GREMLIN Database
Q9HMC2 - GTPase HflX
UniProt: Q9HMC2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (370)
Sequences: 3873 (2316)
Seq/√Len: 120.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_V89_A4.0421.00
52_L60_I3.8001.00
287_L320_V3.6581.00
381_D385_A3.6381.00
64_V92_A3.6281.00
124_R168_R3.5941.00
29_C73_V3.5931.00
57_V86_L3.3081.00
44_R47_D3.0941.00
26_R39_E3.0631.00
194_A283_A3.0381.00
23_D39_E2.9971.00
290_V319_P2.9371.00
27_A30_E2.8671.00
243_T254_L2.8031.00
250_E364_T2.7991.00
362_R365_D2.7121.00
245_R252_R2.6721.00
56_A59_D2.6461.00
64_V72_V2.6081.00
72_V90_V2.5341.00
40_R60_I2.4771.00
29_C34_V2.4031.00
38_A63_L2.3751.00
193_V253_V2.3271.00
61_A65_E2.2991.00
76_D264_D2.2931.00
308_D313_A2.2751.00
40_R63_L2.2631.00
209_R356_L2.2501.00
243_T256_T2.2261.00
119_R163_R2.2141.00
318_V362_R2.2141.00
304_E317_L2.2071.00
205_T350_A2.0621.00
320_V359_L2.0551.00
300_R319_P2.0441.00
292_A321_L2.0331.00
285_A363_L2.0041.00
320_V346_V1.9971.00
362_R366_A1.9951.00
103_D122_E1.9881.00
271_S274_R1.9771.00
294_D299_I1.9761.00
116_L167_R1.9291.00
230_A234_R1.9101.00
86_L90_V1.8901.00
267_R306_S1.8311.00
324_R347_V1.8271.00
31_A108_R1.8261.00
172_D175_D1.8161.00
287_L359_L1.8051.00
134_V137_G1.7951.00
166_D170_E1.7691.00
321_L347_V1.7671.00
61_A89_A1.7531.00
301_A305_A1.7471.00
134_V138_E1.7331.00
155_Q159_D1.7191.00
389_W393_R1.7021.00
208_R231_S1.6841.00
52_L74_V1.6771.00
204_S229_A1.6661.00
186_R282_E1.6331.00
175_D278_A1.6211.00
352_G355_G1.6151.00
229_A242_T1.6141.00
175_D274_R1.6071.00
31_A234_R1.5961.00
47_D54_D1.5931.00
290_V300_R1.5871.00
134_V152_P1.5661.00
58_A62_G1.5651.00
140_Q145_F1.5471.00
113_R178_D1.5381.00
72_V92_A1.5311.00
361_E365_D1.5281.00
355_G358_A1.5271.00
18_T41_T1.5061.00
209_R353_A1.4981.00
196_A286_V1.4841.00
391_H399_P1.4841.00
164_I168_R1.4831.00
293_T326_A1.4821.00
344_A362_R1.4741.00
57_V90_V1.4681.00
298_G301_A1.4621.00
64_V90_V1.4601.00
304_E319_P1.4421.00
63_L67_R1.4271.00
328_T331_D1.4141.00
230_A237_E1.4121.00
288_L303_V1.4101.00
29_C100_L1.4051.00
37_V67_R1.3811.00
120_L164_I1.3771.00
305_A309_E1.3721.00
195_L207_L1.3631.00
175_D275_T1.3421.00
281_R311_A1.3281.00
119_R123_L1.3241.00
211_A246_A1.3241.00
193_V287_L1.3231.00
50_Y57_V1.3201.00
51_D76_D1.3191.00
165_T169_A1.3131.00
178_D278_A1.2941.00
58_A89_A1.2871.00
300_R304_E1.2841.00
359_L363_L1.2801.00
112_K170_E1.2791.00
318_V366_A1.2681.00
85_N88_E1.2681.00
124_R268_W1.2671.00
247_T252_R1.2661.00
136_R152_P1.2651.00
38_A67_R1.2651.00
23_D26_R1.2600.99
387_V399_P1.2540.99
34_V70_D1.2540.99
285_A318_V1.2450.99
26_R30_E1.2400.99
62_G65_E1.2350.99
64_V69_A1.2330.99
213_D228_T1.2280.99
249_G364_T1.2270.99
320_V348_T1.2010.99
38_A69_A1.1820.99
109_A114_A1.1800.99
205_T348_T1.1750.99
180_G183_E1.1740.99
132_A137_G1.1730.99
111_T114_A1.1720.99
268_W309_E1.1660.99
122_E126_E1.1560.99
105_F114_A1.1440.99
140_Q152_P1.1410.99
200_N233_D1.1400.99
62_G66_R1.1290.99
25_I73_V1.1250.99
278_A282_E1.1210.99
137_G156_L1.1210.99
95_V100_L1.1200.99
34_V73_V1.1150.99
192_L254_L1.1140.99
177_A180_G1.1120.99
388_S392_D1.1080.99
127_L161_R1.1060.99
34_V71_L1.1050.99
122_E153_A1.1040.99
31_A262_V1.1000.99
193_V285_A1.0970.99
132_A135_E1.0890.99
143_Q148_G1.0860.98
52_L57_V1.0860.98
196_A280_A1.0850.98
116_L174_L1.0790.98
132_A145_F1.0770.98
37_V69_A1.0760.98
19_P23_D1.0700.98
154_A158_A1.0680.98
63_L69_A1.0670.98
182_R278_A1.0640.98
318_V363_L1.0640.98
248_V253_V1.0610.98
305_A308_D1.0600.98
378_P381_D1.0570.98
71_L93_E1.0390.98
105_F109_A1.0340.98
300_R321_L1.0310.98
152_P159_D1.0280.98
267_R270_L1.0280.98
196_A307_R1.0270.98
288_L300_R1.0260.98
358_A361_E1.0220.98
29_C36_V1.0180.98
173_R176_D1.0170.98
132_A136_R1.0090.98
31_A235_L1.0090.98
302_K306_S1.0020.97
184_A187_E1.0000.97
32_A103_D0.9970.97
312_D315_G0.9950.97
61_A64_V0.9880.97
246_A253_V0.9850.97
169_A172_D0.9850.97
246_A255_L0.9820.97
34_V143_Q0.9800.97
106_G122_E0.9760.97
133_R136_R0.9740.97
136_R159_D0.9710.97
346_V362_R0.9690.97
390_C394_G0.9670.97
319_P345_P0.9650.97
177_A181_L0.9580.97
65_E91_G0.9530.97
109_A113_R0.9530.97
32_A122_E0.9530.97
204_S231_S0.9520.96
54_D58_A0.9480.96
212_D228_T0.9480.96
165_T168_R0.9430.96
122_E148_G0.9420.96
288_L294_D0.9380.96
297_E301_A0.9350.96
175_D271_S0.9340.96
150_E154_A0.9300.96
207_L302_K0.9280.96
288_L317_L0.9270.96
372_R397_H0.9200.96
34_V122_E0.9180.96
108_R230_A0.9160.96
150_E158_A0.9100.95
137_G140_Q0.9090.95
397_H400_D0.9070.95
78_L82_R0.9040.95
381_D386_F0.8990.95
344_A366_A0.8990.95
132_A152_P0.8970.95
142_R145_F0.8960.95
60_I90_V0.8960.95
61_A91_G0.8950.95
61_A90_V0.8940.95
124_R164_I0.8910.95
234_R237_E0.8890.95
293_T327_A0.8890.95
58_A61_A0.8860.95
103_D146_R0.8860.95
138_E152_P0.8850.95
274_R278_A0.8820.95
169_A173_R0.8810.95
107_E114_A0.8810.95
21_E264_D0.8790.95
30_E36_V0.8770.94
330_L333_K0.8760.94
233_D326_A0.8720.94
34_V103_D0.8690.94
249_G360_R0.8660.94
210_L360_R0.8640.94
75_D264_D0.8630.94
302_K305_A0.8610.94
376_S379_N0.8610.94
19_P39_E0.8590.94
22_T25_I0.8540.94
391_H396_V0.8530.94
50_Y54_D0.8490.93
179_D186_R0.8420.93
162_Q166_D0.8400.93
134_V139_T0.8400.93
88_E91_G0.8390.93
376_S402_G0.8350.93
123_L160_Y0.8330.93
398_E402_G0.8300.93
134_V159_D0.8300.93
251_R368_P0.8290.93
329_D332_A0.8270.93
93_E103_D0.8260.93
329_D333_K0.8250.92
106_G148_G0.8240.92
274_R309_E0.8240.92
228_T232_R0.8240.92
232_R237_E0.8230.92
77_H268_W0.8220.92
79_D82_R0.8220.92
140_Q151_R0.8220.92
31_A230_A0.8210.92
20_I296_R0.8180.92
105_F108_R0.8180.92
387_V391_H0.8160.92
26_R36_V0.8160.92
377_V386_F0.8150.92
366_A369_D0.8130.92
22_T39_E0.8120.92
207_L255_L0.8120.92
113_R174_L0.8080.92
348_T356_L0.7950.91
146_R153_A0.7910.91
105_F111_T0.7850.90
33_G107_E0.7840.90
120_L167_R0.7830.90
104_I114_A0.7790.90
35_E39_E0.7780.90
32_A106_G0.7780.90
138_E145_F0.7770.90
190_F254_L0.7760.90
353_A356_L0.7730.90
183_E187_E0.7710.90
97_R109_A0.7700.90
357_D361_E0.7680.90
100_L104_I0.7680.90
332_A347_V0.7660.89
321_L345_P0.7630.89
132_A138_E0.7620.89
31_A232_R0.7620.89
389_W392_D0.7620.89
209_R351_T0.7600.89
140_Q143_Q0.7600.89
162_Q165_T0.7570.89
104_I109_A0.7560.89
397_H401_Y0.7540.89
87_Q93_E0.7520.89
191_D367_L0.7490.88
195_L206_L0.7470.88
280_A286_V0.7420.88
292_A327_A0.7420.88
35_E68_S0.7420.88
103_D107_E0.7410.88
81_G84_H0.7410.88
211_A228_T0.7400.88
135_E138_E0.7390.88
385_A389_W0.7390.88
168_R271_S0.7380.88
193_V366_A0.7330.87
280_A283_A0.7320.87
361_E364_T0.7310.87
22_T41_T0.7310.87
73_V100_L0.7300.87
326_A351_T0.7280.87
327_A332_A0.7270.87
207_L229_A0.7200.86
306_S310_L0.7180.86
332_A354_E0.7140.86
176_D180_G0.7140.86
82_R85_N0.7130.86
34_V93_E0.7120.86
138_E141_G0.7110.86
384_N390_C0.7100.86
101_V104_I0.7080.85
136_R140_Q0.7060.85
114_A148_G0.7040.85
301_A304_E0.7010.85
21_E44_R0.7000.85
27_A263_D0.6970.84
51_D74_V0.6940.84
53_G56_A0.6920.84
40_R69_A0.6920.84
184_A188_S0.6910.84
193_V363_L0.6900.84
204_S255_L0.6890.84
18_T39_E0.6880.84
172_D176_D0.6870.84
50_Y89_A0.6860.84
24_E28_L0.6860.84
40_R67_R0.6850.83
42_Q56_A0.6850.83
131_Q134_V0.6820.83
375_L378_P0.6820.83
114_A241_T0.6790.83
17_D20_I0.6780.83
25_I74_V0.6780.83
126_E133_R0.6770.83
21_E27_A0.6760.83
170_E271_S0.6730.82
391_H394_G0.6710.82
128_P207_L0.6700.82
105_F112_K0.6690.82
27_A31_A0.6690.82
332_A337_L0.6680.82
396_V402_G0.6680.82
18_T43_A0.6680.82
251_R364_T0.6670.82
324_R354_E0.6660.82
113_R272_S0.6660.82
326_A329_D0.6660.82
211_A253_V0.6650.82
307_R310_L0.6610.81
106_G114_A0.6590.81
181_L271_S0.6590.81
127_L131_Q0.6590.81
107_E111_T0.6590.81
93_E122_E0.6580.81
376_S400_D0.6560.81
23_D326_A0.6540.81
32_A107_E0.6540.81
168_R172_D0.6540.81
132_A140_Q0.6530.80
153_A156_L0.6530.80
178_D272_S0.6530.80
171_L174_L0.6520.80
140_Q146_R0.6480.80
338_A341_A0.6470.80
21_E263_D0.6470.80
153_A157_K0.6450.80
328_T333_K0.6450.80
114_A272_S0.6440.80
68_S173_R0.6430.79
294_D297_E0.6410.79
240_N269_L0.6410.79
377_V384_N0.6390.79
83_A99_R0.6380.79
290_V304_E0.6370.79
31_A195_L0.6370.79
297_E335_R0.6360.79
133_R140_Q0.6350.79
173_R177_A0.6350.79
281_R315_G0.6340.78
97_R104_I0.6340.78
377_V381_D0.6330.78
25_I36_V0.6310.78
384_N388_S0.6300.78
103_D106_G0.6270.78
148_G152_P0.6220.77
246_A360_R0.6200.77
200_N232_R0.6190.77
206_L348_T0.6170.77
122_E155_Q0.6130.76
130_A157_K0.6130.76
160_Y164_I0.6130.76
134_V148_G0.6110.76
21_E25_I0.6090.76
177_A231_S0.6080.76
379_N401_Y0.6070.75
353_A357_D0.6070.75
20_I294_D0.6060.75
106_G146_R0.6060.75
231_S234_R0.6060.75
290_V321_L0.6040.75
134_V145_F0.6040.75
144_G148_G0.6040.75
352_G357_D0.6030.75
401_Y404_R0.6020.75
375_L386_F0.6000.75
197_G260_G0.6000.75
84_H87_Q0.5990.74
306_S309_E0.5970.74
192_L280_A0.5960.74
193_V255_L0.5960.74
367_L395_T0.5940.74
20_I26_R0.5920.74
242_T391_H0.5920.74
241_T255_L0.5920.74
182_R279_A0.5910.73
139_T142_R0.5900.73
213_D229_A0.5890.73
385_A388_S0.5890.73
159_D162_Q0.5890.73
131_Q141_G0.5890.73
138_E146_R0.5880.73
104_I111_T0.5870.73
145_F248_V0.5860.73
74_V78_L0.5840.73
376_S404_R0.5830.72
78_L85_N0.5830.72
98_A113_R0.5820.72
42_Q127_L0.5810.72
342_G345_P0.5790.72
37_V70_D0.5770.72
104_I108_R0.5750.71
291_D323_K0.5740.71
78_L96_D0.5730.71
379_N402_G0.5730.71
282_E351_T0.5720.71
130_A153_A0.5710.71
393_R403_E0.5700.71
135_E139_T0.5700.71
195_L229_A0.5690.71
123_L164_I0.5680.71
27_A271_S0.5640.70
61_A92_A0.5640.70
328_T332_A0.5630.70
394_G399_P0.5630.70
132_A156_L0.5610.70
357_D360_R0.5600.69
240_N303_V0.5580.69
70_D275_T0.5580.69
31_A126_E0.5570.69
81_G85_N0.5570.69
251_R371_R0.5570.69
140_Q148_G0.5570.69
251_R367_L0.5560.69
60_I64_V0.5560.69
129_R138_E0.5560.69
74_V83_A0.5540.69
42_Q53_G0.5540.69
398_E401_Y0.5530.68
195_L201_A0.5530.68
165_T173_R0.5530.68
53_G78_L0.5520.68
152_P208_R0.5500.68
289_V348_T0.5500.68
113_R278_A0.5490.68
36_V66_R0.5490.68
204_S230_A0.5480.68
17_D298_G0.5460.68
80_P83_A0.5440.67
108_R114_A0.5410.67
47_D51_D0.5410.67
49_T81_G0.5410.67
212_D385_A0.5390.67
23_D187_E0.5390.67
386_F393_R0.5390.67
95_V103_D0.5380.66
46_R247_T0.5370.66
99_R128_P0.5360.66
246_A363_L0.5350.66
151_R155_Q0.5340.66
358_A362_R0.5340.66
248_V364_T0.5340.66
42_Q128_P0.5330.66
348_T352_G0.5320.66
132_A159_D0.5320.66
85_N90_V0.5320.66
321_L342_G0.5320.66
288_L319_P0.5310.65
77_H98_A0.5310.65
64_V67_R0.5310.65
137_G141_G0.5300.65
139_T152_P0.5300.65
88_E92_A0.5290.65
120_L240_N0.5290.65
25_I31_A0.5290.65
269_L272_S0.5290.65
131_Q157_K0.5280.65
57_V61_A0.5270.65
97_R101_V0.5260.65
312_D317_L0.5250.65
207_L231_S0.5240.64
80_P117_E0.5230.64
360_R364_T0.5230.64
396_V399_P0.5200.64
379_N384_N0.5190.64
253_V363_L0.5190.64
391_H401_Y0.5190.64
140_Q155_Q0.5180.64
311_A315_G0.5180.64
18_T75_D0.5170.63
63_L66_R0.5170.63
63_L313_A0.5170.63
102_L105_F0.5160.63
137_G152_P0.5160.63
384_N387_V0.5150.63
106_G109_A0.5150.63
261_F310_L0.5140.63
99_R153_A0.5140.63
31_A103_D0.5120.63
393_R402_G0.5120.63
41_T65_E0.5120.63
281_R312_D0.5120.63
50_Y85_N0.5120.63
202_G260_G0.5110.62
80_P90_V0.5100.62
267_R309_E0.5090.62
231_S275_T0.5090.62
246_A262_V0.5090.62
292_A324_R0.5070.62
114_A208_R0.5060.62
299_I303_V0.5050.62
348_T359_L0.5040.61
377_V387_V0.5030.61
206_L356_L0.5030.61
327_A331_D0.5030.61
237_E269_L0.5020.61
348_T351_T0.5020.61
93_E180_G0.5010.61
331_D361_E0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qtfA 1 0.6993 100 0.377 Contact Map
3gehA 2 0.8625 100 0.587 Contact Map
3geeA 2 0.8228 100 0.589 Contact Map
1xzpA 4 0.9324 100 0.595 Contact Map
3j65o 1 0.7436 100 0.665 Contact Map
2e87A 1 0.7855 100 0.728 Contact Map
2qm8A 2 0.6014 100 0.73 Contact Map
2j69A 1 0.6294 100 0.733 Contact Map
4xc8A 2 0.8974 100 0.743 Contact Map
1egaA 2 0.5268 100 0.746 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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