GREMLIN Database
HIS2 - Phosphoribosyl-ATP pyrophosphatase
UniProt: Q9HMD4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 95 (88)
Sequences: 2234 (1229)
Seq/√Len: 131.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_T71_Y2.7791.00
37_N56_D2.6191.00
90_E93_D2.5661.00
66_G77_L2.2931.00
14_D18_T2.2581.00
63_A90_E2.1091.00
48_T51_L2.0431.00
44_G48_T1.9661.00
37_N55_K1.8791.00
64_H90_E1.8411.00
66_G73_M1.8351.00
13_E78_A1.7991.00
20_P26_A1.7381.00
9_F78_A1.6841.00
16_K78_A1.6371.00
54_A76_V1.6111.00
59_T86_A1.6021.00
50_F69_V1.5441.00
70_V73_M1.5101.00
16_K29_L1.4811.00
19_M22_N1.4791.00
36_E79_Q1.3921.00
12_I29_L1.3841.00
39_A76_V1.3431.00
9_F84_V1.3351.00
12_I74_L1.3281.00
19_M26_A1.3251.00
9_F13_E1.2831.00
43_V69_V1.2721.00
66_G70_V1.2361.00
36_E80_Q1.2351.00
50_F66_G1.2121.00
83_D86_A1.2010.99
61_E64_H1.2000.99
58_D61_E1.1840.99
62_L82_M1.1840.99
28_L75_V1.1760.99
8_L91_L1.1520.99
34_K38_A1.1190.99
38_A41_E1.0980.99
62_L80_Q1.0980.99
53_A61_E1.0590.99
39_A79_Q1.0570.99
59_T80_Q1.0450.99
41_E48_T1.0300.98
59_T82_M1.0210.98
57_G80_Q1.0180.98
37_N41_E0.9990.98
82_M86_A0.9900.98
84_V88_L0.9560.97
63_A82_M0.9310.97
41_E51_L0.9240.97
6_R88_L0.9230.97
41_E52_L0.9080.96
19_M30_A0.9070.96
63_A93_D0.9050.96
12_I78_A0.8880.96
27_S38_A0.8870.96
74_L84_V0.8720.95
52_L56_D0.8700.95
29_L36_E0.8690.95
67_A91_L0.8670.95
36_E54_A0.8600.95
89_A92_D0.8600.95
44_G51_L0.8560.95
43_V47_A0.8440.95
16_K81_D0.8360.94
26_A30_A0.8350.94
86_A89_A0.8330.94
54_A80_Q0.8330.94
30_A34_K0.8300.94
40_L55_K0.8250.94
10_D83_D0.8210.94
35_G39_A0.8190.94
47_A51_L0.8160.94
50_F62_L0.8100.93
5_L74_L0.8070.93
18_T22_N0.8050.93
7_E10_D0.8000.93
85_E88_L0.8000.93
50_F76_V0.7980.93
14_D17_E0.7820.92
50_F73_M0.7760.92
67_A87_L0.7690.91
13_E83_D0.7670.91
27_S30_A0.7590.91
29_L78_A0.7220.89
40_L43_V0.7050.87
53_A62_L0.6890.86
9_F83_D0.6890.86
38_A61_E0.6860.86
29_L79_Q0.6740.85
36_E40_L0.6660.84
85_E89_A0.6640.84
13_E17_E0.6590.84
85_E92_D0.6580.84
89_A93_D0.6500.83
67_A90_E0.6440.82
36_E39_A0.6390.82
63_A86_A0.6370.82
6_R85_E0.6290.81
6_R10_D0.6220.80
88_L92_D0.6180.80
59_T63_A0.6170.80
22_N30_A0.6150.79
4_P88_L0.6150.79
5_L88_L0.6130.79
62_L77_L0.6070.78
24_Y27_S0.6020.78
13_E16_K0.5880.76
43_V48_T0.5860.76
38_A52_L0.5820.76
16_K26_A0.5800.75
60_D64_H0.5730.74
48_T52_L0.5720.74
11_V14_D0.5670.74
37_N51_L0.5590.73
40_L48_T0.5570.72
24_Y30_A0.5470.71
60_D63_A0.5460.71
43_V76_V0.5440.71
20_P30_A0.5410.70
44_G52_L0.5410.70
63_A87_L0.5390.70
25_T75_V0.5380.70
16_K19_M0.5380.70
40_L79_Q0.5370.70
36_E55_K0.5220.67
55_K61_E0.5120.66
71_Y75_V0.5100.66
24_Y53_A0.5080.65
14_D22_N0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yvwA 4 0.9368 100 0.127 Contact Map
2a7wA 4 0.9474 100 0.129 Contact Map
1y6xA 3 0.9158 100 0.169 Contact Map
1yxbA 4 0.8737 100 0.178 Contact Map
2yxhA 2 0.8737 99 0.685 Contact Map
2gtaA 4 0.8947 98.6 0.721 Contact Map
1vmgA 4 0.8632 98.2 0.753 Contact Map
2oieA 3 0.8842 97.2 0.8 Contact Map
2q73A 4 0.8316 96.6 0.816 Contact Map
2q5zA 4 0.8421 96.4 0.82 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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