GREMLIN Database
Q9HMD3 - Uncharacterized protein
UniProt: Q9HMD3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 152 (137)
Sequences: 1009 (701)
Seq/√Len: 59.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_G43_E3.9981.00
76_V93_L3.9811.00
92_D103_V2.8841.00
65_T68_L2.8741.00
5_I124_V2.7801.00
21_V112_L2.7051.00
106_A111_S2.6881.00
65_T114_L2.5501.00
4_D26_D2.4541.00
77_D96_E2.3501.00
69_V74_G2.3351.00
7_A116_A2.2141.00
74_G95_V2.1901.00
128_V132_G1.9711.00
66_L118_T1.9291.00
20_V38_F1.8991.00
68_L104_V1.8811.00
47_I113_A1.8481.00
97_T100_G1.7890.99
113_A117_R1.7870.99
96_E99_R1.7140.99
82_S92_D1.7020.99
13_T38_F1.6310.99
75_R96_E1.6000.99
35_L129_F1.6000.99
89_Y132_G1.5950.99
65_T69_V1.5520.98
78_R123_A1.5410.98
5_I129_F1.5330.98
62_H113_A1.5220.98
63_D117_R1.4850.98
91_A108_P1.4510.98
78_R94_H1.4410.98
80_V94_H1.4190.97
66_L114_L1.4120.97
79_V111_S1.3990.97
66_L70_E1.3750.97
25_R31_S1.2840.95
126_D130_A1.2770.95
69_V95_V1.2660.95
50_G53_A1.2630.95
35_L117_R1.2600.95
95_V104_V1.2560.94
46_S62_H1.2370.94
37_I108_P1.2160.93
93_L106_A1.2150.93
48_A52_D1.2120.93
13_T19_A1.2110.93
64_V106_A1.2030.93
84_V132_G1.2020.93
46_S61_T1.1780.92
46_S113_A1.1570.92
5_I35_L1.1530.91
12_D24_A1.1360.91
33_D130_A1.1330.91
6_D26_D1.1320.91
19_A44_A1.1190.90
71_E102_T1.1110.90
83_S128_V1.1020.90
13_T20_V1.1010.89
35_L132_G1.1000.89
124_V128_V1.0720.88
10_V34_V1.0520.87
88_T108_P1.0350.86
8_V11_A1.0050.85
68_L95_V0.9920.84
19_A38_F0.9880.84
8_V24_A0.9860.84
13_T16_G0.9840.83
72_L95_V0.9690.82
50_G117_R0.9360.80
44_A47_I0.9310.80
25_R33_D0.9300.80
50_G116_A0.9240.79
82_S108_P0.9220.79
58_R62_H0.9030.78
94_H103_V0.8870.76
20_V24_A0.8820.76
80_V123_A0.8810.76
69_V72_L0.8780.76
32_G100_G0.8770.76
22_V25_R0.8710.75
25_R129_F0.8710.75
74_G114_L0.8600.74
83_S127_D0.8510.73
128_V131_Q0.8510.73
47_I63_D0.8450.73
74_G96_E0.8390.72
88_T124_V0.8380.72
89_Y94_H0.8360.72
33_D133_A0.8210.71
20_V23_L0.8160.70
50_G66_L0.8140.70
91_A121_P0.8110.70
96_E100_G0.8050.69
80_V103_V0.8050.69
7_A11_A0.7970.68
51_L105_D0.7930.68
84_V135_S0.7780.67
21_V39_V0.7780.67
47_I117_R0.7760.66
81_I96_E0.7730.66
37_I112_L0.7700.66
45_A62_H0.7630.65
12_D19_A0.7570.64
83_S90_F0.7560.64
90_F108_P0.7560.64
125_A128_V0.7550.64
58_R61_T0.7540.64
83_S108_P0.7520.64
55_D93_L0.7440.63
77_D101_S0.7430.63
42_E45_A0.7420.63
41_F53_A0.7390.63
25_R30_D0.7380.63
68_L93_L0.7350.62
16_G87_G0.7330.62
70_E75_R0.7320.62
80_V125_A0.7260.61
40_G57_G0.7260.61
7_A112_L0.7260.61
21_V24_A0.7240.61
4_D50_G0.7170.60
39_V43_E0.7110.60
31_S48_A0.7100.60
78_R101_S0.7030.59
10_V50_G0.6990.58
35_L124_V0.6990.58
9_R19_A0.6970.58
140_D143_R0.6890.57
16_G124_V0.6870.57
59_P107_R0.6840.57
11_A14_P0.6830.57
17_T48_A0.6820.56
39_V82_S0.6800.56
13_T18_I0.6770.56
4_D121_P0.6760.56
42_E49_R0.6740.56
16_G20_V0.6730.55
52_D117_R0.6720.55
79_V122_I0.6720.55
39_V119_N0.6670.55
22_V53_A0.6640.54
41_F57_G0.6640.54
53_A73_G0.6640.54
112_L116_A0.6630.54
50_G54_V0.6600.54
7_A25_R0.6590.54
97_T102_T0.6550.53
16_G65_T0.6500.53
7_A37_I0.6480.53
105_D121_P0.6470.53
34_V108_P0.6470.53
46_S60_L0.6460.52
40_G44_A0.6460.52
65_T74_G0.6450.52
68_L82_S0.6430.52
43_E107_R0.6400.52
74_G97_T0.6380.52
21_V87_G0.6350.51
75_R102_T0.6350.51
71_E104_V0.6340.51
11_A34_V0.6160.49
98_P101_S0.6160.49
19_A24_A0.6120.49
4_D133_A0.6100.48
83_S131_Q0.6070.48
24_A84_V0.5980.47
46_S57_G0.5970.47
104_V128_V0.5960.47
138_G141_E0.5900.46
53_A56_I0.5890.46
58_R107_R0.5840.46
5_I50_G0.5830.45
105_D108_P0.5830.45
77_D97_T0.5820.45
43_E58_R0.5810.45
20_V104_V0.5800.45
127_D131_Q0.5790.45
61_T84_V0.5710.44
7_A10_V0.5600.43
63_D113_A0.5590.43
7_A13_T0.5570.43
133_A136_P0.5570.43
71_E100_G0.5550.42
71_E98_P0.5520.42
30_D55_D0.5480.42
51_L116_A0.5440.41
42_E66_L0.5420.41
61_T64_V0.5400.41
30_D142_L0.5400.41
82_S105_D0.5370.40
67_D104_V0.5350.40
45_A52_D0.5340.40
67_D105_D0.5320.40
75_R119_N0.5320.40
17_T38_F0.5320.40
135_S143_R0.5320.40
14_P89_Y0.5240.39
76_V119_N0.5180.38
58_R109_S0.5100.37
9_R13_T0.5100.37
9_R17_T0.5040.37
18_I24_A0.5040.37
33_D126_D0.5010.37
137_D141_E0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vjlA 2 0.9342 100 0.18 Contact Map
4c26A 1 0.4211 9.6 0.948 Contact Map
4yslA 2 0.8026 6.4 0.951 Contact Map
1kyfA 1 0.8158 5.7 0.953 Contact Map
4jb1A 1 0.8026 3.8 0.957 Contact Map
3r2uA 4 0.7237 3.6 0.957 Contact Map
2i9zA 2 0.4276 3.5 0.957 Contact Map
1reqA 1 0.4868 2.6 0.96 Contact Map
1ewqA 2 0.8289 2.5 0.96 Contact Map
1q47A 2 0.5395 2.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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