GREMLIN Database
RUBPS - Putative ribose 1,5-bisphosphate isomerase
UniProt: Q9HMC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (253)
Sequences: 315 (163)
Seq/√Len: 10.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_V286_V4.7471.00
117_A120_T4.3190.99
47_A127_A3.7540.98
55_V287_M3.5850.98
46_A177_V3.2390.96
88_A280_K3.1810.95
247_K250_D3.1240.94
53_R287_M3.0980.94
25_E79_K2.8060.90
15_T19_T2.7850.90
49_E280_K2.7530.90
21_Q98_E2.5990.87
39_G59_I2.5980.87
76_L132_M2.5960.87
47_A59_I2.4700.84
70_F114_A2.4660.84
66_L119_I2.1750.75
84_S105_G2.1660.74
138_I186_V2.1380.73
253_V282_A2.1050.72
117_A124_D2.0970.72
187_V262_V2.0230.69
42_S255_A1.9900.68
78_N117_A1.9760.67
66_L116_S1.9710.67
48_K52_D1.9430.66
9_A14_V1.9220.65
96_P113_H1.9060.64
145_A251_G1.8920.64
189_K192_E1.8660.62
223_G227_P1.8630.62
116_S119_I1.8590.62
280_K284_N1.8570.62
160_P165_C1.7800.59
231_S237_S1.7150.56
70_F115_C1.7080.55
25_E128_R1.7020.55
247_K289_E1.7010.55
101_E105_G1.6960.55
82_V276_L1.6790.54
76_L153_W1.6590.53
141_R147_A1.6590.53
15_T48_K1.6230.51
39_G138_I1.5860.50
91_D97_Y1.5770.49
10_N172_E1.5650.49
58_T130_Q1.5630.49
20_R27_L1.5430.48
62_K134_E1.5410.48
79_K108_V1.5290.47
241_V260_A1.5200.47
65_Y158_S1.5080.46
26_F225_D1.5070.46
146_V190_L1.4950.46
36_I59_I1.4870.45
14_V231_S1.4820.45
61_E74_G1.4820.45
282_A286_V1.4630.44
47_A51_A1.4630.44
191_H225_D1.4600.44
63_N130_Q1.4390.43
175_V253_V1.4220.42
36_I43_G1.4210.42
117_A121_A1.4190.42
146_V290_L1.4050.41
132_M155_P1.3720.40
43_G179_A1.3620.40
177_V253_V1.3600.39
32_T35_I1.3580.39
71_W131_N1.3400.39
240_K266_T1.3400.39
95_V104_D1.3260.38
48_K117_A1.2820.36
77_M153_W1.2680.35
21_Q108_V1.2610.35
154_T158_S1.2470.35
86_A191_H1.2330.34
24_D104_D1.2210.33
14_V93_L1.2130.33
46_A282_A1.2090.33
35_I149_A1.1890.32
175_V286_V1.1850.32
55_V282_A1.1820.32
34_V51_A1.1740.32
248_V255_A1.1730.32
42_S231_S1.1730.32
138_I149_A1.1720.31
259_T265_L1.1700.31
138_I187_V1.1650.31
151_V171_L1.1630.31
36_I120_T1.1630.31
131_N150_V1.1620.31
140_V190_L1.1500.31
139_V147_A1.1440.30
48_K93_L1.1320.30
190_L194_G1.1080.29
177_V286_V1.0990.29
36_I47_A1.0950.28
164_T234_V1.0910.28
71_W150_V1.0880.28
35_I171_L1.0780.28
77_M169_I1.0760.28
131_N152_N1.0730.28
14_V147_A1.0710.28
9_A80_L1.0670.27
78_N124_D1.0660.27
58_T77_M1.0650.27
114_A121_A1.0600.27
20_R103_N1.0580.27
36_I42_S1.0540.27
194_G231_S1.0430.27
80_L89_V1.0400.26
16_R27_L1.0310.26
87_E97_Y1.0250.26
84_S281_V1.0170.26
51_A146_V1.0170.26
20_R24_D1.0150.26
96_P124_D1.0130.25
121_A124_D1.0110.25
17_A102_E1.0110.25
85_P271_T1.0080.25
22_W131_N1.0050.25
72_L165_C1.0040.25
39_G235_A0.9970.25
22_W78_N0.9970.25
66_L129_I0.9960.25
169_I190_L0.9930.25
30_T39_G0.9930.25
28_D290_L0.9870.25
244_Q265_L0.9860.25
180_T186_V0.9840.24
63_N165_C0.9840.24
91_D104_D0.9830.24
85_P239_D0.9810.24
37_V176_V0.9770.24
42_S142_D0.9760.24
29_D58_T0.9680.24
281_V284_N0.9660.24
237_S277_L0.9660.24
56_D135_F0.9660.24
110_D231_S0.9620.24
101_E108_V0.9610.24
92_D149_A0.9560.24
50_L290_L0.9510.23
71_W152_N0.9500.23
139_V194_G0.9310.23
178_D252_L0.9250.22
146_V225_D0.9220.22
72_L271_T0.9190.22
71_W115_C0.9130.22
13_E28_D0.9120.22
285_A288_D0.9110.22
52_D92_D0.9090.22
16_R145_A0.9090.22
63_N270_P0.9050.22
241_V251_G0.9050.22
192_E239_D0.9050.22
117_A224_H0.9040.22
32_T58_T0.9040.22
79_K128_R0.9030.22
48_K124_D0.9010.22
179_A255_A0.9010.22
32_T243_E0.9000.22
177_V262_V0.8990.22
271_T274_A0.8850.21
45_M123_C0.8840.21
178_D184_A0.8750.21
26_F141_R0.8730.21
229_H261_T0.8680.21
64_N72_L0.8670.21
95_V170_A0.8660.21
48_K121_A0.8640.21
113_H123_C0.8610.20
62_K231_S0.8570.20
152_N232_M0.8550.20
58_T117_A0.8430.20
178_D187_V0.8420.20
146_V291_A0.8390.20
15_T149_A0.8350.20
81_T234_V0.8340.20
77_M95_V0.8340.20
29_D128_R0.8310.20
71_W232_M0.8280.20
239_D243_E0.8260.19
177_V255_A0.8240.19
78_N232_M0.8150.19
81_T106_L0.8110.19
123_C179_A0.8090.19
94_G121_A0.8010.19
63_N155_P0.7960.19
82_V177_V0.7960.19
10_N193_R0.7940.19
49_E92_D0.7940.19
35_I155_P0.7900.18
45_M119_I0.7900.18
11_E37_V0.7760.18
15_T92_D0.7750.18
62_K154_T0.7710.18
46_A281_V0.7630.18
96_P174_D0.7550.17
74_G140_V0.7540.17
31_E89_V0.7500.17
175_V282_A0.7490.17
237_S249_H0.7490.17
177_V282_A0.7450.17
85_P274_A0.7440.17
25_E110_D0.7430.17
101_E104_D0.7380.17
266_T290_L0.7380.17
246_G265_L0.7360.17
65_Y92_D0.7350.17
249_H260_A0.7350.17
61_E165_C0.7340.17
72_L75_F0.7320.17
39_G154_T0.7290.17
195_V230_D0.7280.17
21_Q32_T0.7280.17
11_E234_V0.7280.17
87_E91_D0.7270.17
187_V252_L0.7240.17
15_T26_F0.7230.17
91_D94_G0.7210.17
259_T282_A0.7210.17
70_F276_L0.7200.17
37_V237_S0.7190.17
83_R169_I0.7190.17
78_N224_H0.7140.16
82_V149_A0.7120.16
254_T274_A0.7070.16
95_V204_V0.7000.16
9_A103_N0.6990.16
35_I84_S0.6990.16
65_Y81_T0.6980.16
64_N70_F0.6970.16
62_K185_V0.6960.16
35_I60_I0.6960.16
78_N111_A0.6940.16
134_E248_V0.6920.16
15_T74_G0.6870.16
11_E262_V0.6860.16
241_V270_P0.6860.16
74_G141_R0.6860.16
44_L74_G0.6840.16
48_K92_D0.6820.16
56_D255_A0.6780.16
78_N131_N0.6770.15
44_L129_I0.6770.15
94_G255_A0.6750.15
47_A117_A0.6700.15
22_W48_K0.6700.15
35_I58_T0.6700.15
241_V281_V0.6680.15
101_E154_T0.6660.15
130_Q136_T0.6660.15
253_V285_A0.6650.15
11_E111_A0.6630.15
246_G259_T0.6620.15
28_D56_D0.6560.15
49_E57_V0.6550.15
117_A130_Q0.6540.15
243_E287_M0.6540.15
39_G70_F0.6500.15
83_R271_T0.6490.15
72_L229_H0.6460.15
254_T291_A0.6460.15
30_T241_V0.6450.15
21_Q79_K0.6430.15
187_V190_L0.6420.15
251_G286_V0.6410.15
70_F156_V0.6390.15
172_E243_E0.6390.15
132_M139_V0.6380.15
173_A248_V0.6370.15
60_I171_L0.6360.15
114_A276_L0.6350.14
26_F187_V0.6330.14
66_L115_C0.6320.14
63_N156_V0.6310.14
52_D120_T0.6280.14
182_H251_G0.6260.14
42_S187_V0.6250.14
26_F142_D0.6240.14
70_F164_T0.6220.14
59_I66_L0.6220.14
26_F180_T0.6220.14
246_G263_H0.6200.14
14_V149_A0.6190.14
17_A156_V0.6150.14
113_H169_I0.6120.14
42_S253_V0.6120.14
37_V180_T0.6120.14
255_A284_N0.6110.14
185_V282_A0.6090.14
42_S194_G0.6080.14
150_V232_M0.6060.14
31_E103_N0.6060.14
10_N111_A0.6060.14
32_T133_T0.6040.14
116_S124_D0.6040.14
18_I54_D0.6020.14
45_M179_A0.6020.14
37_V135_F0.5980.14
56_D174_D0.5970.14
145_A177_V0.5950.14
86_A236_D0.5940.14
28_D175_V0.5940.14
83_R165_C0.5930.14
94_G104_D0.5920.14
101_E171_L0.5880.13
154_T179_A0.5880.13
48_K153_W0.5870.13
181_G251_G0.5840.13
106_L115_C0.5830.13
254_T258_S0.5830.13
146_V281_V0.5810.13
175_V287_M0.5810.13
81_T229_H0.5800.13
78_N115_C0.5780.13
35_I85_P0.5780.13
65_Y164_T0.5770.13
45_M122_A0.5750.13
189_K194_G0.5750.13
97_Y153_W0.5700.13
75_F169_I0.5700.13
42_S226_S0.5670.13
138_I190_L0.5670.13
52_D281_V0.5660.13
93_L121_A0.5650.13
189_K195_V0.5640.13
171_L291_A0.5630.13
81_T136_T0.5630.13
31_E281_V0.5630.13
35_I165_C0.5630.13
259_T266_T0.5620.13
16_R56_D0.5610.13
93_L153_W0.5600.13
25_E241_V0.5600.13
8_D20_R0.5600.13
145_A286_V0.5590.13
11_E204_V0.5550.13
237_S241_V0.5530.13
15_T30_T0.5530.13
104_D291_A0.5520.13
89_V276_L0.5520.13
41_P258_S0.5510.13
46_A141_R0.5510.13
26_F131_N0.5490.13
271_T288_D0.5470.13
236_D255_A0.5460.13
152_N264_G0.5430.13
133_T234_V0.5430.13
95_V235_A0.5410.12
116_S266_T0.5410.12
47_A94_G0.5410.12
237_S265_L0.5390.12
106_L109_A0.5390.12
62_K97_Y0.5380.12
19_T23_T0.5380.12
45_M177_V0.5360.12
26_F153_W0.5360.12
124_D265_L0.5330.12
178_D241_V0.5320.12
237_S257_L0.5290.12
62_K141_R0.5260.12
106_L237_S0.5240.12
60_I133_T0.5240.12
52_D236_D0.5220.12
75_F229_H0.5210.12
45_M263_H0.5170.12
178_D265_L0.5160.12
121_A158_S0.5150.12
139_V172_E0.5150.12
48_K74_G0.5140.12
80_L95_V0.5120.12
120_T130_Q0.5110.12
27_L154_T0.5090.12
165_C271_T0.5070.12
122_A125_A0.5050.12
281_V285_A0.5040.12
172_E280_K0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fpzA 6 0.8581 100 0.693 Contact Map
3jskA 6 0.8806 100 0.701 Contact Map
1rp0A 5 0.8839 100 0.725 Contact Map
2bs2A 2 0.8742 99.8 0.858 Contact Map
2culA 1 0.6742 99.8 0.858 Contact Map
1kf6A 1 0.8677 99.8 0.859 Contact Map
4at0A 2 0.8387 99.8 0.859 Contact Map
1qo8A 2 0.9065 99.7 0.861 Contact Map
2wdqA 1 0.8839 99.7 0.861 Contact Map
2h88A 2 0.8871 99.7 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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