GREMLIN Database
AUBA - RNA-binding protein AU-1
UniProt: Q9HMA9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 471 (456)
Sequences: 100 (67)
Seq/√Len: 3.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_A110_L5.3170.92
18_L72_V4.0470.75
98_A153_A4.0450.75
371_E399_K4.0380.75
291_A294_F3.2350.57
335_S416_V3.1720.55
6_V187_A3.1260.54
281_I284_G2.8420.47
365_A398_R2.8020.46
324_I380_F2.7990.46
218_A222_L2.7910.45
106_G119_Y2.7170.44
98_A173_L2.5340.39
212_L365_A2.4880.38
164_A215_R2.4380.37
438_R459_L2.4230.36
435_I463_E2.3690.35
141_D464_R2.2600.33
267_H405_V2.2170.32
342_T377_T2.2080.31
393_S397_E2.1860.31
435_I438_R2.1850.31
201_V245_V2.1830.31
40_D343_D2.1540.30
11_A304_E2.1470.30
359_G416_V2.1190.29
184_L187_A2.0930.29
27_A171_D2.0690.28
164_A201_V2.0690.28
17_L84_F2.0660.28
294_F324_I2.0590.28
96_F351_I1.9970.27
32_I36_F1.9830.27
171_D365_A1.9830.27
27_A200_G1.9750.26
15_T32_I1.9660.26
28_A86_W1.9580.26
435_I442_Q1.9540.26
81_R211_S1.9500.26
16_Q40_D1.9270.25
150_R215_R1.8900.25
323_E335_S1.8460.24
47_H61_I1.8270.24
4_V64_H1.8250.24
175_A411_V1.8060.23
358_T370_R1.7720.23
84_F451_S1.7670.22
131_D405_V1.7380.22
54_P442_Q1.7370.22
118_A403_L1.7120.21
164_A200_G1.7050.21
20_N114_D1.6970.21
164_A222_L1.6960.21
111_D451_S1.6870.21
4_V351_I1.6800.21
101_D195_I1.6790.21
351_I438_R1.6270.20
164_A171_D1.6260.20
164_A435_I1.6190.20
8_G13_A1.6040.20
104_V435_I1.5970.20
164_A286_D1.5830.19
29_S363_Y1.5730.19
30_P50_I1.5580.19
3_R465_V1.5520.19
49_D54_P1.5500.19
337_G378_T1.5460.19
19_R465_V1.5450.19
125_V415_A1.5350.19
267_H270_T1.5310.19
351_I427_K1.5300.18
104_V150_R1.5190.18
69_A403_L1.5170.18
10_Y407_T1.5070.18
141_D380_F1.4910.18
49_D72_V1.4850.18
203_W337_G1.4710.18
173_L411_V1.4710.18
101_D198_N1.4710.18
215_R392_R1.4710.18
242_P451_S1.4570.17
292_V363_Y1.4560.17
96_F183_E1.4540.17
179_T298_L1.4510.17
77_A322_I1.4490.17
250_T351_I1.4480.17
58_G277_G1.4430.17
186_R353_V1.4360.17
15_T36_F1.4360.17
54_P106_G1.4240.17
84_F235_D1.4240.17
23_L234_A1.4160.17
195_I335_S1.4060.17
134_T450_V1.3940.16
293_D349_A1.3920.16
98_A452_E1.3830.16
194_D226_A1.3800.16
29_S113_G1.3700.16
70_R234_A1.3690.16
27_A48_A1.3670.16
390_V398_R1.3660.16
153_A446_A1.3630.16
19_R151_P1.3560.16
110_L464_R1.3470.16
201_V249_D1.3430.16
8_G12_T1.3420.16
158_T169_G1.3330.16
304_E347_E1.3260.16
98_A118_A1.3240.16
163_L299_G1.3180.15
200_G465_V1.3050.15
334_I360_G1.3040.15
50_I414_D1.2990.15
175_A179_T1.2870.15
322_I416_V1.2850.15
185_A358_T1.2800.15
271_V300_A1.2800.15
385_W435_I1.2780.15
51_R54_P1.2730.15
187_A273_A1.2670.15
118_A153_A1.2650.15
178_A260_T1.2640.15
67_D415_A1.2620.15
326_H410_E1.2490.15
230_E442_Q1.2470.14
135_L164_A1.2450.14
313_Q365_A1.2420.14
9_I12_T1.2380.14
378_T385_W1.2380.14
45_E309_A1.2370.14
72_V197_D1.2310.14
153_A442_Q1.2250.14
125_V201_V1.2230.14
391_Y418_Y1.2220.14
424_D437_D1.2220.14
404_N437_D1.2220.14
404_N424_D1.2220.14
404_N418_Y1.2220.14
400_G437_D1.2220.14
418_Y424_D1.2220.14
400_G424_D1.2220.14
400_G418_Y1.2220.14
400_G404_N1.2220.14
391_Y404_N1.2220.14
391_Y437_D1.2220.14
391_Y424_D1.2220.14
170_V211_S1.2220.14
418_Y437_D1.2220.14
35_R404_N1.2220.14
35_R400_G1.2220.14
364_D437_D1.2220.14
364_D391_Y1.2220.14
35_R391_Y1.2220.14
364_D400_G1.2220.14
35_R418_Y1.2220.14
364_D424_D1.2220.14
35_R424_D1.2220.14
35_R364_D1.2220.14
391_Y400_G1.2220.14
364_D418_Y1.2220.14
35_R437_D1.2220.14
364_D404_N1.2220.14
290_D347_E1.2080.14
296_E408_P1.2040.14
112_L126_D1.2010.14
29_S374_D1.1970.14
365_A449_L1.1960.14
210_A423_V1.1950.14
282_K436_V1.1940.14
140_R429_A1.1890.14
18_L217_T1.1880.14
82_D283_A1.1830.14
264_L410_E1.1800.14
270_T394_E1.1790.14
151_P334_I1.1720.14
65_G405_V1.1660.13
39_A89_P1.1620.13
231_A394_E1.1610.13
104_V442_Q1.1580.13
121_P422_H1.1560.13
40_D215_R1.1550.13
118_A452_E1.1540.13
389_T406_C1.1530.13
123_G152_T1.1520.13
334_I393_S1.1490.13
251_T379_R1.1470.13
92_R251_T1.1470.13
269_R345_S1.1460.13
125_V359_G1.1450.13
205_Y232_T1.1440.13
103_T435_I1.1440.13
197_D453_E1.1440.13
34_A217_T1.1430.13
254_A467_S1.1410.13
298_L309_A1.1410.13
23_L416_V1.1370.13
357_M360_G1.1340.13
153_A435_I1.1330.13
259_E419_V1.1330.13
302_V368_V1.1280.13
73_R252_L1.1240.13
231_A343_D1.1220.13
238_G254_A1.1210.13
98_A104_V1.1200.13
208_A411_V1.1110.13
63_A198_N1.1080.13
49_D205_Y1.1040.13
67_D131_D1.1030.13
207_G429_A1.1020.13
56_R294_F1.0980.13
77_A435_I1.0980.13
50_I60_G1.0940.13
83_T339_G1.0920.13
19_R92_R1.0910.13
164_A245_V1.0820.13
126_D248_P1.0810.13
84_F309_A1.0810.13
7_R13_A1.0800.12
202_Y251_T1.0780.12
197_D308_G1.0700.12
296_E374_D1.0700.12
140_R148_D1.0700.12
151_P243_G1.0690.12
216_G267_H1.0680.12
175_A178_A1.0650.12
154_T452_E1.0650.12
48_A263_A1.0610.12
47_H453_E1.0600.12
161_G201_V1.0600.12
98_A185_A1.0580.12
18_L285_S1.0580.12
180_D450_V1.0560.12
178_A187_A1.0560.12
3_R158_T1.0510.12
123_G248_P1.0500.12
264_L271_V1.0470.12
85_V229_L1.0450.12
435_I459_L1.0450.12
351_I446_A1.0430.12
97_D248_P1.0430.12
230_E463_E1.0410.12
50_I340_E1.0400.12
277_G376_A1.0390.12
245_V446_A1.0370.12
71_A229_L1.0310.12
25_V405_V1.0280.12
98_A463_E1.0280.12
167_D429_A1.0260.12
157_I287_A1.0240.12
135_L215_R1.0230.12
393_S399_K1.0200.12
6_V240_D1.0200.12
131_D340_E1.0190.12
22_G365_A1.0180.12
27_A379_R1.0170.12
135_L179_T1.0150.12
289_S462_A1.0140.12
17_L114_D1.0140.12
89_P452_E1.0090.12
6_V377_T1.0080.12
85_V463_E1.0070.12
20_N234_A1.0060.12
19_R50_I1.0060.12
324_I465_V1.0030.12
153_A438_R1.0020.12
266_D397_E1.0020.12
94_A357_M0.9990.12
292_V417_R0.9970.12
30_P185_A0.9950.12
93_G319_G0.9950.12
49_D204_E0.9950.12
103_T370_R0.9930.12
5_R203_W0.9930.12
457_K464_R0.9900.12
20_N164_A0.9890.12
347_E415_A0.9880.11
199_W427_K0.9850.11
375_T405_V0.9790.11
244_L380_F0.9740.11
62_T248_P0.9730.11
27_A192_D0.9690.11
99_A122_F0.9640.11
356_E427_K0.9640.11
62_T125_V0.9630.11
155_S215_R0.9630.11
213_D442_Q0.9600.11
59_V434_E0.9590.11
111_D242_P0.9570.11
148_D203_W0.9550.11
161_G270_T0.9550.11
377_T390_V0.9470.11
12_T404_N0.9450.11
12_T424_D0.9450.11
12_T391_Y0.9450.11
12_T437_D0.9450.11
12_T364_D0.9450.11
12_T35_R0.9450.11
12_T400_G0.9450.11
12_T418_Y0.9450.11
157_I238_G0.9450.11
185_A398_R0.9440.11
46_P212_L0.9440.11
374_D408_P0.9430.11
23_L335_S0.9350.11
263_A369_A0.9340.11
354_E450_V0.9330.11
3_R156_T0.9330.11
98_A272_A0.9270.11
200_G330_D0.9250.11
79_L84_F0.9230.11
183_E207_G0.9230.11
256_F277_G0.9210.11
30_P60_G0.9190.11
33_R434_E0.9190.11
147_H449_L0.9150.11
435_I466_Q0.9080.11
102_H466_Q0.9040.11
322_I353_V0.9020.11
20_N224_A0.8990.11
22_G44_A0.8990.11
323_E338_R0.8980.11
371_E393_S0.8970.11
216_G405_V0.8950.11
363_Y374_D0.8950.11
369_A426_I0.8920.11
266_D318_V0.8850.10
119_Y295_A0.8820.10
283_A376_A0.8820.10
347_E456_E0.8800.10
23_L351_I0.8700.10
312_D358_T0.8680.10
174_V205_Y0.8680.10
135_L381_T0.8660.10
337_G376_A0.8660.10
106_G312_D0.8640.10
316_P386_W0.8640.10
60_G150_R0.8620.10
19_R168_R0.8600.10
10_Y15_T0.8580.10
281_I318_V0.8570.10
10_Y374_D0.8560.10
182_A426_I0.8560.10
158_T171_D0.8560.10
50_I416_V0.8550.10
98_A435_I0.8550.10
58_G256_F0.8520.10
282_K374_D0.8510.10
21_A368_V0.8510.10
175_A208_A0.8510.10
249_D369_A0.8490.10
135_L429_A0.8490.10
458_A462_A0.8460.10
168_R333_L0.8460.10
445_V455_A0.8450.10
215_R442_Q0.8430.10
153_A363_Y0.8430.10
110_L156_T0.8430.10
130_T215_R0.8420.10
267_H308_G0.8410.10
88_D311_T0.8400.10
17_L244_L0.8380.10
78_D122_F0.8380.10
240_D377_T0.8370.10
171_D200_G0.8370.10
334_I372_A0.8360.10
18_L55_D0.8320.10
179_T291_A0.8310.10
218_A261_R0.8270.10
62_T175_A0.8260.10
54_P119_Y0.8260.10
103_T438_R0.8220.10
159_V233_L0.8200.10
7_R12_T0.8180.10
201_V222_L0.8170.10
401_T436_V0.8170.10
310_V447_D0.8150.10
46_P171_D0.8130.10
409_V419_V0.8120.10
106_G333_L0.8110.10
254_A350_R0.8100.10
196_P199_W0.8090.10
6_V71_A0.8080.10
161_G405_V0.8070.10
330_D385_W0.8070.10
292_V385_W0.8060.10
354_E396_G0.8050.10
117_E150_R0.8040.10
217_T309_A0.8030.10
4_V157_I0.8030.10
99_A114_D0.8010.10
248_P273_A0.8010.10
416_V465_V0.8010.10
70_R222_L0.8000.10
98_A442_Q0.7990.10
240_D347_E0.7990.10
78_D466_Q0.7980.10
209_D330_D0.7980.10
79_L405_V0.7960.10
15_T58_G0.7960.10
165_S457_K0.7940.10
427_K465_V0.7940.10
16_Q20_N0.7900.10
326_H448_G0.7900.10
155_S300_A0.7880.10
308_G351_I0.7840.10
124_A281_I0.7830.10
106_G311_T0.7790.09
251_T365_A0.7790.09
61_I158_T0.7780.09
71_A214_A0.7770.09
61_I106_G0.7770.09
361_G402_Y0.7740.09
26_V368_V0.7670.09
192_D211_S0.7670.09
158_T435_I0.7660.09
172_A284_G0.7640.09
153_A459_L0.7640.09
286_D451_S0.7620.09
407_T441_L0.7620.09
411_V463_E0.7580.09
72_V465_V0.7530.09
282_K337_G0.7520.09
50_I301_S0.7510.09
251_T465_V0.7510.09
298_L367_G0.7500.09
63_A403_L0.7500.09
229_L465_V0.7500.09
231_A267_H0.7470.09
262_C403_L0.7470.09
15_T31_P0.7440.09
70_R304_E0.7400.09
84_F439_E0.7360.09
218_A225_R0.7350.09
201_V220_D0.7340.09
245_V317_S0.7340.09
46_P286_D0.7270.09
442_Q463_E0.7260.09
23_L99_A0.7200.09
44_A359_G0.7200.09
44_A223_A0.7190.09
74_A220_D0.7180.09
92_R291_A0.7180.09
321_S354_E0.7170.09
326_H418_Y0.7150.09
326_H424_D0.7150.09
326_H404_N0.7150.09
326_H437_D0.7150.09
326_H400_G0.7150.09
326_H364_D0.7150.09
326_H391_Y0.7150.09
35_R326_H0.7150.09
357_M365_A0.7100.09
76_V238_G0.7100.09
220_D266_D0.7100.09
182_A190_L0.7090.09
18_L95_V0.7080.09
155_S390_V0.7050.09
67_D334_I0.7040.09
49_D403_L0.7030.09
288_A314_F0.7030.09
321_S467_S0.7020.09
186_R366_L0.7010.09
67_D241_T0.7000.09
167_D398_R0.6970.09
118_A408_P0.6960.09
184_L248_P0.6950.09
246_A295_A0.6940.09
273_A285_S0.6930.09
164_A390_V0.6910.09
221_T244_L0.6890.09
268_R420_D0.6880.09
265_D355_R0.6880.09
274_T278_H0.6880.09
278_H373_G0.6880.09
278_H420_D0.6880.09
265_D373_G0.6880.09
279_H355_R0.6880.09
279_H373_G0.6880.09
279_H420_D0.6880.09
278_H355_R0.6880.09
274_T279_H0.6880.09
268_R373_G0.6880.09
265_D420_D0.6880.09
268_R278_H0.6880.09
268_R274_T0.6880.09
265_D268_R0.6880.09
268_R355_R0.6880.09
265_D274_T0.6880.09
265_D278_H0.6880.09
265_D279_H0.6880.09
274_T420_D0.6880.09
274_T355_R0.6880.09
355_R373_G0.6880.09
355_R420_D0.6880.09
373_G420_D0.6880.09
268_R279_H0.6880.09
274_T373_G0.6880.09
203_W282_K0.6870.09
3_R405_V0.6870.09
4_V40_D0.6860.09
18_L405_V0.6850.09
79_L158_T0.6840.09
217_T333_L0.6830.09
208_A285_S0.6810.09
240_D369_A0.6800.09
350_R415_A0.6770.09
149_D220_D0.6740.09
235_D242_P0.6730.09
59_V183_E0.6710.09
47_H250_T0.6700.09
182_A187_A0.6700.09
104_V463_E0.6700.09
368_V429_A0.6700.09
34_A202_Y0.6680.09
28_A225_R0.6670.09
330_D456_E0.6660.09
239_G245_V0.6650.09
315_G431_G0.6640.09
19_R46_P0.6630.08
30_P192_D0.6620.08
45_E175_A0.6610.08
228_R351_I0.6600.08
393_S416_V0.6580.08
421_L454_L0.6580.08
183_E186_R0.6570.08
187_A190_L0.6570.08
24_D60_G0.6550.08
158_T439_E0.6530.08
23_L465_V0.6520.08
79_L169_G0.6520.08
366_L426_I0.6500.08
155_S164_A0.6490.08
215_R303_D0.6490.08
256_F315_G0.6480.08
129_V375_T0.6460.08
103_T117_E0.6450.08
205_Y375_T0.6430.08
457_K466_Q0.6410.08
72_V427_K0.6410.08
311_T460_S0.6400.08
137_V296_E0.6390.08
59_V256_F0.6380.08
5_R451_S0.6370.08
276_P354_E0.6360.08
96_F202_Y0.6360.08
294_F380_F0.6350.08
153_A467_S0.6350.08
61_I228_R0.6340.08
124_A248_P0.6330.08
138_A257_G0.6300.08
124_A460_S0.6290.08
27_A63_A0.6280.08
438_R463_E0.6280.08
19_R450_V0.6270.08
74_A241_T0.6260.08
57_Q255_W0.6260.08
169_G405_V0.6260.08
135_L411_V0.6250.08
245_V249_D0.6240.08
271_V465_V0.6220.08
398_R429_A0.6200.08
6_V14_L0.6190.08
73_R427_K0.6190.08
98_A357_M0.6180.08
106_G266_D0.6180.08
162_A211_S0.6180.08
59_V75_V0.6140.08
230_E435_I0.6130.08
110_L463_E0.6130.08
169_G213_D0.6120.08
160_S241_T0.6120.08
145_P256_F0.6080.08
187_A205_Y0.6080.08
23_L317_S0.6050.08
86_W367_G0.6050.08
176_G249_D0.6050.08
157_I240_D0.6020.08
118_A345_S0.5990.08
222_L414_D0.5980.08
48_A74_A0.5970.08
426_I457_K0.5950.08
28_A388_P0.5940.08
80_P183_E0.5930.08
154_T290_D0.5930.08
213_D390_V0.5920.08
100_V112_L0.5920.08
176_G179_T0.5900.08
6_V229_L0.5880.08
375_T411_V0.5850.08
172_A200_G0.5840.08
191_L203_W0.5840.08
174_V245_V0.5810.08
135_L153_A0.5810.08
175_A405_V0.5800.08
98_A301_S0.5760.08
362_T365_A0.5760.08
175_A187_A0.5760.08
96_F248_P0.5740.08
88_D414_D0.5730.08
102_H463_E0.5720.08
36_F440_E0.5720.08
190_L256_F0.5720.08
45_E390_V0.5700.08
30_P442_Q0.5700.08
70_R241_T0.5700.08
27_A46_P0.5690.08
107_G136_R0.5660.08
114_D362_T0.5650.08
3_R169_G0.5620.08
4_V426_I0.5600.08
120_L282_K0.5590.08
246_A405_V0.5590.08
161_G210_A0.5590.08
138_A315_G0.5580.08
50_I254_A0.5580.08
25_V460_S0.5570.08
311_T390_V0.5550.08
328_K440_E0.5540.08
173_L188_T0.5530.08
294_F463_E0.5520.08
113_G271_V0.5510.08
196_P294_F0.5490.08
382_E413_P0.5480.08
154_T428_H0.5480.08
11_A17_L0.5470.08
267_H375_T0.5460.08
39_A370_R0.5440.08
58_G376_A0.5430.08
414_D451_S0.5420.08
87_P248_P0.5410.08
287_A365_A0.5390.08
224_A245_V0.5360.08
133_D191_L0.5340.08
135_L168_R0.5340.08
71_A139_I0.5340.08
33_R303_D0.5340.08
27_A92_R0.5330.08
381_T384_N0.5320.08
23_L159_V0.5310.07
195_I232_T0.5310.07
61_I360_G0.5300.07
204_E247_A0.5290.07
32_I264_L0.5290.07
49_D446_A0.5290.07
20_N239_G0.5280.07
98_A397_E0.5260.07
104_V152_T0.5240.07
256_F339_G0.5230.07
17_L294_F0.5220.07
106_G358_T0.5210.07
27_A42_G0.5200.07
343_D453_E0.5200.07
24_D129_V0.5190.07
229_L242_P0.5190.07
19_R294_F0.5180.07
27_A30_P0.5180.07
188_T451_S0.5170.07
267_H395_D0.5160.07
119_Y442_Q0.5160.07
46_P294_F0.5150.07
4_V30_P0.5150.07
114_D405_V0.5150.07
229_L368_V0.5150.07
118_A199_W0.5140.07
21_A219_L0.5120.07
98_A459_L0.5110.07
54_P358_T0.5110.07
61_I467_S0.5110.07
50_I155_S0.5100.07
58_G108_A0.5090.07
283_A378_T0.5080.07
129_V135_L0.5070.07
61_I79_L0.5070.07
159_V321_S0.5060.07
363_Y441_L0.5050.07
225_R365_A0.5050.07
240_D243_G0.5040.07
3_R164_A0.5040.07
117_E427_K0.5030.07
71_A302_V0.5030.07
19_R39_A0.5020.07
336_L374_D0.5010.07
11_A81_R0.5000.07
327_G389_T0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3exmA 1 0.3333 100 0.834 Contact Map
4oxpA 1 0.3333 99.9 0.887 Contact Map
2p12A 2 0.31 99.8 0.895 Contact Map
2bx2L 3 0.7367 99.7 0.905 Contact Map
3cw2C 1 0.5053 98.1 0.952 Contact Map
4nngA 1 0.31 97.2 0.96 Contact Map
2k52A 1 0.1486 96.2 0.965 Contact Map
4toiA 2 0.2866 95.9 0.965 Contact Map
2khjA 1 0.1699 95.8 0.966 Contact Map
2khiA 1 0.1805 95.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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