GREMLIN Database
Q9HMB2 - Riboflavin synthase alpha subunit
UniProt: Q9HMB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (195)
Sequences: 3751 (2555)
Seq/√Len: 182.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_P97_G3.0471.00
112_T128_F2.5671.00
75_K140_P2.4821.00
127_T162_T2.3511.00
110_T134_H2.2911.00
147_D180_R2.2721.00
60_G63_W2.2631.00
113_E129_A2.2511.00
86_R179_E2.2071.00
138_V153_V2.1451.00
93_L99_L2.0921.00
58_D65_S2.0741.00
137_Y198_E2.0541.00
136_Q198_E2.0421.00
115_V129_A2.0351.00
20_E34_A2.0161.00
18_T34_A1.9901.00
127_T164_S1.9831.00
80_A185_R1.9821.00
124_W172_Y1.9591.00
157_D162_T1.8961.00
18_T86_R1.8891.00
34_A62_D1.8751.00
32_R65_S1.8061.00
95_A103_V1.8051.00
129_A161_G1.7571.00
146_L186_V1.7391.00
180_R184_D1.7331.00
149_I177_L1.7251.00
170_T174_L1.7101.00
70_A74_S1.7091.00
155_D164_S1.6611.00
41_F47_I1.6521.00
15_E35_V1.6181.00
117_I126_F1.6081.00
17_G89_L1.6081.00
24_D29_R1.5771.00
146_L188_V1.5761.00
49_V87_V1.5741.00
42_S45_E1.5731.00
113_E185_R1.5691.00
120_V125_T1.5671.00
95_A99_L1.5601.00
69_A166_A1.5391.00
130_L188_V1.5361.00
117_I124_W1.5101.00
81_V85_D1.5091.00
114_V180_R1.5061.00
114_V126_F1.5011.00
52_V76_T1.4791.00
32_R63_W1.4701.00
116_D127_T1.4341.00
129_A162_T1.4241.00
14_E91_R1.4041.00
15_E36_T1.4041.00
43_H170_T1.3671.00
193_L197_V1.3621.00
114_V128_F1.3301.00
104_V145_A1.3261.00
139_A194_A1.3181.00
157_D161_G1.3061.00
149_I176_S1.2971.00
49_V64_F1.2921.00
123_D166_A1.2771.00
14_E98_R1.2691.00
103_V192_V1.2521.00
125_T164_S1.2451.00
138_V163_F1.2391.00
71_E141_K1.2321.00
154_A164_S1.2271.00
16_T86_R1.2271.00
126_F172_Y1.2181.00
99_L103_V1.2081.00
50_G147_D1.2071.00
147_D176_S1.1941.00
82_S85_D1.1931.00
50_G77_T1.1911.00
154_A166_A1.1891.00
126_F167_V1.1811.00
139_A192_V1.1801.00
172_Y178_S1.1711.00
138_V144_I1.1691.00
112_T146_L1.1641.00
34_A63_W1.1611.00
128_F165_V1.1591.00
20_E63_W1.1581.00
103_V193_L1.1501.00
139_A199_R1.1431.00
146_L165_V1.1311.00
74_S120_V1.1131.00
71_E75_K1.1111.00
77_T185_R1.1041.00
50_G81_V1.1021.00
130_L138_V1.0951.00
115_V162_T1.0901.00
57_E67_F1.0851.00
30_R57_E1.0711.00
149_I167_V1.0681.00
139_A195_K1.0641.00
31_L68_T1.0611.00
91_R98_R1.0571.00
177_L180_R1.0541.00
137_Y190_V1.0541.00
198_E202_S1.0491.00
38_F41_F1.0411.00
111_T185_R1.0371.00
70_A120_V1.0361.00
149_I180_R1.0261.00
41_F56_V1.0180.99
128_F186_V1.0100.99
41_F59_W1.0090.99
119_Q124_W0.9990.99
22_V29_R0.9970.99
125_T166_A0.9880.99
28_G122_E0.9710.99
117_I181_S0.9700.99
69_A154_A0.9650.99
40_A91_R0.9570.99
56_V59_W0.9530.99
86_R178_S0.9520.99
105_Q192_V0.9510.99
94_P99_L0.9430.99
112_T188_V0.9430.99
140_P155_D0.9380.99
181_S184_D0.9310.99
114_V186_V0.9260.99
135_A161_G0.9210.99
16_T176_S0.9190.99
45_E100_D0.9180.99
15_E37_G0.9120.99
23_V30_R0.9110.99
17_G33_I0.9100.99
144_I163_F0.9040.99
125_T154_A0.9020.99
92_A98_R0.9020.99
77_T187_N0.8990.99
40_A98_R0.8990.99
126_F177_L0.8820.99
167_V172_Y0.8820.99
130_L135_A0.8780.98
19_V87_V0.8770.98
21_R83_S0.8760.98
29_R73_L0.8760.98
116_D182_P0.8750.98
21_R32_R0.8720.98
105_Q108_V0.8710.98
28_G121_G0.8700.98
114_V117_I0.8690.98
40_A100_D0.8640.98
19_V33_I0.8480.98
25_D30_R0.8370.98
176_S180_R0.8310.98
43_H59_W0.8260.98
93_L97_G0.8240.98
30_R65_S0.8220.98
19_V22_V0.8140.98
146_L163_F0.8120.97
130_L163_F0.8030.97
78_L81_V0.8000.97
130_L134_H0.7940.97
52_V108_V0.7940.97
67_F169_P0.7880.97
110_T130_L0.7850.97
134_H190_V0.7820.97
117_I182_P0.7800.97
45_E98_R0.7740.97
33_I89_L0.7740.97
149_I175_T0.7710.97
199_R203_Y0.7700.97
158_D161_G0.7670.96
19_V81_V0.7620.96
16_T174_L0.7580.96
110_T131_P0.7520.96
30_R58_D0.7450.96
135_A199_R0.7390.96
35_V38_F0.7380.96
69_A123_D0.7360.96
32_R60_G0.7320.95
27_D70_A0.7320.95
123_D172_Y0.7310.95
163_F188_V0.7230.95
79_S185_R0.7220.95
54_L72_T0.7200.95
193_L201_A0.7170.95
194_A200_M0.7100.95
20_E62_D0.7050.94
73_L79_S0.7040.94
156_I199_R0.7040.94
136_Q200_M0.7040.94
118_E127_T0.7040.94
43_H57_E0.6960.94
33_I66_V0.6940.94
49_V89_L0.6930.94
30_R67_F0.6910.94
118_E125_T0.6880.94
50_G176_S0.6880.94
144_I188_V0.6800.93
132_D161_G0.6790.93
41_F91_R0.6780.93
55_T170_T0.6690.93
108_V145_A0.6690.93
12_I100_D0.6680.93
197_V201_A0.6650.92
194_A197_V0.6640.92
190_V195_K0.6610.92
180_R186_V0.6600.92
59_W63_W0.6560.92
14_E97_G0.6530.92
41_F45_E0.6530.92
22_V83_S0.6410.91
68_T72_T0.6410.91
139_A196_Y0.6390.91
10_T99_L0.6390.91
117_I172_Y0.6390.91
29_R70_A0.6380.91
25_D28_G0.6370.91
20_E32_R0.6370.91
50_G85_D0.6360.91
94_P98_R0.6350.91
137_Y199_R0.6330.91
20_E83_S0.6290.90
54_L68_T0.6290.90
118_E164_S0.6260.90
37_G174_L0.6260.90
49_V81_V0.6230.90
78_L87_V0.6180.89
112_T130_L0.6140.89
128_F146_L0.6080.89
127_T157_D0.6060.89
42_S59_W0.6040.88
78_L85_D0.6010.88
120_V123_D0.5990.88
33_I49_V0.5980.88
107_H143_S0.5950.88
69_A165_V0.5950.88
45_E92_A0.5950.88
138_V188_V0.5930.87
38_F64_F0.5900.87
16_T178_S0.5890.87
77_T147_D0.5890.87
115_V182_P0.5890.87
92_A105_Q0.5880.87
201_A204_D0.5870.87
143_S193_L0.5830.87
43_H174_L0.5820.86
45_E91_R0.5810.86
138_V190_V0.5790.86
143_S149_I0.5760.86
43_H56_V0.5740.86
8_V11_G0.5740.86
125_T155_D0.5650.85
73_L78_L0.5630.85
47_I59_W0.5600.84
75_K154_A0.5600.84
88_N176_S0.5580.84
167_V171_T0.5500.83
12_I92_A0.5480.83
115_V127_T0.5460.83
70_A166_A0.5450.83
69_A122_E0.5450.83
128_F163_F0.5440.83
63_W66_V0.5420.82
86_R116_D0.5390.82
199_R202_S0.5390.82
110_T190_V0.5390.82
35_V89_L0.5380.82
146_L177_L0.5380.82
117_I178_S0.5380.82
136_Q203_Y0.5350.82
143_S175_T0.5350.82
49_V54_L0.5340.81
153_V163_F0.5320.81
19_V78_L0.5310.81
103_V143_S0.5310.81
93_L145_A0.5310.81
196_Y200_M0.5300.81
132_D158_D0.5290.81
190_V194_A0.5270.81
167_V177_L0.5250.80
49_V66_V0.5230.80
102_H150_S0.5230.80
23_V32_R0.5200.80
114_V182_P0.5160.79
113_E182_P0.5110.79
143_S169_P0.5110.79
116_D162_T0.5100.78
43_H58_D0.5100.78
58_D63_W0.5080.78
35_V64_F0.5070.78
158_D162_T0.5010.77
135_A156_I0.5000.77
197_V200_M0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kzlA 1 0.9128 100 0.13 Contact Map
4g6iA 3 0.8945 100 0.134 Contact Map
1i8dA 3 0.9128 100 0.141 Contact Map
3a35A 1 0.8349 100 0.182 Contact Map
3ddyA 1 0.7936 100 0.194 Contact Map
4tkoB 1 0.5046 48.2 0.955 Contact Map
2f1mA 2 0.5321 22.6 0.962 Contact Map
2wg5A 3 0.2798 19.1 0.964 Contact Map
3h43A 5 0.2936 14.3 0.966 Contact Map
4tseA 2 0.5229 14.2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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