Q9HMA7 - HALSA - GREMLIN Contacts

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Q9HMA7 - Glucose kinase

UniProt:	Q9HMA7	Sequences: MHYAGVDLGATNVRGAVSDESGRIVGVDRRKTPSGPTGIAVTETVLAVMRAAAADAGVAPTAIEAAGIGSIGPLDLANGAIDSPANMPASVETIPLVGPLANLLGVDTERVFLHNDTVAGVIGERFYADRTPDDMAYLTISSGIGAGIAVDGTVIGGWDGNAGELGHMVVDPRGRRTCGCGRDGHWEAYCSGNNIPEYARLLADDADGVETALPLDSGGFTAKDVFECAADGDTFAAHVVEQLGVWNGIGVTNLVQAYAPLVVYVGGAVALHNPEQVLGPIRAYIQERVFSNVPEIRLTTLGDDVVLKGAIASALTGGTGDSTHAP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	326 (290)
Sequences:	12597 (9629)
Seq/√Len:	565.4

ECOLI - MLC NANK NAGC YPHH MAK NAGK ALSK
BACSU - GLK XYLR SCRK
HALSA - Q9HMA7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
95_P	98_G	3.318	1.00
114_H	156_G	3.173	1.00
19_D	23_R	3.108	1.00
27_V	304_D	3.076	1.00
46_L	103_L	2.881	1.00
245_V	284_Y	2.701	1.00
132_P	262_V	2.623	1.00
262_V	297_R	2.592	1.00
18_S	311_I	2.527	1.00
186_W	250_G	2.487	1.00
16_A	307_L	2.471	1.00
241_E	280_P	2.342	1.00
129_D	135_M	2.320	1.00
159_D	259_A	2.309	1.00
136_A	254_L	2.303	1.00
75_D	78_N	2.275	1.00
121_V	147_G	2.253	1.00
97_V	101_A	2.240	1.00
65_A	314_A	2.165	1.00
137_Y	266_G	2.151	1.00
15_G	48_V	2.138	1.00
28_D	51_A	2.132	1.00
120_G	137_Y	2.125	1.00
198_Y	242_Q	2.002	1.00
168_M	253_N	1.935	1.00
134_D	261_L	1.924	1.00
114_H	118_V	1.918	1.00
180_C	185_H	1.908	1.00
150_V	155_I	1.877	1.00
158_W	261_L	1.871	1.00
114_H	119_A	1.855	1.00
4_A	49_M	1.852	1.00
121_V	149_A	1.842	1.00
66_A	104_L	1.841	1.00
251_V	263_V	1.822	1.00
126_F	312_A	1.819	1.00
50_R	103_L	1.797	1.00
278_L	282_R	1.793	1.00
26_G	55_D	1.784	1.00
177_T	183_D	1.783	1.00
94_I	99_P	1.782	1.00
43_E	103_L	1.781	1.00
285_I	296_I	1.778	1.00
230_A	276_Q	1.773	1.00
99_P	102_N	1.766	1.00
15_G	52_A	1.758	1.00
98_G	102_N	1.755	1.00
284_Y	287_E	1.753	1.00
248_G	284_Y	1.716	1.00
262_V	295_E	1.697	1.00
244_G	280_P	1.684	1.00
228_C	233_D	1.679	1.00
133_D	261_L	1.647	1.00
68_I	100_L	1.644	1.00
69_G	119_A	1.643	1.00
221_T	224_D	1.641	1.00
133_D	151_D	1.630	1.00
178_C	185_H	1.630	1.00
138_L	251_V	1.607	1.00
28_D	55_D	1.603	1.00
123_G	301_L	1.588	1.00
132_P	261_L	1.576	1.00
227_E	231_D	1.563	1.00
282_R	286_Q	1.546	1.00
244_G	281_I	1.541	1.00
5_G	307_L	1.514	1.00
244_G	248_G	1.509	1.00
280_P	283_A	1.474	1.00
33_P	44_T	1.449	1.00
255_V	285_I	1.443	1.00
274_P	278_L	1.438	1.00
278_L	298_L	1.429	1.00
249_I	253_N	1.423	1.00
12_N	29_R	1.413	1.00
169_V	253_N	1.407	1.00
195_I	243_L	1.396	1.00
223_K	227_E	1.374	1.00
140_I	247_N	1.361	1.00
135_M	149_A	1.353	1.00
6_V	15_G	1.346	1.00
275_E	279_G	1.345	1.00
16_A	24_I	1.343	1.00
199_A	239_V	1.341	1.00
198_Y	201_L	1.339	1.00
284_Y	288_R	1.334	1.00
66_A	106_V	1.332	1.00
114_H	313_S	1.329	1.00
99_P	103_L	1.327	1.00
132_P	135_M	1.318	1.00
178_C	181_G	1.315	1.00
3_Y	315_L	1.310	1.00
202_L	238_H	1.303	1.00
50_R	104_L	1.301	1.00
121_V	135_M	1.296	1.00
26_G	52_A	1.277	1.00
241_E	284_Y	1.275	1.00
144_I	190_C	1.267	1.00
125_R	316_T	1.265	1.00
167_H	180_C	1.262	1.00
43_E	47_A	1.261	1.00
134_D	150_V	1.256	1.00
30_R	48_V	1.254	1.00
46_L	50_R	1.248	1.00
46_L	104_L	1.242	1.00
42_T	99_P	1.238	1.00
28_D	48_V	1.217	1.00
255_V	263_V	1.201	1.00
125_R	312_A	1.199	1.00
254_L	257_A	1.199	1.00
136_A	146_A	1.190	1.00
18_S	24_I	1.184	1.00
229_A	240_V	1.182	1.00
280_P	284_Y	1.175	1.00
224_D	227_E	1.151	1.00
48_V	51_A	1.151	1.00
172_P	249_I	1.150	1.00
6_V	49_M	1.145	1.00
80_A	95_P	1.144	1.00
118_V	154_V	1.108	1.00
134_D	155_I	1.107	1.00
167_H	178_C	1.101	1.00
198_Y	202_L	1.098	1.00
136_A	148_I	1.092	1.00
198_Y	239_V	1.091	1.00
146_A	165_L	1.077	1.00
5_G	310_A	1.073	1.00
69_G	306_V	1.071	1.00
112_F	314_A	1.071	1.00
135_M	264_Y	1.066	1.00
119_A	310_A	1.066	1.00
95_P	99_P	1.065	1.00
283_A	287_E	1.058	1.00
237_A	241_E	1.052	1.00
203_A	220_F	1.048	1.00
30_R	51_A	1.041	1.00
30_R	44_T	1.041	1.00
226_F	240_V	1.038	1.00
51_A	55_D	1.036	1.00
248_G	288_R	1.032	1.00
17_V	56_A	1.031	1.00
6_V	45_V	1.028	1.00
44_T	47_A	1.021	1.00
19_D	25_V	1.017	1.00
39_I	99_P	1.011	1.00
229_A	237_A	1.011	1.00
14_R	29_R	1.006	1.00
12_N	192_G	1.003	1.00
251_V	265_V	1.002	1.00
275_E	298_L	1.000	1.00
249_I	288_R	1.000	1.00
101_A	107_D	0.999	1.00
148_I	155_I	0.992	1.00
24_I	27_V	0.985	1.00
30_R	47_A	0.985	1.00
171_D	249_I	0.981	1.00
230_A	275_E	0.979	1.00
279_G	282_R	0.975	1.00
47_A	51_A	0.974	1.00
203_A	235_F	0.971	1.00
286_Q	293_V	0.968	1.00
244_G	284_Y	0.965	1.00
241_E	283_A	0.962	1.00
167_H	185_H	0.962	1.00
271_L	298_L	0.962	1.00
271_L	303_D	0.961	1.00
17_V	52_A	0.961	1.00
227_E	230_A	0.955	1.00
148_I	258_Y	0.954	1.00
126_F	308_K	0.949	1.00
130_R	300_T	0.949	1.00
199_A	203_A	0.948	1.00
242_Q	246_W	0.948	1.00
121_V	137_Y	0.947	1.00
264_Y	297_R	0.944	1.00
199_A	236_A	0.942	1.00
279_G	283_A	0.942	1.00
100_L	111_V	0.935	1.00
117_T	139_T	0.935	1.00
245_V	249_I	0.934	1.00
26_G	56_A	0.933	1.00
175_R	197_E	0.930	1.00
265_V	270_A	0.929	1.00
63_I	106_V	0.925	1.00
80_A	93_T	0.917	1.00
135_M	262_V	0.917	1.00
264_Y	299_T	0.916	1.00
10_A	142_S	0.913	1.00
75_D	82_D	0.905	1.00
5_G	67_G	0.900	1.00
226_F	230_A	0.898	1.00
133_D	152_G	0.896	1.00
115_N	164_E	0.893	1.00
101_A	111_V	0.888	1.00
3_Y	314_A	0.887	1.00
134_D	151_D	0.884	1.00
4_A	63_I	0.880	1.00
127_Y	130_R	0.876	1.00
278_L	281_I	0.869	1.00
132_P	295_E	0.868	1.00
148_I	163_G	0.867	1.00
224_D	228_C	0.866	1.00
13_V	32_T	0.863	1.00
120_G	306_V	0.861	1.00
274_P	298_L	0.858	1.00
251_V	285_I	0.858	1.00
200_R	218_G	0.855	1.00
5_G	311_I	0.853	1.00
41_V	91_V	0.851	1.00
79_G	97_V	0.845	1.00
18_S	308_K	0.844	1.00
70_S	81_I	0.841	1.00
136_A	263_V	0.838	1.00
8_L	45_V	0.836	1.00
38_G	99_P	0.835	1.00
15_G	28_D	0.833	1.00
118_V	164_E	0.833	1.00
53_A	106_V	0.832	1.00
255_V	294_P	0.831	1.00
38_G	94_I	0.830	1.00
50_R	53_A	0.824	1.00
40_A	43_E	0.818	1.00
70_S	74_L	0.818	1.00
228_C	236_A	0.811	1.00
128_A	300_T	0.810	1.00
175_R	189_Y	0.806	1.00
235_F	238_H	0.805	1.00
170_V	246_W	0.803	1.00
134_D	158_W	0.802	1.00
274_P	279_G	0.802	1.00
46_L	99_P	0.799	1.00
8_L	70_S	0.796	1.00
83_S	92_E	0.795	1.00
136_A	260_P	0.794	1.00
171_D	175_R	0.794	1.00
245_V	288_R	0.793	1.00
248_G	285_I	0.792	1.00
14_R	27_V	0.792	1.00
199_A	225_V	0.790	1.00
101_A	105_G	0.789	1.00
47_A	50_R	0.785	1.00
233_D	236_A	0.777	1.00
202_L	235_F	0.777	1.00
228_C	231_D	0.777	1.00
128_A	297_R	0.775	1.00
157_G	162_A	0.774	1.00
171_D	189_Y	0.773	1.00
247_N	281_I	0.773	1.00
189_Y	246_W	0.772	1.00
151_D	155_I	0.766	1.00
44_T	48_V	0.765	1.00
238_H	242_Q	0.763	1.00
33_P	36_P	0.760	1.00
198_Y	243_L	0.760	1.00
119_A	313_S	0.760	1.00
199_A	204_D	0.758	1.00
196_P	200_R	0.756	1.00
157_G	259_A	0.756	1.00
124_E	127_Y	0.754	1.00
50_R	54_A	0.754	1.00
79_G	101_A	0.752	1.00
265_V	296_I	0.751	1.00
252_T	288_R	0.749	1.00
297_R	300_T	0.746	1.00
16_A	27_V	0.735	1.00
117_T	147_G	0.735	1.00
302_G	305_V	0.731	1.00
182_R	288_R	0.728	1.00
229_A	276_Q	0.722	1.00
220_F	224_D	0.722	1.00
194_N	197_E	0.722	1.00
175_R	188_A	0.718	1.00
36_P	40_A	0.718	1.00
301_L	308_K	0.717	1.00
234_T	238_H	0.713	1.00
252_T	256_Q	0.713	1.00
137_Y	264_Y	0.709	1.00
202_L	239_V	0.708	1.00
157_G	163_G	0.707	1.00
195_I	269_V	0.705	1.00
127_Y	131_T	0.700	1.00
40_A	44_T	0.698	1.00
256_Q	290_F	0.697	1.00
172_P	245_V	0.694	1.00
169_V	249_I	0.692	1.00
186_W	243_L	0.688	1.00
239_V	243_L	0.684	1.00
276_Q	280_P	0.684	1.00
67_G	119_A	0.683	1.00
73_P	84_P	0.681	1.00
128_A	264_Y	0.679	1.00
97_V	113_L	0.678	1.00
42_T	94_I	0.676	1.00
33_P	40_A	0.675	1.00
86_N	179_G	0.675	1.00
175_R	198_Y	0.675	1.00
178_C	182_R	0.674	1.00
67_G	314_A	0.672	1.00
226_F	272_H	0.665	1.00
8_L	13_V	0.664	1.00
248_G	252_T	0.662	1.00
8_L	41_V	0.661	1.00
229_A	232_G	0.661	1.00
48_V	52_A	0.660	1.00
195_I	239_V	0.660	1.00
15_G	30_R	0.660	1.00
4_A	53_A	0.659	1.00
141_S	268_A	0.659	1.00
234_T	237_A	0.659	1.00
170_V	250_G	0.658	1.00
112_F	313_S	0.658	1.00
237_A	276_Q	0.658	1.00
229_A	236_A	0.656	1.00
6_V	66_A	0.654	1.00
239_V	242_Q	0.654	1.00
171_D	174_G	0.654	1.00
129_D	264_Y	0.649	1.00
252_T	285_I	0.648	1.00
245_V	287_E	0.648	1.00
276_Q	279_G	0.644	1.00
282_R	295_E	0.642	1.00
98_G	101_A	0.641	1.00
53_A	63_I	0.640	1.00
251_V	281_I	0.639	1.00
9_G	142_S	0.639	1.00
168_M	250_G	0.638	1.00
124_E	299_T	0.638	1.00
43_E	46_L	0.636	1.00
200_R	219_G	0.634	1.00
193_N	197_E	0.633	1.00
51_A	54_A	0.633	1.00
155_I	258_Y	0.631	1.00
42_T	103_L	0.631	1.00
301_L	305_V	0.628	1.00
277_V	280_P	0.627	1.00
192_G	196_P	0.627	1.00
138_L	165_L	0.626	1.00
185_H	188_A	0.626	1.00
11_T	142_S	0.621	1.00
126_F	301_L	0.621	1.00
169_V	172_P	0.621	1.00
196_P	225_V	0.620	1.00
46_L	100_L	0.613	1.00
169_V	182_R	0.613	1.00
105_G	111_V	0.612	1.00
237_A	280_P	0.611	1.00
39_I	43_E	0.610	1.00
124_E	301_L	0.606	1.00
115_N	143_G	0.604	1.00
195_I	225_V	0.603	1.00
308_K	311_I	0.600	1.00
124_E	300_T	0.599	1.00
170_V	189_Y	0.599	1.00
281_I	285_I	0.599	1.00
180_C	184_G	0.595	1.00
143_G	187_E	0.594	1.00
162_A	259_A	0.593	1.00
139_T	306_V	0.592	1.00
153_T	316_T	0.592	1.00
102_N	105_G	0.592	1.00
182_R	185_H	0.590	1.00
158_W	259_A	0.590	1.00
116_D	145_G	0.589	1.00
9_G	268_A	0.589	1.00
283_A	286_Q	0.588	1.00
190_C	243_L	0.586	1.00
97_V	111_V	0.585	1.00
13_V	30_R	0.584	1.00
243_L	277_V	0.584	1.00
244_G	277_V	0.581	1.00
14_R	307_L	0.581	1.00
65_A	107_D	0.580	1.00
178_C	188_A	0.576	1.00
169_V	174_G	0.576	1.00
138_L	146_A	0.574	1.00
312_A	316_T	0.572	0.99
218_G	224_D	0.571	0.99
17_V	63_I	0.570	0.99
171_D	246_W	0.570	0.99
187_E	191_S	0.569	0.99
196_P	222_A	0.569	0.99
52_A	56_A	0.569	0.99
149_A	154_V	0.567	0.99
194_N	198_Y	0.564	0.99
294_P	298_L	0.556	0.99
192_G	269_V	0.556	0.99
138_L	254_L	0.555	0.99
181_G	185_H	0.554	0.99
74_L	81_I	0.551	0.99
100_L	104_L	0.547	0.99
125_R	315_L	0.547	0.99
272_H	276_Q	0.543	0.99
275_E	278_L	0.543	0.99
91_V	94_I	0.541	0.99
198_Y	246_W	0.541	0.99
122_I	313_S	0.538	0.99
3_Y	20_E	0.538	0.99
143_G	164_E	0.536	0.99
53_A	56_A	0.535	0.99
65_A	106_V	0.533	0.99
173_R	245_V	0.532	0.99
88_P	92_E	0.532	0.99
304_D	308_K	0.532	0.99
13_V	45_V	0.531	0.99
3_Y	18_S	0.529	0.99
174_G	189_Y	0.529	0.99
120_G	266_G	0.528	0.99
79_G	98_G	0.528	0.99
260_P	263_V	0.528	0.99
158_W	260_P	0.527	0.99
175_R	201_L	0.525	0.99
266_G	299_T	0.525	0.99
232_G	237_A	0.524	0.99
197_E	201_L	0.521	0.99
71_I	86_N	0.520	0.99
79_G	95_P	0.520	0.99
84_P	87_M	0.520	0.99
128_A	131_T	0.516	0.99
14_R	304_D	0.516	0.99
115_N	118_V	0.514	0.99
76_L	156_G	0.514	0.99
49_M	104_L	0.513	0.99
38_G	91_V	0.510	0.99
123_G	312_A	0.509	0.99
115_N	145_G	0.508	0.99
127_Y	297_R	0.508	0.99
147_G	154_V	0.505	0.99
28_D	52_A	0.504	0.99
4_A	17_V	0.504	0.99
65_A	112_F	0.504	0.99
165_L	257_A	0.503	0.99
67_G	313_S	0.502	0.99
245_V	280_P	0.502	0.99
120_G	139_T	0.502	0.99
127_Y	301_L	0.501	0.99
188_A	197_E	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1z05A	2	0.9632	100	0.199	Contact Map
1z6rA	3	0.9632	100	0.201	Contact Map
3vovA	3	0.9049	100	0.215	Contact Map
2qm1A	2	0.9601	100	0.218	Contact Map
3vglA	3	0.9294	100	0.226	Contact Map
2yhwA	2	0.9233	100	0.232	Contact Map
2aa4A	2	0.8834	100	0.234	Contact Map
2ap1A	2	0.8926	100	0.236	Contact Map
2hoeA	2	0.8957	100	0.242	Contact Map
3htvA	2	0.8252	100	0.246	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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