Q9HMC4 - HALSA - GREMLIN Contacts

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Q9HMC4 - Uncharacterized protein

UniProt:	Q9HMC4	Sequences: MEVDAVVLDVDGVLVDVAESYRRAIVEAVEHVYGDTIERADIQQFKDAGGFNNDWTVTDAAALWVLASRENGTIGGVGAFTDAIAEHGGGLAGAEAVVDASLGPAAVERVRDAWEPERLRDVFQQLYLGTEYYRRFEGGDPDLAAPGFIHDEDRLLAPETGDALTADWPVCVLTGRPSDEADVALDRVGLDIPGERRFTMDDWAAGKPNPRALIALAERTGADSVVFVGDTLDDVATALNAREADPGREYHAVGVLTGGLTGEAGRQKYHTAGADHVLDSVNDLPALLGQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	290 (277)
Sequences:	234 (180)
Seq/√Len:	10.8

HALSA - Q9HMC4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_K	49_G	4.845	1.00
37_I	40_A	3.701	0.98
279_D	283_D	3.357	0.97
163_A	285_P	3.005	0.94
133_Y	137_E	2.654	0.89
205_A	209_N	2.638	0.89
229_G	234_D	2.606	0.88
226_V	253_V	2.547	0.87
266_R	277_V	2.502	0.86
134_R	141_P	2.465	0.85
42_I	46_K	2.442	0.85
132_Y	228_V	2.403	0.84
280_S	283_D	2.397	0.84
47_D	50_G	2.391	0.83
127_Y	180_E	2.239	0.79
45_F	50_G	2.232	0.79
171_C	198_F	2.200	0.78
9_D	12_G	2.130	0.75
31_H	62_A	2.105	0.74
8_L	11_D	2.095	0.74
176_R	180_E	1.983	0.70
175_G	229_G	1.974	0.69
125_Q	142_D	1.950	0.68
127_Y	152_E	1.916	0.67
52_N	176_R	1.893	0.66
124_Q	256_L	1.856	0.64
43_Q	46_K	1.849	0.64
175_G	234_D	1.827	0.63
173_L	211_R	1.812	0.62
45_F	48_A	1.803	0.62
43_Q	47_D	1.786	0.61
13_V	176_R	1.777	0.61
52_N	127_Y	1.756	0.60
131_E	277_V	1.746	0.59
20_S	123_F	1.728	0.59
55_W	127_Y	1.680	0.56
52_N	175_G	1.663	0.56
232_L	272_A	1.652	0.55
96_A	100_A	1.649	0.55
53_N	59_D	1.633	0.54
45_F	49_G	1.626	0.54
266_R	270_H	1.610	0.53
152_E	180_E	1.610	0.53
180_E	256_L	1.598	0.52
55_W	62_A	1.581	0.52
232_L	261_T	1.550	0.50
259_G	262_G	1.512	0.48
62_A	70_E	1.502	0.48
212_A	216_L	1.500	0.48
235_V	252_A	1.495	0.48
134_R	278_L	1.489	0.47
161_G	190_L	1.476	0.47
13_V	52_N	1.463	0.46
285_P	288_L	1.460	0.46
213_L	227_F	1.459	0.46
150_H	190_L	1.451	0.45
29_V	173_L	1.442	0.45
242_R	270_H	1.427	0.44
40_A	155_L	1.427	0.44
10_V	173_L	1.420	0.44
137_E	206_G	1.416	0.44
25_I	28_A	1.409	0.43
42_I	164_L	1.402	0.43
134_R	140_D	1.402	0.43
5_A	277_V	1.399	0.43
13_V	175_G	1.386	0.42
21_Y	25_I	1.364	0.41
8_L	12_G	1.359	0.41
42_I	49_G	1.354	0.41
205_A	211_R	1.347	0.41
124_Q	128_L	1.345	0.41
166_A	170_V	1.337	0.40
207_K	230_D	1.331	0.40
208_P	230_D	1.331	0.40
15_V	184_A	1.329	0.40
13_V	129_G	1.328	0.40
41_D	49_G	1.327	0.40
124_Q	127_Y	1.322	0.39
41_D	47_D	1.319	0.39
18_A	148_F	1.310	0.39
7_V	231_T	1.307	0.39
42_I	48_A	1.306	0.39
176_R	229_G	1.302	0.39
284_L	288_L	1.301	0.39
129_G	229_G	1.298	0.38
173_L	212_A	1.297	0.38
162_D	273_G	1.289	0.38
178_S	202_D	1.281	0.38
127_Y	175_G	1.269	0.37
20_S	25_I	1.255	0.36
213_L	233_D	1.240	0.36
42_I	57_V	1.237	0.36
152_E	234_D	1.235	0.36
89_G	93_G	1.224	0.35
270_H	276_H	1.220	0.35
257_T	262_G	1.208	0.34
52_N	55_W	1.207	0.34
192_I	195_E	1.195	0.34
21_Y	200_M	1.191	0.34
73_T	104_P	1.180	0.33
152_E	229_G	1.178	0.33
45_F	102_L	1.177	0.33
52_N	229_G	1.169	0.33
87_H	90_G	1.168	0.33
189_G	199_T	1.166	0.33
17_V	20_S	1.166	0.33
58_T	123_F	1.165	0.33
144_A	278_L	1.160	0.32
158_P	278_L	1.155	0.32
17_V	21_Y	1.152	0.32
176_R	234_D	1.151	0.32
227_F	231_T	1.146	0.32
122_V	142_D	1.145	0.32
55_W	66_L	1.144	0.32
129_G	234_D	1.141	0.32
100_A	195_E	1.139	0.32
199_T	257_T	1.137	0.31
200_M	231_T	1.126	0.31
20_S	51_F	1.124	0.31
43_Q	49_G	1.122	0.31
124_Q	199_T	1.119	0.31
15_V	21_Y	1.119	0.31
6_V	188_V	1.114	0.30
21_Y	176_R	1.111	0.30
50_G	66_L	1.110	0.30
123_F	137_E	1.109	0.30
146_P	264_A	1.109	0.30
127_Y	147_G	1.107	0.30
127_Y	176_R	1.107	0.30
141_P	144_A	1.095	0.30
18_A	242_R	1.089	0.29
13_V	256_L	1.073	0.29
256_L	262_G	1.072	0.29
22_R	231_T	1.068	0.29
42_I	185_L	1.061	0.28
46_K	50_G	1.060	0.28
28_A	173_L	1.060	0.28
175_G	180_E	1.058	0.28
161_G	219_R	1.051	0.28
75_G	78_G	1.050	0.28
131_E	263_E	1.048	0.28
55_W	180_E	1.043	0.28
104_P	107_V	1.041	0.28
13_V	229_G	1.037	0.27
16_D	34_G	1.030	0.27
9_D	207_K	1.026	0.27
11_D	207_K	1.026	0.27
11_D	208_P	1.026	0.27
9_D	208_P	1.026	0.27
52_N	234_D	1.024	0.27
70_E	73_T	1.000	0.26
77_V	82_D	0.993	0.26
80_F	87_H	0.988	0.26
180_E	199_T	0.988	0.26
155_L	185_L	0.984	0.25
278_L	284_L	0.982	0.25
86_E	90_G	0.981	0.25
37_I	62_A	0.981	0.25
81_T	85_A	0.979	0.25
6_V	286_A	0.977	0.25
69_R	73_T	0.975	0.25
157_A	287_L	0.974	0.25
111_R	261_T	0.970	0.25
83_A	90_G	0.963	0.25
157_A	214_I	0.961	0.25
256_L	259_G	0.961	0.25
127_Y	234_D	0.959	0.25
129_G	147_G	0.954	0.24
104_P	108_E	0.938	0.24
92_A	194_G	0.937	0.24
177_P	257_T	0.936	0.24
29_V	148_F	0.935	0.24
16_D	51_F	0.931	0.24
52_N	147_G	0.926	0.23
58_T	154_R	0.920	0.23
45_F	63_L	0.912	0.23
135_R	159_E	0.911	0.23
179_D	212_A	0.910	0.23
174_T	208_P	0.909	0.23
174_T	207_K	0.909	0.23
152_E	175_G	0.906	0.23
93_G	190_L	0.904	0.23
36_T	39_R	0.903	0.23
51_F	58_T	0.899	0.23
14_L	20_S	0.896	0.22
175_G	252_A	0.894	0.22
119_L	128_L	0.894	0.22
145_A	161_G	0.894	0.22
41_D	46_K	0.893	0.22
198_F	206_G	0.888	0.22
13_V	234_D	0.887	0.22
96_A	121_D	0.887	0.22
129_G	175_G	0.883	0.22
127_Y	229_G	0.882	0.22
16_D	21_Y	0.881	0.22
147_G	180_E	0.880	0.22
21_Y	57_V	0.877	0.22
12_G	175_G	0.877	0.22
16_D	242_R	0.876	0.22
174_T	199_T	0.873	0.22
157_A	271_T	0.872	0.22
173_L	231_T	0.872	0.22
94_A	98_V	0.871	0.22
226_V	278_L	0.869	0.22
5_A	239_L	0.868	0.22
273_G	281_V	0.863	0.21
228_V	233_D	0.863	0.21
45_F	172_V	0.859	0.21
147_G	152_E	0.857	0.21
24_A	43_Q	0.855	0.21
52_N	129_G	0.855	0.21
125_Q	145_A	0.849	0.21
75_G	159_E	0.843	0.21
76_G	79_A	0.842	0.21
135_R	142_D	0.841	0.21
129_G	152_E	0.834	0.20
124_Q	129_G	0.830	0.20
145_A	148_F	0.828	0.20
14_L	123_F	0.826	0.20
52_N	180_E	0.826	0.20
92_A	96_A	0.823	0.20
47_D	268_K	0.819	0.20
15_V	18_A	0.818	0.20
87_H	91_L	0.816	0.20
43_Q	50_G	0.808	0.20
239_L	273_G	0.805	0.20
42_I	50_G	0.803	0.20
280_S	285_P	0.797	0.19
44_Q	48_A	0.795	0.19
14_L	269_Y	0.791	0.19
82_D	206_G	0.789	0.19
96_A	284_L	0.789	0.19
16_D	36_T	0.787	0.19
116_P	127_Y	0.787	0.19
19_E	227_F	0.785	0.19
267_Q	271_T	0.785	0.19
158_P	251_H	0.784	0.19
76_G	88_G	0.782	0.19
176_R	256_L	0.778	0.19
119_L	125_Q	0.775	0.19
161_G	239_L	0.775	0.19
116_P	145_A	0.774	0.19
48_A	151_D	0.774	0.19
123_F	129_G	0.769	0.19
40_A	62_A	0.769	0.19
11_D	14_L	0.767	0.18
9_D	14_L	0.767	0.18
239_L	269_Y	0.766	0.18
21_Y	180_E	0.765	0.18
28_A	126_L	0.764	0.18
11_D	230_D	0.763	0.18
9_D	230_D	0.763	0.18
83_A	87_H	0.759	0.18
67_A	70_E	0.756	0.18
77_V	88_G	0.753	0.18
20_S	71_N	0.749	0.18
171_C	215_A	0.749	0.18
195_E	271_T	0.745	0.18
42_I	278_L	0.744	0.18
8_L	208_P	0.743	0.18
8_L	207_K	0.743	0.18
180_E	234_D	0.742	0.18
264_A	279_D	0.740	0.18
32_V	109_R	0.739	0.18
152_E	256_L	0.736	0.18
278_L	286_A	0.734	0.18
122_V	278_L	0.733	0.17
209_N	254_G	0.732	0.17
78_G	221_G	0.732	0.17
134_R	142_D	0.730	0.17
61_A	133_Y	0.730	0.17
263_E	271_T	0.729	0.17
20_S	53_N	0.727	0.17
17_V	25_I	0.726	0.17
257_T	260_L	0.723	0.17
135_R	161_G	0.722	0.17
232_L	235_V	0.717	0.17
91_L	117_E	0.716	0.17
133_Y	139_G	0.716	0.17
94_A	120_R	0.713	0.17
55_W	124_Q	0.711	0.17
119_L	136_F	0.707	0.17
16_D	25_I	0.705	0.17
200_M	257_T	0.701	0.17
55_W	152_E	0.698	0.17
155_L	159_E	0.695	0.16
235_V	272_A	0.695	0.16
196_R	219_R	0.694	0.16
15_V	233_D	0.691	0.16
74_I	107_V	0.690	0.16
105_A	111_R	0.686	0.16
104_P	186_D	0.686	0.16
42_I	61_A	0.686	0.16
215_A	220_T	0.684	0.16
124_Q	259_G	0.683	0.16
193_P	198_F	0.683	0.16
13_V	17_V	0.683	0.16
129_G	176_R	0.681	0.16
13_V	147_G	0.679	0.16
55_W	256_L	0.676	0.16
60_A	237_T	0.676	0.16
172_V	267_Q	0.676	0.16
255_V	287_L	0.676	0.16
99_D	155_L	0.675	0.16
13_V	22_R	0.672	0.16
105_A	159_E	0.668	0.16
4_D	53_N	0.668	0.16
123_F	185_L	0.667	0.16
180_E	229_G	0.666	0.16
17_V	200_M	0.664	0.16
142_D	161_G	0.661	0.16
231_T	252_A	0.656	0.15
120_R	123_F	0.654	0.15
199_T	256_L	0.652	0.15
76_G	136_F	0.650	0.15
10_V	278_L	0.649	0.15
10_V	225_V	0.647	0.15
30_E	126_L	0.645	0.15
10_V	21_Y	0.645	0.15
172_V	224_S	0.643	0.15
32_V	62_A	0.638	0.15
54_D	57_V	0.637	0.15
233_D	256_L	0.633	0.15
18_A	260_L	0.633	0.15
138_G	170_V	0.632	0.15
86_E	140_D	0.631	0.15
232_L	254_G	0.624	0.15
112_D	146_P	0.623	0.15
55_W	59_D	0.621	0.15
206_G	216_L	0.618	0.15
106_A	166_A	0.618	0.15
148_F	161_G	0.615	0.14
147_G	175_G	0.612	0.14
171_C	253_V	0.611	0.14
15_V	201_D	0.611	0.14
4_D	202_D	0.609	0.14
59_D	228_V	0.608	0.14
7_V	22_R	0.605	0.14
74_I	169_P	0.605	0.14
54_D	59_D	0.605	0.14
82_D	86_E	0.604	0.14
51_F	60_A	0.603	0.14
17_V	213_L	0.603	0.14
36_T	40_A	0.600	0.14
7_V	213_L	0.599	0.14
16_D	20_S	0.596	0.14
18_A	25_I	0.593	0.14
78_G	134_R	0.589	0.14
12_G	16_D	0.588	0.14
174_T	230_D	0.587	0.14
179_D	220_T	0.586	0.14
159_E	195_E	0.584	0.14
48_A	64_W	0.576	0.14
12_G	207_K	0.570	0.13
12_G	208_P	0.570	0.13
240_N	255_V	0.569	0.13
35_D	195_E	0.569	0.13
117_E	140_D	0.568	0.13
198_F	215_A	0.567	0.13
118_R	286_A	0.564	0.13
263_E	287_L	0.562	0.13
13_V	21_Y	0.562	0.13
66_L	70_E	0.559	0.13
37_I	57_V	0.558	0.13
219_R	231_T	0.558	0.13
183_V	215_A	0.557	0.13
156_L	228_V	0.554	0.13
143_L	195_E	0.554	0.13
184_A	233_D	0.548	0.13
21_Y	54_D	0.546	0.13
71_N	123_F	0.546	0.13
14_L	71_N	0.545	0.13
30_E	55_W	0.543	0.13
75_G	267_Q	0.542	0.13
158_P	280_S	0.542	0.13
211_R	225_V	0.539	0.13
13_V	180_E	0.537	0.13
17_V	184_A	0.536	0.13
17_V	22_R	0.535	0.13
24_A	205_A	0.534	0.13
25_I	32_V	0.533	0.13
20_S	28_A	0.530	0.13
51_F	54_D	0.530	0.13
19_E	22_R	0.529	0.13
169_P	196_R	0.528	0.13
261_T	268_K	0.528	0.13
146_P	162_D	0.523	0.12
9_D	13_V	0.523	0.12
6_V	108_E	0.522	0.12
4_D	214_I	0.522	0.12
191_D	216_L	0.521	0.12
122_V	155_L	0.521	0.12
126_L	145_A	0.519	0.12
56_T	60_A	0.519	0.12
20_S	206_G	0.518	0.12
284_L	287_L	0.518	0.12
8_L	252_A	0.518	0.12
102_L	107_V	0.517	0.12
127_Y	256_L	0.517	0.12
22_R	252_A	0.516	0.12
89_G	131_E	0.514	0.12
183_V	201_D	0.511	0.12
184_A	252_A	0.510	0.12
99_D	111_R	0.510	0.12
79_A	83_A	0.510	0.12
100_A	131_E	0.510	0.12
164_L	241_A	0.509	0.12
109_R	125_Q	0.507	0.12
25_I	173_L	0.506	0.12
180_E	233_D	0.505	0.12
228_V	252_A	0.503	0.12
103_G	114_W	0.503	0.12
76_G	283_D	0.502	0.12
4_D	14_L	0.501	0.12
88_G	91_L	0.500	0.12
117_E	162_D	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qyiA	1	0.9655	100	0.634	Contact Map
3d6jA	1	0.7138	99.9	0.694	Contact Map
3iruA	4	0.7897	99.9	0.695	Contact Map
1swvA	2	0.7862	99.9	0.696	Contact Map
3umcA	2	0.7897	99.9	0.7	Contact Map
4eekA	2	0.7448	99.9	0.7	Contact Map
3qxgA	3	0.7379	99.9	0.701	Contact Map
2hi0A	2	0.8069	99.9	0.702	Contact Map
3umgA	2	0.8	99.9	0.703	Contact Map
3mc1A	2	0.7276	99.9	0.705	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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