GREMLIN Database
Q9HMB1 - Uncharacterized protein
UniProt: Q9HMB1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (326)
Sequences: 537 (386)
Seq/√Len: 21.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_G252_G5.0081.00
273_L277_T4.0191.00
354_A367_P3.9581.00
99_I195_A3.8491.00
168_I273_L3.5881.00
127_A131_N3.4341.00
243_G247_Y3.2961.00
108_E185_D3.1931.00
303_V307_V3.1751.00
171_W251_A3.0310.99
108_E193_Y2.8310.99
186_T256_G2.7490.99
213_E233_V2.5440.98
194_G198_G2.5080.98
103_D108_E2.4850.98
286_A289_N2.4430.97
341_A354_A2.4350.97
210_I238_T2.4250.97
189_D192_V2.3800.97
278_L282_T2.3530.97
352_K371_S2.3490.97
171_W197_A2.3420.97
241_G247_Y2.2340.96
342_H378_P2.2320.96
203_T207_A2.2310.96
267_P271_K2.1870.95
108_E189_D2.1840.95
177_Y255_L2.1670.95
58_V62_I2.1640.95
162_V331_Y2.0520.93
174_V197_A2.0110.92
67_F70_A1.9430.91
244_H280_H1.9110.90
103_D106_G1.8680.89
50_G59_A1.8520.89
163_G283_Y1.7810.87
359_A363_V1.7470.86
265_A269_V1.7450.86
210_I234_A1.7410.86
51_L63_I1.7400.86
60_A64_V1.7320.85
252_G256_G1.7070.84
62_I125_G1.7060.84
248_S251_A1.6960.84
171_W175_R1.6790.83
174_V184_F1.6670.83
364_G367_P1.6470.82
49_T53_P1.6310.82
351_L355_V1.6210.81
167_E170_K1.6190.81
277_T281_A1.6100.81
327_Y354_A1.6060.80
258_A272_G1.5990.80
294_A300_A1.5980.80
160_L281_A1.5650.79
342_H374_S1.5640.79
375_S378_P1.5570.78
299_V303_V1.5570.78
187_V261_N1.5490.78
360_D363_V1.5410.78
344_A347_D1.5320.77
266_G269_V1.5270.77
271_K275_T1.5200.77
189_D193_Y1.5140.76
106_G193_Y1.5060.76
59_A63_I1.4920.75
131_N161_V1.4900.75
87_L198_G1.4900.75
246_I305_F1.4750.74
88_S202_A1.4720.74
51_L54_G1.4590.74
91_P242_P1.4360.72
166_E244_H1.4340.72
166_E280_H1.4340.72
186_T206_N1.4300.72
156_L160_L1.4270.72
175_R251_A1.4230.72
184_F255_L1.4190.71
194_G250_F1.4010.70
88_S206_N1.3990.70
205_E280_H1.3980.70
205_E244_H1.3980.70
243_G313_D1.3910.70
202_A242_P1.3870.70
341_A367_P1.3730.69
209_Y280_H1.3490.67
209_Y244_H1.3490.67
61_L151_V1.3410.67
48_G53_P1.3300.66
174_V177_Y1.3280.66
202_A206_N1.3270.66
234_A256_G1.3190.66
202_A272_G1.3110.65
168_I277_T1.3100.65
101_L211_L1.3080.65
138_L172_L1.3050.65
294_A298_G1.2950.64
185_D193_Y1.2950.64
60_A63_I1.2830.63
111_E293_V1.2770.63
187_V257_L1.2760.63
92_A370_Y1.2740.63
103_D316_F1.2670.62
74_V228_E1.2480.61
286_A297_V1.2410.61
250_F279_I1.2390.61
105_T199_L1.2360.60
60_A268_I1.2280.60
294_A299_V1.2270.60
121_F204_V1.2220.60
185_D216_S1.2100.59
273_L327_Y1.2070.59
327_Y332_N1.2050.58
82_G311_A1.2030.58
203_T210_I1.1860.57
109_P189_D1.1820.57
64_V296_F1.1780.57
239_L304_A1.1770.57
346_W353_P1.1750.56
119_F162_V1.1720.56
278_L281_A1.1710.56
265_A270_V1.1710.56
157_F161_V1.1680.56
126_F349_D1.1670.56
60_A136_V1.1640.56
123_F126_F1.1600.56
294_A313_D1.1570.55
159_F339_V1.1380.54
109_P193_Y1.1340.54
91_P206_N1.1340.54
158_Y163_G1.1320.54
61_L65_A1.1310.54
173_A197_A1.1240.53
99_I245_V1.1190.53
75_F118_V1.0990.51
192_V300_A1.0920.51
327_Y331_Y1.0900.51
190_G256_G1.0880.51
342_H351_L1.0760.50
108_E276_A1.0750.50
61_L231_F1.0690.49
146_T152_A1.0610.49
103_D206_N1.0550.48
300_A337_S1.0500.48
285_T299_V1.0500.48
189_D302_G1.0480.48
260_F312_Y1.0470.48
101_L243_G1.0440.48
202_A245_V1.0410.48
95_V199_L1.0400.47
83_A278_L1.0370.47
114_V299_V1.0350.47
48_G52_R1.0330.47
363_V367_P1.0320.47
159_F332_N1.0320.47
202_A241_G1.0280.47
138_L161_V1.0250.46
87_L273_L1.0240.46
104_A331_Y1.0140.46
205_E209_Y1.0120.46
72_G90_A1.0000.45
136_V278_L0.9960.45
275_T306_L0.9950.44
66_Q123_F0.9930.44
323_K326_A0.9910.44
164_P271_K0.9900.44
242_P272_G0.9880.44
82_G147_G0.9830.44
183_E193_Y0.9810.44
194_G253_Y0.9800.44
131_N158_Y0.9770.43
123_F230_A0.9750.43
199_L316_F0.9740.43
96_A175_R0.9740.43
96_A100_W0.9720.43
105_T169_V0.9690.43
75_F114_V0.9660.43
172_L193_Y0.9610.42
88_S245_V0.9600.42
60_A76_F0.9470.41
145_M153_T0.9430.41
294_A304_A0.9430.41
278_L306_L0.9420.41
183_E376_A0.9420.41
90_A347_D0.9410.41
68_A87_L0.9400.41
93_L115_A0.9360.41
119_F181_S0.9350.41
186_T313_D0.9350.41
351_L370_Y0.9350.41
92_A179_F0.9270.40
88_S91_P0.9210.40
173_A256_G0.9180.39
55_V61_L0.9180.39
96_A124_A0.9150.39
80_V84_Y0.9130.39
303_V328_R0.9120.39
327_Y351_L0.9120.39
166_E205_E0.9110.39
359_A362_G0.9100.39
65_A68_A0.9080.39
371_S380_E0.9030.39
63_I71_T0.9020.38
169_V314_G0.9000.38
61_L271_K0.8980.38
130_I292_P0.8940.38
299_V302_G0.8940.38
173_A376_A0.8930.38
138_L288_T0.8900.38
114_V267_P0.8890.38
85_V223_G0.8860.37
327_Y367_P0.8860.37
253_Y257_L0.8850.37
251_A274_V0.8830.37
198_G250_F0.8810.37
247_Y313_D0.8790.37
318_A322_K0.8750.37
211_L247_Y0.8690.36
58_V115_A0.8650.36
143_D336_A0.8640.36
192_V276_A0.8570.36
50_G54_G0.8570.36
133_M137_V0.8570.36
192_V242_P0.8570.36
231_F257_L0.8500.35
188_V328_R0.8490.35
355_V359_A0.8470.35
131_N134_S0.8460.35
128_A131_N0.8450.35
327_Y374_S0.8390.35
351_L367_P0.8390.35
47_L55_V0.8360.34
86_L297_V0.8290.34
228_E281_A0.8230.34
166_E209_Y0.8230.34
124_A135_S0.8220.34
166_E201_F0.8210.33
131_N209_Y0.8170.33
231_F235_A0.8120.33
47_L60_A0.8120.33
171_W248_S0.8120.33
178_V240_A0.8120.33
104_A119_F0.8100.33
327_Y341_A0.8090.33
106_G109_P0.8080.33
96_A196_M0.8070.33
88_S284_N0.8000.32
124_A153_T0.7990.32
262_P287_V0.7980.32
177_Y283_Y0.7980.32
233_V351_L0.7930.32
119_F173_A0.7910.32
206_N284_N0.7910.32
85_V342_H0.7900.32
193_Y284_N0.7900.32
101_L247_Y0.7890.32
113_L344_A0.7880.32
340_A346_W0.7820.31
80_V257_L0.7820.31
255_L267_P0.7770.31
53_P62_I0.7770.31
215_M296_F0.7690.30
118_V274_V0.7660.30
286_A318_A0.7660.30
341_A349_D0.7660.30
313_D342_H0.7650.30
243_G298_G0.7650.30
185_D284_N0.7610.30
236_L296_F0.7600.30
167_E205_E0.7580.30
170_K205_E0.7580.30
243_G302_G0.7560.30
92_A203_T0.7560.30
128_A136_V0.7560.30
248_S331_Y0.7550.30
96_A268_I0.7540.30
256_G337_S0.7510.29
239_L329_A0.7490.29
56_L346_W0.7430.29
62_I292_P0.7420.29
134_S198_G0.7410.29
173_A370_Y0.7400.29
213_E224_Q0.7380.29
356_R364_G0.7330.28
82_G340_A0.7310.28
115_A340_A0.7300.28
84_Y115_A0.7270.28
356_R359_A0.7240.28
53_P64_V0.7240.28
173_A327_Y0.7240.28
69_T303_V0.7230.28
83_A214_V0.7220.28
104_A171_W0.7200.28
106_G299_V0.7200.28
154_S216_S0.7190.28
203_T206_N0.7180.28
169_V271_K0.7160.28
150_A264_D0.7160.28
281_A285_T0.7120.27
49_T52_R0.7110.27
131_N166_E0.7090.27
312_Y354_A0.7070.27
255_L340_A0.7050.27
374_S378_P0.7030.27
180_R195_A0.7030.27
105_T112_L0.7020.27
225_Q229_V0.7010.27
194_G379_A0.7000.27
80_V304_A0.6980.27
210_I341_A0.6980.27
46_A49_T0.6980.27
190_G249_A0.6920.26
117_F194_G0.6910.26
186_T241_G0.6910.26
184_F256_G0.6910.26
117_F245_V0.6880.26
209_Y237_R0.6850.26
84_Y378_P0.6820.26
120_G312_Y0.6810.26
91_P202_A0.6770.25
170_K200_G0.6770.25
167_E200_G0.6770.25
235_A296_F0.6750.25
55_V151_V0.6690.25
159_F191_A0.6680.25
181_S248_S0.6680.25
92_A204_V0.6680.25
267_P270_V0.6680.25
81_V128_A0.6660.25
195_A294_A0.6660.25
62_I153_T0.6650.25
356_R362_G0.6650.25
227_T365_V0.6650.25
303_V357_R0.6640.25
200_G205_E0.6630.25
300_A330_A0.6610.25
357_R379_A0.6610.25
84_Y184_F0.6590.25
134_S206_N0.6570.24
114_V295_E0.6550.24
147_G152_A0.6550.24
144_P152_A0.6540.24
180_R380_E0.6530.24
269_V368_E0.6530.24
179_F194_G0.6520.24
127_A132_A0.6510.24
64_V145_M0.6450.24
43_L46_A0.6410.24
91_P210_I0.6400.24
174_V252_G0.6390.24
86_L276_A0.6380.24
192_V256_G0.6380.24
84_Y119_F0.6380.24
367_P374_S0.6380.24
108_E242_P0.6370.23
126_F176_L0.6360.23
256_G284_N0.6350.23
241_G283_Y0.6350.23
349_D361_D0.6340.23
45_N53_P0.6320.23
265_A268_I0.6310.23
172_L305_F0.6270.23
191_A304_A0.6260.23
189_D324_L0.6260.23
105_T260_F0.6220.23
168_I274_V0.6210.23
116_T175_R0.6180.23
119_F124_A0.6170.23
104_A162_V0.6160.22
62_I362_G0.6160.22
108_E252_G0.6120.22
127_A169_V0.6110.22
153_T236_L0.6090.22
205_E237_R0.6080.22
143_D278_L0.6070.22
234_A238_T0.6070.22
63_I281_A0.6050.22
128_A279_I0.6040.22
56_L64_V0.6040.22
355_V377_P0.6020.22
90_A373_A0.5980.22
63_I68_A0.5980.22
105_T257_L0.5970.22
81_V233_V0.5970.22
202_A237_R0.5960.22
195_A328_R0.5950.22
119_F324_L0.5950.22
144_P147_G0.5950.22
152_A249_A0.5940.21
352_K367_P0.5940.21
211_L256_G0.5930.21
311_A328_R0.5920.21
177_Y349_D0.5910.21
49_T55_V0.5890.21
48_G51_L0.5870.21
92_A298_G0.5860.21
49_T61_L0.5840.21
257_L261_N0.5810.21
130_I307_V0.5790.21
369_D373_A0.5790.21
153_T291_K0.5770.21
156_L358_I0.5760.21
94_A369_D0.5730.21
354_A363_V0.5730.21
82_G138_L0.5730.21
102_A334_T0.5720.21
260_F279_I0.5720.21
163_G206_N0.5700.20
206_N237_R0.5700.20
251_A273_L0.5680.20
243_G294_A0.5680.20
240_A300_A0.5680.20
170_K201_F0.5670.20
167_E201_F0.5670.20
162_V283_Y0.5670.20
72_G114_V0.5670.20
170_K280_H0.5670.20
170_K244_H0.5670.20
167_E280_H0.5670.20
167_E244_H0.5670.20
104_A120_G0.5650.20
162_V186_T0.5640.20
92_A206_N0.5640.20
178_V183_E0.5620.20
88_S207_A0.5620.20
51_L58_V0.5620.20
113_L296_F0.5610.20
261_N267_P0.5590.20
53_P89_V0.5590.20
111_E187_V0.5570.20
103_D185_D0.5560.20
63_I97_G0.5550.20
57_V311_A0.5550.20
118_V130_I0.5550.20
157_F322_K0.5540.20
56_L215_M0.5530.20
201_F205_E0.5530.20
255_L273_L0.5520.20
136_V265_A0.5520.20
52_R67_F0.5510.20
154_S267_P0.5500.20
111_E299_V0.5490.20
360_D366_D0.5490.20
176_L290_L0.5470.19
275_T295_E0.5460.19
175_R312_Y0.5410.19
125_G281_A0.5410.19
305_F343_A0.5410.19
243_G300_A0.5400.19
157_F372_A0.5400.19
175_R328_R0.5390.19
206_N245_V0.5380.19
90_A356_R0.5380.19
45_N48_G0.5370.19
164_P328_R0.5340.19
57_V365_V0.5340.19
254_Y261_N0.5320.19
254_Y271_K0.5320.19
163_G207_A0.5310.19
210_I323_K0.5300.19
157_F164_P0.5290.19
69_T229_V0.5280.19
122_L187_V0.5270.19
198_G231_F0.5270.19
112_L334_T0.5250.19
255_L266_G0.5240.18
356_R361_D0.5240.18
174_V329_A0.5230.18
358_I361_D0.5230.18
189_D241_G0.5210.18
155_A228_E0.5200.18
341_A351_L0.5200.18
54_G58_V0.5180.18
72_G75_F0.5170.18
173_A312_Y0.5170.18
46_A69_T0.5170.18
63_I230_A0.5160.18
213_E335_G0.5160.18
298_G302_G0.5160.18
207_A316_F0.5160.18
274_V278_L0.5160.18
256_G259_K0.5150.18
90_A335_G0.5110.18
130_I134_S0.5110.18
113_L283_Y0.5070.18
335_G360_D0.5040.18
349_D373_A0.5030.18
196_M223_G0.5010.18
249_A296_F0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cadC 1 0.6286 93.6 0.943 Contact Map
5a63C 1 0.5844 48.9 0.964 Contact Map
2m20A 2 0.1506 8.3 0.975 Contact Map
1n7lA 1 0.1351 4.9 0.978 Contact Map
1ohfA 8 0.0519 4.7 0.978 Contact Map
4kytB 2 0.0753 4.2 0.978 Contact Map
3s6pA 9 0.0649 4.2 0.978 Contact Map
2mkfA 1 0.0675 4.1 0.979 Contact Map
2mfqB 1 0.0597 3.9 0.979 Contact Map
4y3uB 1 0.0779 3.2 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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