GREMLIN Database
Q9HMC6 - Hydroxymethylpyrimidine phosphate kinase
UniProt: Q9HMC6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (381)
Sequences: 476 (374)
Seq/√Len: 19.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_L33_G7.1661.00
26_F216_A5.2261.00
31_A216_A4.9051.00
11_S41_T4.3691.00
36_A63_I4.3391.00
26_F31_A4.0821.00
77_T102_V3.8181.00
86_V123_V3.4011.00
11_S37_I3.3451.00
133_L171_L3.3071.00
52_D55_A3.2881.00
39_A53_I3.2751.00
45_T246_G3.1320.99
345_A349_D3.0910.99
151_D154_D3.0800.99
108_S112_D3.0460.99
77_T100_V2.9070.99
50_H61_A2.8360.99
5_A26_F2.6860.98
142_E149_I2.6660.98
40_V54_L2.6270.98
133_L224_L2.5980.98
14_G41_T2.5350.97
101_T218_L2.5110.97
40_V58_T2.4880.97
94_A130_R2.4480.97
223_A226_P2.3820.96
15_G21_A2.3100.95
7_T35_S2.2950.95
26_F33_G2.2760.95
115_L119_G2.2290.94
214_I228_V2.1360.93
163_C170_T2.1030.92
377_R381_P2.0990.92
45_T248_G2.0840.92
49_T65_A2.0430.91
376_D379_T2.0260.90
102_V131_A1.9850.89
171_L210_L1.9470.89
20_Q35_S1.9420.88
156_R190_T1.9360.88
283_W287_L1.9180.88
75_V212_A1.8830.87
29_G217_R1.8700.86
46_H247_G1.8490.86
232_I236_A1.8410.86
291_V298_A1.8390.85
203_T239_I1.8380.85
87_D126_E1.8180.85
186_A190_T1.8120.85
375_V378_T1.7980.84
159_A239_I1.7870.84
79_M114_L1.7850.84
171_L193_F1.7750.83
60_R91_T1.7460.82
11_S20_Q1.7380.82
13_S41_T1.7120.81
11_S14_G1.6970.80
371_D375_V1.6960.80
193_F228_V1.6770.80
19_I23_L1.6690.79
283_W291_V1.6370.78
290_E295_V1.6130.77
128_L162_V1.6120.77
289_P292_G1.5930.76
37_I41_T1.5870.76
291_V295_V1.5840.75
169_A224_L1.5830.75
48_V208_C1.5680.75
290_E294_N1.5670.75
195_R236_A1.5500.74
7_T26_F1.5490.74
67_T72_V1.5460.74
142_E158_A1.5370.73
75_V100_V1.5330.73
5_A31_A1.5320.73
7_T23_L1.5290.73
200_T250_G1.5280.73
39_A107_V1.5270.73
99_P132_T1.5250.73
253_D259_A1.5020.71
137_N140_E1.4700.70
41_T70_F1.4560.69
150_T154_D1.4440.68
350_V353_A1.4340.68
44_N211_S1.4330.68
349_D357_R1.4170.67
287_L290_E1.4060.66
335_H338_R1.3990.66
372_T376_D1.3970.66
290_E298_A1.3790.65
8_I89_V1.3660.64
4_V73_S1.3440.63
290_E296_A1.3440.63
10_G17_A1.3280.62
291_V296_A1.3210.61
218_L221_G1.3140.61
63_I92_A1.3110.61
202_T249_D1.3110.61
290_E293_M1.2900.59
60_R88_A1.2850.59
36_A62_Q1.2840.59
12_D17_A1.2750.58
100_V146_D1.2680.58
124_R144_L1.2680.58
145_A162_V1.2680.58
276_V279_L1.2670.58
64_D92_A1.2620.58
185_F193_F1.2580.57
9_A23_L1.2560.57
283_W289_P1.2530.57
286_A289_P1.2530.57
147_T161_A1.2510.57
133_L214_I1.2510.57
10_G16_G1.2510.57
171_L253_D1.2450.57
12_D16_G1.2360.56
49_T68_T1.2310.56
12_D22_D1.2150.55
203_T250_G1.2130.55
8_I38_T1.2070.54
271_A279_L1.2030.54
94_A148_E1.2030.54
372_T379_T1.1950.53
376_D381_P1.1940.53
202_T250_G1.1860.53
138_I149_I1.1600.51
218_L224_L1.1600.51
4_V34_T1.1590.51
149_I158_A1.1580.51
315_L379_T1.1490.50
350_V354_T1.1480.50
9_A17_A1.1360.50
39_A81_G1.1280.49
113_R143_L1.1270.49
19_I33_G1.1200.49
16_G22_D1.1140.48
62_Q115_L1.1080.48
59_V88_A1.1050.48
100_V212_A1.1030.48
347_D350_V1.1030.48
287_L293_M1.1020.47
160_E247_G1.1010.47
5_A219_A1.0930.47
243_L252_V1.0750.46
355_N358_W1.0720.46
295_V298_A1.0620.45
349_D352_A1.0610.45
19_I37_I1.0590.45
64_D162_V1.0540.44
310_A332_A1.0530.44
237_A257_A1.0510.44
305_P312_D1.0510.44
335_H339_F1.0500.44
20_Q211_S1.0490.44
84_A132_T1.0460.44
51_S133_L1.0460.44
217_R222_D1.0460.44
375_V379_T1.0370.43
101_T133_L1.0350.43
120_I329_E1.0300.43
99_P169_A1.0250.43
372_T381_P1.0230.43
293_M296_A1.0230.43
4_V70_F1.0210.42
45_T69_D1.0200.42
372_T378_T1.0160.42
291_V294_N1.0140.42
162_V171_L1.0090.42
20_Q36_A1.0090.42
315_L319_T1.0090.42
152_E156_R1.0080.42
9_A176_H1.0070.42
35_S279_L1.0040.41
55_A145_A1.0000.41
292_G298_A0.9990.41
227_A303_T0.9980.41
48_V80_L0.9940.41
10_G18_G0.9840.40
18_G22_D0.9840.40
10_G22_D0.9810.40
56_P88_A0.9810.40
171_L185_F0.9740.40
144_L172_L0.9710.39
13_S141_A0.9710.39
299_P345_A0.9670.39
24_K234_A0.9620.39
29_G230_R0.9620.39
9_A16_G0.9590.39
113_R245_V0.9580.39
128_L163_C0.9550.38
29_G214_I0.9550.38
120_I167_P0.9530.38
311_V315_L0.9530.38
69_D246_G0.9530.38
162_V170_T0.9440.38
305_P319_T0.9380.37
185_F228_V0.9370.37
289_P294_N0.9350.37
88_A91_T0.9350.37
184_V221_G0.9320.37
322_V326_G0.9310.37
276_V280_E0.9290.37
90_A129_P0.9280.37
136_P140_E0.9270.37
289_P296_A0.9250.37
107_V254_H0.9250.37
212_A275_V0.9190.36
275_V279_L0.9190.36
57_E178_D0.9180.36
20_Q62_Q0.9180.36
293_M298_A0.9170.36
69_D248_G0.9150.36
228_V231_G0.9120.36
294_N297_V0.9110.36
153_T199_E0.9110.36
75_V98_A0.9100.36
300_P305_P0.9080.36
26_F131_A0.9050.35
156_R192_A0.9030.35
20_Q23_L0.9020.35
141_A168_D0.8980.35
377_R380_E0.8970.35
311_V316_H0.8970.35
14_G70_F0.8960.35
4_V71_D0.8910.35
331_G340_L0.8880.34
287_L291_V0.8870.34
171_L228_V0.8840.34
162_V220_H0.8840.34
130_R361_A0.8820.34
52_D213_A0.8800.34
24_K44_N0.8790.34
378_T381_P0.8780.34
6_L34_T0.8770.34
62_Q66_V0.8730.34
309_V330_P0.8730.34
47_G291_V0.8680.33
173_T250_G0.8660.33
345_A348_A0.8590.33
17_A137_N0.8520.32
168_D188_D0.8490.32
3_P267_A0.8490.32
28_A324_A0.8460.32
7_T37_I0.8450.32
356_V360_A0.8450.32
87_D127_L0.8380.32
114_L246_G0.8330.31
93_L97_P0.8280.31
227_A232_I0.8240.31
166_G304_T0.8220.31
33_G299_P0.8210.31
312_D319_T0.8200.31
374_S378_T0.8180.31
8_I121_A0.8170.30
283_W286_A0.8150.30
21_A48_V0.8110.30
378_T382_A0.8100.30
12_D18_G0.8050.30
15_G48_V0.8040.30
140_E206_S0.8030.30
34_T89_V0.8020.30
108_S353_A0.8010.30
48_V110_S0.8010.30
153_T156_R0.8000.30
362_R365_A0.7970.29
109_Q254_H0.7970.29
23_L35_S0.7960.29
104_P136_P0.7920.29
81_G106_V0.7920.29
77_T252_V0.7870.29
237_A260_T0.7870.29
374_S380_E0.7860.29
348_A352_A0.7860.29
133_L258_T0.7830.29
17_A22_D0.7820.29
346_H355_N0.7810.29
73_S209_T0.7790.28
370_W374_S0.7790.28
74_A99_P0.7740.28
133_L138_I0.7730.28
131_A134_A0.7710.28
133_L228_V0.7690.28
75_V133_L0.7660.28
316_H319_T0.7650.28
100_V149_I0.7640.28
41_T50_H0.7640.28
354_T358_W0.7640.28
296_A310_A0.7630.28
9_A208_C0.7630.28
44_N248_G0.7620.28
59_V172_L0.7620.28
305_P308_V0.7620.28
354_T357_R0.7610.28
284_P288_V0.7600.28
292_G296_A0.7580.27
110_S251_P0.7580.27
84_A189_T0.7580.27
5_A225_R0.7570.27
173_T206_S0.7550.27
67_T92_A0.7540.27
37_I253_D0.7530.27
197_R235_V0.7530.27
128_L167_P0.7520.27
7_T19_I0.7510.27
22_D76_K0.7510.27
17_A48_V0.7500.27
204_H207_G0.7500.27
168_D172_L0.7480.27
134_A323_R0.7480.27
28_A159_A0.7430.27
292_G295_V0.7410.27
42_A58_T0.7390.26
286_A291_V0.7390.26
111_G140_E0.7380.26
126_E150_T0.7380.26
9_A206_S0.7320.26
44_N246_G0.7320.26
113_R120_I0.7320.26
106_V143_L0.7300.26
32_F254_H0.7300.26
288_V293_M0.7290.26
91_T212_A0.7270.26
177_L214_I0.7240.26
376_D380_E0.7240.26
36_A89_V0.7220.26
72_V77_T0.7210.26
44_N69_D0.7190.25
28_A311_V0.7190.25
57_E180_D0.7190.25
105_V251_P0.7160.25
8_I12_D0.7150.25
239_I249_D0.7150.25
9_A107_V0.7130.25
123_V128_L0.7040.25
358_W361_A0.7030.25
221_G253_D0.7020.25
195_R232_I0.7020.25
287_L295_V0.7010.25
379_T383_D0.6990.25
138_I177_L0.6990.25
86_V214_I0.6990.25
103_D136_P0.6980.24
159_A172_L0.6980.24
381_P386_G0.6980.24
83_A118_S0.6960.24
35_S67_T0.6960.24
14_G25_T0.6910.24
53_I81_G0.6880.24
101_T134_A0.6880.24
287_L296_A0.6860.24
286_A292_G0.6860.24
291_V330_P0.6820.24
157_A161_A0.6810.24
56_P327_G0.6810.24
7_T33_G0.6790.24
20_Q127_L0.6790.24
339_F375_V0.6790.24
300_P315_L0.6770.24
33_G212_A0.6770.24
283_W296_A0.6750.23
300_P316_H0.6750.23
333_S336_I0.6730.23
108_S309_V0.6720.23
45_T203_T0.6700.23
82_D236_A0.6680.23
105_V174_G0.6680.23
137_N208_C0.6680.23
87_D122_A0.6660.23
305_P311_V0.6650.23
308_V319_T0.6650.23
33_G332_A0.6650.23
299_P303_T0.6650.23
106_V119_G0.6650.23
173_T210_L0.6640.23
163_C186_A0.6620.23
111_G114_L0.6600.23
218_L233_D0.6600.23
113_R122_A0.6580.23
164_E247_G0.6580.23
52_D58_T0.6570.23
232_I276_V0.6560.23
66_V144_L0.6550.23
230_R233_D0.6520.22
212_A215_T0.6520.22
350_V358_W0.6500.22
353_A356_V0.6490.22
116_T211_S0.6480.22
51_S181_P0.6470.22
116_T160_E0.6460.22
75_V81_G0.6460.22
162_V255_R0.6450.22
42_A69_D0.6450.22
6_L185_F0.6430.22
171_L214_I0.6430.22
35_S39_A0.6410.22
109_Q171_L0.6410.22
289_P293_M0.6390.22
16_G43_Q0.6380.22
145_A258_T0.6380.22
19_I99_P0.6360.22
7_T209_T0.6360.22
142_E148_E0.6340.22
9_A137_N0.6320.22
69_D79_M0.6320.22
63_I93_L0.6310.21
311_V319_T0.6300.21
13_S42_A0.6270.21
68_T120_I0.6250.21
41_T141_A0.6230.21
72_V102_V0.6230.21
19_I231_G0.6230.21
11_S70_F0.6200.21
32_F320_R0.6190.21
15_G80_L0.6180.21
374_S383_D0.6160.21
56_P59_V0.6150.21
16_G79_M0.6150.21
88_A279_L0.6140.21
27_E32_F0.6140.21
308_V311_V0.6130.21
27_E255_R0.6130.21
209_T251_P0.6120.21
66_V72_V0.6120.21
59_V129_P0.6100.21
26_F327_G0.6100.21
198_I238_A0.6100.21
381_P384_A0.6090.21
144_L163_C0.6070.20
102_V116_T0.6060.20
162_V190_T0.6050.20
372_T375_V0.6050.20
206_S312_D0.6050.20
37_I269_I0.6030.20
21_A25_T0.6030.20
226_P229_E0.6030.20
308_V316_H0.6020.20
300_P311_V0.6000.20
345_A352_A0.5990.20
95_E214_I0.5980.20
315_L376_D0.5970.20
14_G50_H0.5960.20
291_V308_V0.5940.20
231_G242_D0.5930.20
4_V119_G0.5920.20
111_G170_T0.5920.20
275_V278_M0.5920.20
11_S19_I0.5910.20
167_P170_T0.5900.20
289_P313_G0.5880.20
103_D135_T0.5880.20
334_S338_R0.5870.20
289_P298_A0.5850.20
203_T251_P0.5840.20
283_W290_E0.5840.20
7_T20_Q0.5840.20
69_D114_L0.5840.20
72_V161_A0.5830.19
271_A276_V0.5820.19
150_T199_E0.5820.19
335_H355_N0.5790.19
123_V251_P0.5770.19
24_K45_T0.5770.19
250_G254_H0.5770.19
349_D375_V0.5760.19
29_G213_A0.5760.19
115_L246_G0.5760.19
82_D116_T0.5710.19
151_D334_S0.5690.19
5_A98_A0.5680.19
339_F342_G0.5670.19
213_A231_G0.5660.19
25_T213_A0.5660.19
102_V159_A0.5660.19
126_E157_A0.5630.19
48_V112_D0.5630.19
110_S176_H0.5620.19
42_A214_I0.5610.19
137_N206_S0.5610.19
136_P173_T0.5610.19
340_L350_V0.5600.19
12_D15_G0.5590.19
9_A106_V0.5590.19
68_T238_A0.5580.19
369_R374_S0.5570.18
82_D351_T0.5560.18
308_V320_R0.5560.18
7_T310_A0.5550.18
357_R381_P0.5540.18
28_A213_A0.5530.18
138_I376_D0.5530.18
115_L248_G0.5520.18
52_D216_A0.5520.18
339_F343_V0.5510.18
60_R87_D0.5510.18
150_T370_W0.5490.18
274_D280_E0.5490.18
238_A340_L0.5480.18
11_S234_A0.5470.18
109_Q210_L0.5470.18
305_P316_H0.5450.18
39_A51_S0.5450.18
94_A118_S0.5440.18
91_T317_A0.5440.18
136_P248_G0.5440.18
26_F215_T0.5430.18
70_F123_V0.5430.18
294_N335_H0.5420.18
26_F240_D0.5400.18
35_S163_C0.5390.18
64_D193_F0.5390.18
191_S229_E0.5390.18
154_D253_D0.5370.18
308_V315_L0.5370.18
6_L75_V0.5360.18
157_A164_E0.5360.18
27_E218_L0.5350.18
106_V128_L0.5350.18
378_T383_D0.5350.18
108_S120_I0.5340.18
47_G246_G0.5340.18
184_V301_A0.5340.18
56_P193_F0.5330.18
181_P194_T0.5330.18
280_E307_D0.5320.18
222_D233_D0.5320.18
38_T46_H0.5290.17
248_G251_P0.5250.17
203_T345_A0.5250.17
268_G271_A0.5240.17
74_A215_T0.5240.17
37_I183_D0.5240.17
206_S311_V0.5220.17
347_D354_T0.5200.17
326_G332_A0.5200.17
121_A172_L0.5190.17
10_G38_T0.5190.17
59_V80_L0.5180.17
346_H349_D0.5170.17
42_A45_T0.5170.17
17_A140_E0.5170.17
14_G66_V0.5160.17
105_V135_T0.5160.17
369_R381_P0.5160.17
176_H206_S0.5150.17
80_L89_V0.5150.17
81_G99_P0.5150.17
43_Q204_H0.5130.17
372_T380_E0.5120.17
263_T271_A0.5110.17
70_F73_S0.5110.17
29_G279_L0.5110.17
145_A221_G0.5100.17
312_D328_I0.5100.17
161_A186_A0.5100.17
74_A197_R0.5090.17
375_V386_G0.5090.17
77_T221_G0.5060.17
109_Q249_D0.5060.17
152_E184_V0.5060.17
5_A73_S0.5040.17
148_E226_P0.5040.17
5_A324_A0.5040.17
127_L231_G0.5040.17
289_P315_L0.5030.17
212_A326_G0.5030.17
347_D351_T0.5020.16
183_D232_I0.5020.16
163_C169_A0.5020.16
380_E386_G0.5010.16
75_V215_T0.5010.16
8_I359_S0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rm5A 2 0.9708 100 0.538 Contact Map
2i5bA 2 0.591 100 0.637 Contact Map
1ub0A 2 0.5461 100 0.664 Contact Map
4yl5A 2 0.4989 100 0.675 Contact Map
1jxhA 2 0.5416 100 0.679 Contact Map
4c5kA 2 0.6045 100 0.681 Contact Map
3h74A 2 0.6045 100 0.681 Contact Map
3mbhA 5 0.609 100 0.691 Contact Map
2ddmA 2 0.5685 100 0.698 Contact Map
4jjpA 2 0.5146 100 0.706 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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