Q9HMB3 - HALSA - GREMLIN Contacts

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Q9HMB3 - Uncharacterized protein

UniProt:	Q9HMB3	Sequences: MRAPPFATALADADADAFVHVGPPGDPVVSYLAGTQLPCRAAVVYGGRVAVVPERSLPGASGVPAEVTVLDPHSVPARRLPGLASDAVLAPRMLPHDAALYLEEAGIDVSSTVVHKHARRSKTPAEQKTLREAVAAAEAGLGAAGGLLADGVADDLGTPEAVRRAANAGIADDGAVPATTVRPASAEPDTPLRVTATAVVDGYHAPVRRTFVAGADGGWDRRATLGCEYGVDAAIDVIEAGETTAERAGEEATAELASLGFPPEDTTVDVHGVGLERREAPTGEATLAEGAVVSVSAGVTDDGRTVGVSDVAVVGADGAERVGSFPRSVVPKADY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	335 (320)
Sequences:	11002 (8268)
Seq/√Len:	462.2

ECOLI - YPDF AMPP PEPQ MAP1
BACSU - YQHT YKVY MAP11 MAP12
HALSA - Q9HMB3 Q9HRF6 Q9HQC0 Q9HP03
SULSO - Q981D7 Q980E9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
131_R	320_E	5.435	1.00
289_E	316_A	4.616	1.00
238_I	314_V	3.417	1.00
127_Q	313_V	3.301	1.00
225_L	229_Y	2.687	1.00
246_E	284_E	2.610	1.00
217_G	220_D	2.583	1.00
219_W	304_R	2.578	1.00
233_A	255_E	2.575	1.00
132_E	135_A	2.516	1.00
219_W	222_R	2.461	1.00
121_S	288_A	2.424	1.00
254_A	258_S	2.423	1.00
237_V	251_E	2.416	1.00
130_L	292_V	2.407	1.00
243_T	247_R	2.388	1.00
249_G	253_T	2.348	1.00
27_P	276_E	2.339	1.00
175_A	184_A	2.328	1.00
232_D	236_D	2.319	1.00
218_G	222_R	2.307	1.00
234_A	252_A	2.232	1.00
273_V	311_V	2.225	1.00
52_V	79_R	2.208	1.00
131_R	135_A	2.087	1.00
129_T	201_D	2.063	1.00
187_E	190_T	2.059	1.00
315_G	320_E	2.052	1.00
226_G	259_L	2.017	1.00
9_A	12_D	2.012	1.00
15_A	89_L	2.008	1.00
100_L	103_E	2.003	1.00
153_A	185_S	1.998	1.00
233_A	236_D	1.970	1.00
243_T	246_E	1.938	1.00
186_A	213_A	1.927	1.00
54_E	57_L	1.913	1.00
184_A	190_T	1.831	1.00
191_P	220_D	1.800	1.00
221_R	225_L	1.798	1.00
295_V	312_A	1.796	1.00
239_E	242_E	1.749	1.00
250_E	254_A	1.744	1.00
229_Y	233_A	1.739	1.00
145_G	211_F	1.723	1.00
212_V	216_D	1.711	1.00
223_A	306_V	1.693	1.00
227_C	306_V	1.686	1.00
138_E	325_F	1.670	1.00
232_D	328_S	1.655	1.00
243_T	286_T	1.654	1.00
171_A	192_L	1.647	1.00
75_V	78_R	1.634	1.00
153_A	156_L	1.631	1.00
235_I	312_A	1.629	1.00
288_A	291_A	1.613	1.00
255_E	259_L	1.590	1.00
120_R	291_A	1.585	1.00
228_E	232_D	1.584	1.00
229_Y	259_L	1.575	1.00
142_G	146_G	1.573	1.00
256_L	299_V	1.560	1.00
313_V	322_V	1.550	1.00
143_A	146_G	1.550	1.00
166_A	204_H	1.518	1.00
234_A	248_A	1.495	1.00
199_V	204_H	1.459	1.00
9_A	13_A	1.459	1.00
139_A	160_E	1.454	1.00
191_P	212_V	1.437	1.00
124_P	128_K	1.432	1.00
79_R	82_G	1.429	1.00
128_K	132_E	1.426	1.00
294_S	311_V	1.422	1.00
230_G	255_E	1.412	1.00
195_T	206_P	1.406	1.00
257_A	262_P	1.405	1.00
30_S	202_G	1.394	1.00
173_D	184_A	1.390	1.00
223_A	301_D	1.388	1.00
231_V	235_I	1.383	1.00
50_A	71_D	1.380	1.00
252_A	269_D	1.379	1.00
48_R	69_V	1.365	1.00
154_D	157_G	1.342	1.00
287_L	314_V	1.342	1.00
206_P	309_S	1.335	1.00
315_G	318_G	1.322	1.00
87_A	108_D	1.320	1.00
173_D	186_A	1.317	1.00
240_A	289_E	1.309	1.00
150_D	188_P	1.309	1.00
242_E	247_R	1.297	1.00
246_E	250_E	1.289	1.00
132_E	200_V	1.289	1.00
8_T	12_D	1.283	1.00
218_G	221_R	1.280	1.00
135_A	139_A	1.277	1.00
125_A	129_T	1.271	1.00
235_I	321_R	1.252	1.00
71_D	75_V	1.251	1.00
247_R	250_E	1.249	1.00
233_A	251_E	1.248	1.00
229_Y	255_E	1.246	1.00
11_A	46_G	1.236	1.00
232_D	327_R	1.232	1.00
287_L	293_V	1.223	1.00
72_P	75_V	1.220	1.00
28_V	31_Y	1.220	1.00
96_H	99_A	1.213	1.00
99_A	103_E	1.209	1.00
96_H	100_L	1.199	1.00
32_L	118_A	1.194	1.00
238_I	248_A	1.188	1.00
222_R	226_G	1.188	1.00
136_A	202_G	1.185	1.00
157_G	186_A	1.185	1.00
231_V	310_D	1.184	1.00
231_V	327_R	1.173	1.00
195_T	309_S	1.157	1.00
117_H	288_A	1.155	1.00
37_L	40_R	1.153	1.00
155_D	183_P	1.150	1.00
6_F	18_F	1.146	1.00
141_L	207_V	1.144	1.00
137_A	207_V	1.143	1.00
61_S	65_A	1.135	1.00
229_Y	258_S	1.128	1.00
224_T	308_V	1.126	1.00
290_G	313_V	1.103	1.00
10_L	15_A	1.103	1.00
238_I	295_V	1.102	1.00
121_S	291_A	1.102	1.00
292_V	313_V	1.101	1.00
191_P	210_T	1.098	1.00
301_D	304_R	1.097	1.00
130_L	134_V	1.093	1.00
15_A	110_S	1.091	1.00
134_V	138_E	1.089	1.00
237_V	242_E	1.076	1.00
142_G	325_F	1.075	1.00
125_A	128_K	1.072	1.00
57_L	60_A	1.063	1.00
226_G	256_L	1.061	1.00
313_V	320_E	1.054	1.00
184_A	187_E	1.054	1.00
5_P	8_T	1.053	1.00
308_V	327_R	1.044	1.00
234_A	251_E	1.039	1.00
148_L	211_F	1.036	1.00
219_W	301_D	1.033	1.00
235_I	295_V	1.032	1.00
162_V	165_A	1.030	1.00
249_G	269_D	1.030	1.00
222_R	225_L	1.028	1.00
251_E	254_A	1.028	1.00
194_V	211_F	1.022	1.00
174_G	190_T	1.018	1.00
78_R	82_G	1.016	1.00
149_A	152_V	1.014	1.00
61_S	64_P	1.008	1.00
131_R	313_V	1.005	1.00
72_P	76_P	1.004	1.00
134_V	311_V	1.002	1.00
87_A	110_S	1.001	1.00
33_A	42_A	0.999	1.00
242_E	251_E	0.995	1.00
293_V	314_V	0.993	1.00
226_G	255_E	0.989	1.00
9_A	117_H	0.989	1.00
143_A	147_L	0.988	1.00
91_P	100_L	0.987	1.00
222_R	259_L	0.986	1.00
152_V	156_L	0.985	1.00
176_V	184_A	0.978	1.00
312_A	321_R	0.978	1.00
176_V	181_V	0.972	1.00
63_V	67_V	0.971	1.00
128_K	131_R	0.968	1.00
65_A	68_T	0.966	1.00
5_P	118_A	0.958	1.00
158_T	161_A	0.952	1.00
132_E	136_A	0.947	1.00
233_A	237_V	0.947	1.00
62_G	65_A	0.943	1.00
10_L	17_A	0.942	1.00
117_H	285_A	0.941	1.00
225_L	228_E	0.941	1.00
66_E	70_L	0.940	1.00
172_D	177_P	0.938	1.00
37_L	44_V	0.935	1.00
173_D	190_T	0.935	1.00
248_A	251_E	0.934	1.00
65_A	70_L	0.934	1.00
254_A	257_A	0.931	1.00
172_D	181_V	0.930	1.00
223_A	261_F	0.930	1.00
192_L	213_A	0.929	1.00
141_L	211_F	0.926	1.00
165_A	169_G	0.924	1.00
238_I	319_A	0.924	1.00
62_G	66_E	0.923	1.00
66_E	71_D	0.922	1.00
75_V	79_R	0.922	1.00
230_G	256_L	0.921	1.00
138_E	324_S	0.910	1.00
248_A	287_L	0.910	1.00
162_V	198_A	0.907	1.00
245_A	287_L	0.906	1.00
312_A	319_A	0.899	1.00
212_V	220_D	0.898	1.00
285_A	288_A	0.895	1.00
241_G	288_A	0.894	1.00
219_W	223_A	0.894	1.00
64_P	67_V	0.891	1.00
7_A	49_V	0.887	1.00
273_V	292_V	0.884	1.00
238_I	312_A	0.882	1.00
226_G	229_Y	0.878	1.00
100_L	104_E	0.875	1.00
7_A	10_L	0.873	1.00
251_E	255_E	0.871	1.00
78_R	81_P	0.869	1.00
90_A	96_H	0.864	1.00
129_T	132_E	0.863	1.00
310_D	327_R	0.862	1.00
28_V	116_K	0.861	1.00
97_D	101_Y	0.859	1.00
124_P	315_G	0.854	1.00
139_A	142_G	0.852	1.00
148_L	157_G	0.842	1.00
235_I	319_A	0.841	1.00
153_A	157_G	0.838	1.00
177_P	193_R	0.834	1.00
63_V	66_E	0.828	1.00
314_V	319_A	0.827	1.00
255_E	258_S	0.823	1.00
120_R	288_A	0.820	1.00
27_P	275_L	0.819	1.00
137_A	205_A	0.817	1.00
127_Q	131_R	0.816	1.00
79_R	83_L	0.816	1.00
234_A	295_V	0.813	1.00
20_H	115_H	0.813	1.00
8_T	11_A	0.809	1.00
64_P	68_T	0.809	1.00
73_H	76_P	0.806	1.00
114_V	117_H	0.793	1.00
242_E	248_A	0.791	1.00
146_G	150_D	0.789	1.00
62_G	70_L	0.788	1.00
136_A	200_V	0.787	1.00
132_E	201_D	0.786	1.00
30_S	275_L	0.786	1.00
134_V	323_G	0.784	1.00
237_V	248_A	0.780	1.00
138_E	142_G	0.780	1.00
272_G	279_E	0.776	1.00
37_L	41_A	0.774	1.00
240_A	316_A	0.773	1.00
67_V	71_D	0.773	1.00
240_A	315_G	0.773	1.00
150_D	213_A	0.770	1.00
7_A	46_G	0.767	1.00
32_L	43_V	0.764	1.00
171_A	194_V	0.763	1.00
272_G	281_P	0.760	1.00
220_D	304_R	0.759	1.00
62_G	67_V	0.758	1.00
135_A	138_E	0.758	1.00
62_G	68_T	0.757	1.00
95_P	99_A	0.756	1.00
81_P	84_A	0.754	1.00
243_T	284_E	0.754	1.00
91_P	94_L	0.749	1.00
144_A	194_V	0.749	1.00
142_G	326_P	0.748	1.00
91_P	95_P	0.747	1.00
134_V	205_A	0.747	1.00
63_V	70_L	0.745	1.00
61_S	71_D	0.743	1.00
95_P	98_A	0.742	1.00
156_L	159_P	0.738	1.00
180_T	278_R	0.738	1.00
50_A	69_V	0.737	1.00
240_A	288_A	0.736	1.00
143_A	160_E	0.735	1.00
16_D	20_H	0.731	1.00
67_V	70_L	0.728	1.00
209_R	310_D	0.727	1.00
216_D	221_R	0.724	1.00
66_E	69_V	0.723	1.00
76_P	84_A	0.723	1.00
20_H	32_L	0.721	1.00
77_A	81_P	0.720	1.00
237_V	240_A	0.720	1.00
230_G	234_A	0.720	1.00
126_E	203_Y	0.719	1.00
233_A	252_A	0.718	1.00
6_F	32_L	0.717	1.00
129_T	200_V	0.714	1.00
264_E	302_D	0.711	1.00
228_E	308_V	0.708	1.00
188_P	215_A	0.705	1.00
7_A	47_G	0.704	1.00
45_Y	49_V	0.702	1.00
179_T	267_T	0.699	1.00
224_T	228_E	0.699	1.00
141_L	144_A	0.698	1.00
292_V	322_V	0.694	1.00
134_V	322_V	0.692	1.00
257_A	263_P	0.691	1.00
141_L	325_F	0.691	1.00
300_T	307_G	0.689	1.00
260_G	263_P	0.687	1.00
137_A	140_G	0.686	1.00
63_V	68_T	0.684	1.00
240_A	314_V	0.683	1.00
289_E	315_G	0.683	1.00
273_V	294_S	0.682	1.00
204_H	277_R	0.680	1.00
195_T	296_S	0.680	1.00
75_V	84_A	0.680	1.00
247_R	251_E	0.678	1.00
283_G	286_T	0.677	1.00
120_R	285_A	0.677	1.00
231_V	295_V	0.676	1.00
239_E	319_A	0.676	1.00
50_A	79_R	0.676	1.00
71_D	79_R	0.675	1.00
7_A	11_A	0.674	1.00
17_A	20_H	0.671	1.00
190_T	220_D	0.670	1.00
223_A	226_G	0.669	1.00
158_T	162_V	0.666	1.00
141_L	196_A	0.666	1.00
230_G	251_E	0.665	1.00
87_A	90_A	0.665	1.00
61_S	68_T	0.664	1.00
68_T	71_D	0.664	1.00
226_G	261_F	0.664	1.00
296_S	309_S	0.664	1.00
77_A	84_A	0.662	1.00
256_L	261_F	0.656	1.00
143_A	159_P	0.655	1.00
189_D	213_A	0.655	1.00
74_S	77_A	0.655	1.00
136_A	198_A	0.653	1.00
175_A	303_G	0.652	1.00
137_A	196_A	0.647	1.00
9_A	114_V	0.647	1.00
26_D	29_V	0.646	1.00
38_P	44_V	0.646	1.00
30_S	36_Q	0.644	1.00
157_G	192_L	0.643	1.00
173_D	213_A	0.641	1.00
216_D	220_D	0.640	1.00
285_A	291_A	0.640	1.00
177_P	305_T	0.639	1.00
245_A	283_G	0.639	1.00
163_R	201_D	0.638	1.00
271_H	309_S	0.637	1.00
72_P	77_A	0.637	1.00
267_T	278_R	0.635	0.99
5_P	9_A	0.635	0.99
159_P	162_V	0.634	0.99
233_A	254_A	0.632	0.99
134_V	207_V	0.632	0.99
10_L	18_F	0.630	0.99
191_P	216_D	0.630	0.99
177_P	191_P	0.628	0.99
39_C	44_V	0.626	0.99
63_V	71_D	0.624	0.99
206_P	271_H	0.622	0.99
144_A	147_L	0.622	0.99
124_P	290_G	0.619	0.99
286_T	289_E	0.619	0.99
165_A	168_A	0.617	0.99
261_F	264_E	0.616	0.99
56_S	59_G	0.614	0.99
6_F	29_V	0.613	0.99
230_G	252_A	0.612	0.99
38_P	41_A	0.609	0.99
148_L	192_L	0.607	0.99
6_F	118_A	0.607	0.99
228_E	328_S	0.607	0.99
41_A	45_Y	0.606	0.99
234_A	269_D	0.602	0.99
228_E	327_R	0.600	0.99
55_R	72_P	0.598	0.99
207_V	323_G	0.597	0.99
298_G	307_G	0.596	0.99
61_S	66_E	0.595	0.99
101_Y	105_A	0.595	0.99
282_T	293_V	0.594	0.99
41_A	44_V	0.594	0.99
117_H	120_R	0.594	0.99
300_T	305_T	0.590	0.99
16_D	87_A	0.588	0.99
101_Y	104_E	0.588	0.99
55_R	266_T	0.587	0.99
55_R	59_G	0.586	0.99
46_G	49_V	0.585	0.99
212_V	217_G	0.582	0.99
152_V	157_G	0.582	0.99
206_P	296_S	0.580	0.99
321_R	324_S	0.580	0.99
56_S	60_A	0.576	0.99
9_A	118_A	0.576	0.99
176_V	183_P	0.571	0.99
266_T	302_D	0.571	0.99
173_D	176_V	0.569	0.99
234_A	237_V	0.566	0.99
315_G	319_A	0.566	0.99
151_G	154_D	0.566	0.99
72_P	84_A	0.565	0.99
175_A	178_A	0.565	0.99
61_S	67_V	0.564	0.99
116_K	280_A	0.562	0.99
63_V	69_V	0.562	0.99
139_A	143_A	0.558	0.99
127_Q	292_V	0.558	0.99
140_G	198_A	0.556	0.99
246_E	283_G	0.556	0.99
198_A	205_A	0.555	0.99
71_D	74_S	0.555	0.99
229_Y	232_D	0.553	0.99
226_G	299_V	0.553	0.99
32_L	115_H	0.552	0.99
260_G	264_E	0.550	0.99
158_T	163_R	0.548	0.99
232_D	235_I	0.547	0.99
128_K	135_A	0.545	0.98
122_K	126_E	0.545	0.98
108_D	111_S	0.545	0.98
292_V	311_V	0.544	0.98
14_D	87_A	0.544	0.98
137_A	197_T	0.544	0.98
91_P	96_H	0.543	0.98
7_A	44_V	0.542	0.98
241_G	286_T	0.541	0.98
159_P	163_R	0.541	0.98
245_A	270_V	0.540	0.98
238_I	287_L	0.540	0.98
240_A	319_A	0.540	0.98
148_L	213_A	0.538	0.98
49_V	67_V	0.538	0.98
29_V	40_R	0.535	0.98
248_A	269_D	0.535	0.98
162_V	166_A	0.534	0.98
70_L	75_V	0.531	0.98
188_P	214_G	0.530	0.98
320_E	324_S	0.530	0.98
39_C	45_Y	0.528	0.98
151_G	157_G	0.527	0.98
223_A	299_V	0.527	0.98
61_S	70_L	0.526	0.98
189_D	215_A	0.525	0.98
124_P	289_E	0.524	0.98
224_T	327_R	0.521	0.98
160_E	163_R	0.520	0.98
24_P	119_R	0.518	0.98
261_F	265_D	0.518	0.98
70_L	73_H	0.517	0.98
90_A	99_A	0.517	0.98
68_T	72_P	0.516	0.98
79_R	84_A	0.515	0.98
144_A	148_L	0.513	0.98
54_E	60_A	0.513	0.98
133_A	137_A	0.511	0.98
42_A	45_Y	0.511	0.98
70_L	74_S	0.509	0.98
137_A	198_A	0.509	0.98
217_G	304_R	0.507	0.98
140_G	143_A	0.507	0.98
24_P	27_P	0.507	0.98
298_G	305_T	0.503	0.97
24_P	199_V	0.501	0.97
173_D	193_R	0.500	0.97
145_G	325_F	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fkcA	2	0.9791	100	0.199	Contact Map
3q6dA	1	0.9791	100	0.199	Contact Map
2zsgA	2	0.9791	100	0.2	Contact Map
1wn1A	2	0.9791	100	0.21	Contact Map
1wy2A	2	0.9642	100	0.219	Contact Map
4r60A	2	0.9851	100	0.221	Contact Map
4egeA	2	0.9791	100	0.23	Contact Map
3ig4A	4	0.997	100	0.231	Contact Map
2v3zA	3	0.994	100	0.243	Contact Map
1kp0A	2	0.8806	100	0.243	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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