GREMLIN Database
Q9HMD8 - Uncharacterized protein
UniProt: Q9HMD8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (263)
Sequences: 777 (621)
Seq/√Len: 38.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_G25_F9.7881.00
36_V136_V9.0411.00
117_V129_A4.9221.00
47_A119_I3.5841.00
4_A119_I3.1371.00
90_V151_L2.7211.00
44_A121_I2.6821.00
7_L105_A2.6451.00
117_V133_A2.5291.00
202_T206_V2.5091.00
18_V151_L2.3691.00
40_V117_V2.3691.00
99_S102_V2.3681.00
77_L98_S2.3151.00
37_A184_V2.1720.99
167_A170_A2.1330.99
256_L261_A2.0910.99
71_R106_I2.0820.99
199_A203_E2.0370.99
16_G87_V2.0340.99
120_G128_L1.8760.98
238_P247_I1.8330.98
82_A139_N1.8320.98
6_L113_P1.8170.98
85_S108_V1.8100.97
89_G102_V1.7310.97
140_V151_L1.7160.97
80_V84_G1.6960.96
89_G104_V1.6940.96
10_A120_G1.6450.96
95_S222_V1.6210.95
40_V43_A1.6170.95
45_A245_L1.6120.95
78_S114_A1.6100.95
71_R135_L1.5860.95
11_M101_L1.5750.94
67_E139_N1.5630.94
4_A84_G1.5490.94
88_A104_V1.5490.94
30_R34_V1.5450.94
10_A78_S1.5380.94
82_A105_A1.5360.94
13_A32_Q1.5040.93
9_P113_P1.5030.93
14_S84_G1.4890.92
46_F75_D1.4540.92
4_A14_S1.4540.92
68_V116_T1.4530.92
2_V65_L1.4510.91
9_P35_G1.4420.91
27_R48_F1.4370.91
6_L106_I1.4360.91
4_A108_V1.4320.91
256_L259_S1.4290.91
81_V131_G1.4190.91
216_Q219_H1.4130.90
35_G77_L1.4130.90
183_A187_A1.4120.90
65_L68_V1.4110.90
3_I111_I1.4100.90
134_V185_L1.4030.90
35_G43_A1.3950.90
106_I110_L1.3820.89
108_V143_I1.3820.89
94_M154_S1.3670.89
99_S150_G1.3360.88
111_I114_A1.3330.88
6_L111_I1.3310.87
50_V129_A1.3300.87
71_R74_P1.3270.87
45_A251_Q1.3230.87
258_Q262_K1.3200.87
221_S225_V1.3200.87
74_P109_A1.3190.87
69_R72_L1.3090.87
4_A142_S1.2920.86
257_A261_A1.2900.86
25_F28_G1.2850.86
243_V247_I1.2820.85
145_L221_S1.2800.85
203_E207_D1.2760.85
89_G93_L1.2720.85
261_A274_V1.2700.85
105_A139_N1.2570.84
94_M101_L1.2540.84
8_G120_G1.2470.84
28_G183_A1.2430.84
149_V184_V1.2360.83
32_Q144_N1.2340.83
94_M146_A1.2240.83
258_Q266_T1.2180.82
57_P85_S1.2130.82
74_P131_G1.2120.82
117_V171_L1.2080.82
27_R155_G1.2070.82
99_S116_T1.2040.82
82_A113_P1.2040.82
236_R241_V1.2030.81
194_L198_E1.2010.81
97_V147_A1.1860.81
245_L249_P1.1850.80
46_F50_V1.1840.80
32_Q140_V1.1730.80
229_Y232_G1.1630.79
168_H172_V1.1600.79
144_N151_L1.1560.79
255_A259_S1.1450.78
6_L71_R1.1410.78
121_I124_G1.1270.77
50_V108_V1.1210.77
74_P139_N1.1190.76
9_P92_S1.1050.76
79_L142_S1.1000.75
37_A180_V1.0900.75
134_V138_V1.0780.74
3_I69_R1.0760.74
114_A133_A1.0670.73
37_A41_V1.0670.73
2_V143_I1.0510.72
111_I119_I1.0500.72
37_A270_R1.0490.72
38_L83_L1.0430.71
77_L92_S1.0280.70
14_S119_I1.0190.69
7_L143_I1.0140.69
95_S98_S1.0090.69
265_E272_L1.0030.68
71_R110_L0.9950.68
79_L138_V0.9940.67
7_L113_P0.9910.67
89_G107_A0.9780.66
249_P252_Q0.9700.66
49_L244_T0.9570.64
67_E82_A0.9530.64
108_V119_I0.9490.64
74_P82_A0.9480.64
45_A273_A0.9480.64
254_P257_A0.9400.63
10_A114_A0.9310.62
4_A47_A0.9300.62
169_A266_T0.9290.62
2_V152_W0.9260.62
173_K176_V0.9210.61
2_V108_V0.9200.61
83_L146_A0.9150.61
33_V180_V0.9150.61
189_L196_S0.9130.61
100_A178_L0.9100.61
74_P105_A0.9090.60
28_G45_A0.9060.60
261_A265_E0.9020.60
49_L241_V0.8940.59
50_V144_N0.8930.59
85_S142_S0.8900.59
233_L236_R0.8890.59
236_R247_I0.8850.58
31_L35_G0.8810.58
196_S200_A0.8750.58
3_I119_I0.8750.58
12_S186_S0.8680.57
15_V19_V0.8660.57
7_L82_A0.8640.57
67_E113_P0.8630.56
59_G119_I0.8600.56
11_M216_Q0.8590.56
229_Y245_L0.8580.56
177_T262_K0.8560.56
3_I117_V0.8560.56
36_V67_E0.8550.56
11_M189_L0.8550.56
8_G88_A0.8540.56
10_A92_S0.8530.56
92_S96_G0.8470.55
108_V142_S0.8420.55
19_V31_L0.8390.54
263_R266_T0.8390.54
83_L230_D0.8350.54
14_S123_W0.8350.54
130_V208_R0.8320.54
45_A230_D0.8310.54
15_V157_R0.8310.54
2_V84_G0.8310.54
106_I135_L0.8280.53
2_V111_I0.8260.53
255_A258_Q0.8260.53
260_L273_A0.8250.53
268_T271_E0.8230.53
178_L218_A0.8210.53
43_A162_F0.8110.52
252_Q256_L0.8100.52
258_Q273_A0.8080.52
6_L9_P0.8050.51
195_A226_Q0.8030.51
40_V140_V0.8030.51
229_Y243_V0.8000.51
95_S190_G0.7960.50
202_T241_V0.7950.50
39_A111_I0.7950.50
12_S82_A0.7950.50
78_S105_A0.7920.50
33_V228_Q0.7890.50
88_A119_I0.7890.50
49_L184_V0.7870.50
95_S99_S0.7830.49
45_A181_A0.7810.49
255_A273_A0.7790.49
102_V142_S0.7770.49
7_L85_S0.7720.48
105_A108_V0.7700.48
2_V14_S0.7680.48
177_T201_D0.7640.48
8_G185_L0.7630.48
95_S214_T0.7630.48
39_A136_V0.7620.47
7_L119_I0.7600.47
17_T148_L0.7590.47
125_V212_D0.7580.47
204_Q226_Q0.7510.46
21_D264_I0.7510.46
37_A45_A0.7490.46
237_Q259_S0.7460.46
105_A111_I0.7340.45
233_L241_V0.7300.45
97_V101_L0.7300.45
168_H171_L0.7280.44
261_A267_D0.7260.44
206_V210_I0.7260.44
11_M90_V0.7230.44
116_T132_S0.7220.44
21_D222_V0.7210.44
47_A122_A0.7210.44
252_Q255_A0.7200.44
231_R251_Q0.7150.43
8_G86_G0.7130.43
7_L71_R0.7110.43
43_A95_S0.7080.43
39_A146_A0.7070.43
204_Q208_R0.7070.43
81_V109_A0.7060.42
87_V206_V0.7030.42
69_R143_I0.7010.42
71_R139_N0.7000.42
237_Q243_V0.6980.42
90_V150_G0.6970.42
4_A111_I0.6940.41
88_A100_A0.6930.41
58_P213_V0.6920.41
118_G122_A0.6920.41
4_A50_V0.6900.41
29_I250_G0.6900.41
105_A113_P0.6890.41
44_A215_A0.6850.41
95_S150_G0.6840.41
76_F187_A0.6840.41
71_R131_G0.6830.40
257_A263_R0.6800.40
34_V207_D0.6780.40
10_A105_A0.6780.40
4_A18_V0.6750.40
28_G249_P0.6720.40
187_A217_A0.6680.39
257_A260_L0.6680.39
29_I127_T0.6680.39
187_A202_T0.6670.39
85_S105_A0.6670.39
43_A190_G0.6660.39
262_K270_R0.6650.39
251_Q258_Q0.6650.39
70_E114_A0.6650.39
26_A30_R0.6650.39
210_I264_I0.6610.39
43_A115_A0.6600.38
81_V140_V0.6580.38
67_E105_A0.6580.38
11_M85_S0.6570.38
93_L181_A0.6560.38
111_I115_A0.6550.38
49_L258_Q0.6510.38
11_M88_A0.6500.38
47_A94_M0.6480.37
14_S128_L0.6480.37
215_A244_T0.6460.37
207_D212_D0.6450.37
85_S128_L0.6450.37
245_L264_I0.6420.37
2_V119_I0.6390.37
83_L147_A0.6390.37
124_G178_L0.6380.37
180_V237_Q0.6370.37
185_L188_F0.6360.36
127_T218_A0.6340.36
108_V133_A0.6330.36
28_G207_D0.6310.36
271_E274_V0.6300.36
11_M104_V0.6290.36
49_L213_V0.6270.36
146_A210_I0.6260.36
254_P264_I0.6260.36
204_Q270_R0.6230.35
78_S138_V0.6220.35
8_G104_V0.6210.35
165_G245_L0.6190.35
30_R204_Q0.6160.35
16_G28_G0.6150.35
91_Y171_L0.6140.35
170_A173_K0.6120.34
250_G266_T0.6100.34
267_D270_R0.6080.34
46_F134_V0.6070.34
250_G256_L0.6060.34
38_L42_G0.6050.34
254_P261_A0.6050.34
31_L84_G0.6010.34
216_Q266_T0.6000.34
32_Q43_A0.5970.33
111_I145_L0.5950.33
35_G141_L0.5950.33
3_I8_G0.5940.33
236_R249_P0.5940.33
11_M151_L0.5920.33
48_F180_V0.5920.33
42_G253_Y0.5890.33
4_A100_A0.5850.32
137_A221_S0.5840.32
234_V260_L0.5830.32
172_V176_V0.5810.32
76_F186_S0.5810.32
107_A150_G0.5810.32
78_S113_P0.5770.32
33_V48_F0.5760.32
91_Y134_V0.5750.32
18_V68_V0.5750.32
126_P260_L0.5730.31
77_L95_S0.5730.31
222_V255_A0.5660.31
58_P274_V0.5650.31
30_R73_R0.5640.31
115_A185_L0.5630.31
64_S132_S0.5600.30
188_F194_L0.5580.30
94_M156_Y0.5570.30
91_Y264_I0.5570.30
248_P256_L0.5570.30
78_S136_V0.5530.30
25_F190_G0.5520.30
262_K274_V0.5500.30
79_L180_V0.5500.30
63_L128_L0.5470.29
75_D81_V0.5460.29
96_G100_A0.5450.29
27_R31_L0.5450.29
230_D233_L0.5450.29
270_R274_V0.5450.29
239_H245_L0.5440.29
83_L251_Q0.5430.29
244_T249_P0.5400.29
183_A186_S0.5390.29
72_L190_G0.5380.29
28_G148_L0.5360.29
18_V111_I0.5360.29
24_L86_G0.5350.29
80_V237_Q0.5350.29
41_V222_V0.5350.29
253_Y257_A0.5340.28
43_A246_G0.5330.28
138_V188_F0.5320.28
37_A269_G0.5310.28
113_P139_N0.5290.28
201_D205_A0.5270.28
47_A85_S0.5260.28
10_A104_V0.5260.28
227_F244_T0.5250.28
33_V37_A0.5200.27
92_S156_Y0.5200.27
209_A213_V0.5170.27
123_W132_S0.5160.27
72_L106_I0.5160.27
265_E268_T0.5160.27
38_L50_V0.5110.27
228_Q245_L0.5110.27
19_V148_L0.5100.27
180_V235_S0.5090.27
47_A185_L0.5090.27
5_P120_G0.5090.27
145_L155_G0.5070.27
151_L189_L0.5050.26
3_I47_A0.5030.26
113_P136_V0.5030.26
4_A140_V0.5030.26
69_R149_V0.5020.26
199_A272_L0.5020.26
17_T177_T0.5010.26
185_L189_L0.5000.26
16_G39_A0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.8625 76.8 0.945 Contact Map
3h90A 3 0.8729 54.9 0.953 Contact Map
3ux2A 2 0.3162 41.5 0.956 Contact Map
3lnoA 1 0.3299 31.5 0.959 Contact Map
3j7aD 1 0.1959 21 0.962 Contact Map
2dyjA 1 0.3127 20.6 0.963 Contact Map
3zeyX 1 0.3196 18.1 0.963 Contact Map
3cq1A 2 0.3162 18.1 0.964 Contact Map
1wh9A 1 0.2921 16.2 0.964 Contact Map
3j20C 1 0.3162 15.3 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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