GREMLIN Database
Q9HMB9 - Uncharacterized protein
UniProt: Q9HMB9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 90 (71)
Sequences: 165 (79)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_K24_E3.3990.96
21_K25_Y2.9010.90
39_M69_Q2.4170.79
6_D9_L2.1190.69
60_E63_Y1.9160.61
19_V22_V1.7440.53
32_K69_Q1.7440.53
63_Y71_L1.6830.51
16_A29_L1.6350.49
16_A19_V1.5830.46
58_V73_D1.5380.44
46_R67_A1.5190.43
45_V48_A1.4970.42
9_L57_A1.4590.41
22_V67_A1.4580.41
12_L50_E1.4420.40
20_F69_Q1.4320.40
30_T42_A1.3890.38
34_I39_M1.3710.37
33_R39_M1.3630.37
18_L31_Q1.3230.35
51_R64_F1.2980.34
53_E60_E1.2570.33
20_F60_E1.2210.31
58_V70_S1.2170.31
6_D57_A1.1810.30
31_Q67_A1.1790.30
27_G42_A1.1660.29
48_A64_F1.1450.28
22_V27_G1.1310.28
35_V49_L1.1130.27
53_E58_V1.1100.27
28_P33_R1.0780.26
11_D28_P1.0680.26
29_L56_D1.0420.25
42_A49_L1.0330.24
42_A47_Y1.0270.24
41_S71_L1.0200.24
39_M58_V1.0110.24
6_D20_F1.0090.24
30_T75_T1.0010.23
54_D58_V0.9850.23
7_S75_T0.9790.23
11_D37_E0.9780.23
7_S26_D0.9760.23
19_V48_A0.9430.22
41_S61_D0.9280.21
9_L54_D0.9240.21
10_E51_R0.9230.21
47_Y61_D0.9160.21
9_L28_P0.8840.20
37_E57_A0.8650.19
7_S59_D0.8570.19
36_E51_R0.8540.19
48_A67_A0.8520.19
37_E47_Y0.8420.19
12_L61_D0.8390.19
26_D51_R0.8280.18
34_I74_L0.8220.18
51_R71_L0.8030.18
18_L25_Y0.7960.18
19_V67_A0.7840.17
62_I70_S0.7820.17
49_L58_V0.7790.17
29_L36_E0.7700.17
19_V51_R0.7650.17
37_E59_D0.7630.17
7_S73_D0.7560.17
38_T45_V0.7510.16
19_V29_L0.7380.16
9_L56_D0.7360.16
26_D74_L0.7360.16
46_R72_Y0.7280.16
63_Y73_D0.7030.15
16_A48_A0.6890.15
26_D71_L0.6800.15
55_R61_D0.6780.15
8_V57_A0.6760.15
38_T54_D0.6720.15
53_E59_D0.6670.14
28_P38_T0.6620.14
25_Y35_V0.6600.14
17_K31_Q0.6540.14
17_K46_R0.6500.14
7_S34_I0.6330.14
32_K73_D0.6300.14
16_A55_R0.6200.13
7_S28_P0.6180.13
35_V46_R0.6120.13
38_T65_A0.6110.13
13_P47_Y0.6090.13
34_I49_L0.5850.13
35_V67_A0.5820.13
20_F70_S0.5700.12
19_V64_F0.5680.12
13_P23_L0.5600.12
54_D61_D0.5560.12
50_E63_Y0.5490.12
18_L63_Y0.5460.12
33_R37_E0.5390.12
32_K35_V0.5360.12
10_E60_E0.5340.12
36_E50_E0.5220.12
37_E60_E0.5070.11
6_D32_K0.5020.11
63_Y67_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dk5A 1 0.9222 98.5 0.723 Contact Map
3nqoA 2 1 98.4 0.733 Contact Map
2p4wA 2 0.9889 98.3 0.738 Contact Map
1hsjA 2 1 98.3 0.74 Contact Map
2nnnA 2 0.9778 98.3 0.742 Contact Map
2nyxA 2 1 98.2 0.743 Contact Map
4yifA 2 0.9667 98.2 0.743 Contact Map
2hztA 2 0.9444 98.2 0.743 Contact Map
4rbrA 2 1 98.2 0.744 Contact Map
3bddA 2 1 98.2 0.745 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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