Q9HMC5 - HALSA - GREMLIN Contacts

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Q9HMC5 - Uncharacterized protein

UniProt:	Q9HMC5	Sequences: MRIALLGGTGDIGAGLALRWATDSDHDIVIGSRDPEKARETAAAYEDTLADQGVDRKLTGFANEMAADRADVVVVAVPAYHVTDVMGAVADRLDADTLVISPAVGIASGEHGLHYNPPSAGSVTALVADAAPDGVDVVGAFHNLAADRLADLDTELDADTLVVGNDEGARTRVAELADDITGLRALDAGPVENAAEVESLTPLLINLARYNDDLRDVGVTFE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	222 (193)
Sequences:	2370 (1550)
Seq/√Len:	111.6

HALSA - Q9HMC5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
170_R	187_D	6.365	1.00
162_V	174_A	3.485	1.00
17_A	30_I	3.357	1.00
26_H	179_D	3.327	1.00
2_R	27_D	3.281	1.00
62_A	65_M	3.145	1.00
100_I	173_V	3.134	1.00
121_G	129_D	2.993	1.00
124_T	191_V	2.749	1.00
141_F	177_A	2.319	1.00
136_D	166_D	2.296	1.00
29_V	61_F	2.266	1.00
175_E	179_D	2.248	1.00
20_W	74_V	2.195	1.00
125_A	192_E	2.133	1.00
164_G	170_R	2.076	1.00
99_V	131_A	2.051	1.00
100_I	140_A	2.035	1.00
12_I	102_P	2.020	1.00
29_V	69_R	1.994	1.00
76_A	102_P	1.921	1.00
94_D	133_D	1.903	1.00
42_A	60_G	1.896	1.00
18_L	44_A	1.869	1.00
78_P	81_H	1.846	1.00
16_L	20_W	1.845	1.00
98_L	172_R	1.838	1.00
20_W	176_L	1.793	1.00
39_R	43_A	1.786	1.00
166_D	169_A	1.677	1.00
178_D	185_A	1.670	1.00
34_D	37_K	1.663	1.00
162_V	177_A	1.630	1.00
74_V	100_I	1.627	1.00
9_T	32_S	1.623	1.00
174_A	185_A	1.622	1.00
4_A	61_F	1.596	1.00
26_H	176_L	1.576	1.00
72_V	172_R	1.576	1.00
122_S	125_A	1.561	1.00
171_T	175_E	1.559	1.00
138_V	164_G	1.495	1.00
66_A	73_V	1.464	1.00
104_V	142_H	1.462	1.00
159_D	184_R	1.453	1.00
4_A	70_A	1.441	1.00
138_V	169_A	1.438	1.00
31_G	63_N	1.433	1.00
3_I	26_H	1.401	1.00
61_F	65_M	1.375	1.00
11_D	146_A	1.351	1.00
99_V	134_G	1.347	1.00
163_V	197_V	1.347	1.00
29_V	70_A	1.332	1.00
106_I	204_L	1.325	1.00
72_V	173_V	1.317	1.00
12_I	149_L	1.314	1.00
4_A	66_A	1.285	0.99
16_L	74_V	1.265	0.99
21_A	58_L	1.265	0.99
83_T	130_A	1.264	0.99
131_A	134_G	1.263	0.99
143_N	161_L	1.234	0.99
140_A	177_A	1.230	0.99
72_V	98_L	1.229	0.99
98_L	136_D	1.226	0.99
75_V	127_V	1.222	0.99
27_D	57_K	1.221	0.99
172_R	175_E	1.219	0.99
27_D	59_T	1.210	0.99
125_A	195_A	1.202	0.99
61_F	69_R	1.179	0.99
98_L	169_A	1.171	0.99
40_E	44_A	1.161	0.99
157_D	178_D	1.157	0.99
46_E	58_L	1.140	0.99
19_R	22_T	1.124	0.98
126_L	129_D	1.109	0.98
121_G	126_L	1.103	0.98
190_P	193_N	1.100	0.98
139_G	142_H	1.096	0.98
127_V	137_V	1.092	0.98
144_L	148_R	1.086	0.98
82_V	103_A	1.079	0.98
165_N	190_P	1.076	0.98
122_S	198_E	1.073	0.98
40_E	43_A	1.073	0.98
96_D	133_D	1.071	0.98
41_T	44_A	1.068	0.98
5_L	13_G	1.062	0.98
64_E	68_D	1.055	0.98
104_V	139_G	1.047	0.98
14_A	18_L	1.027	0.97
79_A	123_V	1.002	0.97
165_N	192_E	1.001	0.97
140_A	162_V	0.997	0.97
105_G	123_V	0.986	0.96
175_E	178_D	0.985	0.96
167_E	171_T	0.984	0.96
176_L	180_I	0.972	0.96
145_A	204_L	0.968	0.96
66_A	70_A	0.962	0.96
157_D	184_R	0.961	0.96
77_V	82_V	0.959	0.96
6_L	63_N	0.956	0.96
7_G	10_G	0.953	0.96
98_L	173_V	0.945	0.95
125_A	128_A	0.945	0.95
82_V	127_V	0.936	0.95
136_D	172_R	0.928	0.95
109_G	112_G	0.915	0.95
188_A	197_V	0.914	0.95
115_Y	118_P	0.905	0.94
77_V	85_V	0.904	0.94
5_L	16_L	0.887	0.94
26_H	172_R	0.886	0.94
29_V	59_T	0.883	0.93
15_G	150_A	0.874	0.93
21_A	28_I	0.869	0.93
168_G	171_T	0.864	0.93
138_V	173_V	0.864	0.93
164_G	189_G	0.864	0.93
101_S	139_G	0.863	0.93
103_A	127_V	0.860	0.93
67_A	89_V	0.849	0.92
126_L	130_A	0.846	0.92
18_L	22_T	0.838	0.92
15_G	149_L	0.830	0.91
134_G	137_V	0.829	0.91
91_D	94_D	0.829	0.91
74_V	102_P	0.828	0.91
2_R	69_R	0.827	0.91
82_V	130_A	0.819	0.91
178_D	184_R	0.811	0.90
73_V	93_L	0.797	0.89
2_R	26_H	0.796	0.89
143_N	160_T	0.793	0.89
141_F	180_I	0.792	0.89
148_R	207_L	0.791	0.89
161_L	188_A	0.788	0.89
136_D	168_G	0.786	0.89
15_G	146_A	0.786	0.89
79_A	105_G	0.783	0.89
103_A	123_V	0.783	0.89
127_V	132_P	0.782	0.89
68_D	92_R	0.780	0.88
106_I	205_I	0.776	0.88
107_A	111_H	0.775	0.88
2_R	29_V	0.774	0.88
128_A	191_V	0.772	0.88
69_R	97_T	0.766	0.87
168_G	172_R	0.762	0.87
21_A	45_Y	0.762	0.87
145_A	205_I	0.758	0.87
20_W	179_D	0.754	0.87
31_G	66_A	0.753	0.87
84_D	87_G	0.749	0.86
3_I	72_V	0.748	0.86
14_A	41_T	0.746	0.86
78_P	85_V	0.744	0.86
6_L	67_A	0.737	0.85
186_L	210_Y	0.735	0.85
117_P	120_A	0.734	0.85
75_V	78_P	0.733	0.85
164_G	187_D	0.732	0.85
143_N	205_I	0.730	0.85
85_V	92_R	0.726	0.85
3_I	20_W	0.724	0.84
174_A	178_D	0.719	0.84
125_A	129_D	0.717	0.84
64_E	91_D	0.713	0.83
144_L	160_T	0.708	0.83
38_A	42_A	0.706	0.83
151_D	154_T	0.702	0.83
200_L	205_I	0.697	0.82
19_R	180_I	0.696	0.82
125_A	190_P	0.694	0.82
163_V	188_A	0.693	0.82
30_I	41_T	0.691	0.82
67_A	70_A	0.690	0.81
87_G	92_R	0.689	0.81
193_N	196_E	0.688	0.81
70_A	97_T	0.685	0.81
177_A	185_A	0.685	0.81
5_L	17_A	0.684	0.81
139_G	198_E	0.684	0.81
36_E	39_R	0.683	0.81
4_A	69_R	0.680	0.80
75_V	103_A	0.676	0.80
144_L	158_A	0.674	0.80
64_E	88_A	0.672	0.80
165_N	191_V	0.670	0.80
14_A	44_A	0.664	0.79
59_T	69_R	0.664	0.79
85_V	89_V	0.661	0.79
93_L	97_T	0.658	0.78
125_A	165_N	0.654	0.78
65_M	68_D	0.648	0.77
138_V	170_R	0.639	0.76
205_I	208_A	0.639	0.76
64_E	92_R	0.634	0.76
12_I	146_A	0.628	0.75
4_A	67_A	0.627	0.75
72_V	100_I	0.626	0.75
17_A	58_L	0.626	0.75
72_V	176_L	0.624	0.75
29_V	66_A	0.623	0.74
152_L	158_A	0.622	0.74
4_A	29_V	0.622	0.74
12_I	106_I	0.621	0.74
32_S	38_A	0.621	0.74
83_T	171_T	0.617	0.74
107_A	110_E	0.608	0.73
5_L	31_G	0.604	0.72
9_T	30_I	0.601	0.72
99_V	157_D	0.598	0.71
25_D	101_S	0.597	0.71
118_P	121_G	0.596	0.71
170_R	177_A	0.595	0.71
32_S	37_K	0.595	0.71
18_L	150_A	0.592	0.71
20_W	180_I	0.590	0.70
124_T	139_G	0.588	0.70
42_A	45_Y	0.588	0.70
139_G	163_V	0.588	0.70
33_R	37_K	0.584	0.70
81_H	103_A	0.581	0.69
29_V	65_M	0.572	0.68
67_A	93_L	0.568	0.67
76_A	112_G	0.568	0.67
108_S	111_H	0.567	0.67
35_P	39_R	0.565	0.67
139_G	197_V	0.565	0.67
65_M	69_R	0.565	0.67
30_I	45_Y	0.562	0.67
11_D	81_H	0.560	0.66
143_N	201_T	0.558	0.66
99_V	137_V	0.558	0.66
138_V	187_D	0.556	0.66
24_S	180_I	0.551	0.65
160_T	177_A	0.549	0.65
81_H	84_D	0.549	0.65
122_S	194_A	0.547	0.65
179_D	190_P	0.545	0.64
19_R	204_L	0.543	0.64
118_P	199_S	0.543	0.64
170_R	189_G	0.542	0.64
46_E	56_R	0.538	0.63
27_D	69_R	0.538	0.63
73_V	97_T	0.538	0.63
9_T	31_G	0.538	0.63
59_T	175_E	0.537	0.63
2_R	176_L	0.535	0.63
72_V	179_D	0.534	0.63
45_Y	57_K	0.534	0.63
59_T	65_M	0.532	0.62
61_F	66_A	0.531	0.62
93_L	198_E	0.528	0.62
106_I	146_A	0.527	0.62
161_L	184_R	0.527	0.62
145_A	148_R	0.527	0.62
163_V	189_G	0.521	0.61
34_D	38_A	0.520	0.61
170_R	174_A	0.520	0.61
5_L	76_A	0.519	0.61
17_A	151_D	0.519	0.61
142_H	163_V	0.519	0.61
69_R	72_V	0.519	0.61
16_L	141_F	0.518	0.60
116_N	121_G	0.516	0.60
75_V	99_V	0.514	0.60
86_M	90_A	0.513	0.60
152_L	207_L	0.512	0.60
167_E	170_R	0.512	0.60
86_M	122_S	0.510	0.59
136_D	169_A	0.509	0.59
198_E	203_L	0.508	0.59
131_A	137_V	0.508	0.59
123_V	199_S	0.508	0.59
20_W	141_F	0.508	0.59
16_L	102_P	0.507	0.59
116_N	126_L	0.506	0.59
108_S	112_G	0.506	0.59
79_A	126_L	0.506	0.59
36_E	42_A	0.504	0.58
9_T	38_A	0.503	0.58
139_G	194_A	0.502	0.58
105_G	122_S	0.502	0.58
198_E	201_T	0.501	0.58
162_V	197_V	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jayA	2	0.955	100	0.538	Contact Map
2rafA	2	0.8423	100	0.566	Contact Map
3dttA	2	0.9505	100	0.566	Contact Map
2vnsA	2	0.8108	100	0.57	Contact Map
2yjzA	1	0.7793	99.9	0.595	Contact Map
4hujA	2	0.8694	99.9	0.608	Contact Map
4ol9A	2	0.8874	99.8	0.684	Contact Map
2zydA	2	0.8514	99.8	0.69	Contact Map
3k96A	2	0.9144	99.8	0.691	Contact Map
3i83A	2	0.9009	99.8	0.695	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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