RUBPS - HALSA - GREMLIN Contacts

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RUBPS - Putative ribose 1,5-bisphosphate isomerase

UniProt:	Q9HMC7	Sequences: MTFDSFADANEAEVTRAITRQWTDEFLDDTETDVIIVGGGPSGLMAAKELADRDVDVTIIEKNNYLGGGFWLGGFLMNKLTVRSPAEAVLDDLGVPYEYDEENDGLAVADAPHACSAMITAACDAGARIQNMTEFTDIVVRDDHAVAGAVVNWTPVHSLPRELTCVDPIALEADVVVDATGHDAVVVSKLHERGVLEADGIEHVEEHATGMDQSGDGEYGAPGHDSPGHDSMWVADSEDKVVEQTGKVHDGLVTAGLSTATVHGLTRMGPTFGAMLLSGKVAANAVMDELAVDEPRVDLPSTAAPAADDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	310 (253)
Sequences:	315 (163)
Seq/√Len:	10.2

HALSA - RUBPS
SULSO - RUBPS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
253_V	286_V	4.747	1.00
117_A	120_T	4.319	0.99
47_A	127_A	3.754	0.98
55_V	287_M	3.585	0.98
46_A	177_V	3.239	0.96
88_A	280_K	3.181	0.95
247_K	250_D	3.124	0.94
53_R	287_M	3.098	0.94
25_E	79_K	2.806	0.90
15_T	19_T	2.785	0.90
49_E	280_K	2.753	0.90
21_Q	98_E	2.599	0.87
39_G	59_I	2.598	0.87
76_L	132_M	2.596	0.87
47_A	59_I	2.470	0.84
70_F	114_A	2.466	0.84
66_L	119_I	2.175	0.75
84_S	105_G	2.166	0.74
138_I	186_V	2.138	0.73
253_V	282_A	2.105	0.72
117_A	124_D	2.097	0.72
187_V	262_V	2.023	0.69
42_S	255_A	1.990	0.68
78_N	117_A	1.976	0.67
66_L	116_S	1.971	0.67
48_K	52_D	1.943	0.66
9_A	14_V	1.922	0.65
96_P	113_H	1.906	0.64
145_A	251_G	1.892	0.64
189_K	192_E	1.866	0.62
223_G	227_P	1.863	0.62
116_S	119_I	1.859	0.62
280_K	284_N	1.857	0.62
160_P	165_C	1.780	0.59
231_S	237_S	1.715	0.56
70_F	115_C	1.708	0.55
25_E	128_R	1.702	0.55
247_K	289_E	1.701	0.55
101_E	105_G	1.696	0.55
82_V	276_L	1.679	0.54
76_L	153_W	1.659	0.53
141_R	147_A	1.659	0.53
15_T	48_K	1.623	0.51
39_G	138_I	1.586	0.50
91_D	97_Y	1.577	0.49
10_N	172_E	1.565	0.49
58_T	130_Q	1.563	0.49
20_R	27_L	1.543	0.48
62_K	134_E	1.541	0.48
79_K	108_V	1.529	0.47
241_V	260_A	1.520	0.47
65_Y	158_S	1.508	0.46
26_F	225_D	1.507	0.46
146_V	190_L	1.495	0.46
36_I	59_I	1.487	0.45
14_V	231_S	1.482	0.45
61_E	74_G	1.482	0.45
282_A	286_V	1.463	0.44
47_A	51_A	1.463	0.44
191_H	225_D	1.460	0.44
63_N	130_Q	1.439	0.43
175_V	253_V	1.422	0.42
36_I	43_G	1.421	0.42
117_A	121_A	1.419	0.42
146_V	290_L	1.405	0.41
132_M	155_P	1.372	0.40
43_G	179_A	1.362	0.40
177_V	253_V	1.360	0.39
32_T	35_I	1.358	0.39
71_W	131_N	1.340	0.39
240_K	266_T	1.340	0.39
95_V	104_D	1.326	0.38
48_K	117_A	1.282	0.36
77_M	153_W	1.268	0.35
21_Q	108_V	1.261	0.35
154_T	158_S	1.247	0.35
86_A	191_H	1.233	0.34
24_D	104_D	1.221	0.33
14_V	93_L	1.213	0.33
46_A	282_A	1.209	0.33
35_I	149_A	1.189	0.32
175_V	286_V	1.185	0.32
55_V	282_A	1.182	0.32
34_V	51_A	1.174	0.32
248_V	255_A	1.173	0.32
42_S	231_S	1.173	0.32
138_I	149_A	1.172	0.31
259_T	265_L	1.170	0.31
138_I	187_V	1.165	0.31
151_V	171_L	1.163	0.31
36_I	120_T	1.163	0.31
131_N	150_V	1.162	0.31
140_V	190_L	1.150	0.31
139_V	147_A	1.144	0.30
48_K	93_L	1.132	0.30
190_L	194_G	1.108	0.29
177_V	286_V	1.099	0.29
36_I	47_A	1.095	0.28
164_T	234_V	1.091	0.28
71_W	150_V	1.088	0.28
35_I	171_L	1.078	0.28
77_M	169_I	1.076	0.28
131_N	152_N	1.073	0.28
14_V	147_A	1.071	0.28
9_A	80_L	1.067	0.27
78_N	124_D	1.066	0.27
58_T	77_M	1.065	0.27
114_A	121_A	1.060	0.27
20_R	103_N	1.058	0.27
36_I	42_S	1.054	0.27
194_G	231_S	1.043	0.27
80_L	89_V	1.040	0.26
16_R	27_L	1.031	0.26
87_E	97_Y	1.025	0.26
84_S	281_V	1.017	0.26
51_A	146_V	1.017	0.26
20_R	24_D	1.015	0.26
96_P	124_D	1.013	0.25
121_A	124_D	1.011	0.25
17_A	102_E	1.011	0.25
85_P	271_T	1.008	0.25
22_W	131_N	1.005	0.25
72_L	165_C	1.004	0.25
39_G	235_A	0.997	0.25
22_W	78_N	0.997	0.25
66_L	129_I	0.996	0.25
169_I	190_L	0.993	0.25
30_T	39_G	0.993	0.25
28_D	290_L	0.987	0.25
244_Q	265_L	0.986	0.25
180_T	186_V	0.984	0.24
63_N	165_C	0.984	0.24
91_D	104_D	0.983	0.24
85_P	239_D	0.981	0.24
37_V	176_V	0.977	0.24
42_S	142_D	0.976	0.24
29_D	58_T	0.968	0.24
281_V	284_N	0.966	0.24
237_S	277_L	0.966	0.24
56_D	135_F	0.966	0.24
110_D	231_S	0.962	0.24
101_E	108_V	0.961	0.24
92_D	149_A	0.956	0.24
50_L	290_L	0.951	0.23
71_W	152_N	0.950	0.23
139_V	194_G	0.931	0.23
178_D	252_L	0.925	0.22
146_V	225_D	0.922	0.22
72_L	271_T	0.919	0.22
71_W	115_C	0.913	0.22
13_E	28_D	0.912	0.22
285_A	288_D	0.911	0.22
52_D	92_D	0.909	0.22
16_R	145_A	0.909	0.22
63_N	270_P	0.905	0.22
241_V	251_G	0.905	0.22
192_E	239_D	0.905	0.22
117_A	224_H	0.904	0.22
32_T	58_T	0.904	0.22
79_K	128_R	0.903	0.22
48_K	124_D	0.901	0.22
179_A	255_A	0.901	0.22
32_T	243_E	0.900	0.22
177_V	262_V	0.899	0.22
271_T	274_A	0.885	0.21
45_M	123_C	0.884	0.21
178_D	184_A	0.875	0.21
26_F	141_R	0.873	0.21
229_H	261_T	0.868	0.21
64_N	72_L	0.867	0.21
95_V	170_A	0.866	0.21
48_K	121_A	0.864	0.21
113_H	123_C	0.861	0.20
62_K	231_S	0.857	0.20
152_N	232_M	0.855	0.20
58_T	117_A	0.843	0.20
178_D	187_V	0.842	0.20
146_V	291_A	0.839	0.20
15_T	149_A	0.835	0.20
81_T	234_V	0.834	0.20
77_M	95_V	0.834	0.20
29_D	128_R	0.831	0.20
71_W	232_M	0.828	0.20
239_D	243_E	0.826	0.19
177_V	255_A	0.824	0.19
78_N	232_M	0.815	0.19
81_T	106_L	0.811	0.19
123_C	179_A	0.809	0.19
94_G	121_A	0.801	0.19
63_N	155_P	0.796	0.19
82_V	177_V	0.796	0.19
10_N	193_R	0.794	0.19
49_E	92_D	0.794	0.19
35_I	155_P	0.790	0.18
45_M	119_I	0.790	0.18
11_E	37_V	0.776	0.18
15_T	92_D	0.775	0.18
62_K	154_T	0.771	0.18
46_A	281_V	0.763	0.18
96_P	174_D	0.755	0.17
74_G	140_V	0.754	0.17
31_E	89_V	0.750	0.17
175_V	282_A	0.749	0.17
237_S	249_H	0.749	0.17
177_V	282_A	0.745	0.17
85_P	274_A	0.744	0.17
25_E	110_D	0.743	0.17
101_E	104_D	0.738	0.17
266_T	290_L	0.738	0.17
246_G	265_L	0.736	0.17
65_Y	92_D	0.735	0.17
249_H	260_A	0.735	0.17
61_E	165_C	0.734	0.17
72_L	75_F	0.732	0.17
39_G	154_T	0.729	0.17
195_V	230_D	0.728	0.17
21_Q	32_T	0.728	0.17
11_E	234_V	0.728	0.17
87_E	91_D	0.727	0.17
187_V	252_L	0.724	0.17
15_T	26_F	0.723	0.17
91_D	94_G	0.721	0.17
259_T	282_A	0.721	0.17
70_F	276_L	0.720	0.17
37_V	237_S	0.719	0.17
83_R	169_I	0.719	0.17
78_N	224_H	0.714	0.16
82_V	149_A	0.712	0.16
254_T	274_A	0.707	0.16
95_V	204_V	0.700	0.16
9_A	103_N	0.699	0.16
35_I	84_S	0.699	0.16
65_Y	81_T	0.698	0.16
64_N	70_F	0.697	0.16
62_K	185_V	0.696	0.16
35_I	60_I	0.696	0.16
78_N	111_A	0.694	0.16
134_E	248_V	0.692	0.16
15_T	74_G	0.687	0.16
11_E	262_V	0.686	0.16
241_V	270_P	0.686	0.16
74_G	141_R	0.686	0.16
44_L	74_G	0.684	0.16
48_K	92_D	0.682	0.16
56_D	255_A	0.678	0.16
78_N	131_N	0.677	0.15
44_L	129_I	0.677	0.15
94_G	255_A	0.675	0.15
47_A	117_A	0.670	0.15
22_W	48_K	0.670	0.15
35_I	58_T	0.670	0.15
241_V	281_V	0.668	0.15
101_E	154_T	0.666	0.15
130_Q	136_T	0.666	0.15
253_V	285_A	0.665	0.15
11_E	111_A	0.663	0.15
246_G	259_T	0.662	0.15
28_D	56_D	0.656	0.15
49_E	57_V	0.655	0.15
117_A	130_Q	0.654	0.15
243_E	287_M	0.654	0.15
39_G	70_F	0.650	0.15
83_R	271_T	0.649	0.15
72_L	229_H	0.646	0.15
254_T	291_A	0.646	0.15
30_T	241_V	0.645	0.15
21_Q	79_K	0.643	0.15
187_V	190_L	0.642	0.15
251_G	286_V	0.641	0.15
70_F	156_V	0.639	0.15
172_E	243_E	0.639	0.15
132_M	139_V	0.638	0.15
173_A	248_V	0.637	0.15
60_I	171_L	0.636	0.15
114_A	276_L	0.635	0.14
26_F	187_V	0.633	0.14
66_L	115_C	0.632	0.14
63_N	156_V	0.631	0.14
52_D	120_T	0.628	0.14
182_H	251_G	0.626	0.14
42_S	187_V	0.625	0.14
26_F	142_D	0.624	0.14
70_F	164_T	0.622	0.14
59_I	66_L	0.622	0.14
26_F	180_T	0.622	0.14
246_G	263_H	0.620	0.14
14_V	149_A	0.619	0.14
17_A	156_V	0.615	0.14
113_H	169_I	0.612	0.14
42_S	253_V	0.612	0.14
37_V	180_T	0.612	0.14
255_A	284_N	0.611	0.14
185_V	282_A	0.609	0.14
42_S	194_G	0.608	0.14
150_V	232_M	0.606	0.14
31_E	103_N	0.606	0.14
10_N	111_A	0.606	0.14
32_T	133_T	0.604	0.14
116_S	124_D	0.604	0.14
18_I	54_D	0.602	0.14
45_M	179_A	0.602	0.14
37_V	135_F	0.598	0.14
56_D	174_D	0.597	0.14
145_A	177_V	0.595	0.14
86_A	236_D	0.594	0.14
28_D	175_V	0.594	0.14
83_R	165_C	0.593	0.14
94_G	104_D	0.592	0.14
101_E	171_L	0.588	0.13
154_T	179_A	0.588	0.13
48_K	153_W	0.587	0.13
181_G	251_G	0.584	0.13
106_L	115_C	0.583	0.13
254_T	258_S	0.583	0.13
146_V	281_V	0.581	0.13
175_V	287_M	0.581	0.13
81_T	229_H	0.580	0.13
78_N	115_C	0.578	0.13
35_I	85_P	0.578	0.13
65_Y	164_T	0.577	0.13
45_M	122_A	0.575	0.13
189_K	194_G	0.575	0.13
97_Y	153_W	0.570	0.13
75_F	169_I	0.570	0.13
42_S	226_S	0.567	0.13
138_I	190_L	0.567	0.13
52_D	281_V	0.566	0.13
93_L	121_A	0.565	0.13
189_K	195_V	0.564	0.13
171_L	291_A	0.563	0.13
81_T	136_T	0.563	0.13
31_E	281_V	0.563	0.13
35_I	165_C	0.563	0.13
259_T	266_T	0.562	0.13
16_R	56_D	0.561	0.13
93_L	153_W	0.560	0.13
25_E	241_V	0.560	0.13
8_D	20_R	0.560	0.13
145_A	286_V	0.559	0.13
11_E	204_V	0.555	0.13
237_S	241_V	0.553	0.13
15_T	30_T	0.553	0.13
104_D	291_A	0.552	0.13
89_V	276_L	0.552	0.13
41_P	258_S	0.551	0.13
46_A	141_R	0.551	0.13
26_F	131_N	0.549	0.13
271_T	288_D	0.547	0.13
236_D	255_A	0.546	0.13
152_N	264_G	0.543	0.13
133_T	234_V	0.543	0.13
95_V	235_A	0.541	0.12
116_S	266_T	0.541	0.12
47_A	94_G	0.541	0.12
237_S	265_L	0.539	0.12
106_L	109_A	0.539	0.12
62_K	97_Y	0.538	0.12
19_T	23_T	0.538	0.12
45_M	177_V	0.536	0.12
26_F	153_W	0.536	0.12
124_D	265_L	0.533	0.12
178_D	241_V	0.532	0.12
237_S	257_L	0.529	0.12
62_K	141_R	0.526	0.12
106_L	237_S	0.524	0.12
60_I	133_T	0.524	0.12
52_D	236_D	0.522	0.12
75_F	229_H	0.521	0.12
45_M	263_H	0.517	0.12
178_D	265_L	0.516	0.12
121_A	158_S	0.515	0.12
139_V	172_E	0.515	0.12
48_K	74_G	0.514	0.12
80_L	95_V	0.512	0.12
120_T	130_Q	0.511	0.12
27_L	154_T	0.509	0.12
165_C	271_T	0.507	0.12
122_A	125_A	0.505	0.12
281_V	285_A	0.504	0.12
172_E	280_K	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fpzA	6	0.8581	100	0.693	Contact Map
3jskA	6	0.8806	100	0.701	Contact Map
1rp0A	5	0.8839	100	0.725	Contact Map
2bs2A	2	0.8742	99.8	0.858	Contact Map
2culA	1	0.6742	99.8	0.858	Contact Map
1kf6A	1	0.8677	99.8	0.859	Contact Map
4at0A	2	0.8387	99.8	0.859	Contact Map
1qo8A	2	0.9065	99.7	0.861	Contact Map
2wdqA	1	0.8839	99.7	0.861	Contact Map
2h88A	2	0.8871	99.7	0.861	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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