GREMLIN Database
AMZA - Archaemetzincin
UniProt: Q9HMC3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 173 (166)
Sequences: 349 (270)
Seq/√Len: 20.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_L99_S3.8281.00
53_A88_L3.4091.00
70_I128_V3.1261.00
83_N151_S2.8050.99
100_T124_V2.6690.99
131_E134_H2.5380.98
123_R158_D2.5300.98
134_H148_M2.5010.98
78_F84_Y2.4990.98
130_H140_H2.4740.98
73_T99_S2.3920.97
87_G140_H2.3200.96
130_H134_H2.2020.95
131_E140_H2.1760.95
127_E160_K2.1510.94
165_C168_C2.0790.93
73_T77_L2.0740.93
83_N150_F2.0730.93
83_N152_P1.9080.90
103_L157_V1.8790.89
98_V128_V1.8650.89
131_E148_M1.8320.88
27_Y133_G1.8130.87
134_H140_H1.7830.86
23_L169_Q1.7600.86
87_G130_H1.7290.85
14_H72_I1.7240.84
68_K135_T1.7080.84
150_F156_E1.6820.83
149_N157_V1.6580.82
85_V151_S1.6270.81
86_F160_K1.5830.79
76_D102_R1.5740.78
78_F83_N1.5500.77
60_A71_A1.5350.77
50_Q76_D1.4960.75
143_N149_N1.4930.74
91_L135_T1.4830.74
158_D168_C1.4670.73
29_C77_L1.4590.73
86_F152_P1.4350.71
22_S26_V1.4340.71
138_L168_C1.4190.71
87_G131_E1.3980.69
141_C148_M1.3920.69
53_A86_F1.3730.68
85_V89_A1.3260.65
6_V71_A1.3030.64
83_N153_T1.2850.63
82_R152_P1.2710.62
31_V61_T1.2680.62
24_R30_E1.2650.61
134_H141_C1.2600.61
50_Q78_F1.2070.58
98_V124_V1.2050.58
94_R135_T1.2010.57
62_R69_T1.1840.56
84_Y108_D1.1790.56
130_H148_M1.1650.55
60_A69_T1.1490.54
98_V103_L1.1350.53
138_L148_M1.1260.52
136_L157_V1.1150.52
89_A109_G1.1100.51
106_S109_G1.0970.50
133_G158_D1.0840.50
51_Y169_Q1.0800.49
141_C146_C1.0740.49
134_H138_L1.0710.49
50_Q150_F1.0430.47
86_F158_D1.0360.46
52_R88_L1.0300.46
53_A93_G1.0200.45
45_D80_R1.0160.45
166_G169_Q1.0100.45
129_V164_L1.0080.45
68_K93_G1.0020.44
72_I128_V0.9810.43
11_V72_I0.9750.42
128_V149_N0.9700.42
40_P97_V0.9700.42
50_Q84_Y0.9680.42
131_E138_L0.9670.42
34_A64_T0.9670.42
48_R103_L0.9620.42
85_V158_D0.9580.41
148_M165_C0.9580.41
4_D65_S0.9550.41
78_F152_P0.9410.40
114_R117_S0.9400.40
138_L154_V0.9270.39
77_L154_V0.9230.39
73_T97_V0.9220.39
85_V96_C0.9200.39
110_G115_S0.9190.39
132_L162_E0.9140.39
103_L127_E0.9130.39
48_R133_G0.9120.38
144_N149_N0.9110.38
121_D125_R0.9100.38
80_R83_N0.9070.38
82_R86_F0.9060.38
82_R96_C0.9020.38
105_T110_G0.8960.37
50_Q89_A0.8900.37
94_R162_E0.8880.37
60_A156_E0.8830.37
83_N157_V0.8780.36
29_C67_D0.8770.36
146_C168_C0.8690.36
4_D66_G0.8630.35
147_A154_V0.8620.35
19_A29_C0.8580.35
26_V171_T0.8580.35
51_Y171_T0.8510.35
68_K136_L0.8500.35
74_P132_L0.8500.35
141_C165_C0.8440.34
110_G116_S0.8440.34
46_E122_D0.8440.34
89_A140_H0.8400.34
140_H165_C0.8390.34
28_D74_P0.8380.34
56_F115_S0.8350.34
74_P94_R0.8310.33
19_A98_V0.8280.33
87_G134_H0.8160.33
134_H165_C0.8140.32
44_Y160_K0.8110.32
7_P37_Q0.8100.32
136_L159_R0.8090.32
28_D164_L0.8040.32
50_Q102_R0.8000.32
141_C168_C0.7870.31
96_C135_T0.7840.31
50_Q156_E0.7830.31
157_V160_K0.7830.31
76_D84_Y0.7760.30
75_H99_S0.7740.30
129_V136_L0.7730.30
145_R161_E0.7720.30
78_F92_D0.7520.29
67_D94_R0.7420.28
40_P51_Y0.7380.28
79_Y82_R0.7310.28
137_G141_C0.7290.28
83_N88_L0.7270.28
70_I101_Y0.7260.28
70_I98_V0.7190.27
47_A136_L0.7160.27
6_V34_A0.7160.27
93_G135_T0.7150.27
145_R166_G0.7150.27
63_A96_C0.7100.27
133_G147_A0.7060.27
127_E135_T0.7050.26
99_S102_R0.7040.26
23_L67_D0.6930.26
6_V27_Y0.6890.26
15_V18_Q0.6890.26
98_V157_V0.6890.26
94_R132_L0.6820.25
57_I170_R0.6800.25
120_F164_L0.6790.25
48_R127_E0.6780.25
138_L147_A0.6770.25
119_V122_D0.6760.25
146_C165_C0.6760.25
12_P16_K0.6660.25
18_Q97_V0.6660.25
78_F89_A0.6640.24
72_I90_Y0.6640.24
147_A157_V0.6620.24
35_S38_D0.6620.24
48_R158_D0.6600.24
19_A27_Y0.6600.24
17_R70_I0.6560.24
9_G71_A0.6520.24
138_L141_C0.6510.24
28_D169_Q0.6510.24
20_S58_D0.6490.24
77_L97_V0.6480.24
57_I90_Y0.6470.24
44_Y103_L0.6470.24
8_V163_N0.6470.24
27_Y125_R0.6450.24
163_N166_G0.6430.23
27_Y164_L0.6390.23
23_L129_V0.6380.23
166_G171_T0.6370.23
6_V9_G0.6360.23
103_L140_H0.6240.23
29_C37_Q0.6190.22
131_E141_C0.6180.22
74_P120_F0.6160.22
54_A80_R0.6160.22
90_Y156_E0.6150.22
11_V92_D0.6110.22
27_Y56_F0.6100.22
85_V88_L0.6080.22
103_L160_K0.6070.22
104_Q107_S0.6030.22
79_Y96_C0.6020.22
8_V72_I0.6010.21
126_K130_H0.6010.21
124_V145_R0.5950.21
106_S116_S0.5940.21
12_P17_R0.5920.21
4_D27_Y0.5920.21
100_T162_E0.5900.21
36_E97_V0.5900.21
120_F124_V0.5790.21
127_E130_H0.5780.20
79_Y93_G0.5770.20
147_A150_F0.5770.20
14_H58_D0.5710.20
65_S96_C0.5700.20
49_S136_L0.5700.20
50_Q77_L0.5670.20
133_G140_H0.5650.20
17_R97_V0.5630.20
45_D126_K0.5610.20
149_N161_E0.5590.20
68_K132_L0.5570.20
84_Y152_P0.5550.19
53_A103_L0.5540.19
118_D122_D0.5510.19
140_H151_S0.5510.19
81_R153_T0.5450.19
69_T85_V0.5440.19
40_P71_A0.5410.19
72_I109_G0.5410.19
86_F157_V0.5400.19
15_V121_D0.5370.19
63_A156_E0.5350.19
152_P160_K0.5330.19
47_A97_V0.5290.18
79_Y100_T0.5280.18
11_V30_E0.5250.18
82_R88_L0.5190.18
84_Y101_Y0.5190.18
30_E154_V0.5140.18
9_G38_D0.5110.18
123_R133_G0.5100.18
54_A88_L0.5100.18
27_Y105_T0.5090.18
125_R168_C0.5070.18
51_Y155_R0.5020.17
41_T126_K0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lmcA 1 0.9769 100 0.383 Contact Map
3zvsA 1 0.9191 100 0.385 Contact Map
2x7mA 1 0.9364 100 0.469 Contact Map
1atlA 2 0.8671 98.2 0.844 Contact Map
2eroA 2 0.8671 98.2 0.844 Contact Map
4j4mA 1 0.8671 98.2 0.845 Contact Map
1kufA 1 0.8671 98.2 0.845 Contact Map
2e3xA 1 0.8671 98.1 0.846 Contact Map
1budA 1 0.8671 98.1 0.846 Contact Map
1r55A 1 0.8671 98.1 0.846 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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