GREMLIN Database
Q9HMD9 - Uncharacterized protein
UniProt: Q9HMD9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (220)
Sequences: 3192 (2590)
Seq/√Len: 174.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D74_A3.3261.00
69_G75_V3.3101.00
51_T234_T3.3091.00
91_A97_A2.8281.00
110_Q124_R2.8011.00
60_V160_T2.7121.00
67_A79_L2.6951.00
135_D138_A2.6521.00
48_A180_N2.6111.00
50_G173_A2.4031.00
182_R186_D2.4011.00
99_T134_N2.2461.00
45_T240_Q2.1861.00
52_V173_A2.1431.00
78_S81_A1.9301.00
84_Q88_D1.9161.00
53_D232_P1.8331.00
54_A169_L1.8241.00
68_S110_Q1.8171.00
52_V176_T1.8141.00
66_T153_T1.8101.00
88_D92_D1.7821.00
175_N190_S1.7701.00
174_L188_L1.7561.00
186_D190_S1.7551.00
178_M191_A1.7431.00
69_G74_A1.7351.00
57_N162_S1.7061.00
176_T179_A1.6941.00
202_I241_V1.6861.00
171_N187_T1.6851.00
178_M241_V1.6611.00
200_H244_N1.6591.00
198_G244_N1.6411.00
59_A139_A1.6361.00
171_N183_Q1.6331.00
83_V129_L1.6121.00
144_D226_T1.6111.00
138_A141_E1.6091.00
81_A85_S1.5851.00
199_V241_V1.5781.00
58_Q132_T1.5741.00
109_Q120_Y1.5561.00
79_L125_G1.5511.00
52_V172_D1.5491.00
68_S124_R1.5331.00
53_D234_T1.5261.00
183_Q186_D1.5141.00
133_T142_L1.5111.00
181_A241_V1.4891.00
76_R80_A1.4881.00
175_N179_A1.4691.00
66_T124_R1.4651.00
103_T130_E1.4531.00
69_G78_S1.4181.00
58_Q160_T1.4161.00
73_T77_E1.4121.00
163_D168_R1.4011.00
87_R91_A1.3911.00
107_I125_G1.3811.00
172_D176_T1.3771.00
178_M192_G1.3661.00
89_A145_V1.3551.00
174_L204_S1.3531.00
75_V125_G1.3521.00
173_A237_A1.3511.00
74_A78_S1.3471.00
77_E81_A1.3471.00
205_A238_S1.3271.00
46_V181_A1.3261.00
172_D175_N1.3181.00
43_A242_T1.3161.00
111_R122_G1.3151.00
63_V146_A1.3081.00
163_D167_D1.3041.00
201_A242_T1.2731.00
134_N162_S1.2661.00
112_D121_S1.2651.00
51_T236_T1.2631.00
174_L187_T1.2441.00
215_A219_V1.2421.00
43_A200_H1.2381.00
72_S107_I1.2281.00
86_V129_L1.2271.00
167_D180_N1.2241.00
175_N191_A1.2031.00
76_R105_F1.2031.00
87_R229_D1.1971.00
161_L235_V1.1961.00
216_G220_P1.1951.00
78_S82_D1.1821.00
58_Q162_S1.1771.00
188_L204_S1.1731.00
85_S88_D1.1701.00
62_D155_D1.1691.00
186_D196_V1.1671.00
31_P34_A1.1611.00
182_R243_Y1.1581.00
22_A25_T1.1521.00
184_R204_S1.1521.00
83_V127_H1.1321.00
127_H227_T1.1261.00
67_A78_S1.1261.00
199_V202_I1.1111.00
44_I194_L1.1101.00
112_D119_E1.1091.00
54_A173_A1.1071.00
136_T139_A1.0961.00
72_S125_G1.0951.00
179_A182_R1.0911.00
23_G26_A1.0911.00
96_P99_T1.0771.00
214_E218_M1.0721.00
59_A133_T1.0691.00
111_R118_V1.0661.00
89_A93_D1.0621.00
64_A151_A1.0601.00
80_A226_T1.0531.00
105_F125_G1.0451.00
32_A35_D1.0451.00
141_E145_V1.0350.99
68_S121_S1.0200.99
110_Q121_S1.0170.99
215_A218_M0.9980.99
20_G23_G0.9950.99
216_G219_V0.9920.99
74_A77_E0.9880.99
87_R100_V0.9860.99
54_A161_L0.9710.99
34_A38_T0.9690.99
187_T191_A0.9680.99
192_G202_I0.9650.99
55_T232_P0.9590.99
182_R193_G0.9550.99
80_A84_Q0.9420.99
44_I197_A0.9410.99
58_Q134_N0.9370.99
109_Q122_G0.9340.99
93_D142_L0.9330.99
108_R124_R0.9260.99
180_N183_Q0.9240.99
111_R120_Y0.9230.99
33_S36_T0.9200.99
22_A27_L0.9050.99
101_R130_E0.8960.98
42_K194_L0.8950.98
196_V243_Y0.8930.98
56_A233_V0.8820.98
67_A82_D0.8780.98
161_L169_L0.8720.98
101_R231_G0.8660.98
112_D120_Y0.8650.98
105_F127_H0.8630.98
31_P35_D0.8540.98
178_M188_L0.8480.98
62_D158_S0.8430.98
102_T127_H0.8410.98
217_G222_S0.8410.98
90_L131_I0.8390.98
113_R118_V0.8390.98
217_G220_P0.8360.98
35_D38_T0.8350.98
170_H174_L0.8330.98
174_L178_M0.8310.97
99_T132_T0.8270.97
144_D148_T0.8260.97
48_A181_A0.8200.97
133_T139_A0.8150.97
173_A235_V0.8120.97
93_D145_V0.8100.97
73_T148_T0.8080.97
49_A236_T0.8080.97
204_S237_A0.8070.97
219_V223_T0.8060.97
175_N187_T0.8010.97
60_V132_T0.7970.97
176_T180_N0.7950.97
114_T119_E0.7910.97
60_V130_E0.7820.96
210_H213_A0.7790.96
219_V222_S0.7760.96
79_L127_H0.7730.96
64_A128_D0.7720.96
188_L202_I0.7710.96
154_I157_T0.7700.96
88_D91_A0.7620.96
221_Q224_T0.7530.96
205_A240_Q0.7510.95
128_D155_D0.7510.95
106_D126_V0.7500.95
212_R216_G0.7400.95
113_R117_G0.7320.95
45_T242_T0.7320.95
95_V131_I0.7270.95
60_V158_S0.7260.95
90_L142_L0.7250.95
52_V169_L0.7230.94
189_A196_V0.7200.94
22_A26_A0.7200.94
145_V149_N0.7170.94
46_V196_V0.7160.94
67_A75_V0.7160.94
42_K198_G0.7160.94
21_I25_T0.7150.94
63_V151_A0.7130.94
50_G176_T0.7080.94
146_A151_A0.7070.94
194_L199_V0.7070.94
46_V188_L0.6970.93
89_A149_N0.6930.93
66_T126_V0.6870.93
47_S238_S0.6860.93
212_R215_A0.6840.93
139_A228_I0.6830.93
63_V131_I0.6820.93
76_R140_G0.6820.93
94_G97_A0.6800.92
161_L233_V0.6790.92
98_N232_P0.6790.92
47_S240_Q0.6770.92
120_Y123_Y0.6730.92
33_S37_H0.6720.92
127_H228_I0.6680.92
62_D156_G0.6660.92
110_Q122_G0.6650.92
169_L235_V0.6650.92
64_A126_V0.6630.91
61_I133_T0.6620.91
168_R172_D0.6600.91
114_T117_G0.6590.91
86_V151_A0.6540.91
108_R126_V0.6520.91
218_M221_Q0.6510.91
147_V154_I0.6510.91
95_V99_T0.6510.91
167_D170_H0.6440.90
21_I32_A0.6430.90
62_D130_E0.6420.90
179_A191_A0.6390.90
91_A100_V0.6390.90
109_Q121_S0.6370.90
195_G198_G0.6370.90
62_D103_T0.6360.90
180_N184_R0.6350.90
178_M239_V0.6350.90
80_A127_H0.6330.89
31_P36_T0.6320.89
164_A167_D0.6300.89
113_R120_Y0.6280.89
26_A32_A0.6280.89
87_R97_A0.6240.89
184_R202_I0.6240.89
213_A218_M0.6230.89
43_A201_A0.6230.89
32_A36_T0.6220.89
174_L237_A0.6210.89
136_T159_F0.6200.88
119_E122_G0.6140.88
89_A92_D0.6070.87
107_I152_D0.6050.87
64_A155_D0.6010.87
164_A168_R0.6010.87
194_L197_A0.5990.87
197_A244_N0.5980.87
218_M222_S0.5980.87
49_A238_S0.5980.87
80_A105_F0.5960.86
146_A149_N0.5960.86
64_A152_D0.5950.86
71_D75_V0.5950.86
62_D128_D0.5900.86
85_S149_N0.5890.86
170_H204_S0.5890.86
97_A229_D0.5860.86
237_A241_V0.5840.85
20_G24_A0.5840.85
20_G27_L0.5820.85
215_A222_S0.5760.85
169_L173_A0.5760.85
204_S239_V0.5750.84
127_H226_T0.5750.84
68_S122_G0.5750.84
107_I154_I0.5750.84
80_A140_G0.5670.84
87_R129_L0.5620.83
216_G223_T0.5580.83
41_S200_H0.5570.83
105_F154_I0.5560.82
26_A33_S0.5560.82
76_R127_H0.5530.82
102_T129_L0.5510.82
23_G92_D0.5490.82
127_H140_G0.5490.82
89_A142_L0.5490.82
105_F226_T0.5460.81
20_G25_T0.5450.81
213_A216_G0.5420.81
159_F231_G0.5380.80
59_A136_T0.5330.80
33_S38_T0.5310.80
41_S244_N0.5280.79
142_L146_A0.5250.79
20_G26_A0.5250.79
55_T137_S0.5250.79
167_D171_N0.5250.79
79_L152_D0.5240.79
23_G37_H0.5220.78
26_A38_T0.5220.78
45_T203_D0.5210.78
200_H242_T0.5210.78
72_S144_D0.5200.78
34_A37_H0.5190.78
47_S205_A0.5180.78
24_A27_L0.5140.77
46_V180_N0.5140.77
46_V239_V0.5130.77
59_A159_F0.5130.77
203_D240_Q0.5130.77
95_V142_L0.5120.77
80_A147_V0.5110.77
23_G34_A0.5090.77
217_G221_Q0.5070.76
100_V129_L0.5060.76
27_L38_T0.5060.76
83_V102_T0.5030.76
23_G31_P0.5030.76
133_T146_A0.5020.76
76_R226_T0.5010.76
86_V146_A0.5010.76
45_T201_A0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hvzA 5 0.8259 100 0.234 Contact Map
4kyzA 1 0.6235 31.4 0.936 Contact Map
4n4rB 1 0.5425 25.1 0.939 Contact Map
2kgwA 1 0.4615 14 0.946 Contact Map
4g4xA 1 0.413 11.1 0.948 Contact Map
3aqpA 1 0.7773 9.3 0.95 Contact Map
3qhoA 1 0.8178 8.4 0.951 Contact Map
2aizP 1 0.4858 8.1 0.951 Contact Map
3u7vA 3 0.7409 7.8 0.952 Contact Map
4wyqB 1 0.2955 7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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