Q9HMD8 - HALSA - GREMLIN Contacts

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Q9HMD8 - Uncharacterized protein

UniProt:	Q9HMD8	Sequences: MVIAPLLGPAMSASVGTVVDDDDLFARGIRLQVVGVALAVVGAAAFAFLVKTTHLVPPGLDVLSLSEVRERLRPDFLSLVVALGSGVAGVYSLMSGVSSALVGVAIAVALIPPAATVGIGIAWGVPTLAVGSAVLVAVNVLSINLAALVGLWYSGYRPQRFFAVGDAHAALVKRGVTLAVAIAVLSAFLGGVTLASVEAADTEQAVDRAIDDVTAQAAHTSVVDVQFQYDRGLVSRQPHTVIVTLGIPPGQQYPALAQSLAKRIETDTGRELAVEVRYVETQRVAPSRPNE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	291 (263)
Sequences:	777 (621)
Seq/√Len:	38.3

HALSA - Q9HMD8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_G	25_F	9.788	1.00
36_V	136_V	9.041	1.00
117_V	129_A	4.922	1.00
47_A	119_I	3.584	1.00
4_A	119_I	3.137	1.00
90_V	151_L	2.721	1.00
44_A	121_I	2.682	1.00
7_L	105_A	2.645	1.00
117_V	133_A	2.529	1.00
202_T	206_V	2.509	1.00
18_V	151_L	2.369	1.00
40_V	117_V	2.369	1.00
99_S	102_V	2.368	1.00
77_L	98_S	2.315	1.00
37_A	184_V	2.172	0.99
167_A	170_A	2.133	0.99
256_L	261_A	2.091	0.99
71_R	106_I	2.082	0.99
199_A	203_E	2.037	0.99
16_G	87_V	2.034	0.99
120_G	128_L	1.876	0.98
238_P	247_I	1.833	0.98
82_A	139_N	1.832	0.98
6_L	113_P	1.817	0.98
85_S	108_V	1.810	0.97
89_G	102_V	1.731	0.97
140_V	151_L	1.716	0.97
80_V	84_G	1.696	0.96
89_G	104_V	1.694	0.96
10_A	120_G	1.645	0.96
95_S	222_V	1.621	0.95
40_V	43_A	1.617	0.95
45_A	245_L	1.612	0.95
78_S	114_A	1.610	0.95
71_R	135_L	1.586	0.95
11_M	101_L	1.575	0.94
67_E	139_N	1.563	0.94
4_A	84_G	1.549	0.94
88_A	104_V	1.549	0.94
30_R	34_V	1.545	0.94
10_A	78_S	1.538	0.94
82_A	105_A	1.536	0.94
13_A	32_Q	1.504	0.93
9_P	113_P	1.503	0.93
14_S	84_G	1.489	0.92
46_F	75_D	1.454	0.92
4_A	14_S	1.454	0.92
68_V	116_T	1.453	0.92
2_V	65_L	1.451	0.91
9_P	35_G	1.442	0.91
27_R	48_F	1.437	0.91
6_L	106_I	1.436	0.91
4_A	108_V	1.432	0.91
256_L	259_S	1.429	0.91
81_V	131_G	1.419	0.91
216_Q	219_H	1.413	0.90
35_G	77_L	1.413	0.90
183_A	187_A	1.412	0.90
65_L	68_V	1.411	0.90
3_I	111_I	1.410	0.90
134_V	185_L	1.403	0.90
35_G	43_A	1.395	0.90
106_I	110_L	1.382	0.89
108_V	143_I	1.382	0.89
94_M	154_S	1.367	0.89
99_S	150_G	1.336	0.88
111_I	114_A	1.333	0.88
6_L	111_I	1.331	0.87
50_V	129_A	1.330	0.87
71_R	74_P	1.327	0.87
45_A	251_Q	1.323	0.87
258_Q	262_K	1.320	0.87
221_S	225_V	1.320	0.87
74_P	109_A	1.319	0.87
69_R	72_L	1.309	0.87
4_A	142_S	1.292	0.86
257_A	261_A	1.290	0.86
25_F	28_G	1.285	0.86
243_V	247_I	1.282	0.85
145_L	221_S	1.280	0.85
203_E	207_D	1.276	0.85
89_G	93_L	1.272	0.85
261_A	274_V	1.270	0.85
105_A	139_N	1.257	0.84
94_M	101_L	1.254	0.84
8_G	120_G	1.247	0.84
28_G	183_A	1.243	0.84
149_V	184_V	1.236	0.83
32_Q	144_N	1.234	0.83
94_M	146_A	1.224	0.83
258_Q	266_T	1.218	0.82
57_P	85_S	1.213	0.82
74_P	131_G	1.212	0.82
117_V	171_L	1.208	0.82
27_R	155_G	1.207	0.82
99_S	116_T	1.204	0.82
82_A	113_P	1.204	0.82
236_R	241_V	1.203	0.81
194_L	198_E	1.201	0.81
97_V	147_A	1.186	0.81
245_L	249_P	1.185	0.80
46_F	50_V	1.184	0.80
32_Q	140_V	1.173	0.80
229_Y	232_G	1.163	0.79
168_H	172_V	1.160	0.79
144_N	151_L	1.156	0.79
255_A	259_S	1.145	0.78
6_L	71_R	1.141	0.78
121_I	124_G	1.127	0.77
50_V	108_V	1.121	0.77
74_P	139_N	1.119	0.76
9_P	92_S	1.105	0.76
79_L	142_S	1.100	0.75
37_A	180_V	1.090	0.75
134_V	138_V	1.078	0.74
3_I	69_R	1.076	0.74
114_A	133_A	1.067	0.73
37_A	41_V	1.067	0.73
2_V	143_I	1.051	0.72
111_I	119_I	1.050	0.72
37_A	270_R	1.049	0.72
38_L	83_L	1.043	0.71
77_L	92_S	1.028	0.70
14_S	119_I	1.019	0.69
7_L	143_I	1.014	0.69
95_S	98_S	1.009	0.69
265_E	272_L	1.003	0.68
71_R	110_L	0.995	0.68
79_L	138_V	0.994	0.67
7_L	113_P	0.991	0.67
89_G	107_A	0.978	0.66
249_P	252_Q	0.970	0.66
49_L	244_T	0.957	0.64
67_E	82_A	0.953	0.64
108_V	119_I	0.949	0.64
74_P	82_A	0.948	0.64
45_A	273_A	0.948	0.64
254_P	257_A	0.940	0.63
10_A	114_A	0.931	0.62
4_A	47_A	0.930	0.62
169_A	266_T	0.929	0.62
2_V	152_W	0.926	0.62
173_K	176_V	0.921	0.61
2_V	108_V	0.920	0.61
83_L	146_A	0.915	0.61
33_V	180_V	0.915	0.61
189_L	196_S	0.913	0.61
100_A	178_L	0.910	0.61
74_P	105_A	0.909	0.60
28_G	45_A	0.906	0.60
261_A	265_E	0.902	0.60
49_L	241_V	0.894	0.59
50_V	144_N	0.893	0.59
85_S	142_S	0.890	0.59
233_L	236_R	0.889	0.59
236_R	247_I	0.885	0.58
31_L	35_G	0.881	0.58
196_S	200_A	0.875	0.58
3_I	119_I	0.875	0.58
12_S	186_S	0.868	0.57
15_V	19_V	0.866	0.57
7_L	82_A	0.864	0.57
67_E	113_P	0.863	0.56
59_G	119_I	0.860	0.56
11_M	216_Q	0.859	0.56
229_Y	245_L	0.858	0.56
177_T	262_K	0.856	0.56
3_I	117_V	0.856	0.56
36_V	67_E	0.855	0.56
11_M	189_L	0.855	0.56
8_G	88_A	0.854	0.56
10_A	92_S	0.853	0.56
92_S	96_G	0.847	0.55
108_V	142_S	0.842	0.55
19_V	31_L	0.839	0.54
263_R	266_T	0.839	0.54
83_L	230_D	0.835	0.54
14_S	123_W	0.835	0.54
130_V	208_R	0.832	0.54
45_A	230_D	0.831	0.54
15_V	157_R	0.831	0.54
2_V	84_G	0.831	0.54
106_I	135_L	0.828	0.53
2_V	111_I	0.826	0.53
255_A	258_Q	0.826	0.53
260_L	273_A	0.825	0.53
268_T	271_E	0.823	0.53
178_L	218_A	0.821	0.53
43_A	162_F	0.811	0.52
252_Q	256_L	0.810	0.52
258_Q	273_A	0.808	0.52
6_L	9_P	0.805	0.51
195_A	226_Q	0.803	0.51
40_V	140_V	0.803	0.51
229_Y	243_V	0.800	0.51
95_S	190_G	0.796	0.50
202_T	241_V	0.795	0.50
39_A	111_I	0.795	0.50
12_S	82_A	0.795	0.50
78_S	105_A	0.792	0.50
33_V	228_Q	0.789	0.50
88_A	119_I	0.789	0.50
49_L	184_V	0.787	0.50
95_S	99_S	0.783	0.49
45_A	181_A	0.781	0.49
255_A	273_A	0.779	0.49
102_V	142_S	0.777	0.49
7_L	85_S	0.772	0.48
105_A	108_V	0.770	0.48
2_V	14_S	0.768	0.48
177_T	201_D	0.764	0.48
8_G	185_L	0.763	0.48
95_S	214_T	0.763	0.48
39_A	136_V	0.762	0.47
7_L	119_I	0.760	0.47
17_T	148_L	0.759	0.47
125_V	212_D	0.758	0.47
204_Q	226_Q	0.751	0.46
21_D	264_I	0.751	0.46
37_A	45_A	0.749	0.46
237_Q	259_S	0.746	0.46
105_A	111_I	0.734	0.45
233_L	241_V	0.730	0.45
97_V	101_L	0.730	0.45
168_H	171_L	0.728	0.44
261_A	267_D	0.726	0.44
206_V	210_I	0.726	0.44
11_M	90_V	0.723	0.44
116_T	132_S	0.722	0.44
21_D	222_V	0.721	0.44
47_A	122_A	0.721	0.44
252_Q	255_A	0.720	0.44
231_R	251_Q	0.715	0.43
8_G	86_G	0.713	0.43
7_L	71_R	0.711	0.43
43_A	95_S	0.708	0.43
39_A	146_A	0.707	0.43
204_Q	208_R	0.707	0.43
81_V	109_A	0.706	0.42
87_V	206_V	0.703	0.42
69_R	143_I	0.701	0.42
71_R	139_N	0.700	0.42
237_Q	243_V	0.698	0.42
90_V	150_G	0.697	0.42
4_A	111_I	0.694	0.41
88_A	100_A	0.693	0.41
58_P	213_V	0.692	0.41
118_G	122_A	0.692	0.41
4_A	50_V	0.690	0.41
29_I	250_G	0.690	0.41
105_A	113_P	0.689	0.41
44_A	215_A	0.685	0.41
95_S	150_G	0.684	0.41
76_F	187_A	0.684	0.41
71_R	131_G	0.683	0.40
257_A	263_R	0.680	0.40
34_V	207_D	0.678	0.40
10_A	105_A	0.678	0.40
4_A	18_V	0.675	0.40
28_G	249_P	0.672	0.40
187_A	217_A	0.668	0.39
257_A	260_L	0.668	0.39
29_I	127_T	0.668	0.39
187_A	202_T	0.667	0.39
85_S	105_A	0.667	0.39
43_A	190_G	0.666	0.39
262_K	270_R	0.665	0.39
251_Q	258_Q	0.665	0.39
70_E	114_A	0.665	0.39
26_A	30_R	0.665	0.39
210_I	264_I	0.661	0.39
43_A	115_A	0.660	0.38
81_V	140_V	0.658	0.38
67_E	105_A	0.658	0.38
11_M	85_S	0.657	0.38
93_L	181_A	0.656	0.38
111_I	115_A	0.655	0.38
49_L	258_Q	0.651	0.38
11_M	88_A	0.650	0.38
47_A	94_M	0.648	0.37
14_S	128_L	0.648	0.37
215_A	244_T	0.646	0.37
207_D	212_D	0.645	0.37
85_S	128_L	0.645	0.37
245_L	264_I	0.642	0.37
2_V	119_I	0.639	0.37
83_L	147_A	0.639	0.37
124_G	178_L	0.638	0.37
180_V	237_Q	0.637	0.37
185_L	188_F	0.636	0.36
127_T	218_A	0.634	0.36
108_V	133_A	0.633	0.36
28_G	207_D	0.631	0.36
271_E	274_V	0.630	0.36
11_M	104_V	0.629	0.36
49_L	213_V	0.627	0.36
146_A	210_I	0.626	0.36
254_P	264_I	0.626	0.36
204_Q	270_R	0.623	0.35
78_S	138_V	0.622	0.35
8_G	104_V	0.621	0.35
165_G	245_L	0.619	0.35
30_R	204_Q	0.616	0.35
16_G	28_G	0.615	0.35
91_Y	171_L	0.614	0.35
170_A	173_K	0.612	0.34
250_G	266_T	0.610	0.34
267_D	270_R	0.608	0.34
46_F	134_V	0.607	0.34
250_G	256_L	0.606	0.34
38_L	42_G	0.605	0.34
254_P	261_A	0.605	0.34
31_L	84_G	0.601	0.34
216_Q	266_T	0.600	0.34
32_Q	43_A	0.597	0.33
111_I	145_L	0.595	0.33
35_G	141_L	0.595	0.33
3_I	8_G	0.594	0.33
236_R	249_P	0.594	0.33
11_M	151_L	0.592	0.33
48_F	180_V	0.592	0.33
42_G	253_Y	0.589	0.33
4_A	100_A	0.585	0.32
137_A	221_S	0.584	0.32
234_V	260_L	0.583	0.32
172_V	176_V	0.581	0.32
76_F	186_S	0.581	0.32
107_A	150_G	0.581	0.32
78_S	113_P	0.577	0.32
33_V	48_F	0.576	0.32
91_Y	134_V	0.575	0.32
18_V	68_V	0.575	0.32
126_P	260_L	0.573	0.31
77_L	95_S	0.573	0.31
222_V	255_A	0.566	0.31
58_P	274_V	0.565	0.31
30_R	73_R	0.564	0.31
115_A	185_L	0.563	0.31
64_S	132_S	0.560	0.30
188_F	194_L	0.558	0.30
94_M	156_Y	0.557	0.30
91_Y	264_I	0.557	0.30
248_P	256_L	0.557	0.30
78_S	136_V	0.553	0.30
25_F	190_G	0.552	0.30
262_K	274_V	0.550	0.30
79_L	180_V	0.550	0.30
63_L	128_L	0.547	0.29
75_D	81_V	0.546	0.29
96_G	100_A	0.545	0.29
27_R	31_L	0.545	0.29
230_D	233_L	0.545	0.29
270_R	274_V	0.545	0.29
239_H	245_L	0.544	0.29
83_L	251_Q	0.543	0.29
244_T	249_P	0.540	0.29
183_A	186_S	0.539	0.29
72_L	190_G	0.538	0.29
28_G	148_L	0.536	0.29
18_V	111_I	0.536	0.29
24_L	86_G	0.535	0.29
80_V	237_Q	0.535	0.29
41_V	222_V	0.535	0.29
253_Y	257_A	0.534	0.28
43_A	246_G	0.533	0.28
138_V	188_F	0.532	0.28
37_A	269_G	0.531	0.28
113_P	139_N	0.529	0.28
201_D	205_A	0.527	0.28
47_A	85_S	0.526	0.28
10_A	104_V	0.526	0.28
227_F	244_T	0.525	0.28
33_V	37_A	0.520	0.27
92_S	156_Y	0.520	0.27
209_A	213_V	0.517	0.27
123_W	132_S	0.516	0.27
72_L	106_I	0.516	0.27
265_E	268_T	0.516	0.27
38_L	50_V	0.511	0.27
228_Q	245_L	0.511	0.27
19_V	148_L	0.510	0.27
180_V	235_S	0.509	0.27
47_A	185_L	0.509	0.27
5_P	120_G	0.509	0.27
145_L	155_G	0.507	0.27
151_L	189_L	0.505	0.26
3_I	47_A	0.503	0.26
113_P	136_V	0.503	0.26
4_A	140_V	0.503	0.26
69_R	149_V	0.502	0.26
199_A	272_L	0.502	0.26
17_T	177_T	0.501	0.26
185_L	189_L	0.500	0.26
16_G	39_A	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3j1zP	8	0.8625	76.8	0.945	Contact Map
3h90A	3	0.8729	54.9	0.953	Contact Map
3ux2A	2	0.3162	41.5	0.956	Contact Map
3lnoA	1	0.3299	31.5	0.959	Contact Map
3j7aD	1	0.1959	21	0.962	Contact Map
2dyjA	1	0.3127	20.6	0.963	Contact Map
3zeyX	1	0.3196	18.1	0.963	Contact Map
3cq1A	2	0.3162	18.1	0.964	Contact Map
1wh9A	1	0.2921	16.2	0.964	Contact Map
3j20C	1	0.3162	15.3	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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