194_D	0.928	1.00
77_A	80_T	0.925	1.00
152_L	173_A	0.919	1.00
136_V	192_H	0.919	1.00
79_K	82_V	0.912	1.00
27_R	34_V	0.912	1.00
25_L	174_P	0.911	1.00
117_E	122_V	0.908	1.00
157_D	161_L	0.903	1.00
79_K	83_V	0.896	1.00
116_D	121_V	0.892	1.00
29_V	58_L	0.891	1.00
91_D	131_L	0.888	1.00
11_E	59_T	0.888	1.00
125_Y	128_L	0.887	1.00
174_P	185_L	0.884	1.00
25_L	138_A	0.878	1.00
124_L	128_L	0.874	1.00
35_P	42_V	0.873	1.00
85_Y	88_S	0.861	1.00
178_K	181_R	0.856	1.00
101_D	140_N	0.856	1.00
125_Y	129_E	0.855	1.00
12_V	58_L	0.854	1.00
120_H	124_L	0.847	1.00
50_D	53_S	0.830	1.00
102_G	145_V	0.826	1.00
124_L	127_L	0.822	1.00
83_V	86_V	0.821	1.00
15_V	96_G	0.816	1.00
17_R	120_H	0.809	1.00
78_I	82_V	0.807	1.00
100_L	139_V	0.804	1.00
93_I	96_G	0.802	1.00
157_D	160_G	0.798	1.00
158_R	161_L	0.796	1.00
174_P	182_I	0.795	1.00
170_D	191_S	0.792	1.00
13_V	61_L	0.790	1.00
149_D	153_N	0.787	1.00
15_V	90_A	0.785	1.00
102_G	142_M	0.780	1.00
12_V	56_F	0.768	1.00
88_S	91_D	0.764	1.00
25_L	176_T	0.761	1.00
62_P	82_V	0.760	1.00
142_M	180_D	0.755	1.00
11_E	94_M	0.753	1.00
64_F	86_V	0.752	1.00
179_K	182_I	0.746	1.00
52_A	187_D	0.741	1.00
172_I	184_A	0.731	1.00
128_L	131_L	0.730	1.00
122_V	158_R	0.729	1.00
98_L	137_V	0.729	1.00
51_W	56_F	0.720	1.00
150_E	154_D	0.715	1.00
25_L	182_I	0.714	1.00
183_A	186_E	0.711	1.00
28_A	176_T	0.709	1.00
170_D	173_A	0.703	1.00
104_A	118_I	0.700	1.00
121_V	127_L	0.682	1.00
146_D	149_D	0.682	1.00
98_L	128_L	0.680	1.00
80_T	84_R	0.679	1.00
161_L	169_Q	0.677	1.00
101_D	141_K	0.675	1.00
65_G	86_V	0.673	1.00
104_A	116_D	0.672	1.00
138_A	172_I	0.670	1.00
50_D	54_E	0.665	1.00
14_L	34_V	0.665	1.00
96_G	133_V	0.663	1.00
11_E	92_N	0.663	1.00
28_A	177_A	0.662	1.00
116_D	119_P	0.662	1.00
74_H	79_K	0.660	1.00
14_L	25_L	0.660	1.00
17_R	104_A	0.658	1.00
48_H	92_N	0.656	1.00
51_W	186_E	0.655	1.00
78_I	81_E	0.653	1.00
125_Y	135_P	0.650	1.00
135_P	169_Q	0.648	1.00
24_T	36_T	0.647	1.00
82_V	86_V	0.641	1.00
74_H	77_A	0.641	1.00
121_V	128_L	0.639	1.00
95_V	189_V	0.639	1.00
149_D	152_L	0.638	1.00
187_D	190_N	0.638	1.00
76_E	80_T	0.632	1.00
26_M	30_T	0.625	1.00
30_T	49_F	0.622	1.00
172_I	181_R	0.622	1.00
51_W	183_A	0.620	1.00
77_A	81_E	0.617	1.00
95_V	134_Q	0.613	1.00
75_E	79_K	0.613	1.00
20_V	101_D	0.612	1.00
80_T	83_V	0.607	1.00
85_Y	89_H	0.606	1.00
24_T	174_P	0.604	1.00
121_V	131_L	0.600	1.00
62_P	86_V	0.596	1.00
117_E	120_H	0.595	1.00
152_L	159_L	0.591	1.00
90_A	93_I	0.583	1.00
136_V	170_D	0.583	1.00
41_G	65_G	0.582	1.00
146_D	173_A	0.575	1.00
89_H	92_N	0.573	1.00
104_A	117_E	0.572	1.00
192_H	195_A	0.571	1.00
64_F	124_L	0.570	1.00
46_P	85_Y	0.565	1.00
156_A	173_A	0.565	1.00
34_V	37_G	0.560	1.00
28_A	174_P	0.556	1.00
17_R	118_I	0.552	1.00
86_V	89_H	0.550	1.00
121_V	129_E	0.547	1.00
59_T	89_H	0.543	1.00
30_T	34_V	0.541	1.00
155_I	160_G	0.535	1.00
10_D	56_F	0.534	1.00
116_D	120_H	0.534	1.00
99_V	174_P	0.533	1.00
43_T	46_P	0.531	1.00
83_V	127_L	0.529	1.00
75_E	78_I	0.528	1.00
11_E	48_H	0.522	1.00
137_V	168_W	0.520	1.00
84_R	87_E	0.516	1.00
24_T	27_R	0.511	1.00
160_G	168_W	0.507	1.00
44_R	74_H	0.506	1.00
35_P	39_K	0.504	1.00
20_V	23_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1mkyA	1	0.8495	100	0.311	Contact Map
4dcuA	1	0.8981	100	0.334	Contact Map
1egaA	2	0.8738	100	0.344	Contact Map
3j8gX	1	0.8932	100	0.351	Contact Map
1xzpA	4	0.8689	100	0.367	Contact Map
3ievA	1	0.8835	100	0.367	Contact Map
3geeA	2	0.6845	100	0.374	Contact Map
3j65o	1	0.8932	100	0.375	Contact Map
3gehA	2	0.7621	99.9	0.38	Contact Map
1wf3A	1	0.8592	99.9	0.382	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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