Q9HMD6 - HALSA - GREMLIN Contacts

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Q9HMD6 - GTP-binding protein homolog

UniProt:	Q9HMD6	Sequences: MIFESLPTTPTSEELIDQAFSRAARAGRAKQGVEAQQSMLQTASNILGDNLHNVVTEWPDFDHVDPFYGELADAILREEFASEDGIDELRQHLSELSWASSKTHDLGREYIGRLPNDAEKARSLRKQGFGRMGSVMDQVEDDLEAVGAARDALKTLPEIQPDVPTVVVAGYPNVGKSSFVNAVTNASIETAEYPFTTKSVDIGHFERDHITWQLVDTPGLLDRPADERNEIEDQAVSALTHVGDVILFFVDASAACGYPVADQQALRAEVGDRFGDAPLVTVCSKTDLSAEIEADCYMSVEGGEGVTETLTAAVDAVGHEPELPFEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	327 (282)
Sequences:	5102 (3227)
Seq/√Len:	192.2

ECOLI - HFLX MNME DER YKFA YFJP ERA
BACSU - HFLX MNME DER
HALSA - Q9HMD6 Q9HMC2 Q9HQ88
SULSO - Q7LXR6 HFLX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
267_R	271_G	3.893	1.00
167_V	243_G	3.624	1.00
247_L	282_V	3.624	1.00
208_D	314_V	3.556	1.00
30_K	61_F	3.556	1.00
204_H	211_T	3.509	1.00
312_A	315_D	3.346	1.00
250_V	281_T	3.315	1.00
97_S	140_E	3.121	1.00
182_A	306_V	3.109	1.00
182_A	303_G	3.063	1.00
37_Q	64_V	3.047	1.00
202_I	213_Q	2.776	1.00
49_D	223_R	2.593	1.00
305_G	308_E	2.465	1.00
166_V	212_W	2.451	1.00
202_I	215_V	2.449	1.00
283_C	297_Y	2.412	1.00
312_A	316_A	2.339	1.00
282_V	309_T	2.322	1.00
264_Q	268_A	2.317	1.00
178_S	300_V	2.306	1.00
34_E	38_S	2.258	1.00
280_V	312_A	2.166	1.00
267_R	270_V	2.116	1.00
37_Q	45_N	2.099	1.00
302_G	305_G	2.047	1.00
30_K	58_W	1.994	1.00
189_E	193_Y	1.884	1.00
206_E	211_T	1.872	1.00
168_V	180_V	1.871	1.00
31_Q	35_A	1.840	1.00
284_S	300_V	1.822	1.00
45_N	62_D	1.818	1.00
286_T	297_Y	1.809	1.00
36_Q	40_L	1.798	1.00
282_V	296_C	1.798	1.00
252_A	283_C	1.780	1.00
245_V	313_A	1.757	1.00
183_V	310_L	1.670	1.00
177_S	188_I	1.653	1.00
181_N	190_T	1.650	1.00
311_T	315_D	1.644	1.00
127_Q	131_R	1.639	1.00
92_H	135_V	1.638	1.00
265_A	269_E	1.636	1.00
266_L	270_V	1.616	1.00
58_W	62_D	1.610	1.00
107_G	111_I	1.598	1.00
189_E	196_T	1.592	1.00
259_P	262_D	1.579	1.00
261_A	265_A	1.578	1.00
233_D	236_V	1.532	1.00
205_F	214_L	1.508	1.00
179_F	309_T	1.507	1.00
264_Q	281_T	1.501	1.00
138_Q	142_D	1.486	1.00
144_E	147_G	1.473	1.00
149_A	152_A	1.462	1.00
69_G	73_D	1.453	1.00
35_A	39_M	1.429	1.00
296_C	312_A	1.425	1.00
280_V	316_A	1.424	1.00
253_S	288_L	1.408	1.00
75_I	95_E	1.406	1.00
30_K	34_E	1.387	1.00
226_D	270_V	1.384	1.00
292_I	295_D	1.373	1.00
57_E	60_D	1.356	1.00
245_V	280_V	1.344	1.00
32_G	36_Q	1.342	1.00
89_L	139_V	1.334	1.00
280_V	313_A	1.332	1.00
269_E	272_D	1.322	1.00
116_N	120_K	1.321	1.00
34_E	37_Q	1.312	1.00
272_D	275_G	1.305	1.00
265_A	268_A	1.299	1.00
31_Q	34_E	1.273	1.00
249_F	284_S	1.272	1.00
45_N	64_V	1.269	1.00
267_R	273_R	1.262	1.00
267_R	274_F	1.262	1.00
230_E	233_D	1.257	1.00
95_E	99_A	1.240	1.00
269_E	273_R	1.236	1.00
92_H	96_L	1.236	1.00
147_G	236_V	1.234	1.00
263_Q	267_R	1.229	1.00
137_D	141_D	1.221	1.00
262_D	265_A	1.216	1.00
35_A	38_S	1.203	1.00
259_P	263_Q	1.201	1.00
210_I	318_G	1.200	1.00
254_A	263_Q	1.200	1.00
268_A	271_G	1.194	1.00
205_F	212_W	1.190	1.00
178_S	298_M	1.162	1.00
118_A	125_R	1.150	1.00
260_V	264_Q	1.147	1.00
165_T	213_Q	1.143	1.00
34_E	61_F	1.140	1.00
36_Q	42_T	1.137	1.00
270_V	274_F	1.137	1.00
247_L	309_T	1.133	1.00
119_E	126_K	1.125	1.00
247_L	313_A	1.117	1.00
30_K	62_D	1.114	1.00
262_D	266_L	1.113	1.00
271_G	274_F	1.112	1.00
254_A	260_V	1.105	1.00
37_Q	62_D	1.104	1.00
184_T	205_F	1.103	1.00
250_V	264_Q	1.096	1.00
113_R	117_D	1.095	1.00
226_D	232_E	1.091	1.00
188_I	201_D	1.090	1.00
263_Q	266_L	1.085	1.00
207_R	212_W	1.082	1.00
33_V	36_Q	1.073	1.00
107_G	110_Y	1.071	1.00
290_A	295_D	1.060	1.00
172_P	194_P	1.059	1.00
252_A	260_V	1.042	1.00
56_T	60_D	1.039	1.00
31_Q	61_F	1.036	1.00
56_T	59_P	1.035	1.00
111_I	114_L	1.031	1.00
303_G	306_V	1.031	1.00
114_L	117_D	1.024	1.00
308_E	311_T	1.023	1.00
152_A	155_T	1.022	1.00
252_A	289_S	1.022	1.00
250_V	283_C	1.020	1.00
173_N	192_E	1.018	1.00
136_M	140_E	1.015	1.00
164_P	317_V	1.013	1.00
169_A	246_I	1.011	1.00
149_A	153_L	1.011	1.00
291_E	294_A	1.010	1.00
282_V	298_M	1.007	1.00
249_F	298_M	1.006	1.00
85_G	142_D	1.001	1.00
166_V	245_V	1.000	1.00
286_T	304_E	0.986	0.99
290_A	293_E	0.985	0.99
126_K	130_G	0.982	0.99
37_Q	42_T	0.976	0.99
177_S	190_T	0.967	0.99
182_A	301_E	0.965	0.99
44_S	65_D	0.962	0.99
268_A	279_L	0.962	0.99
251_D	285_K	0.953	0.99
248_F	254_A	0.948	0.99
309_T	313_A	0.947	0.99
183_V	306_V	0.943	0.99
268_A	281_T	0.938	0.99
246_I	279_L	0.936	0.99
245_V	316_A	0.934	0.99
60_D	64_V	0.932	0.99
97_S	230_E	0.931	0.99
134_S	137_D	0.930	0.99
118_A	121_A	0.924	0.99
261_A	264_Q	0.916	0.99
107_G	114_L	0.912	0.99
144_E	148_A	0.911	0.99
66_P	69_G	0.907	0.99
106_L	109_E	0.907	0.99
248_F	279_L	0.906	0.99
147_G	237_S	0.906	0.99
193_Y	196_T	0.902	0.99
207_R	210_I	0.897	0.99
167_V	246_I	0.895	0.99
33_V	37_Q	0.886	0.99
184_T	212_W	0.883	0.99
179_F	249_F	0.880	0.99
266_L	271_G	0.873	0.99
263_Q	271_G	0.873	0.99
182_A	300_V	0.872	0.99
32_G	37_Q	0.872	0.99
32_G	42_T	0.871	0.99
178_S	302_G	0.870	0.99
65_D	69_G	0.868	0.99
107_G	124_L	0.867	0.99
166_V	247_L	0.867	0.99
210_I	314_V	0.866	0.99
266_L	269_E	0.863	0.99
147_G	240_T	0.863	0.99
36_Q	39_M	0.862	0.99
70_E	73_D	0.860	0.99
118_A	122_R	0.853	0.98
248_F	264_Q	0.851	0.98
134_S	138_Q	0.846	0.98
66_P	70_E	0.844	0.98
298_M	306_V	0.843	0.98
260_V	263_Q	0.843	0.98
122_R	125_R	0.843	0.98
250_V	260_V	0.841	0.98
179_F	183_V	0.839	0.98
248_F	281_T	0.838	0.98
119_E	123_S	0.836	0.98
234_Q	238_A	0.834	0.98
226_D	230_E	0.834	0.98
112_G	115_P	0.832	0.98
105_D	108_R	0.831	0.98
291_E	295_D	0.830	0.98
298_M	301_E	0.829	0.98
122_R	126_K	0.829	0.98
48_G	51_L	0.828	0.98
30_K	37_Q	0.827	0.98
180_V	214_L	0.822	0.98
37_Q	40_L	0.819	0.98
143_L	146_V	0.818	0.98
270_V	273_R	0.818	0.98
260_V	283_C	0.817	0.98
105_D	109_E	0.814	0.98
125_R	128_G	0.810	0.98
84_D	88_E	0.806	0.98
141_D	144_E	0.804	0.98
109_E	124_L	0.803	0.98
104_H	107_G	0.803	0.98
54_V	57_E	0.801	0.98
298_M	302_G	0.801	0.98
294_A	297_Y	0.800	0.98
59_P	65_D	0.799	0.98
306_V	310_L	0.799	0.98
207_R	211_T	0.797	0.98
84_D	87_D	0.793	0.98
113_R	123_S	0.793	0.98
223_R	232_E	0.791	0.97
177_S	214_L	0.791	0.97
110_Y	113_R	0.788	0.97
307_T	311_T	0.780	0.97
62_D	65_D	0.777	0.97
75_I	79_E	0.772	0.97
67_F	71_L	0.769	0.97
298_M	309_T	0.767	0.97
48_G	223_R	0.762	0.97
254_A	259_P	0.761	0.97
268_A	272_D	0.758	0.97
89_L	93_L	0.758	0.97
267_R	272_D	0.756	0.97
46_I	72_A	0.753	0.97
145_A	148_A	0.750	0.97
120_K	124_L	0.748	0.96
289_S	294_A	0.747	0.96
95_E	114_L	0.744	0.96
131_R	134_S	0.744	0.96
31_Q	40_L	0.744	0.96
100_S	103_T	0.741	0.96
192_E	288_L	0.737	0.96
224_P	240_T	0.734	0.96
31_Q	37_Q	0.733	0.96
87_D	90_R	0.730	0.96
55_V	71_L	0.729	0.96
57_E	61_F	0.729	0.96
90_R	94_S	0.728	0.96
174_V	254_A	0.728	0.96
212_W	313_A	0.726	0.96
148_A	152_A	0.726	0.96
85_G	88_E	0.725	0.96
132_M	136_M	0.723	0.96
120_K	126_K	0.722	0.96
119_E	122_R	0.722	0.96
238_A	241_H	0.717	0.96
191_A	196_T	0.713	0.95
192_E	226_D	0.710	0.95
43_A	47_L	0.709	0.95
308_E	312_A	0.709	0.95
31_Q	39_M	0.704	0.95
264_Q	267_R	0.703	0.95
93_L	136_M	0.701	0.95
87_D	91_Q	0.696	0.95
100_S	133_G	0.694	0.95
53_N	56_T	0.691	0.95
117_D	120_K	0.689	0.94
304_E	308_E	0.687	0.94
299_S	305_G	0.686	0.94
150_R	240_T	0.685	0.94
108_R	112_G	0.683	0.94
60_D	63_H	0.679	0.94
61_F	64_V	0.678	0.94
35_A	40_L	0.676	0.94
288_L	291_E	0.675	0.94
236_V	273_R	0.672	0.94
47_L	51_L	0.670	0.94
81_A	189_E	0.669	0.94
73_D	76_L	0.664	0.93
111_I	115_P	0.663	0.93
122_R	130_G	0.662	0.93
235_A	238_A	0.661	0.93
85_G	89_L	0.659	0.93
86_I	150_R	0.658	0.93
181_N	184_T	0.657	0.93
301_E	304_E	0.657	0.93
140_E	233_D	0.647	0.92
292_I	297_Y	0.645	0.92
38_S	41_Q	0.642	0.92
147_G	151_D	0.639	0.92
180_V	184_T	0.638	0.92
122_R	128_G	0.638	0.92
69_G	76_L	0.637	0.92
53_N	57_E	0.635	0.92
37_Q	41_Q	0.635	0.92
210_I	317_V	0.635	0.92
179_F	298_M	0.633	0.92
65_D	95_E	0.633	0.92
68_Y	73_D	0.633	0.92
103_T	113_R	0.632	0.92
126_K	129_F	0.629	0.91
231_I	234_Q	0.628	0.91
34_E	40_L	0.625	0.91
180_V	188_I	0.621	0.91
32_G	35_A	0.620	0.91
119_E	124_L	0.618	0.91
82_S	121_A	0.617	0.91
42_T	45_N	0.617	0.91
265_A	304_E	0.617	0.91
166_V	313_A	0.617	0.91
129_F	132_M	0.615	0.90
91_Q	95_E	0.612	0.90
178_S	301_E	0.610	0.90
289_S	293_E	0.609	0.90
64_V	68_Y	0.609	0.90
100_S	104_H	0.608	0.90
225_A	238_A	0.607	0.90
187_S	191_A	0.606	0.90
187_S	207_R	0.606	0.90
311_T	314_V	0.605	0.90
116_N	119_E	0.604	0.90
94_S	98_W	0.602	0.89
76_L	82_S	0.601	0.89
121_A	126_K	0.600	0.89
116_N	121_A	0.597	0.89
87_D	120_K	0.596	0.89
131_R	135_V	0.596	0.89
68_Y	79_E	0.594	0.89
147_G	233_D	0.593	0.89
259_P	266_L	0.587	0.88
71_L	106_L	0.587	0.88
105_D	110_Y	0.586	0.88
166_V	214_L	0.585	0.88
107_G	112_G	0.581	0.88
189_E	201_D	0.580	0.88
95_E	120_K	0.579	0.88
168_V	179_F	0.578	0.87
310_L	314_V	0.578	0.87
297_Y	308_E	0.577	0.87
94_S	119_E	0.576	0.87
150_R	154_K	0.575	0.87
168_V	178_S	0.571	0.87
109_E	114_L	0.570	0.87
182_A	302_G	0.569	0.87
184_T	201_D	0.567	0.86
103_T	107_G	0.566	0.86
59_P	63_H	0.565	0.86
146_V	150_R	0.563	0.86
263_Q	270_V	0.563	0.86
132_M	138_Q	0.562	0.86
252_A	286_T	0.561	0.86
50_N	230_E	0.559	0.86
179_F	300_V	0.559	0.86
167_V	277_A	0.554	0.85
105_D	114_L	0.553	0.85
46_I	50_N	0.553	0.85
163_V	213_Q	0.551	0.85
35_A	41_Q	0.550	0.85
116_N	127_Q	0.549	0.85
251_D	254_A	0.548	0.85
307_T	310_L	0.548	0.85
69_G	75_I	0.544	0.84
91_Q	94_S	0.543	0.84
174_V	235_A	0.542	0.84
123_S	126_K	0.542	0.84
120_K	130_G	0.542	0.84
165_T	202_I	0.542	0.84
67_F	75_I	0.541	0.84
113_R	124_L	0.541	0.84
181_N	188_I	0.541	0.84
171_Y	235_A	0.539	0.84
168_V	221_L	0.538	0.83
54_V	74_A	0.537	0.83
66_P	73_D	0.535	0.83
58_W	61_F	0.535	0.83
99_A	106_L	0.535	0.83
139_V	143_L	0.534	0.83
68_Y	74_A	0.534	0.83
169_A	251_D	0.533	0.83
56_T	81_A	0.532	0.83
45_N	49_D	0.532	0.83
262_D	291_E	0.530	0.83
124_L	128_G	0.530	0.83
199_S	218_P	0.529	0.82
34_E	62_D	0.529	0.82
294_A	304_E	0.526	0.82
51_L	66_P	0.526	0.82
299_S	302_G	0.525	0.82
101_S	105_D	0.524	0.82
250_V	267_R	0.523	0.82
39_M	43_A	0.523	0.82
46_I	51_L	0.521	0.82
156_L	160_Q	0.520	0.81
51_L	68_Y	0.519	0.81
263_Q	269_E	0.519	0.81
133_G	140_E	0.518	0.81
55_V	61_F	0.516	0.81
182_A	298_M	0.515	0.81
123_S	127_Q	0.513	0.81
178_S	182_A	0.512	0.80
59_P	66_P	0.511	0.80
41_Q	145_A	0.509	0.80
153_L	233_D	0.507	0.80
280_V	296_C	0.507	0.80
72_A	76_L	0.506	0.80
69_G	92_H	0.506	0.80
34_E	64_V	0.505	0.80
264_Q	270_V	0.505	0.80
121_A	125_R	0.505	0.80
118_A	124_L	0.503	0.79
95_E	117_D	0.502	0.79
165_T	215_V	0.502	0.79
165_T	242_V	0.501	0.79
115_P	119_E	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3j65o	1	0.9694	100	0.367	Contact Map
2e87A	1	0.9755	100	0.384	Contact Map
2qtfA	1	0.8287	100	0.449	Contact Map
3gehA	2	0.896	100	0.476	Contact Map
3geeA	2	0.844	100	0.48	Contact Map
1xzpA	4	0.9511	100	0.494	Contact Map
1mkyA	1	0.4434	100	0.533	Contact Map
3j8gX	1	0.4128	100	0.541	Contact Map
1egaA	2	0.4954	100	0.555	Contact Map
3j4jA	1	0.6697	100	0.558	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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