Q9HMB1 - HALSA - GREMLIN Contacts

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Q9HMB1 - Uncharacterized protein

UniProt:	Q9HMB1	Sequences: MRKTGHMTADQDPVQRAADDDMDLYDVVTWEPRSRLDYAATWLYNALGTGLRPGVLVVAALIIVAQFATATGLVFFDRPVVGAYVLLSVAPALAVAGYIWLADATGQEPIELLVATFVFGFLFAGFAAAINAMSSVVLFGSSDPMTGSTAVATSALFYFLVVGPVEEIVKWLAVRLYVFRSDEFDTVVDGAVYGAMAGLGFATVENAIYILREVMSVMQTAGGQQATEVAFQVAALRTLAGPGHVIYSAFAGYYLGLAKFNPDDAGPIVVKGLVTATLIHATYNTAVTNLKPVAEFVGVAQGVAFLVFVIAYDGVFLAVLGKKLRAYRAAYNHTGASAVAAHAATWDGDTLKPAVRRIADDGVGVDPEDYSAASSAPPAESTEES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	385 (326)
Sequences:	537 (386)
Seq/√Len:	21.4

HALSA - Q9HMB1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
190_G	252_G	5.008	1.00
273_L	277_T	4.019	1.00
354_A	367_P	3.958	1.00
99_I	195_A	3.849	1.00
168_I	273_L	3.588	1.00
127_A	131_N	3.434	1.00
243_G	247_Y	3.296	1.00
108_E	185_D	3.193	1.00
303_V	307_V	3.175	1.00
171_W	251_A	3.031	0.99
108_E	193_Y	2.831	0.99
186_T	256_G	2.749	0.99
213_E	233_V	2.544	0.98
194_G	198_G	2.508	0.98
103_D	108_E	2.485	0.98
286_A	289_N	2.443	0.97
341_A	354_A	2.435	0.97
210_I	238_T	2.425	0.97
189_D	192_V	2.380	0.97
278_L	282_T	2.353	0.97
352_K	371_S	2.349	0.97
171_W	197_A	2.342	0.97
241_G	247_Y	2.234	0.96
342_H	378_P	2.232	0.96
203_T	207_A	2.231	0.96
267_P	271_K	2.187	0.95
108_E	189_D	2.184	0.95
177_Y	255_L	2.167	0.95
58_V	62_I	2.164	0.95
162_V	331_Y	2.052	0.93
174_V	197_A	2.011	0.92
67_F	70_A	1.943	0.91
244_H	280_H	1.911	0.90
103_D	106_G	1.868	0.89
50_G	59_A	1.852	0.89
163_G	283_Y	1.781	0.87
359_A	363_V	1.747	0.86
265_A	269_V	1.745	0.86
210_I	234_A	1.741	0.86
51_L	63_I	1.740	0.86
60_A	64_V	1.732	0.85
252_G	256_G	1.707	0.84
62_I	125_G	1.706	0.84
248_S	251_A	1.696	0.84
171_W	175_R	1.679	0.83
174_V	184_F	1.667	0.83
364_G	367_P	1.647	0.82
49_T	53_P	1.631	0.82
351_L	355_V	1.621	0.81
167_E	170_K	1.619	0.81
277_T	281_A	1.610	0.81
327_Y	354_A	1.606	0.80
258_A	272_G	1.599	0.80
294_A	300_A	1.598	0.80
160_L	281_A	1.565	0.79
342_H	374_S	1.564	0.79
375_S	378_P	1.557	0.78
299_V	303_V	1.557	0.78
187_V	261_N	1.549	0.78
360_D	363_V	1.541	0.78
344_A	347_D	1.532	0.77
266_G	269_V	1.527	0.77
271_K	275_T	1.520	0.77
189_D	193_Y	1.514	0.76
106_G	193_Y	1.506	0.76
59_A	63_I	1.492	0.75
131_N	161_V	1.490	0.75
87_L	198_G	1.490	0.75
246_I	305_F	1.475	0.74
88_S	202_A	1.472	0.74
51_L	54_G	1.459	0.74
91_P	242_P	1.436	0.72
166_E	244_H	1.434	0.72
166_E	280_H	1.434	0.72
186_T	206_N	1.430	0.72
156_L	160_L	1.427	0.72
175_R	251_A	1.423	0.72
184_F	255_L	1.419	0.71
194_G	250_F	1.401	0.70
88_S	206_N	1.399	0.70
205_E	280_H	1.398	0.70
205_E	244_H	1.398	0.70
243_G	313_D	1.391	0.70
202_A	242_P	1.387	0.70
341_A	367_P	1.373	0.69
209_Y	280_H	1.349	0.67
209_Y	244_H	1.349	0.67
61_L	151_V	1.341	0.67
48_G	53_P	1.330	0.66
174_V	177_Y	1.328	0.66
202_A	206_N	1.327	0.66
234_A	256_G	1.319	0.66
202_A	272_G	1.311	0.65
168_I	277_T	1.310	0.65
101_L	211_L	1.308	0.65
138_L	172_L	1.305	0.65
294_A	298_G	1.295	0.64
185_D	193_Y	1.295	0.64
60_A	63_I	1.283	0.63
111_E	293_V	1.277	0.63
187_V	257_L	1.276	0.63
92_A	370_Y	1.274	0.63
103_D	316_F	1.267	0.62
74_V	228_E	1.248	0.61
286_A	297_V	1.241	0.61
250_F	279_I	1.239	0.61
105_T	199_L	1.236	0.60
60_A	268_I	1.228	0.60
294_A	299_V	1.227	0.60
121_F	204_V	1.222	0.60
185_D	216_S	1.210	0.59
273_L	327_Y	1.207	0.59
327_Y	332_N	1.205	0.58
82_G	311_A	1.203	0.58
203_T	210_I	1.186	0.57
109_P	189_D	1.182	0.57
64_V	296_F	1.178	0.57
239_L	304_A	1.177	0.57
346_W	353_P	1.175	0.56
119_F	162_V	1.172	0.56
278_L	281_A	1.171	0.56
265_A	270_V	1.171	0.56
157_F	161_V	1.168	0.56
126_F	349_D	1.167	0.56
60_A	136_V	1.164	0.56
123_F	126_F	1.160	0.56
294_A	313_D	1.157	0.55
159_F	339_V	1.138	0.54
109_P	193_Y	1.134	0.54
91_P	206_N	1.134	0.54
158_Y	163_G	1.132	0.54
61_L	65_A	1.131	0.54
173_A	197_A	1.124	0.53
99_I	245_V	1.119	0.53
75_F	118_V	1.099	0.51
192_V	300_A	1.092	0.51
327_Y	331_Y	1.090	0.51
190_G	256_G	1.088	0.51
342_H	351_L	1.076	0.50
108_E	276_A	1.075	0.50
61_L	231_F	1.069	0.49
146_T	152_A	1.061	0.49
103_D	206_N	1.055	0.48
300_A	337_S	1.050	0.48
285_T	299_V	1.050	0.48
189_D	302_G	1.048	0.48
260_F	312_Y	1.047	0.48
101_L	243_G	1.044	0.48
202_A	245_V	1.041	0.48
95_V	199_L	1.040	0.47
83_A	278_L	1.037	0.47
114_V	299_V	1.035	0.47
48_G	52_R	1.033	0.47
363_V	367_P	1.032	0.47
159_F	332_N	1.032	0.47
202_A	241_G	1.028	0.47
138_L	161_V	1.025	0.46
87_L	273_L	1.024	0.46
104_A	331_Y	1.014	0.46
205_E	209_Y	1.012	0.46
72_G	90_A	1.000	0.45
136_V	278_L	0.996	0.45
275_T	306_L	0.995	0.44
66_Q	123_F	0.993	0.44
323_K	326_A	0.991	0.44
164_P	271_K	0.990	0.44
242_P	272_G	0.988	0.44
82_G	147_G	0.983	0.44
183_E	193_Y	0.981	0.44
194_G	253_Y	0.980	0.44
131_N	158_Y	0.977	0.43
123_F	230_A	0.975	0.43
199_L	316_F	0.974	0.43
96_A	175_R	0.974	0.43
96_A	100_W	0.972	0.43
105_T	169_V	0.969	0.43
75_F	114_V	0.966	0.43
172_L	193_Y	0.961	0.42
88_S	245_V	0.960	0.42
60_A	76_F	0.947	0.41
145_M	153_T	0.943	0.41
294_A	304_A	0.943	0.41
278_L	306_L	0.942	0.41
183_E	376_A	0.942	0.41
90_A	347_D	0.941	0.41
68_A	87_L	0.940	0.41
93_L	115_A	0.936	0.41
119_F	181_S	0.935	0.41
186_T	313_D	0.935	0.41
351_L	370_Y	0.935	0.41
92_A	179_F	0.927	0.40
88_S	91_P	0.921	0.40
173_A	256_G	0.918	0.39
55_V	61_L	0.918	0.39
96_A	124_A	0.915	0.39
80_V	84_Y	0.913	0.39
303_V	328_R	0.912	0.39
327_Y	351_L	0.912	0.39
166_E	205_E	0.911	0.39
359_A	362_G	0.910	0.39
65_A	68_A	0.908	0.39
371_S	380_E	0.903	0.39
63_I	71_T	0.902	0.38
169_V	314_G	0.900	0.38
61_L	271_K	0.898	0.38
130_I	292_P	0.894	0.38
299_V	302_G	0.894	0.38
173_A	376_A	0.893	0.38
138_L	288_T	0.890	0.38
114_V	267_P	0.889	0.38
85_V	223_G	0.886	0.37
327_Y	367_P	0.886	0.37
253_Y	257_L	0.885	0.37
251_A	274_V	0.883	0.37
198_G	250_F	0.881	0.37
247_Y	313_D	0.879	0.37
318_A	322_K	0.875	0.37
211_L	247_Y	0.869	0.36
58_V	115_A	0.865	0.36
143_D	336_A	0.864	0.36
192_V	276_A	0.857	0.36
50_G	54_G	0.857	0.36
133_M	137_V	0.857	0.36
192_V	242_P	0.857	0.36
231_F	257_L	0.850	0.35
188_V	328_R	0.849	0.35
355_V	359_A	0.847	0.35
131_N	134_S	0.846	0.35
128_A	131_N	0.845	0.35
327_Y	374_S	0.839	0.35
351_L	367_P	0.839	0.35
47_L	55_V	0.836	0.34
86_L	297_V	0.829	0.34
228_E	281_A	0.823	0.34
166_E	209_Y	0.823	0.34
124_A	135_S	0.822	0.34
166_E	201_F	0.821	0.33
131_N	209_Y	0.817	0.33
231_F	235_A	0.812	0.33
47_L	60_A	0.812	0.33
171_W	248_S	0.812	0.33
178_V	240_A	0.812	0.33
104_A	119_F	0.810	0.33
327_Y	341_A	0.809	0.33
106_G	109_P	0.808	0.33
96_A	196_M	0.807	0.33
88_S	284_N	0.800	0.32
124_A	153_T	0.799	0.32
262_P	287_V	0.798	0.32
177_Y	283_Y	0.798	0.32
233_V	351_L	0.793	0.32
119_F	173_A	0.791	0.32
206_N	284_N	0.791	0.32
85_V	342_H	0.790	0.32
193_Y	284_N	0.790	0.32
101_L	247_Y	0.789	0.32
113_L	344_A	0.788	0.32
340_A	346_W	0.782	0.31
80_V	257_L	0.782	0.31
255_L	267_P	0.777	0.31
53_P	62_I	0.777	0.31
215_M	296_F	0.769	0.30
118_V	274_V	0.766	0.30
286_A	318_A	0.766	0.30
341_A	349_D	0.766	0.30
313_D	342_H	0.765	0.30
243_G	298_G	0.765	0.30
185_D	284_N	0.761	0.30
236_L	296_F	0.760	0.30
167_E	205_E	0.758	0.30
170_K	205_E	0.758	0.30
243_G	302_G	0.756	0.30
92_A	203_T	0.756	0.30
128_A	136_V	0.756	0.30
248_S	331_Y	0.755	0.30
96_A	268_I	0.754	0.30
256_G	337_S	0.751	0.29
239_L	329_A	0.749	0.29
56_L	346_W	0.743	0.29
62_I	292_P	0.742	0.29
134_S	198_G	0.741	0.29
173_A	370_Y	0.740	0.29
213_E	224_Q	0.738	0.29
356_R	364_G	0.733	0.28
82_G	340_A	0.731	0.28
115_A	340_A	0.730	0.28
84_Y	115_A	0.727	0.28
356_R	359_A	0.724	0.28
53_P	64_V	0.724	0.28
173_A	327_Y	0.724	0.28
69_T	303_V	0.723	0.28
83_A	214_V	0.722	0.28
104_A	171_W	0.720	0.28
106_G	299_V	0.720	0.28
154_S	216_S	0.719	0.28
203_T	206_N	0.718	0.28
169_V	271_K	0.716	0.28
150_A	264_D	0.716	0.28
281_A	285_T	0.712	0.27
49_T	52_R	0.711	0.27
131_N	166_E	0.709	0.27
312_Y	354_A	0.707	0.27
255_L	340_A	0.705	0.27
374_S	378_P	0.703	0.27
180_R	195_A	0.703	0.27
105_T	112_L	0.702	0.27
225_Q	229_V	0.701	0.27
194_G	379_A	0.700	0.27
80_V	304_A	0.698	0.27
210_I	341_A	0.698	0.27
46_A	49_T	0.698	0.27
190_G	249_A	0.692	0.26
117_F	194_G	0.691	0.26
186_T	241_G	0.691	0.26
184_F	256_G	0.691	0.26
117_F	245_V	0.688	0.26
209_Y	237_R	0.685	0.26
84_Y	378_P	0.682	0.26
120_G	312_Y	0.681	0.26
91_P	202_A	0.677	0.25
170_K	200_G	0.677	0.25
167_E	200_G	0.677	0.25
235_A	296_F	0.675	0.25
55_V	151_V	0.669	0.25
159_F	191_A	0.668	0.25
181_S	248_S	0.668	0.25
92_A	204_V	0.668	0.25
267_P	270_V	0.668	0.25
81_V	128_A	0.666	0.25
195_A	294_A	0.666	0.25
62_I	153_T	0.665	0.25
356_R	362_G	0.665	0.25
227_T	365_V	0.665	0.25
303_V	357_R	0.664	0.25
200_G	205_E	0.663	0.25
300_A	330_A	0.661	0.25
357_R	379_A	0.661	0.25
84_Y	184_F	0.659	0.25
134_S	206_N	0.657	0.24
114_V	295_E	0.655	0.24
147_G	152_A	0.655	0.24
144_P	152_A	0.654	0.24
180_R	380_E	0.653	0.24
269_V	368_E	0.653	0.24
179_F	194_G	0.652	0.24
127_A	132_A	0.651	0.24
64_V	145_M	0.645	0.24
43_L	46_A	0.641	0.24
91_P	210_I	0.640	0.24
174_V	252_G	0.639	0.24
86_L	276_A	0.638	0.24
192_V	256_G	0.638	0.24
84_Y	119_F	0.638	0.24
367_P	374_S	0.638	0.24
108_E	242_P	0.637	0.23
126_F	176_L	0.636	0.23
256_G	284_N	0.635	0.23
241_G	283_Y	0.635	0.23
349_D	361_D	0.634	0.23
45_N	53_P	0.632	0.23
265_A	268_I	0.631	0.23
172_L	305_F	0.627	0.23
191_A	304_A	0.626	0.23
189_D	324_L	0.626	0.23
105_T	260_F	0.622	0.23
168_I	274_V	0.621	0.23
116_T	175_R	0.618	0.23
119_F	124_A	0.617	0.23
104_A	162_V	0.616	0.22
62_I	362_G	0.616	0.22
108_E	252_G	0.612	0.22
127_A	169_V	0.611	0.22
153_T	236_L	0.609	0.22
205_E	237_R	0.608	0.22
143_D	278_L	0.607	0.22
234_A	238_T	0.607	0.22
63_I	281_A	0.605	0.22
128_A	279_I	0.604	0.22
56_L	64_V	0.604	0.22
355_V	377_P	0.602	0.22
90_A	373_A	0.598	0.22
63_I	68_A	0.598	0.22
105_T	257_L	0.597	0.22
81_V	233_V	0.597	0.22
202_A	237_R	0.596	0.22
195_A	328_R	0.595	0.22
119_F	324_L	0.595	0.22
144_P	147_G	0.595	0.22
152_A	249_A	0.594	0.21
352_K	367_P	0.594	0.21
211_L	256_G	0.593	0.21
311_A	328_R	0.592	0.21
177_Y	349_D	0.591	0.21
49_T	55_V	0.589	0.21
48_G	51_L	0.587	0.21
92_A	298_G	0.586	0.21
49_T	61_L	0.584	0.21
257_L	261_N	0.581	0.21
130_I	307_V	0.579	0.21
369_D	373_A	0.579	0.21
153_T	291_K	0.577	0.21
156_L	358_I	0.576	0.21
94_A	369_D	0.573	0.21
354_A	363_V	0.573	0.21
82_G	138_L	0.573	0.21
102_A	334_T	0.572	0.21
260_F	279_I	0.572	0.21
163_G	206_N	0.570	0.20
206_N	237_R	0.570	0.20
251_A	273_L	0.568	0.20
243_G	294_A	0.568	0.20
240_A	300_A	0.568	0.20
170_K	201_F	0.567	0.20
167_E	201_F	0.567	0.20
162_V	283_Y	0.567	0.20
72_G	114_V	0.567	0.20
170_K	280_H	0.567	0.20
170_K	244_H	0.567	0.20
167_E	280_H	0.567	0.20
167_E	244_H	0.567	0.20
104_A	120_G	0.565	0.20
162_V	186_T	0.564	0.20
92_A	206_N	0.564	0.20
178_V	183_E	0.562	0.20
88_S	207_A	0.562	0.20
51_L	58_V	0.562	0.20
113_L	296_F	0.561	0.20
261_N	267_P	0.559	0.20
53_P	89_V	0.559	0.20
111_E	187_V	0.557	0.20
103_D	185_D	0.556	0.20
63_I	97_G	0.555	0.20
57_V	311_A	0.555	0.20
118_V	130_I	0.555	0.20
157_F	322_K	0.554	0.20
56_L	215_M	0.553	0.20
201_F	205_E	0.553	0.20
255_L	273_L	0.552	0.20
136_V	265_A	0.552	0.20
52_R	67_F	0.551	0.20
154_S	267_P	0.550	0.20
111_E	299_V	0.549	0.20
360_D	366_D	0.549	0.20
176_L	290_L	0.547	0.19
275_T	295_E	0.546	0.19
175_R	312_Y	0.541	0.19
125_G	281_A	0.541	0.19
305_F	343_A	0.541	0.19
243_G	300_A	0.540	0.19
157_F	372_A	0.540	0.19
175_R	328_R	0.539	0.19
206_N	245_V	0.538	0.19
90_A	356_R	0.538	0.19
45_N	48_G	0.537	0.19
164_P	328_R	0.534	0.19
57_V	365_V	0.534	0.19
254_Y	261_N	0.532	0.19
254_Y	271_K	0.532	0.19
163_G	207_A	0.531	0.19
210_I	323_K	0.530	0.19
157_F	164_P	0.529	0.19
69_T	229_V	0.528	0.19
122_L	187_V	0.527	0.19
198_G	231_F	0.527	0.19
112_L	334_T	0.525	0.19
255_L	266_G	0.524	0.18
356_R	361_D	0.524	0.18
174_V	329_A	0.523	0.18
358_I	361_D	0.523	0.18
189_D	241_G	0.521	0.18
155_A	228_E	0.520	0.18
341_A	351_L	0.520	0.18
54_G	58_V	0.518	0.18
72_G	75_F	0.517	0.18
173_A	312_Y	0.517	0.18
46_A	69_T	0.517	0.18
63_I	230_A	0.516	0.18
213_E	335_G	0.516	0.18
298_G	302_G	0.516	0.18
207_A	316_F	0.516	0.18
274_V	278_L	0.516	0.18
256_G	259_K	0.515	0.18
90_A	335_G	0.511	0.18
130_I	134_S	0.511	0.18
113_L	283_Y	0.507	0.18
335_G	360_D	0.504	0.18
349_D	373_A	0.503	0.18
196_M	223_G	0.501	0.18
249_A	296_F	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cadC	1	0.6286	93.6	0.943	Contact Map
5a63C	1	0.5844	48.9	0.964	Contact Map
2m20A	2	0.1506	8.3	0.975	Contact Map
1n7lA	1	0.1351	4.9	0.978	Contact Map
1ohfA	8	0.0519	4.7	0.978	Contact Map
4kytB	2	0.0753	4.2	0.978	Contact Map
3s6pA	9	0.0649	4.2	0.978	Contact Map
2mkfA	1	0.0675	4.1	0.979	Contact Map
2mfqB	1	0.0597	3.9	0.979	Contact Map
4y3uB	1	0.0779	3.2	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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