GREMLIN Database
Q9HMB6 - Alcohol dehydrogenase
UniProt: Q9HMB6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (300)
Sequences: 52783 (36578)
Seq/√Len: 2111.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_T140_D2.9861.00
31_R66_E2.9441.00
33_T64_I2.8751.00
327_G330_E2.7201.00
172_T196_R2.5721.00
7_Q15_E2.5701.00
29_V66_E2.4971.00
76_A79_D2.4831.00
80_R134_V2.3981.00
79_D133_R2.3301.00
28_A131_L2.3061.00
178_D199_A2.2961.00
19_K121_Y2.2861.00
7_Q13_A2.2651.00
139_A142_E2.2521.00
190_Q216_T2.2231.00
323_V334_A2.2231.00
31_R121_Y2.2001.00
321_K334_A2.1611.00
31_R64_I2.1601.00
173_A189_A2.1531.00
168_G171_D2.0951.00
61_P117_G2.0951.00
5_V15_E2.0821.00
229_R232_D2.0791.00
61_P83_A2.0701.00
141_D322_T2.0511.00
207_L211_A2.0371.00
24_S27_D2.0201.00
25_P70_D2.0111.00
163_V192_L1.9951.00
25_P71_D1.9781.00
29_V123_K1.9651.00
196_R217_D1.9631.00
137_R309_L1.9421.00
186_V215_A1.9291.00
66_E121_Y1.9201.00
26_E71_D1.9151.00
324_D327_G1.9031.00
208_E212_E1.9011.00
46_R336_D1.8901.00
191_R312_T1.8581.00
333_A337_D1.8361.00
306_A310_Q1.8281.00
155_M184_C1.7981.00
80_R140_D1.7901.00
208_E211_A1.7631.00
207_L218_T1.7531.00
62_M140_D1.7321.00
163_V303_E1.7251.00
174_V200_M1.7131.00
334_A339_E1.7121.00
174_V238_A1.6801.00
239_N259_R1.6801.00
263_T289_T1.6801.00
134_V140_D1.6611.00
217_D233_L1.6471.00
263_T291_R1.6441.00
330_E333_A1.6141.00
330_E334_A1.6011.00
198_I238_A1.5961.00
209_L212_E1.5951.00
4_A328_V1.5931.00
21_D67_E1.5561.00
64_I80_R1.5511.00
29_V121_Y1.5491.00
196_R216_T1.5371.00
323_V331_G1.5311.00
258_A264_V1.5161.00
176_V254_A1.4941.00
201_G207_L1.4931.00
67_E77_P1.4921.00
204_E220_S1.4771.00
68_V77_P1.4651.00
75_V79_D1.4611.00
29_V67_E1.4611.00
204_E208_E1.4521.00
241_V258_A1.4521.00
329_P333_A1.4381.00
204_E223_G1.4371.00
125_P129_G1.4371.00
32_V61_P1.4361.00
118_Q332_Y1.4261.00
258_A288_I1.4201.00
27_D125_P1.4031.00
27_D123_K1.3961.00
26_E125_P1.3951.00
75_V133_R1.3951.00
258_A262_G1.3781.00
220_S223_G1.3741.00
3_A17_V1.3721.00
165_A240_H1.3681.00
69_G72_V1.3661.00
320_T334_A1.3581.00
171_D263_T1.3531.00
241_V254_A1.3531.00
191_R307_D1.3491.00
80_R136_D1.3491.00
134_V148_L1.3331.00
4_A14_V1.3321.00
225_D228_E1.3281.00
224_D229_R1.3261.00
159_H163_V1.3171.00
34_H141_D1.3091.00
28_A75_V1.3051.00
202_H221_A1.2991.00
45_Y332_Y1.2891.00
204_E207_L1.2821.00
306_A309_L1.2761.00
64_I140_D1.2731.00
65_V75_V1.2691.00
33_T80_R1.2621.00
172_T198_I1.2581.00
185_G242_M1.2551.00
176_V200_M1.2441.00
22_I123_K1.2411.00
229_R233_L1.2281.00
32_V122_V1.2201.00
228_E232_D1.2111.00
22_I29_V1.2101.00
19_K29_V1.1901.00
186_V199_A1.1691.00
8_G11_E1.1681.00
75_V131_L1.1671.00
187_L314_D1.1631.00
314_D317_P1.1541.00
212_E317_P1.1521.00
227_I256_A1.1511.00
207_L220_S1.1341.00
211_A218_T1.1231.00
5_V17_V1.1201.00
307_D312_T1.1121.00
172_T239_N1.1121.00
303_E306_A1.0961.00
167_V194_A1.0931.00
256_A282_T1.0771.00
171_D239_N1.0661.00
209_L340_A1.0591.00
189_A194_A1.0441.00
158_G185_G1.0441.00
45_Y336_D1.0401.00
124_C131_L1.0391.00
198_I217_D1.0381.00
225_D229_R1.0361.00
167_V171_D1.0361.00
14_V326_D1.0331.00
298_R302_E1.0321.00
30_I81_V1.0171.00
227_I253_S1.0161.00
253_S256_A1.0151.00
328_V345_V1.0151.00
160_H300_Y1.0111.00
7_Q11_E1.0091.00
4_A325_L1.0031.00
34_H140_D1.0001.00
245_V250_A1.0001.00
333_A336_D0.9991.00
30_I63_G0.9951.00
66_E77_P0.9941.00
22_I27_D0.9931.00
165_A265_G0.9921.00
161_A267_V0.9921.00
159_H303_E0.9881.00
35_T118_Q0.9871.00
37_V331_G0.9811.00
323_V327_G0.9771.00
227_I231_R0.9771.00
202_H222_R0.9691.00
334_A343_V0.9611.00
303_E307_D0.9581.00
158_G188_A0.9561.00
199_A210_A0.9551.00
211_A217_D0.9541.00
163_V300_Y0.9501.00
161_A242_M0.9431.00
155_M304_L0.9421.00
203_H206_R0.9381.00
178_D201_G0.9361.00
302_E306_A0.9351.00
178_D186_V0.9251.00
35_T117_G0.9241.00
142_E314_D0.9221.00
230_A238_A0.9141.00
252_D256_A0.9131.00
42_L335_M0.9121.00
183_L209_L0.9091.00
178_D210_A0.9071.00
282_T286_D0.9061.00
171_D240_H0.8971.00
223_G229_R0.8961.00
4_A12_I0.8951.00
186_V197_I0.8921.00
82_I305_M0.8911.00
68_V76_A0.8901.00
138_Y148_L0.8881.00
199_A215_A0.8871.00
249_S253_S0.8861.00
234_T237_G0.8851.00
200_M221_A0.8811.00
205_D208_E0.8781.00
33_T62_M0.8761.00
9_P53_A0.8761.00
38_C60_E0.8761.00
206_R340_A0.8751.00
174_V257_I0.8721.00
118_Q328_V0.8641.00
34_H344_L0.8631.00
198_I219_I0.8631.00
243_E246_G0.8611.00
5_V56_R0.8591.00
19_K67_E0.8461.00
261_G287_N0.8431.00
31_R120_E0.8421.00
176_V241_V0.8361.00
38_C59_H0.8361.00
3_A56_R0.8291.00
151_L308_V0.8281.00
175_V189_A0.8271.00
68_V72_V0.8231.00
132_V302_E0.8201.00
210_A215_A0.8171.00
192_L303_E0.8101.00
189_A197_I0.8031.00
19_K66_E0.8021.00
201_G218_T0.7971.00
283_M290_I0.7951.00
202_H207_L0.7941.00
61_P122_V0.7921.00
198_I233_L0.7911.00
299_A303_E0.7901.00
241_V264_V0.7891.00
117_G122_V0.7861.00
198_I230_A0.7851.00
188_A304_L0.7851.00
173_A194_A0.7841.00
254_A264_V0.7821.00
176_V250_A0.7791.00
162_A189_A0.7791.00
37_V335_M0.7781.00
323_V343_V0.7771.00
307_D310_Q0.7771.00
83_A124_C0.7761.00
226_A253_S0.7761.00
136_D309_L0.7751.00
36_A60_E0.7741.00
175_V185_G0.7731.00
17_V56_R0.7711.00
24_S123_K0.7701.00
172_T238_A0.7651.00
118_Q345_V0.7631.00
14_V325_L0.7631.00
38_C41_D0.7601.00
244_C267_V0.7591.00
166_G289_T0.7561.00
76_A133_R0.7541.00
21_D29_V0.7541.00
321_K330_E0.7531.00
279_D282_T0.7501.00
197_I216_T0.7491.00
305_M309_L0.7451.00
166_G263_T0.7441.00
158_G184_C0.7401.00
319_F322_T0.7371.00
4_A329_P0.7361.00
225_D253_S0.7321.00
283_M292_G0.7321.00
334_A337_D0.7291.00
188_A307_D0.7291.00
228_E231_R0.7281.00
227_I257_I0.7281.00
40_S59_H0.7221.00
161_A185_G0.7211.00
81_V131_L0.7211.00
252_D282_T0.7121.00
82_I134_V0.7101.00
266_Y290_I0.7081.00
26_E69_G0.7051.00
299_A302_E0.7051.00
28_A65_V0.6981.00
156_G300_Y0.6961.00
135_P309_L0.6961.00
42_L336_D0.6931.00
159_H307_D0.6931.00
160_H287_N0.6901.00
26_E70_D0.6881.00
138_Y308_V0.6871.00
209_L213_F0.6871.00
34_H322_T0.6871.00
167_V240_H0.6851.00
297_V300_Y0.6841.00
238_A241_V0.6841.00
194_A240_H0.6781.00
323_V345_V0.6781.00
132_V301_A0.6771.00
252_D275_D0.6751.00
158_G181_V0.6741.00
251_M264_V0.6741.00
52_E55_S0.6731.00
335_M343_V0.6731.00
159_H304_L0.6711.00
32_V35_T0.6701.00
79_D136_D0.6701.00
82_I152_T0.6691.00
51_R55_S0.6691.00
60_E153_D0.6681.00
217_D229_R0.6681.00
243_E264_V0.6681.00
175_V199_A0.6641.00
22_I67_E0.6631.00
10_G45_Y0.6581.00
283_M288_I0.6571.00
150_P344_L0.6561.00
20_P123_K0.6521.00
83_A131_L0.6511.00
203_H220_S0.6501.00
163_V188_A0.6491.00
186_V213_F0.6471.00
34_H62_M0.6471.00
282_T285_S0.6451.00
38_C153_D0.6421.00
157_T181_V0.6401.00
166_G291_R0.6401.00
219_I233_L0.6371.00
187_L213_F0.6371.00
212_E314_D0.6351.00
247_A250_A0.6351.00
26_E129_G0.6341.00
240_H265_G0.6301.00
307_D311_G0.6301.00
296_P300_Y0.6291.00
154_V184_C0.6291.00
158_G162_A0.6281.00
231_R237_G0.6281.00
74_S298_R0.6271.00
80_R137_R0.6261.00
59_H153_D0.6261.00
240_H263_T0.6251.00
160_H164_S0.6221.00
62_M80_R0.6221.00
260_P286_D0.6221.00
226_A230_A0.6221.00
194_A197_I0.6221.00
40_S44_F0.6211.00
321_K343_V0.6211.00
62_M134_V0.6191.00
43_W48_D0.6181.00
42_L46_R0.6151.00
296_P299_A0.6141.00
201_G221_A0.6141.00
132_V305_M0.6131.00
183_L318_I0.6121.00
190_Q197_I0.6111.00
275_D279_D0.6111.00
164_S300_Y0.6101.00
321_K340_A0.6071.00
30_I83_A0.6051.00
185_G267_V0.6051.00
154_V180_A0.6011.00
38_C154_V0.6001.00
169_E192_L0.5981.00
215_A218_T0.5981.00
22_I69_G0.5981.00
35_T345_V0.5971.00
230_A257_I0.5961.00
174_V241_V0.5961.00
8_G13_A0.5921.00
219_I229_R0.5891.00
250_A254_A0.5891.00
84_P132_V0.5861.00
165_A263_T0.5851.00
159_H300_Y0.5841.00
238_A257_I0.5831.00
161_A265_G0.5811.00
202_H210_A0.5811.00
20_P27_D0.5811.00
37_V118_Q0.5791.00
12_I332_Y0.5781.00
332_Y336_D0.5771.00
39_G43_W0.5751.00
209_L318_I0.5751.00
74_S77_P0.5731.00
62_M149_L0.5721.00
301_A305_M0.5701.00
20_P121_Y0.5691.00
188_A192_L0.5691.00
73_T76_A0.5681.00
125_P130_T0.5661.00
68_V79_D0.5641.00
172_T234_T0.5641.00
30_I131_L0.5621.00
164_S289_T0.5621.00
207_L210_A0.5611.00
40_S43_W0.5581.00
157_T267_V0.5571.00
18_P21_D0.5551.00
173_A240_H0.5551.00
300_Y303_E0.5551.00
249_S252_D0.5541.00
186_V210_A0.5531.00
74_S133_R0.5511.00
83_A117_G0.5501.00
210_A218_T0.5501.00
87_I130_T0.5481.00
162_A188_A0.5481.00
172_T217_D0.5471.00
58_G118_Q0.5461.00
183_L213_F0.5461.00
175_V186_V0.5451.00
320_T341_I0.5441.00
323_V330_E0.5431.00
281_F285_S0.5431.00
321_K327_G0.5421.00
169_E193_G0.5411.00
19_K22_I0.5411.00
164_S296_P0.5381.00
184_C188_A0.5371.00
153_D157_T0.5371.00
184_C313_L0.5361.00
285_S294_V0.5351.00
231_R234_T0.5351.00
252_D277_G0.5311.00
251_M266_Y0.5271.00
241_V257_I0.5271.00
159_H188_A0.5271.00
162_A185_G0.5271.00
132_V298_R0.5251.00
265_G293_G0.5251.00
250_A253_S0.5251.00
68_V75_V0.5241.00
288_I292_G0.5231.00
265_G291_R0.5221.00
234_T238_A0.5221.00
134_V149_L0.5211.00
32_V83_A0.5201.00
311_G314_D0.5181.00
302_E305_M0.5171.00
190_Q215_A0.5161.00
340_A343_V0.5151.00
133_R136_D0.5151.00
161_A293_G0.5151.00
6_Y45_Y0.5131.00
159_H192_L0.5121.00
201_G220_S0.5111.00
50_D53_A0.5081.00
206_R339_E0.5051.00
186_V190_Q0.5051.00
319_F344_L0.5021.00
38_C342_K0.5011.00
185_G244_C0.5011.00
237_G259_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cpdA 2 0.9712 100 0.14 Contact Map
4ej6A 1 0.9683 100 0.146 Contact Map
1f8fA 4 0.9712 100 0.148 Contact Map
3ukoA 4 0.9741 100 0.157 Contact Map
1e3iA 2 0.9683 100 0.158 Contact Map
2jhfA 2 0.9741 100 0.16 Contact Map
2dq4A 4 0.9597 100 0.161 Contact Map
1cdoA 2 0.9712 100 0.161 Contact Map
1vj0A 4 0.9741 100 0.162 Contact Map
1p0fA 2 0.9712 100 0.164 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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