GREMLIN Database
Q9HMD6 - GTP-binding protein homolog
UniProt: Q9HMD6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (282)
Sequences: 5102 (3227)
Seq/√Len: 192.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_R271_G3.8931.00
167_V243_G3.6241.00
247_L282_V3.6241.00
208_D314_V3.5561.00
30_K61_F3.5561.00
204_H211_T3.5091.00
312_A315_D3.3461.00
250_V281_T3.3151.00
97_S140_E3.1211.00
182_A306_V3.1091.00
182_A303_G3.0631.00
37_Q64_V3.0471.00
202_I213_Q2.7761.00
49_D223_R2.5931.00
305_G308_E2.4651.00
166_V212_W2.4511.00
202_I215_V2.4491.00
283_C297_Y2.4121.00
312_A316_A2.3391.00
282_V309_T2.3221.00
264_Q268_A2.3171.00
178_S300_V2.3061.00
34_E38_S2.2581.00
280_V312_A2.1661.00
267_R270_V2.1161.00
37_Q45_N2.0991.00
302_G305_G2.0471.00
30_K58_W1.9941.00
189_E193_Y1.8841.00
206_E211_T1.8721.00
168_V180_V1.8711.00
31_Q35_A1.8401.00
284_S300_V1.8221.00
45_N62_D1.8181.00
286_T297_Y1.8091.00
36_Q40_L1.7981.00
282_V296_C1.7981.00
252_A283_C1.7801.00
245_V313_A1.7571.00
183_V310_L1.6701.00
177_S188_I1.6531.00
181_N190_T1.6501.00
311_T315_D1.6441.00
127_Q131_R1.6391.00
92_H135_V1.6381.00
265_A269_E1.6361.00
266_L270_V1.6161.00
58_W62_D1.6101.00
107_G111_I1.5981.00
189_E196_T1.5921.00
259_P262_D1.5791.00
261_A265_A1.5781.00
233_D236_V1.5321.00
205_F214_L1.5081.00
179_F309_T1.5071.00
264_Q281_T1.5011.00
138_Q142_D1.4861.00
144_E147_G1.4731.00
149_A152_A1.4621.00
69_G73_D1.4531.00
35_A39_M1.4291.00
296_C312_A1.4251.00
280_V316_A1.4241.00
253_S288_L1.4081.00
75_I95_E1.4061.00
30_K34_E1.3871.00
226_D270_V1.3841.00
292_I295_D1.3731.00
57_E60_D1.3561.00
245_V280_V1.3441.00
32_G36_Q1.3421.00
89_L139_V1.3341.00
280_V313_A1.3321.00
269_E272_D1.3221.00
116_N120_K1.3211.00
34_E37_Q1.3121.00
272_D275_G1.3051.00
265_A268_A1.2991.00
31_Q34_E1.2731.00
249_F284_S1.2721.00
45_N64_V1.2691.00
267_R273_R1.2621.00
267_R274_F1.2621.00
230_E233_D1.2571.00
95_E99_A1.2401.00
269_E273_R1.2361.00
92_H96_L1.2361.00
147_G236_V1.2341.00
263_Q267_R1.2291.00
137_D141_D1.2211.00
262_D265_A1.2161.00
35_A38_S1.2031.00
259_P263_Q1.2011.00
210_I318_G1.2001.00
254_A263_Q1.2001.00
268_A271_G1.1941.00
205_F212_W1.1901.00
178_S298_M1.1621.00
118_A125_R1.1501.00
260_V264_Q1.1471.00
165_T213_Q1.1431.00
34_E61_F1.1401.00
36_Q42_T1.1371.00
270_V274_F1.1371.00
247_L309_T1.1331.00
119_E126_K1.1251.00
247_L313_A1.1171.00
30_K62_D1.1141.00
262_D266_L1.1131.00
271_G274_F1.1121.00
254_A260_V1.1051.00
37_Q62_D1.1041.00
184_T205_F1.1031.00
250_V264_Q1.0961.00
113_R117_D1.0951.00
226_D232_E1.0911.00
188_I201_D1.0901.00
263_Q266_L1.0851.00
207_R212_W1.0821.00
33_V36_Q1.0731.00
107_G110_Y1.0711.00
290_A295_D1.0601.00
172_P194_P1.0591.00
252_A260_V1.0421.00
56_T60_D1.0391.00
31_Q61_F1.0361.00
56_T59_P1.0351.00
111_I114_L1.0311.00
303_G306_V1.0311.00
114_L117_D1.0241.00
308_E311_T1.0231.00
152_A155_T1.0221.00
252_A289_S1.0221.00
250_V283_C1.0201.00
173_N192_E1.0181.00
136_M140_E1.0151.00
164_P317_V1.0131.00
169_A246_I1.0111.00
149_A153_L1.0111.00
291_E294_A1.0101.00
282_V298_M1.0071.00
249_F298_M1.0061.00
85_G142_D1.0011.00
166_V245_V1.0001.00
286_T304_E0.9860.99
290_A293_E0.9850.99
126_K130_G0.9820.99
37_Q42_T0.9760.99
177_S190_T0.9670.99
182_A301_E0.9650.99
44_S65_D0.9620.99
268_A279_L0.9620.99
251_D285_K0.9530.99
248_F254_A0.9480.99
309_T313_A0.9470.99
183_V306_V0.9430.99
268_A281_T0.9380.99
246_I279_L0.9360.99
245_V316_A0.9340.99
60_D64_V0.9320.99
97_S230_E0.9310.99
134_S137_D0.9300.99
118_A121_A0.9240.99
261_A264_Q0.9160.99
107_G114_L0.9120.99
144_E148_A0.9110.99
66_P69_G0.9070.99
106_L109_E0.9070.99
248_F279_L0.9060.99
147_G237_S0.9060.99
193_Y196_T0.9020.99
207_R210_I0.8970.99
167_V246_I0.8950.99
33_V37_Q0.8860.99
184_T212_W0.8830.99
179_F249_F0.8800.99
266_L271_G0.8730.99
263_Q271_G0.8730.99
182_A300_V0.8720.99
32_G37_Q0.8720.99
32_G42_T0.8710.99
178_S302_G0.8700.99
65_D69_G0.8680.99
107_G124_L0.8670.99
166_V247_L0.8670.99
210_I314_V0.8660.99
266_L269_E0.8630.99
147_G240_T0.8630.99
36_Q39_M0.8620.99
70_E73_D0.8600.99
118_A122_R0.8530.98
248_F264_Q0.8510.98
134_S138_Q0.8460.98
66_P70_E0.8440.98
298_M306_V0.8430.98
260_V263_Q0.8430.98
122_R125_R0.8430.98
250_V260_V0.8410.98
179_F183_V0.8390.98
248_F281_T0.8380.98
119_E123_S0.8360.98
234_Q238_A0.8340.98
226_D230_E0.8340.98
112_G115_P0.8320.98
105_D108_R0.8310.98
291_E295_D0.8300.98
298_M301_E0.8290.98
122_R126_K0.8290.98
48_G51_L0.8280.98
30_K37_Q0.8270.98
180_V214_L0.8220.98
37_Q40_L0.8190.98
143_L146_V0.8180.98
270_V273_R0.8180.98
260_V283_C0.8170.98
105_D109_E0.8140.98
125_R128_G0.8100.98
84_D88_E0.8060.98
141_D144_E0.8040.98
109_E124_L0.8030.98
104_H107_G0.8030.98
54_V57_E0.8010.98
298_M302_G0.8010.98
294_A297_Y0.8000.98
59_P65_D0.7990.98
306_V310_L0.7990.98
207_R211_T0.7970.98
84_D87_D0.7930.98
113_R123_S0.7930.98
223_R232_E0.7910.97
177_S214_L0.7910.97
110_Y113_R0.7880.97
307_T311_T0.7800.97
62_D65_D0.7770.97
75_I79_E0.7720.97
67_F71_L0.7690.97
298_M309_T0.7670.97
48_G223_R0.7620.97
254_A259_P0.7610.97
268_A272_D0.7580.97
89_L93_L0.7580.97
267_R272_D0.7560.97
46_I72_A0.7530.97
145_A148_A0.7500.97
120_K124_L0.7480.96
289_S294_A0.7470.96
95_E114_L0.7440.96
131_R134_S0.7440.96
31_Q40_L0.7440.96
100_S103_T0.7410.96
192_E288_L0.7370.96
224_P240_T0.7340.96
31_Q37_Q0.7330.96
87_D90_R0.7300.96
55_V71_L0.7290.96
57_E61_F0.7290.96
90_R94_S0.7280.96
174_V254_A0.7280.96
212_W313_A0.7260.96
148_A152_A0.7260.96
85_G88_E0.7250.96
132_M136_M0.7230.96
120_K126_K0.7220.96
119_E122_R0.7220.96
238_A241_H0.7170.96
191_A196_T0.7130.95
192_E226_D0.7100.95
43_A47_L0.7090.95
308_E312_A0.7090.95
31_Q39_M0.7040.95
264_Q267_R0.7030.95
93_L136_M0.7010.95
87_D91_Q0.6960.95
100_S133_G0.6940.95
53_N56_T0.6910.95
117_D120_K0.6890.94
304_E308_E0.6870.94
299_S305_G0.6860.94
150_R240_T0.6850.94
108_R112_G0.6830.94
60_D63_H0.6790.94
61_F64_V0.6780.94
35_A40_L0.6760.94
288_L291_E0.6750.94
236_V273_R0.6720.94
47_L51_L0.6700.94
81_A189_E0.6690.94
73_D76_L0.6640.93
111_I115_P0.6630.93
122_R130_G0.6620.93
235_A238_A0.6610.93
85_G89_L0.6590.93
86_I150_R0.6580.93
181_N184_T0.6570.93
301_E304_E0.6570.93
140_E233_D0.6470.92
292_I297_Y0.6450.92
38_S41_Q0.6420.92
147_G151_D0.6390.92
180_V184_T0.6380.92
122_R128_G0.6380.92
69_G76_L0.6370.92
53_N57_E0.6350.92
37_Q41_Q0.6350.92
210_I317_V0.6350.92
179_F298_M0.6330.92
65_D95_E0.6330.92
68_Y73_D0.6330.92
103_T113_R0.6320.92
126_K129_F0.6290.91
231_I234_Q0.6280.91
34_E40_L0.6250.91
180_V188_I0.6210.91
32_G35_A0.6200.91
119_E124_L0.6180.91
82_S121_A0.6170.91
42_T45_N0.6170.91
265_A304_E0.6170.91
166_V313_A0.6170.91
129_F132_M0.6150.90
91_Q95_E0.6120.90
178_S301_E0.6100.90
289_S293_E0.6090.90
64_V68_Y0.6090.90
100_S104_H0.6080.90
225_A238_A0.6070.90
187_S191_A0.6060.90
187_S207_R0.6060.90
311_T314_V0.6050.90
116_N119_E0.6040.90
94_S98_W0.6020.89
76_L82_S0.6010.89
121_A126_K0.6000.89
116_N121_A0.5970.89
87_D120_K0.5960.89
131_R135_V0.5960.89
68_Y79_E0.5940.89
147_G233_D0.5930.89
259_P266_L0.5870.88
71_L106_L0.5870.88
105_D110_Y0.5860.88
166_V214_L0.5850.88
107_G112_G0.5810.88
189_E201_D0.5800.88
95_E120_K0.5790.88
168_V179_F0.5780.87
310_L314_V0.5780.87
297_Y308_E0.5770.87
94_S119_E0.5760.87
150_R154_K0.5750.87
168_V178_S0.5710.87
109_E114_L0.5700.87
182_A302_G0.5690.87
184_T201_D0.5670.86
103_T107_G0.5660.86
59_P63_H0.5650.86
146_V150_R0.5630.86
263_Q270_V0.5630.86
132_M138_Q0.5620.86
252_A286_T0.5610.86
50_N230_E0.5590.86
179_F300_V0.5590.86
167_V277_A0.5540.85
105_D114_L0.5530.85
46_I50_N0.5530.85
163_V213_Q0.5510.85
35_A41_Q0.5500.85
116_N127_Q0.5490.85
251_D254_A0.5480.85
307_T310_L0.5480.85
69_G75_I0.5440.84
91_Q94_S0.5430.84
174_V235_A0.5420.84
123_S126_K0.5420.84
120_K130_G0.5420.84
165_T202_I0.5420.84
67_F75_I0.5410.84
113_R124_L0.5410.84
181_N188_I0.5410.84
171_Y235_A0.5390.84
168_V221_L0.5380.83
54_V74_A0.5370.83
66_P73_D0.5350.83
58_W61_F0.5350.83
99_A106_L0.5350.83
139_V143_L0.5340.83
68_Y74_A0.5340.83
169_A251_D0.5330.83
56_T81_A0.5320.83
45_N49_D0.5320.83
262_D291_E0.5300.83
124_L128_G0.5300.83
199_S218_P0.5290.82
34_E62_D0.5290.82
294_A304_E0.5260.82
51_L66_P0.5260.82
299_S302_G0.5250.82
101_S105_D0.5240.82
250_V267_R0.5230.82
39_M43_A0.5230.82
46_I51_L0.5210.82
156_L160_Q0.5200.81
51_L68_Y0.5190.81
263_Q269_E0.5190.81
133_G140_E0.5180.81
55_V61_F0.5160.81
182_A298_M0.5150.81
123_S127_Q0.5130.81
178_S182_A0.5120.80
59_P66_P0.5110.80
41_Q145_A0.5090.80
153_L233_D0.5070.80
280_V296_C0.5070.80
72_A76_L0.5060.80
69_G92_H0.5060.80
34_E64_V0.5050.80
264_Q270_V0.5050.80
121_A125_R0.5050.80
118_A124_L0.5030.79
95_E117_D0.5020.79
165_T215_V0.5020.79
165_T242_V0.5010.79
115_P119_E0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j65o 1 0.9694 100 0.367 Contact Map
2e87A 1 0.9755 100 0.384 Contact Map
2qtfA 1 0.8287 100 0.449 Contact Map
3gehA 2 0.896 100 0.476 Contact Map
3geeA 2 0.844 100 0.48 Contact Map
1xzpA 4 0.9511 100 0.494 Contact Map
1mkyA 1 0.4434 100 0.533 Contact Map
3j8gX 1 0.4128 100 0.541 Contact Map
1egaA 2 0.4954 100 0.555 Contact Map
3j4jA 1 0.6697 100 0.558 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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