GREMLIN Database
PDXT - Glutamine amidotransferase subunit PdxT
UniProt: Q9HMD2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (186)
Sequences: 1652 (1099)
Seq/√Len: 80.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_H80_K3.5581.00
167_R193_D3.2171.00
166_I173_A3.1921.00
4_T33_D2.8451.00
89_L173_A2.7541.00
146_I166_I2.7071.00
76_V82_L2.6031.00
154_T167_R2.4481.00
188_E192_F2.3531.00
95_D110_T2.3241.00
21_I50_L2.3181.00
107_L166_I2.2531.00
108_D168_D2.2301.00
165_A174_T2.1611.00
7_V18_A2.1511.00
145_V162_R2.1461.00
74_S78_A2.1141.00
112_D147_D2.0381.00
126_P137_P2.0361.00
95_D148_E2.0121.00
21_I32_A1.9911.00
83_L174_T1.9901.00
18_A34_V1.9581.00
18_A36_E1.9351.00
107_L171_V1.9231.00
9_A36_E1.8851.00
4_T35_R1.8161.00
172_V193_D1.8041.00
165_A186_L1.8011.00
139_V181_T1.7631.00
89_L146_I1.7561.00
5_A48_V1.7441.00
51_L91_V1.6811.00
109_V173_A1.6771.00
94_T108_D1.6421.00
158_S161_G1.6381.00
34_V50_L1.6291.00
184_V188_E1.6071.00
69_D104_L1.5941.00
19_A22_R1.5741.00
97_N147_D1.5701.00
60_S102_E1.5671.00
89_L175_S1.5490.99
130_D154_T1.5250.99
126_P135_P1.5150.99
23_R184_V1.5120.99
6_G46_C1.4890.99
69_D73_R1.4620.99
106_V171_V1.4560.99
96_A103_T1.4540.99
110_T148_E1.4340.99
107_L173_A1.4330.99
115_A145_V1.4110.99
116_F175_S1.3980.99
127_L138_A1.3760.99
94_T106_V1.3720.99
60_S103_T1.3520.99
145_V175_S1.3440.99
108_D150_G1.3420.99
60_S64_D1.3400.99
76_V106_V1.3360.98
89_L111_V1.3270.98
136_F185_R1.2970.98
149_V163_P1.2550.98
72_I75_H1.2330.97
25_A32_A1.2310.97
18_A22_R1.2190.97
63_L91_V1.2020.97
97_N112_D1.2000.97
155_V163_P1.1970.97
73_R77_A1.1880.97
35_R45_E1.1820.97
129_V186_L1.1660.96
93_S111_V1.1620.96
64_D69_D1.1560.96
40_A67_G1.1410.96
84_A174_T1.1360.96
149_V155_V1.1200.95
124_E137_P1.1190.95
167_R189_L1.1100.95
20_A184_V1.1100.95
5_A191_F1.1000.95
14_V38_R1.0890.95
15_S19_A1.0650.94
4_T45_E1.0640.94
46_C81_P1.0420.93
20_A24_A1.0410.93
59_I91_V1.0400.93
83_L186_L1.0330.93
158_S163_P1.0300.93
172_V190_A1.0280.93
39_T42_V1.0160.93
37_I46_C1.0130.92
22_R34_V1.0110.92
46_C75_H1.0030.92
35_R46_C1.0010.92
32_A50_L0.9880.91
156_L165_A0.9780.91
129_V136_F0.9700.91
60_S101_V0.9700.91
135_P185_R0.9660.90
124_E139_V0.9630.90
150_G153_A0.9590.90
24_A32_A0.9530.90
68_I71_E0.9490.90
63_L104_L0.9490.90
83_L172_V0.9450.90
24_A191_F0.9370.89
83_L190_A0.9320.89
58_A62_L0.9300.89
131_G154_T0.9300.89
124_E181_T0.9140.88
43_V46_C0.9120.88
64_D102_E0.9080.88
70_A74_S0.9080.88
116_F163_P0.9010.87
192_F195_T0.8980.87
76_V171_V0.8930.87
8_V49_L0.8870.86
40_A71_E0.8730.85
37_I68_I0.8690.85
153_A156_L0.8640.85
21_I187_H0.8620.85
43_V72_I0.8580.84
20_A187_H0.8570.84
127_L157_A0.8520.84
43_V75_H0.8470.84
82_L106_V0.8450.84
129_V165_A0.8420.83
9_A14_V0.8380.83
155_V158_S0.8310.82
20_A23_R0.8290.82
5_A194_R0.8260.82
92_S171_V0.8200.82
22_R33_D0.8200.82
129_V157_A0.8030.80
61_R65_R0.7960.80
14_V36_E0.7900.79
139_V180_L0.7890.79
107_L168_D0.7890.79
129_V132_L0.7750.78
136_F186_L0.7730.78
50_L84_A0.7650.77
10_V62_L0.7650.77
189_L193_D0.7600.76
46_C80_K0.7600.76
96_A99_D0.7560.76
60_S100_R0.7520.76
102_E105_D0.7480.75
36_E42_V0.7470.75
96_A100_R0.7450.75
48_V80_K0.7430.75
118_R186_L0.7410.75
81_P170_P0.7350.74
172_V189_L0.7310.74
14_V24_A0.7290.73
72_I106_V0.7280.73
130_D158_S0.7260.73
138_A157_A0.7240.73
136_F183_D0.7200.73
15_S18_A0.7170.72
146_I175_S0.7110.72
109_V146_I0.7060.71
6_G43_V0.7030.71
42_V68_I0.7010.71
128_D135_P0.6990.70
124_E127_L0.6950.70
116_F138_A0.6940.70
42_V45_E0.6930.70
159_W174_T0.6890.69
132_L136_F0.6880.69
112_D145_V0.6870.69
163_P166_I0.6780.68
110_T147_D0.6770.68
162_R175_S0.6740.68
132_L135_P0.6680.67
101_V105_D0.6670.67
49_L82_L0.6640.66
24_A184_V0.6620.66
165_A172_V0.6610.66
154_T193_D0.6570.66
93_S109_V0.6560.65
130_D133_A0.6540.65
132_L186_L0.6480.64
37_I49_L0.6460.64
76_V104_L0.6460.64
115_A162_R0.6450.64
14_V18_A0.6420.64
13_D180_L0.6420.64
116_F165_A0.6400.64
43_V68_I0.6380.63
57_T123_F0.6350.63
163_P175_S0.6340.63
62_L65_R0.6320.63
60_S69_D0.6290.62
24_A118_R0.6280.62
69_D102_E0.6270.62
112_D115_A0.6250.62
116_F120_V0.6240.62
134_D185_R0.6200.61
94_T109_V0.6190.61
62_L66_E0.6180.61
14_V61_R0.6180.61
94_T171_V0.6180.61
4_T195_T0.6160.61
125_A138_A0.6150.60
131_G189_L0.6150.60
59_I72_I0.6140.60
13_D145_V0.6130.60
159_W162_R0.6110.60
21_I34_V0.6090.60
19_A23_R0.6080.60
40_A68_I0.6080.60
115_A173_A0.6010.59
72_I80_K0.5950.58
90_I146_I0.5940.58
128_D134_D0.5940.58
73_R106_V0.5910.57
13_D58_A0.5910.57
60_S99_D0.5890.57
95_D151_A0.5870.57
49_L72_I0.5850.57
159_W165_A0.5850.57
152_D168_D0.5830.56
10_V63_L0.5780.56
92_S106_V0.5780.56
116_F127_L0.5770.56
89_L145_V0.5730.55
78_A151_A0.5690.55
76_V92_S0.5680.55
42_V66_E0.5670.54
38_R115_A0.5650.54
181_T189_L0.5640.54
132_L137_P0.5630.54
124_E138_A0.5610.54
97_N110_T0.5610.54
34_V42_V0.5610.54
169_G192_F0.5600.53
84_A107_L0.5570.53
136_F181_T0.5550.53
152_D155_V0.5550.53
48_V190_A0.5540.53
7_V34_V0.5540.53
170_P193_D0.5520.52
62_L93_S0.5510.52
76_V170_P0.5500.52
93_S96_A0.5490.52
76_V81_P0.5480.52
99_D103_T0.5480.52
116_F124_E0.5470.52
63_L76_V0.5430.51
94_T168_D0.5400.51
44_P71_E0.5380.51
6_G124_E0.5370.50
35_R42_V0.5350.50
9_A105_D0.5350.50
126_P136_F0.5320.50
190_A194_R0.5290.49
62_L115_A0.5290.49
136_F139_V0.5250.49
61_R64_D0.5240.49
4_T94_T0.5220.49
22_R50_L0.5220.49
147_D162_R0.5210.48
121_D159_W0.5190.48
48_V191_F0.5170.48
73_R191_F0.5150.48
127_L164_V0.5140.47
63_L69_D0.5130.47
168_D186_L0.5120.47
13_D83_L0.5090.47
41_G44_P0.5080.47
128_D158_S0.5060.46
32_A191_F0.5050.46
7_V21_I0.5040.46
39_T46_C0.5040.46
39_T45_E0.5020.46
24_A78_A0.5010.46
74_S77_A0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nv0A 1 0.9458 100 0.63 Contact Map
1q7rA 1 0.9704 100 0.632 Contact Map
2abwA 1 0.9852 100 0.637 Contact Map
2issD 1 0.9064 100 0.638 Contact Map
2ywdA 1 0.9212 100 0.649 Contact Map
2ywjA 1 0.9015 100 0.659 Contact Map
3en0A 2 0.9212 100 0.665 Contact Map
1jvnA 1 0.9557 100 0.695 Contact Map
1ka9H 1 0.9064 99.9 0.703 Contact Map
2vdjA 2 0.9409 99.9 0.723 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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