GREMLIN Database
Q9HMB3 - Uncharacterized protein
UniProt: Q9HMB3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (320)
Sequences: 11002 (8268)
Seq/√Len: 462.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_R320_E5.4351.00
289_E316_A4.6161.00
238_I314_V3.4171.00
127_Q313_V3.3011.00
225_L229_Y2.6871.00
246_E284_E2.6101.00
217_G220_D2.5831.00
219_W304_R2.5781.00
233_A255_E2.5751.00
132_E135_A2.5161.00
219_W222_R2.4611.00
121_S288_A2.4241.00
254_A258_S2.4231.00
237_V251_E2.4161.00
130_L292_V2.4071.00
243_T247_R2.3881.00
249_G253_T2.3481.00
27_P276_E2.3391.00
175_A184_A2.3281.00
232_D236_D2.3191.00
218_G222_R2.3071.00
234_A252_A2.2321.00
273_V311_V2.2251.00
52_V79_R2.2081.00
131_R135_A2.0871.00
129_T201_D2.0631.00
187_E190_T2.0591.00
315_G320_E2.0521.00
226_G259_L2.0171.00
9_A12_D2.0121.00
15_A89_L2.0081.00
100_L103_E2.0031.00
153_A185_S1.9981.00
233_A236_D1.9701.00
243_T246_E1.9381.00
186_A213_A1.9271.00
54_E57_L1.9131.00
184_A190_T1.8311.00
191_P220_D1.8001.00
221_R225_L1.7981.00
295_V312_A1.7961.00
239_E242_E1.7491.00
250_E254_A1.7441.00
229_Y233_A1.7391.00
145_G211_F1.7231.00
212_V216_D1.7111.00
223_A306_V1.6931.00
227_C306_V1.6861.00
138_E325_F1.6701.00
232_D328_S1.6551.00
243_T286_T1.6541.00
171_A192_L1.6471.00
75_V78_R1.6341.00
153_A156_L1.6311.00
235_I312_A1.6291.00
288_A291_A1.6131.00
255_E259_L1.5901.00
120_R291_A1.5851.00
228_E232_D1.5841.00
229_Y259_L1.5751.00
142_G146_G1.5731.00
256_L299_V1.5601.00
313_V322_V1.5501.00
143_A146_G1.5501.00
166_A204_H1.5181.00
234_A248_A1.4951.00
199_V204_H1.4591.00
9_A13_A1.4591.00
139_A160_E1.4541.00
191_P212_V1.4371.00
124_P128_K1.4321.00
79_R82_G1.4291.00
128_K132_E1.4261.00
294_S311_V1.4221.00
230_G255_E1.4121.00
195_T206_P1.4061.00
257_A262_P1.4051.00
30_S202_G1.3941.00
173_D184_A1.3901.00
223_A301_D1.3881.00
231_V235_I1.3831.00
50_A71_D1.3801.00
252_A269_D1.3791.00
48_R69_V1.3651.00
154_D157_G1.3421.00
287_L314_V1.3421.00
206_P309_S1.3351.00
315_G318_G1.3221.00
87_A108_D1.3201.00
173_D186_A1.3171.00
240_A289_E1.3091.00
150_D188_P1.3091.00
242_E247_R1.2971.00
246_E250_E1.2891.00
132_E200_V1.2891.00
8_T12_D1.2831.00
218_G221_R1.2801.00
135_A139_A1.2771.00
125_A129_T1.2711.00
235_I321_R1.2521.00
71_D75_V1.2511.00
247_R250_E1.2491.00
233_A251_E1.2481.00
229_Y255_E1.2461.00
11_A46_G1.2361.00
232_D327_R1.2321.00
287_L293_V1.2231.00
72_P75_V1.2201.00
28_V31_Y1.2201.00
96_H99_A1.2131.00
99_A103_E1.2091.00
96_H100_L1.1991.00
32_L118_A1.1941.00
238_I248_A1.1881.00
222_R226_G1.1881.00
136_A202_G1.1851.00
157_G186_A1.1851.00
231_V310_D1.1841.00
231_V327_R1.1731.00
195_T309_S1.1571.00
117_H288_A1.1551.00
37_L40_R1.1531.00
155_D183_P1.1501.00
6_F18_F1.1461.00
141_L207_V1.1441.00
137_A207_V1.1431.00
61_S65_A1.1351.00
229_Y258_S1.1281.00
224_T308_V1.1261.00
290_G313_V1.1031.00
10_L15_A1.1031.00
238_I295_V1.1021.00
121_S291_A1.1021.00
292_V313_V1.1011.00
191_P210_T1.0981.00
301_D304_R1.0971.00
130_L134_V1.0931.00
15_A110_S1.0911.00
134_V138_E1.0891.00
237_V242_E1.0761.00
142_G325_F1.0751.00
125_A128_K1.0721.00
57_L60_A1.0631.00
226_G256_L1.0611.00
313_V320_E1.0541.00
184_A187_E1.0541.00
5_P8_T1.0531.00
308_V327_R1.0441.00
234_A251_E1.0391.00
148_L211_F1.0361.00
219_W301_D1.0331.00
235_I295_V1.0321.00
162_V165_A1.0301.00
249_G269_D1.0301.00
222_R225_L1.0281.00
251_E254_A1.0281.00
194_V211_F1.0221.00
174_G190_T1.0181.00
78_R82_G1.0161.00
149_A152_V1.0141.00
61_S64_P1.0081.00
131_R313_V1.0051.00
72_P76_P1.0041.00
134_V311_V1.0021.00
87_A110_S1.0011.00
33_A42_A0.9991.00
242_E251_E0.9951.00
293_V314_V0.9931.00
226_G255_E0.9891.00
9_A117_H0.9891.00
143_A147_L0.9881.00
91_P100_L0.9871.00
222_R259_L0.9861.00
152_V156_L0.9851.00
176_V184_A0.9781.00
312_A321_R0.9781.00
176_V181_V0.9721.00
63_V67_V0.9711.00
128_K131_R0.9681.00
65_A68_T0.9661.00
5_P118_A0.9581.00
158_T161_A0.9521.00
132_E136_A0.9471.00
233_A237_V0.9471.00
62_G65_A0.9431.00
10_L17_A0.9421.00
117_H285_A0.9411.00
225_L228_E0.9411.00
66_E70_L0.9401.00
172_D177_P0.9381.00
37_L44_V0.9351.00
173_D190_T0.9351.00
248_A251_E0.9341.00
65_A70_L0.9341.00
254_A257_A0.9311.00
172_D181_V0.9301.00
223_A261_F0.9301.00
192_L213_A0.9291.00
141_L211_F0.9261.00
165_A169_G0.9241.00
238_I319_A0.9241.00
62_G66_E0.9231.00
66_E71_D0.9221.00
75_V79_R0.9221.00
230_G256_L0.9211.00
138_E324_S0.9101.00
248_A287_L0.9101.00
162_V198_A0.9071.00
245_A287_L0.9061.00
312_A319_A0.8991.00
212_V220_D0.8981.00
285_A288_A0.8951.00
241_G288_A0.8941.00
219_W223_A0.8941.00
64_P67_V0.8911.00
7_A49_V0.8871.00
273_V292_V0.8841.00
238_I312_A0.8821.00
226_G229_Y0.8781.00
100_L104_E0.8751.00
7_A10_L0.8731.00
251_E255_E0.8711.00
78_R81_P0.8691.00
90_A96_H0.8641.00
129_T132_E0.8631.00
310_D327_R0.8621.00
28_V116_K0.8611.00
97_D101_Y0.8591.00
124_P315_G0.8541.00
139_A142_G0.8521.00
148_L157_G0.8421.00
235_I319_A0.8411.00
153_A157_G0.8381.00
177_P193_R0.8341.00
63_V66_E0.8281.00
314_V319_A0.8271.00
255_E258_S0.8231.00
120_R288_A0.8201.00
27_P275_L0.8191.00
137_A205_A0.8171.00
127_Q131_R0.8161.00
79_R83_L0.8161.00
234_A295_V0.8131.00
20_H115_H0.8131.00
8_T11_A0.8091.00
64_P68_T0.8091.00
73_H76_P0.8061.00
114_V117_H0.7931.00
242_E248_A0.7911.00
146_G150_D0.7891.00
62_G70_L0.7881.00
136_A200_V0.7871.00
132_E201_D0.7861.00
30_S275_L0.7861.00
134_V323_G0.7841.00
237_V248_A0.7801.00
138_E142_G0.7801.00
272_G279_E0.7761.00
37_L41_A0.7741.00
240_A316_A0.7731.00
67_V71_D0.7731.00
240_A315_G0.7731.00
150_D213_A0.7701.00
7_A46_G0.7671.00
32_L43_V0.7641.00
171_A194_V0.7631.00
272_G281_P0.7601.00
220_D304_R0.7591.00
62_G67_V0.7581.00
135_A138_E0.7581.00
62_G68_T0.7571.00
95_P99_A0.7561.00
81_P84_A0.7541.00
243_T284_E0.7541.00
91_P94_L0.7491.00
144_A194_V0.7491.00
142_G326_P0.7481.00
91_P95_P0.7471.00
134_V205_A0.7471.00
63_V70_L0.7451.00
61_S71_D0.7431.00
95_P98_A0.7421.00
156_L159_P0.7381.00
180_T278_R0.7381.00
50_A69_V0.7371.00
240_A288_A0.7361.00
143_A160_E0.7351.00
16_D20_H0.7311.00
67_V70_L0.7281.00
209_R310_D0.7271.00
216_D221_R0.7241.00
66_E69_V0.7231.00
76_P84_A0.7231.00
20_H32_L0.7211.00
77_A81_P0.7201.00
237_V240_A0.7201.00
230_G234_A0.7201.00
126_E203_Y0.7191.00
233_A252_A0.7181.00
6_F32_L0.7171.00
129_T200_V0.7141.00
264_E302_D0.7111.00
228_E308_V0.7081.00
188_P215_A0.7051.00
7_A47_G0.7041.00
45_Y49_V0.7021.00
179_T267_T0.6991.00
224_T228_E0.6991.00
141_L144_A0.6981.00
292_V322_V0.6941.00
134_V322_V0.6921.00
257_A263_P0.6911.00
141_L325_F0.6911.00
300_T307_G0.6891.00
260_G263_P0.6871.00
137_A140_G0.6861.00
63_V68_T0.6841.00
240_A314_V0.6831.00
289_E315_G0.6831.00
273_V294_S0.6821.00
204_H277_R0.6801.00
195_T296_S0.6801.00
75_V84_A0.6801.00
247_R251_E0.6781.00
283_G286_T0.6771.00
120_R285_A0.6771.00
231_V295_V0.6761.00
239_E319_A0.6761.00
50_A79_R0.6761.00
71_D79_R0.6751.00
7_A11_A0.6741.00
17_A20_H0.6711.00
190_T220_D0.6701.00
223_A226_G0.6691.00
158_T162_V0.6661.00
141_L196_A0.6661.00
230_G251_E0.6651.00
87_A90_A0.6651.00
61_S68_T0.6641.00
68_T71_D0.6641.00
226_G261_F0.6641.00
296_S309_S0.6641.00
77_A84_A0.6621.00
256_L261_F0.6561.00
143_A159_P0.6551.00
189_D213_A0.6551.00
74_S77_A0.6551.00
136_A198_A0.6531.00
175_A303_G0.6521.00
137_A196_A0.6471.00
9_A114_V0.6471.00
26_D29_V0.6461.00
38_P44_V0.6461.00
30_S36_Q0.6441.00
157_G192_L0.6431.00
173_D213_A0.6411.00
216_D220_D0.6401.00
285_A291_A0.6401.00
177_P305_T0.6391.00
245_A283_G0.6391.00
163_R201_D0.6381.00
271_H309_S0.6371.00
72_P77_A0.6371.00
267_T278_R0.6350.99
5_P9_A0.6350.99
159_P162_V0.6340.99
233_A254_A0.6320.99
134_V207_V0.6320.99
10_L18_F0.6300.99
191_P216_D0.6300.99
177_P191_P0.6280.99
39_C44_V0.6260.99
63_V71_D0.6240.99
206_P271_H0.6220.99
144_A147_L0.6220.99
124_P290_G0.6190.99
286_T289_E0.6190.99
165_A168_A0.6170.99
261_F264_E0.6160.99
56_S59_G0.6140.99
6_F29_V0.6130.99
230_G252_A0.6120.99
38_P41_A0.6090.99
148_L192_L0.6070.99
6_F118_A0.6070.99
228_E328_S0.6070.99
41_A45_Y0.6060.99
234_A269_D0.6020.99
228_E327_R0.6000.99
55_R72_P0.5980.99
207_V323_G0.5970.99
298_G307_G0.5960.99
61_S66_E0.5950.99
101_Y105_A0.5950.99
282_T293_V0.5940.99
41_A44_V0.5940.99
117_H120_R0.5940.99
300_T305_T0.5900.99
16_D87_A0.5880.99
101_Y104_E0.5880.99
55_R266_T0.5870.99
55_R59_G0.5860.99
46_G49_V0.5850.99
212_V217_G0.5820.99
152_V157_G0.5820.99
206_P296_S0.5800.99
321_R324_S0.5800.99
56_S60_A0.5760.99
9_A118_A0.5760.99
176_V183_P0.5710.99
266_T302_D0.5710.99
173_D176_V0.5690.99
234_A237_V0.5660.99
315_G319_A0.5660.99
151_G154_D0.5660.99
72_P84_A0.5650.99
175_A178_A0.5650.99
61_S67_V0.5640.99
116_K280_A0.5620.99
63_V69_V0.5620.99
139_A143_A0.5580.99
127_Q292_V0.5580.99
140_G198_A0.5560.99
246_E283_G0.5560.99
198_A205_A0.5550.99
71_D74_S0.5550.99
229_Y232_D0.5530.99
226_G299_V0.5530.99
32_L115_H0.5520.99
260_G264_E0.5500.99
158_T163_R0.5480.99
232_D235_I0.5470.99
128_K135_A0.5450.98
122_K126_E0.5450.98
108_D111_S0.5450.98
292_V311_V0.5440.98
14_D87_A0.5440.98
137_A197_T0.5440.98
91_P96_H0.5430.98
7_A44_V0.5420.98
241_G286_T0.5410.98
159_P163_R0.5410.98
245_A270_V0.5400.98
238_I287_L0.5400.98
240_A319_A0.5400.98
148_L213_A0.5380.98
49_V67_V0.5380.98
29_V40_R0.5350.98
248_A269_D0.5350.98
162_V166_A0.5340.98
70_L75_V0.5310.98
188_P214_G0.5300.98
320_E324_S0.5300.98
39_C45_Y0.5280.98
151_G157_G0.5270.98
223_A299_V0.5270.98
61_S70_L0.5260.98
189_D215_A0.5250.98
124_P289_E0.5240.98
224_T327_R0.5210.98
160_E163_R0.5200.98
24_P119_R0.5180.98
261_F265_D0.5180.98
70_L73_H0.5170.98
90_A99_A0.5170.98
68_T72_P0.5160.98
79_R84_A0.5150.98
144_A148_L0.5130.98
54_E60_A0.5130.98
133_A137_A0.5110.98
42_A45_Y0.5110.98
70_L74_S0.5090.98
137_A198_A0.5090.98
217_G304_R0.5070.98
140_G143_A0.5070.98
24_P27_P0.5070.98
298_G305_T0.5030.97
24_P199_V0.5010.97
173_D193_R0.5000.97
145_G325_F0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fkcA 2 0.9791 100 0.199 Contact Map
3q6dA 1 0.9791 100 0.199 Contact Map
2zsgA 2 0.9791 100 0.2 Contact Map
1wn1A 2 0.9791 100 0.21 Contact Map
1wy2A 2 0.9642 100 0.219 Contact Map
4r60A 2 0.9851 100 0.221 Contact Map
4egeA 2 0.9791 100 0.23 Contact Map
3ig4A 4 0.997 100 0.231 Contact Map
2v3zA 3 0.994 100 0.243 Contact Map
1kp0A 2 0.8806 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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