Q9HMD9 - HALSA - GREMLIN Contacts

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Q9HMD9 - Uncharacterized protein

UniProt:	Q9HMD9	Sequences: MNARSTLSVCAVAAVLVVAGIAGATALGMGPASADTHTTDSKAITVSAAGTVDATANQAVIDVAVTASGNDSTAVRESLAADVQSVRDALADDGVPANTVRTTNFDIRQQRDRTPNGVEYSGYRGVHDLEITTNDTSAAGELIDVAVTNGADTIDGTSFTLSDAKRDRLHNDALNTAMANARQRADTLASAGGLGVAGVHAIDSADTTAHPRAEAGGMVPQSTTATTIDSGPVTVTASVQVTYNATA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	247 (220)
Sequences:	3192 (2590)
Seq/√Len:	174.6

ECOLI - YGGE
HALSA - Q9HMD9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
71_D	74_A	3.326	1.00
69_G	75_V	3.310	1.00
51_T	234_T	3.309	1.00
91_A	97_A	2.828	1.00
110_Q	124_R	2.801	1.00
60_V	160_T	2.712	1.00
67_A	79_L	2.695	1.00
135_D	138_A	2.652	1.00
48_A	180_N	2.611	1.00
50_G	173_A	2.403	1.00
182_R	186_D	2.401	1.00
99_T	134_N	2.246	1.00
45_T	240_Q	2.186	1.00
52_V	173_A	2.143	1.00
78_S	81_A	1.930	1.00
84_Q	88_D	1.916	1.00
53_D	232_P	1.833	1.00
54_A	169_L	1.824	1.00
68_S	110_Q	1.817	1.00
52_V	176_T	1.814	1.00
66_T	153_T	1.810	1.00
88_D	92_D	1.782	1.00
175_N	190_S	1.770	1.00
174_L	188_L	1.756	1.00
186_D	190_S	1.755	1.00
178_M	191_A	1.743	1.00
69_G	74_A	1.735	1.00
57_N	162_S	1.706	1.00
176_T	179_A	1.694	1.00
202_I	241_V	1.686	1.00
171_N	187_T	1.685	1.00
178_M	241_V	1.661	1.00
200_H	244_N	1.659	1.00
198_G	244_N	1.641	1.00
59_A	139_A	1.636	1.00
171_N	183_Q	1.633	1.00
83_V	129_L	1.612	1.00
144_D	226_T	1.611	1.00
138_A	141_E	1.609	1.00
81_A	85_S	1.585	1.00
199_V	241_V	1.578	1.00
58_Q	132_T	1.574	1.00
109_Q	120_Y	1.556	1.00
79_L	125_G	1.551	1.00
52_V	172_D	1.549	1.00
68_S	124_R	1.533	1.00
53_D	234_T	1.526	1.00
183_Q	186_D	1.514	1.00
133_T	142_L	1.511	1.00
181_A	241_V	1.489	1.00
76_R	80_A	1.488	1.00
175_N	179_A	1.469	1.00
66_T	124_R	1.465	1.00
103_T	130_E	1.453	1.00
69_G	78_S	1.418	1.00
58_Q	160_T	1.416	1.00
73_T	77_E	1.412	1.00
163_D	168_R	1.401	1.00
87_R	91_A	1.391	1.00
107_I	125_G	1.381	1.00
172_D	176_T	1.377	1.00
178_M	192_G	1.366	1.00
89_A	145_V	1.355	1.00
174_L	204_S	1.353	1.00
75_V	125_G	1.352	1.00
173_A	237_A	1.351	1.00
74_A	78_S	1.347	1.00
77_E	81_A	1.347	1.00
205_A	238_S	1.327	1.00
46_V	181_A	1.326	1.00
172_D	175_N	1.318	1.00
43_A	242_T	1.316	1.00
111_R	122_G	1.315	1.00
63_V	146_A	1.308	1.00
163_D	167_D	1.304	1.00
201_A	242_T	1.273	1.00
134_N	162_S	1.266	1.00
112_D	121_S	1.265	1.00
51_T	236_T	1.263	1.00
174_L	187_T	1.244	1.00
215_A	219_V	1.242	1.00
43_A	200_H	1.238	1.00
72_S	107_I	1.228	1.00
86_V	129_L	1.227	1.00
167_D	180_N	1.224	1.00
175_N	191_A	1.203	1.00
76_R	105_F	1.203	1.00
87_R	229_D	1.197	1.00
161_L	235_V	1.196	1.00
216_G	220_P	1.195	1.00
78_S	82_D	1.182	1.00
58_Q	162_S	1.177	1.00
188_L	204_S	1.173	1.00
85_S	88_D	1.170	1.00
62_D	155_D	1.169	1.00
186_D	196_V	1.167	1.00
31_P	34_A	1.161	1.00
182_R	243_Y	1.158	1.00
22_A	25_T	1.152	1.00
184_R	204_S	1.152	1.00
83_V	127_H	1.132	1.00
127_H	227_T	1.126	1.00
67_A	78_S	1.126	1.00
199_V	202_I	1.111	1.00
44_I	194_L	1.110	1.00
112_D	119_E	1.109	1.00
54_A	173_A	1.107	1.00
136_T	139_A	1.096	1.00
72_S	125_G	1.095	1.00
179_A	182_R	1.091	1.00
23_G	26_A	1.091	1.00
96_P	99_T	1.077	1.00
214_E	218_M	1.072	1.00
59_A	133_T	1.069	1.00
111_R	118_V	1.066	1.00
89_A	93_D	1.062	1.00
64_A	151_A	1.060	1.00
80_A	226_T	1.053	1.00
105_F	125_G	1.045	1.00
32_A	35_D	1.045	1.00
141_E	145_V	1.035	0.99
68_S	121_S	1.020	0.99
110_Q	121_S	1.017	0.99
215_A	218_M	0.998	0.99
20_G	23_G	0.995	0.99
216_G	219_V	0.992	0.99
74_A	77_E	0.988	0.99
87_R	100_V	0.986	0.99
54_A	161_L	0.971	0.99
34_A	38_T	0.969	0.99
187_T	191_A	0.968	0.99
192_G	202_I	0.965	0.99
55_T	232_P	0.959	0.99
182_R	193_G	0.955	0.99
80_A	84_Q	0.942	0.99
44_I	197_A	0.941	0.99
58_Q	134_N	0.937	0.99
109_Q	122_G	0.934	0.99
93_D	142_L	0.933	0.99
108_R	124_R	0.926	0.99
180_N	183_Q	0.924	0.99
111_R	120_Y	0.923	0.99
33_S	36_T	0.920	0.99
22_A	27_L	0.905	0.99
101_R	130_E	0.896	0.98
42_K	194_L	0.895	0.98
196_V	243_Y	0.893	0.98
56_A	233_V	0.882	0.98
67_A	82_D	0.878	0.98
161_L	169_L	0.872	0.98
101_R	231_G	0.866	0.98
112_D	120_Y	0.865	0.98
105_F	127_H	0.863	0.98
31_P	35_D	0.854	0.98
178_M	188_L	0.848	0.98
62_D	158_S	0.843	0.98
102_T	127_H	0.841	0.98
217_G	222_S	0.841	0.98
90_L	131_I	0.839	0.98
113_R	118_V	0.839	0.98
217_G	220_P	0.836	0.98
35_D	38_T	0.835	0.98
170_H	174_L	0.833	0.98
174_L	178_M	0.831	0.97
99_T	132_T	0.827	0.97
144_D	148_T	0.826	0.97
48_A	181_A	0.820	0.97
133_T	139_A	0.815	0.97
173_A	235_V	0.812	0.97
93_D	145_V	0.810	0.97
73_T	148_T	0.808	0.97
49_A	236_T	0.808	0.97
204_S	237_A	0.807	0.97
219_V	223_T	0.806	0.97
175_N	187_T	0.801	0.97
60_V	132_T	0.797	0.97
176_T	180_N	0.795	0.97
114_T	119_E	0.791	0.97
60_V	130_E	0.782	0.96
210_H	213_A	0.779	0.96
219_V	222_S	0.776	0.96
79_L	127_H	0.773	0.96
64_A	128_D	0.772	0.96
188_L	202_I	0.771	0.96
154_I	157_T	0.770	0.96
88_D	91_A	0.762	0.96
221_Q	224_T	0.753	0.96
205_A	240_Q	0.751	0.95
128_D	155_D	0.751	0.95
106_D	126_V	0.750	0.95
212_R	216_G	0.740	0.95
113_R	117_G	0.732	0.95
45_T	242_T	0.732	0.95
95_V	131_I	0.727	0.95
60_V	158_S	0.726	0.95
90_L	142_L	0.725	0.95
52_V	169_L	0.723	0.94
189_A	196_V	0.720	0.94
22_A	26_A	0.720	0.94
145_V	149_N	0.717	0.94
46_V	196_V	0.716	0.94
67_A	75_V	0.716	0.94
42_K	198_G	0.716	0.94
21_I	25_T	0.715	0.94
63_V	151_A	0.713	0.94
50_G	176_T	0.708	0.94
146_A	151_A	0.707	0.94
194_L	199_V	0.707	0.94
46_V	188_L	0.697	0.93
89_A	149_N	0.693	0.93
66_T	126_V	0.687	0.93
47_S	238_S	0.686	0.93
212_R	215_A	0.684	0.93
139_A	228_I	0.683	0.93
63_V	131_I	0.682	0.93
76_R	140_G	0.682	0.93
94_G	97_A	0.680	0.92
161_L	233_V	0.679	0.92
98_N	232_P	0.679	0.92
47_S	240_Q	0.677	0.92
120_Y	123_Y	0.673	0.92
33_S	37_H	0.672	0.92
127_H	228_I	0.668	0.92
62_D	156_G	0.666	0.92
110_Q	122_G	0.665	0.92
169_L	235_V	0.665	0.92
64_A	126_V	0.663	0.91
61_I	133_T	0.662	0.91
168_R	172_D	0.660	0.91
114_T	117_G	0.659	0.91
86_V	151_A	0.654	0.91
108_R	126_V	0.652	0.91
218_M	221_Q	0.651	0.91
147_V	154_I	0.651	0.91
95_V	99_T	0.651	0.91
167_D	170_H	0.644	0.90
21_I	32_A	0.643	0.90
62_D	130_E	0.642	0.90
179_A	191_A	0.639	0.90
91_A	100_V	0.639	0.90
109_Q	121_S	0.637	0.90
195_G	198_G	0.637	0.90
62_D	103_T	0.636	0.90
180_N	184_R	0.635	0.90
178_M	239_V	0.635	0.90
80_A	127_H	0.633	0.89
31_P	36_T	0.632	0.89
164_A	167_D	0.630	0.89
113_R	120_Y	0.628	0.89
26_A	32_A	0.628	0.89
87_R	97_A	0.624	0.89
184_R	202_I	0.624	0.89
213_A	218_M	0.623	0.89
43_A	201_A	0.623	0.89
32_A	36_T	0.622	0.89
174_L	237_A	0.621	0.89
136_T	159_F	0.620	0.88
119_E	122_G	0.614	0.88
89_A	92_D	0.607	0.87
107_I	152_D	0.605	0.87
64_A	155_D	0.601	0.87
164_A	168_R	0.601	0.87
194_L	197_A	0.599	0.87
197_A	244_N	0.598	0.87
218_M	222_S	0.598	0.87
49_A	238_S	0.598	0.87
80_A	105_F	0.596	0.86
146_A	149_N	0.596	0.86
64_A	152_D	0.595	0.86
71_D	75_V	0.595	0.86
62_D	128_D	0.590	0.86
85_S	149_N	0.589	0.86
170_H	204_S	0.589	0.86
97_A	229_D	0.586	0.86
237_A	241_V	0.584	0.85
20_G	24_A	0.584	0.85
20_G	27_L	0.582	0.85
215_A	222_S	0.576	0.85
169_L	173_A	0.576	0.85
204_S	239_V	0.575	0.84
127_H	226_T	0.575	0.84
68_S	122_G	0.575	0.84
107_I	154_I	0.575	0.84
80_A	140_G	0.567	0.84
87_R	129_L	0.562	0.83
216_G	223_T	0.558	0.83
41_S	200_H	0.557	0.83
105_F	154_I	0.556	0.82
26_A	33_S	0.556	0.82
76_R	127_H	0.553	0.82
102_T	129_L	0.551	0.82
23_G	92_D	0.549	0.82
127_H	140_G	0.549	0.82
89_A	142_L	0.549	0.82
105_F	226_T	0.546	0.81
20_G	25_T	0.545	0.81
213_A	216_G	0.542	0.81
159_F	231_G	0.538	0.80
59_A	136_T	0.533	0.80
33_S	38_T	0.531	0.80
41_S	244_N	0.528	0.79
142_L	146_A	0.525	0.79
20_G	26_A	0.525	0.79
55_T	137_S	0.525	0.79
167_D	171_N	0.525	0.79
79_L	152_D	0.524	0.79
23_G	37_H	0.522	0.78
26_A	38_T	0.522	0.78
45_T	203_D	0.521	0.78
200_H	242_T	0.521	0.78
72_S	144_D	0.520	0.78
34_A	37_H	0.519	0.78
47_S	205_A	0.518	0.78
24_A	27_L	0.514	0.77
46_V	180_N	0.514	0.77
46_V	239_V	0.513	0.77
59_A	159_F	0.513	0.77
203_D	240_Q	0.513	0.77
95_V	142_L	0.512	0.77
80_A	147_V	0.511	0.77
23_G	34_A	0.509	0.77
217_G	221_Q	0.507	0.76
100_V	129_L	0.506	0.76
27_L	38_T	0.506	0.76
83_V	102_T	0.503	0.76
23_G	31_P	0.503	0.76
133_T	146_A	0.502	0.76
76_R	226_T	0.501	0.76
86_V	146_A	0.501	0.76
45_T	201_A	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4hvzA	5	0.8259	100	0.234	Contact Map
4kyzA	1	0.6235	31.4	0.936	Contact Map
4n4rB	1	0.5425	25.1	0.939	Contact Map
2kgwA	1	0.4615	14	0.946	Contact Map
4g4xA	1	0.413	11.1	0.948	Contact Map
3aqpA	1	0.7773	9.3	0.95	Contact Map
3qhoA	1	0.8178	8.4	0.951	Contact Map
2aizP	1	0.4858	8.1	0.951	Contact Map
3u7vA	3	0.7409	7.8	0.952	Contact Map
4wyqB	1	0.2955	7	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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