GREMLIN Database
Q9HMC5 - Uncharacterized protein
UniProt: Q9HMC5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (193)
Sequences: 2370 (1550)
Seq/√Len: 111.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_R187_D6.3651.00
162_V174_A3.4851.00
17_A30_I3.3571.00
26_H179_D3.3271.00
2_R27_D3.2811.00
62_A65_M3.1451.00
100_I173_V3.1341.00
121_G129_D2.9931.00
124_T191_V2.7491.00
141_F177_A2.3191.00
136_D166_D2.2961.00
29_V61_F2.2661.00
175_E179_D2.2481.00
20_W74_V2.1951.00
125_A192_E2.1331.00
164_G170_R2.0761.00
99_V131_A2.0511.00
100_I140_A2.0351.00
12_I102_P2.0201.00
29_V69_R1.9941.00
76_A102_P1.9211.00
94_D133_D1.9031.00
42_A60_G1.8961.00
18_L44_A1.8691.00
78_P81_H1.8461.00
16_L20_W1.8451.00
98_L172_R1.8381.00
20_W176_L1.7931.00
39_R43_A1.7861.00
166_D169_A1.6771.00
178_D185_A1.6701.00
34_D37_K1.6631.00
162_V177_A1.6301.00
74_V100_I1.6271.00
9_T32_S1.6231.00
174_A185_A1.6221.00
4_A61_F1.5961.00
26_H176_L1.5761.00
72_V172_R1.5761.00
122_S125_A1.5611.00
171_T175_E1.5591.00
138_V164_G1.4951.00
66_A73_V1.4641.00
104_V142_H1.4621.00
159_D184_R1.4531.00
4_A70_A1.4411.00
138_V169_A1.4381.00
31_G63_N1.4331.00
3_I26_H1.4011.00
61_F65_M1.3751.00
11_D146_A1.3511.00
99_V134_G1.3471.00
163_V197_V1.3471.00
29_V70_A1.3321.00
106_I204_L1.3251.00
72_V173_V1.3171.00
12_I149_L1.3141.00
4_A66_A1.2850.99
16_L74_V1.2650.99
21_A58_L1.2650.99
83_T130_A1.2640.99
131_A134_G1.2630.99
143_N161_L1.2340.99
140_A177_A1.2300.99
72_V98_L1.2290.99
98_L136_D1.2260.99
75_V127_V1.2220.99
27_D57_K1.2210.99
172_R175_E1.2190.99
27_D59_T1.2100.99
125_A195_A1.2020.99
61_F69_R1.1790.99
98_L169_A1.1710.99
40_E44_A1.1610.99
157_D178_D1.1570.99
46_E58_L1.1400.99
19_R22_T1.1240.98
126_L129_D1.1090.98
121_G126_L1.1030.98
190_P193_N1.1000.98
139_G142_H1.0960.98
127_V137_V1.0920.98
144_L148_R1.0860.98
82_V103_A1.0790.98
165_N190_P1.0760.98
122_S198_E1.0730.98
40_E43_A1.0730.98
96_D133_D1.0710.98
41_T44_A1.0680.98
5_L13_G1.0620.98
64_E68_D1.0550.98
104_V139_G1.0470.98
14_A18_L1.0270.97
79_A123_V1.0020.97
165_N192_E1.0010.97
140_A162_V0.9970.97
105_G123_V0.9860.96
175_E178_D0.9850.96
167_E171_T0.9840.96
176_L180_I0.9720.96
145_A204_L0.9680.96
66_A70_A0.9620.96
157_D184_R0.9610.96
77_V82_V0.9590.96
6_L63_N0.9560.96
7_G10_G0.9530.96
98_L173_V0.9450.95
125_A128_A0.9450.95
82_V127_V0.9360.95
136_D172_R0.9280.95
109_G112_G0.9150.95
188_A197_V0.9140.95
115_Y118_P0.9050.94
77_V85_V0.9040.94
5_L16_L0.8870.94
26_H172_R0.8860.94
29_V59_T0.8830.93
15_G150_A0.8740.93
21_A28_I0.8690.93
168_G171_T0.8640.93
138_V173_V0.8640.93
164_G189_G0.8640.93
101_S139_G0.8630.93
103_A127_V0.8600.93
67_A89_V0.8490.92
126_L130_A0.8460.92
18_L22_T0.8380.92
15_G149_L0.8300.91
134_G137_V0.8290.91
91_D94_D0.8290.91
74_V102_P0.8280.91
2_R69_R0.8270.91
82_V130_A0.8190.91
178_D184_R0.8110.90
73_V93_L0.7970.89
2_R26_H0.7960.89
143_N160_T0.7930.89
141_F180_I0.7920.89
148_R207_L0.7910.89
161_L188_A0.7880.89
136_D168_G0.7860.89
15_G146_A0.7860.89
79_A105_G0.7830.89
103_A123_V0.7830.89
127_V132_P0.7820.89
68_D92_R0.7800.88
106_I205_I0.7760.88
107_A111_H0.7750.88
2_R29_V0.7740.88
128_A191_V0.7720.88
69_R97_T0.7660.87
168_G172_R0.7620.87
21_A45_Y0.7620.87
145_A205_I0.7580.87
20_W179_D0.7540.87
31_G66_A0.7530.87
84_D87_G0.7490.86
3_I72_V0.7480.86
14_A41_T0.7460.86
78_P85_V0.7440.86
6_L67_A0.7370.85
186_L210_Y0.7350.85
117_P120_A0.7340.85
75_V78_P0.7330.85
164_G187_D0.7320.85
143_N205_I0.7300.85
85_V92_R0.7260.85
3_I20_W0.7240.84
174_A178_D0.7190.84
125_A129_D0.7170.84
64_E91_D0.7130.83
144_L160_T0.7080.83
38_A42_A0.7060.83
151_D154_T0.7020.83
200_L205_I0.6970.82
19_R180_I0.6960.82
125_A190_P0.6940.82
163_V188_A0.6930.82
30_I41_T0.6910.82
67_A70_A0.6900.81
87_G92_R0.6890.81
193_N196_E0.6880.81
70_A97_T0.6850.81
177_A185_A0.6850.81
5_L17_A0.6840.81
139_G198_E0.6840.81
36_E39_R0.6830.81
4_A69_R0.6800.80
75_V103_A0.6760.80
144_L158_A0.6740.80
64_E88_A0.6720.80
165_N191_V0.6700.80
14_A44_A0.6640.79
59_T69_R0.6640.79
85_V89_V0.6610.79
93_L97_T0.6580.78
125_A165_N0.6540.78
65_M68_D0.6480.77
138_V170_R0.6390.76
205_I208_A0.6390.76
64_E92_R0.6340.76
12_I146_A0.6280.75
4_A67_A0.6270.75
72_V100_I0.6260.75
17_A58_L0.6260.75
72_V176_L0.6240.75
29_V66_A0.6230.74
152_L158_A0.6220.74
4_A29_V0.6220.74
12_I106_I0.6210.74
32_S38_A0.6210.74
83_T171_T0.6170.74
107_A110_E0.6080.73
5_L31_G0.6040.72
9_T30_I0.6010.72
99_V157_D0.5980.71
25_D101_S0.5970.71
118_P121_G0.5960.71
170_R177_A0.5950.71
32_S37_K0.5950.71
18_L150_A0.5920.71
20_W180_I0.5900.70
124_T139_G0.5880.70
42_A45_Y0.5880.70
139_G163_V0.5880.70
33_R37_K0.5840.70
81_H103_A0.5810.69
29_V65_M0.5720.68
67_A93_L0.5680.67
76_A112_G0.5680.67
108_S111_H0.5670.67
35_P39_R0.5650.67
139_G197_V0.5650.67
65_M69_R0.5650.67
30_I45_Y0.5620.67
11_D81_H0.5600.66
143_N201_T0.5580.66
99_V137_V0.5580.66
138_V187_D0.5560.66
24_S180_I0.5510.65
160_T177_A0.5490.65
81_H84_D0.5490.65
122_S194_A0.5470.65
179_D190_P0.5450.64
19_R204_L0.5430.64
118_P199_S0.5430.64
170_R189_G0.5420.64
46_E56_R0.5380.63
27_D69_R0.5380.63
73_V97_T0.5380.63
9_T31_G0.5380.63
59_T175_E0.5370.63
2_R176_L0.5350.63
72_V179_D0.5340.63
45_Y57_K0.5340.63
59_T65_M0.5320.62
61_F66_A0.5310.62
93_L198_E0.5280.62
106_I146_A0.5270.62
161_L184_R0.5270.62
145_A148_R0.5270.62
163_V189_G0.5210.61
34_D38_A0.5200.61
170_R174_A0.5200.61
5_L76_A0.5190.61
17_A151_D0.5190.61
142_H163_V0.5190.61
69_R72_V0.5190.61
16_L141_F0.5180.60
116_N121_G0.5160.60
75_V99_V0.5140.60
86_M90_A0.5130.60
152_L207_L0.5120.60
167_E170_R0.5120.60
86_M122_S0.5100.59
136_D169_A0.5090.59
198_E203_L0.5080.59
131_A137_V0.5080.59
123_V199_S0.5080.59
20_W141_F0.5080.59
16_L102_P0.5070.59
116_N126_L0.5060.59
108_S112_G0.5060.59
79_A126_L0.5060.59
36_E42_A0.5040.58
9_T38_A0.5030.58
139_G194_A0.5020.58
105_G122_S0.5020.58
198_E201_T0.5010.58
162_V197_V0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jayA 2 0.955 100 0.538 Contact Map
2rafA 2 0.8423 100 0.566 Contact Map
3dttA 2 0.9505 100 0.566 Contact Map
2vnsA 2 0.8108 100 0.57 Contact Map
2yjzA 1 0.7793 99.9 0.595 Contact Map
4hujA 2 0.8694 99.9 0.608 Contact Map
4ol9A 2 0.8874 99.8 0.684 Contact Map
2zydA 2 0.8514 99.8 0.69 Contact Map
3k96A 2 0.9144 99.8 0.691 Contact Map
3i83A 2 0.9009 99.8 0.695 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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