GREMLIN Database
Q9HMC4 - Uncharacterized protein
UniProt: Q9HMC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (277)
Sequences: 234 (180)
Seq/√Len: 10.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_K49_G4.8451.00
37_I40_A3.7010.98
279_D283_D3.3570.97
163_A285_P3.0050.94
133_Y137_E2.6540.89
205_A209_N2.6380.89
229_G234_D2.6060.88
226_V253_V2.5470.87
266_R277_V2.5020.86
134_R141_P2.4650.85
42_I46_K2.4420.85
132_Y228_V2.4030.84
280_S283_D2.3970.84
47_D50_G2.3910.83
127_Y180_E2.2390.79
45_F50_G2.2320.79
171_C198_F2.2000.78
9_D12_G2.1300.75
31_H62_A2.1050.74
8_L11_D2.0950.74
176_R180_E1.9830.70
175_G229_G1.9740.69
125_Q142_D1.9500.68
127_Y152_E1.9160.67
52_N176_R1.8930.66
124_Q256_L1.8560.64
43_Q46_K1.8490.64
175_G234_D1.8270.63
173_L211_R1.8120.62
45_F48_A1.8030.62
43_Q47_D1.7860.61
13_V176_R1.7770.61
52_N127_Y1.7560.60
131_E277_V1.7460.59
20_S123_F1.7280.59
55_W127_Y1.6800.56
52_N175_G1.6630.56
232_L272_A1.6520.55
96_A100_A1.6490.55
53_N59_D1.6330.54
45_F49_G1.6260.54
266_R270_H1.6100.53
152_E180_E1.6100.53
180_E256_L1.5980.52
55_W62_A1.5810.52
232_L261_T1.5500.50
259_G262_G1.5120.48
62_A70_E1.5020.48
212_A216_L1.5000.48
235_V252_A1.4950.48
134_R278_L1.4890.47
161_G190_L1.4760.47
13_V52_N1.4630.46
285_P288_L1.4600.46
213_L227_F1.4590.46
150_H190_L1.4510.45
29_V173_L1.4420.45
242_R270_H1.4270.44
40_A155_L1.4270.44
10_V173_L1.4200.44
137_E206_G1.4160.44
25_I28_A1.4090.43
42_I164_L1.4020.43
134_R140_D1.4020.43
5_A277_V1.3990.43
13_V175_G1.3860.42
21_Y25_I1.3640.41
8_L12_G1.3590.41
42_I49_G1.3540.41
205_A211_R1.3470.41
124_Q128_L1.3450.41
166_A170_V1.3370.40
207_K230_D1.3310.40
208_P230_D1.3310.40
15_V184_A1.3290.40
13_V129_G1.3280.40
41_D49_G1.3270.40
124_Q127_Y1.3220.39
41_D47_D1.3190.39
18_A148_F1.3100.39
7_V231_T1.3070.39
42_I48_A1.3060.39
176_R229_G1.3020.39
284_L288_L1.3010.39
129_G229_G1.2980.38
173_L212_A1.2970.38
162_D273_G1.2890.38
178_S202_D1.2810.38
127_Y175_G1.2690.37
20_S25_I1.2550.36
213_L233_D1.2400.36
42_I57_V1.2370.36
152_E234_D1.2350.36
89_G93_G1.2240.35
270_H276_H1.2200.35
257_T262_G1.2080.34
52_N55_W1.2070.34
192_I195_E1.1950.34
21_Y200_M1.1910.34
73_T104_P1.1800.33
152_E229_G1.1780.33
45_F102_L1.1770.33
52_N229_G1.1690.33
87_H90_G1.1680.33
189_G199_T1.1660.33
17_V20_S1.1660.33
58_T123_F1.1650.33
144_A278_L1.1600.32
158_P278_L1.1550.32
17_V21_Y1.1520.32
176_R234_D1.1510.32
227_F231_T1.1460.32
122_V142_D1.1450.32
55_W66_L1.1440.32
129_G234_D1.1410.32
100_A195_E1.1390.32
199_T257_T1.1370.31
200_M231_T1.1260.31
20_S51_F1.1240.31
43_Q49_G1.1220.31
124_Q199_T1.1190.31
15_V21_Y1.1190.31
6_V188_V1.1140.30
21_Y176_R1.1110.30
50_G66_L1.1100.30
123_F137_E1.1090.30
146_P264_A1.1090.30
127_Y147_G1.1070.30
127_Y176_R1.1070.30
141_P144_A1.0950.30
18_A242_R1.0890.29
13_V256_L1.0730.29
256_L262_G1.0720.29
22_R231_T1.0680.29
42_I185_L1.0610.28
46_K50_G1.0600.28
28_A173_L1.0600.28
175_G180_E1.0580.28
161_G219_R1.0510.28
75_G78_G1.0500.28
131_E263_E1.0480.28
55_W180_E1.0430.28
104_P107_V1.0410.28
13_V229_G1.0370.27
16_D34_G1.0300.27
9_D207_K1.0260.27
11_D207_K1.0260.27
11_D208_P1.0260.27
9_D208_P1.0260.27
52_N234_D1.0240.27
70_E73_T1.0000.26
77_V82_D0.9930.26
80_F87_H0.9880.26
180_E199_T0.9880.26
155_L185_L0.9840.25
278_L284_L0.9820.25
86_E90_G0.9810.25
37_I62_A0.9810.25
81_T85_A0.9790.25
6_V286_A0.9770.25
69_R73_T0.9750.25
157_A287_L0.9740.25
111_R261_T0.9700.25
83_A90_G0.9630.25
157_A214_I0.9610.25
256_L259_G0.9610.25
127_Y234_D0.9590.25
129_G147_G0.9540.24
104_P108_E0.9380.24
92_A194_G0.9370.24
177_P257_T0.9360.24
29_V148_F0.9350.24
16_D51_F0.9310.24
52_N147_G0.9260.23
58_T154_R0.9200.23
45_F63_L0.9120.23
135_R159_E0.9110.23
179_D212_A0.9100.23
174_T208_P0.9090.23
174_T207_K0.9090.23
152_E175_G0.9060.23
93_G190_L0.9040.23
36_T39_R0.9030.23
51_F58_T0.8990.23
14_L20_S0.8960.22
175_G252_A0.8940.22
119_L128_L0.8940.22
145_A161_G0.8940.22
41_D46_K0.8930.22
198_F206_G0.8880.22
13_V234_D0.8870.22
96_A121_D0.8870.22
129_G175_G0.8830.22
127_Y229_G0.8820.22
16_D21_Y0.8810.22
147_G180_E0.8800.22
21_Y57_V0.8770.22
12_G175_G0.8770.22
16_D242_R0.8760.22
174_T199_T0.8730.22
157_A271_T0.8720.22
173_L231_T0.8720.22
94_A98_V0.8710.22
226_V278_L0.8690.22
5_A239_L0.8680.22
273_G281_V0.8630.21
228_V233_D0.8630.21
45_F172_V0.8590.21
147_G152_E0.8570.21
24_A43_Q0.8550.21
52_N129_G0.8550.21
125_Q145_A0.8490.21
75_G159_E0.8430.21
76_G79_A0.8420.21
135_R142_D0.8410.21
129_G152_E0.8340.20
124_Q129_G0.8300.20
145_A148_F0.8280.20
14_L123_F0.8260.20
52_N180_E0.8260.20
92_A96_A0.8230.20
47_D268_K0.8190.20
15_V18_A0.8180.20
87_H91_L0.8160.20
43_Q50_G0.8080.20
239_L273_G0.8050.20
42_I50_G0.8030.20
280_S285_P0.7970.19
44_Q48_A0.7950.19
14_L269_Y0.7910.19
82_D206_G0.7890.19
96_A284_L0.7890.19
16_D36_T0.7870.19
116_P127_Y0.7870.19
19_E227_F0.7850.19
267_Q271_T0.7850.19
158_P251_H0.7840.19
76_G88_G0.7820.19
176_R256_L0.7780.19
119_L125_Q0.7750.19
161_G239_L0.7750.19
116_P145_A0.7740.19
48_A151_D0.7740.19
123_F129_G0.7690.19
40_A62_A0.7690.19
11_D14_L0.7670.18
9_D14_L0.7670.18
239_L269_Y0.7660.18
21_Y180_E0.7650.18
28_A126_L0.7640.18
11_D230_D0.7630.18
9_D230_D0.7630.18
83_A87_H0.7590.18
67_A70_E0.7560.18
77_V88_G0.7530.18
20_S71_N0.7490.18
171_C215_A0.7490.18
195_E271_T0.7450.18
42_I278_L0.7440.18
8_L208_P0.7430.18
8_L207_K0.7430.18
180_E234_D0.7420.18
264_A279_D0.7400.18
32_V109_R0.7390.18
152_E256_L0.7360.18
278_L286_A0.7340.18
122_V278_L0.7330.17
209_N254_G0.7320.17
78_G221_G0.7320.17
134_R142_D0.7300.17
61_A133_Y0.7300.17
263_E271_T0.7290.17
20_S53_N0.7270.17
17_V25_I0.7260.17
257_T260_L0.7230.17
135_R161_G0.7220.17
232_L235_V0.7170.17
91_L117_E0.7160.17
133_Y139_G0.7160.17
94_A120_R0.7130.17
55_W124_Q0.7110.17
119_L136_F0.7070.17
16_D25_I0.7050.17
200_M257_T0.7010.17
55_W152_E0.6980.17
155_L159_E0.6950.16
235_V272_A0.6950.16
196_R219_R0.6940.16
15_V233_D0.6910.16
74_I107_V0.6900.16
105_A111_R0.6860.16
104_P186_D0.6860.16
42_I61_A0.6860.16
215_A220_T0.6840.16
124_Q259_G0.6830.16
193_P198_F0.6830.16
13_V17_V0.6830.16
129_G176_R0.6810.16
13_V147_G0.6790.16
55_W256_L0.6760.16
60_A237_T0.6760.16
172_V267_Q0.6760.16
255_V287_L0.6760.16
99_D155_L0.6750.16
13_V22_R0.6720.16
105_A159_E0.6680.16
4_D53_N0.6680.16
123_F185_L0.6670.16
180_E229_G0.6660.16
17_V200_M0.6640.16
142_D161_G0.6610.16
231_T252_A0.6560.15
120_R123_F0.6540.15
199_T256_L0.6520.15
76_G136_F0.6500.15
10_V278_L0.6490.15
10_V225_V0.6470.15
30_E126_L0.6450.15
10_V21_Y0.6450.15
172_V224_S0.6430.15
32_V62_A0.6380.15
54_D57_V0.6370.15
233_D256_L0.6330.15
18_A260_L0.6330.15
138_G170_V0.6320.15
86_E140_D0.6310.15
232_L254_G0.6240.15
112_D146_P0.6230.15
55_W59_D0.6210.15
206_G216_L0.6180.15
106_A166_A0.6180.15
148_F161_G0.6150.14
147_G175_G0.6120.14
171_C253_V0.6110.14
15_V201_D0.6110.14
4_D202_D0.6090.14
59_D228_V0.6080.14
7_V22_R0.6050.14
74_I169_P0.6050.14
54_D59_D0.6050.14
82_D86_E0.6040.14
51_F60_A0.6030.14
17_V213_L0.6030.14
36_T40_A0.6000.14
7_V213_L0.5990.14
16_D20_S0.5960.14
18_A25_I0.5930.14
78_G134_R0.5890.14
12_G16_D0.5880.14
174_T230_D0.5870.14
179_D220_T0.5860.14
159_E195_E0.5840.14
48_A64_W0.5760.14
12_G207_K0.5700.13
12_G208_P0.5700.13
240_N255_V0.5690.13
35_D195_E0.5690.13
117_E140_D0.5680.13
198_F215_A0.5670.13
118_R286_A0.5640.13
263_E287_L0.5620.13
13_V21_Y0.5620.13
66_L70_E0.5590.13
37_I57_V0.5580.13
219_R231_T0.5580.13
183_V215_A0.5570.13
156_L228_V0.5540.13
143_L195_E0.5540.13
184_A233_D0.5480.13
21_Y54_D0.5460.13
71_N123_F0.5460.13
14_L71_N0.5450.13
30_E55_W0.5430.13
75_G267_Q0.5420.13
158_P280_S0.5420.13
211_R225_V0.5390.13
13_V180_E0.5370.13
17_V184_A0.5360.13
17_V22_R0.5350.13
24_A205_A0.5340.13
25_I32_V0.5330.13
20_S28_A0.5300.13
51_F54_D0.5300.13
19_E22_R0.5290.13
169_P196_R0.5280.13
261_T268_K0.5280.13
146_P162_D0.5230.12
9_D13_V0.5230.12
6_V108_E0.5220.12
4_D214_I0.5220.12
191_D216_L0.5210.12
122_V155_L0.5210.12
126_L145_A0.5190.12
56_T60_A0.5190.12
20_S206_G0.5180.12
284_L287_L0.5180.12
8_L252_A0.5180.12
102_L107_V0.5170.12
127_Y256_L0.5170.12
22_R252_A0.5160.12
89_G131_E0.5140.12
183_V201_D0.5110.12
184_A252_A0.5100.12
99_D111_R0.5100.12
79_A83_A0.5100.12
100_A131_E0.5100.12
164_L241_A0.5090.12
109_R125_Q0.5070.12
25_I173_L0.5060.12
180_E233_D0.5050.12
228_V252_A0.5030.12
103_G114_W0.5030.12
76_G283_D0.5020.12
4_D14_L0.5010.12
88_G91_L0.5000.12
117_E162_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qyiA 1 0.9655 100 0.634 Contact Map
3d6jA 1 0.7138 99.9 0.694 Contact Map
3iruA 4 0.7897 99.9 0.695 Contact Map
1swvA 2 0.7862 99.9 0.696 Contact Map
3umcA 2 0.7897 99.9 0.7 Contact Map
4eekA 2 0.7448 99.9 0.7 Contact Map
3qxgA 3 0.7379 99.9 0.701 Contact Map
2hi0A 2 0.8069 99.9 0.702 Contact Map
3umgA 2 0.8 99.9 0.703 Contact Map
3mc1A 2 0.7276 99.9 0.705 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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