GREMLIN Database
Q9HMA7 - Glucose kinase
UniProt: Q9HMA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 326 (290)
Sequences: 12597 (9629)
Seq/√Len: 565.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_P98_G3.3181.00
114_H156_G3.1731.00
19_D23_R3.1081.00
27_V304_D3.0761.00
46_L103_L2.8811.00
245_V284_Y2.7011.00
132_P262_V2.6231.00
262_V297_R2.5921.00
18_S311_I2.5271.00
186_W250_G2.4871.00
16_A307_L2.4711.00
241_E280_P2.3421.00
129_D135_M2.3201.00
159_D259_A2.3091.00
136_A254_L2.3031.00
75_D78_N2.2751.00
121_V147_G2.2531.00
97_V101_A2.2401.00
65_A314_A2.1651.00
137_Y266_G2.1511.00
15_G48_V2.1381.00
28_D51_A2.1321.00
120_G137_Y2.1251.00
198_Y242_Q2.0021.00
168_M253_N1.9351.00
134_D261_L1.9241.00
114_H118_V1.9181.00
180_C185_H1.9081.00
150_V155_I1.8771.00
158_W261_L1.8711.00
114_H119_A1.8551.00
4_A49_M1.8521.00
121_V149_A1.8421.00
66_A104_L1.8411.00
251_V263_V1.8221.00
126_F312_A1.8191.00
50_R103_L1.7971.00
278_L282_R1.7931.00
26_G55_D1.7841.00
177_T183_D1.7831.00
94_I99_P1.7821.00
43_E103_L1.7811.00
285_I296_I1.7781.00
230_A276_Q1.7731.00
99_P102_N1.7661.00
15_G52_A1.7581.00
98_G102_N1.7551.00
284_Y287_E1.7531.00
248_G284_Y1.7161.00
262_V295_E1.6971.00
244_G280_P1.6841.00
228_C233_D1.6791.00
133_D261_L1.6471.00
68_I100_L1.6441.00
69_G119_A1.6431.00
221_T224_D1.6411.00
133_D151_D1.6301.00
178_C185_H1.6301.00
138_L251_V1.6071.00
28_D55_D1.6031.00
123_G301_L1.5881.00
132_P261_L1.5761.00
227_E231_D1.5631.00
282_R286_Q1.5461.00
244_G281_I1.5411.00
5_G307_L1.5141.00
244_G248_G1.5091.00
280_P283_A1.4741.00
33_P44_T1.4491.00
255_V285_I1.4431.00
274_P278_L1.4381.00
278_L298_L1.4291.00
249_I253_N1.4231.00
12_N29_R1.4131.00
169_V253_N1.4071.00
195_I243_L1.3961.00
223_K227_E1.3741.00
140_I247_N1.3611.00
135_M149_A1.3531.00
6_V15_G1.3461.00
275_E279_G1.3451.00
16_A24_I1.3431.00
199_A239_V1.3411.00
198_Y201_L1.3391.00
284_Y288_R1.3341.00
66_A106_V1.3321.00
114_H313_S1.3291.00
99_P103_L1.3271.00
132_P135_M1.3181.00
178_C181_G1.3151.00
3_Y315_L1.3101.00
202_L238_H1.3031.00
50_R104_L1.3011.00
121_V135_M1.2961.00
26_G52_A1.2771.00
241_E284_Y1.2751.00
144_I190_C1.2671.00
125_R316_T1.2651.00
167_H180_C1.2621.00
43_E47_A1.2611.00
134_D150_V1.2561.00
30_R48_V1.2541.00
46_L50_R1.2481.00
46_L104_L1.2421.00
42_T99_P1.2381.00
28_D48_V1.2171.00
255_V263_V1.2011.00
125_R312_A1.1991.00
254_L257_A1.1991.00
136_A146_A1.1901.00
18_S24_I1.1841.00
229_A240_V1.1821.00
280_P284_Y1.1751.00
224_D227_E1.1511.00
48_V51_A1.1511.00
172_P249_I1.1501.00
6_V49_M1.1451.00
80_A95_P1.1441.00
118_V154_V1.1081.00
134_D155_I1.1071.00
167_H178_C1.1011.00
198_Y202_L1.0981.00
136_A148_I1.0921.00
198_Y239_V1.0911.00
146_A165_L1.0771.00
5_G310_A1.0731.00
69_G306_V1.0711.00
112_F314_A1.0711.00
135_M264_Y1.0661.00
119_A310_A1.0661.00
95_P99_P1.0651.00
283_A287_E1.0581.00
237_A241_E1.0521.00
203_A220_F1.0481.00
30_R51_A1.0411.00
30_R44_T1.0411.00
226_F240_V1.0381.00
51_A55_D1.0361.00
248_G288_R1.0321.00
17_V56_A1.0311.00
6_V45_V1.0281.00
44_T47_A1.0211.00
19_D25_V1.0171.00
39_I99_P1.0111.00
229_A237_A1.0111.00
14_R29_R1.0061.00
12_N192_G1.0031.00
251_V265_V1.0021.00
275_E298_L1.0001.00
249_I288_R1.0001.00
101_A107_D0.9991.00
148_I155_I0.9921.00
24_I27_V0.9851.00
30_R47_A0.9851.00
171_D249_I0.9811.00
230_A275_E0.9791.00
279_G282_R0.9751.00
47_A51_A0.9741.00
203_A235_F0.9711.00
286_Q293_V0.9681.00
244_G284_Y0.9651.00
241_E283_A0.9621.00
167_H185_H0.9621.00
271_L298_L0.9621.00
271_L303_D0.9611.00
17_V52_A0.9611.00
227_E230_A0.9551.00
148_I258_Y0.9541.00
126_F308_K0.9491.00
130_R300_T0.9491.00
199_A203_A0.9481.00
242_Q246_W0.9481.00
121_V137_Y0.9471.00
264_Y297_R0.9441.00
199_A236_A0.9421.00
279_G283_A0.9421.00
100_L111_V0.9351.00
117_T139_T0.9351.00
245_V249_I0.9341.00
26_G56_A0.9331.00
175_R197_E0.9301.00
265_V270_A0.9291.00
63_I106_V0.9251.00
80_A93_T0.9171.00
135_M262_V0.9171.00
264_Y299_T0.9161.00
10_A142_S0.9131.00
75_D82_D0.9051.00
5_G67_G0.9001.00
226_F230_A0.8981.00
133_D152_G0.8961.00
115_N164_E0.8931.00
101_A111_V0.8881.00
3_Y314_A0.8871.00
134_D151_D0.8841.00
4_A63_I0.8801.00
127_Y130_R0.8761.00
278_L281_I0.8691.00
132_P295_E0.8681.00
148_I163_G0.8671.00
224_D228_C0.8661.00
13_V32_T0.8631.00
120_G306_V0.8611.00
274_P298_L0.8581.00
251_V285_I0.8581.00
200_R218_G0.8551.00
5_G311_I0.8531.00
41_V91_V0.8511.00
79_G97_V0.8451.00
18_S308_K0.8441.00
70_S81_I0.8411.00
136_A263_V0.8381.00
8_L45_V0.8361.00
38_G99_P0.8351.00
15_G28_D0.8331.00
118_V164_E0.8331.00
53_A106_V0.8321.00
255_V294_P0.8311.00
38_G94_I0.8301.00
50_R53_A0.8241.00
40_A43_E0.8181.00
70_S74_L0.8181.00
228_C236_A0.8111.00
128_A300_T0.8101.00
175_R189_Y0.8061.00
235_F238_H0.8051.00
170_V246_W0.8031.00
134_D158_W0.8021.00
274_P279_G0.8021.00
46_L99_P0.7991.00
8_L70_S0.7961.00
83_S92_E0.7951.00
136_A260_P0.7941.00
171_D175_R0.7941.00
245_V288_R0.7931.00
248_G285_I0.7921.00
14_R27_V0.7921.00
199_A225_V0.7901.00
101_A105_G0.7891.00
47_A50_R0.7851.00
233_D236_A0.7771.00
202_L235_F0.7771.00
228_C231_D0.7771.00
128_A297_R0.7751.00
157_G162_A0.7741.00
171_D189_Y0.7731.00
247_N281_I0.7731.00
189_Y246_W0.7721.00
151_D155_I0.7661.00
44_T48_V0.7651.00
238_H242_Q0.7631.00
33_P36_P0.7601.00
198_Y243_L0.7601.00
119_A313_S0.7601.00
199_A204_D0.7581.00
196_P200_R0.7561.00
157_G259_A0.7561.00
124_E127_Y0.7541.00
50_R54_A0.7541.00
79_G101_A0.7521.00
265_V296_I0.7511.00
252_T288_R0.7491.00
297_R300_T0.7461.00
16_A27_V0.7351.00
117_T147_G0.7351.00
302_G305_V0.7311.00
182_R288_R0.7281.00
229_A276_Q0.7221.00
220_F224_D0.7221.00
194_N197_E0.7221.00
175_R188_A0.7181.00
36_P40_A0.7181.00
301_L308_K0.7171.00
234_T238_H0.7131.00
252_T256_Q0.7131.00
137_Y264_Y0.7091.00
202_L239_V0.7081.00
157_G163_G0.7071.00
195_I269_V0.7051.00
127_Y131_T0.7001.00
40_A44_T0.6981.00
256_Q290_F0.6971.00
172_P245_V0.6941.00
169_V249_I0.6921.00
186_W243_L0.6881.00
239_V243_L0.6841.00
276_Q280_P0.6841.00
67_G119_A0.6831.00
73_P84_P0.6811.00
128_A264_Y0.6791.00
97_V113_L0.6781.00
42_T94_I0.6761.00
33_P40_A0.6751.00
86_N179_G0.6751.00
175_R198_Y0.6751.00
178_C182_R0.6741.00
67_G314_A0.6721.00
226_F272_H0.6651.00
8_L13_V0.6641.00
248_G252_T0.6621.00
8_L41_V0.6611.00
229_A232_G0.6611.00
48_V52_A0.6601.00
195_I239_V0.6601.00
15_G30_R0.6601.00
4_A53_A0.6591.00
141_S268_A0.6591.00
234_T237_A0.6591.00
170_V250_G0.6581.00
112_F313_S0.6581.00
237_A276_Q0.6581.00
229_A236_A0.6561.00
6_V66_A0.6541.00
239_V242_Q0.6541.00
171_D174_G0.6541.00
129_D264_Y0.6491.00
252_T285_I0.6481.00
245_V287_E0.6481.00
276_Q279_G0.6441.00
282_R295_E0.6421.00
98_G101_A0.6411.00
53_A63_I0.6401.00
251_V281_I0.6391.00
9_G142_S0.6391.00
168_M250_G0.6381.00
124_E299_T0.6381.00
43_E46_L0.6361.00
200_R219_G0.6341.00
193_N197_E0.6331.00
51_A54_A0.6331.00
155_I258_Y0.6311.00
42_T103_L0.6311.00
301_L305_V0.6281.00
277_V280_P0.6271.00
192_G196_P0.6271.00
138_L165_L0.6261.00
185_H188_A0.6261.00
11_T142_S0.6211.00
126_F301_L0.6211.00
169_V172_P0.6211.00
196_P225_V0.6201.00
46_L100_L0.6131.00
169_V182_R0.6131.00
105_G111_V0.6121.00
237_A280_P0.6111.00
39_I43_E0.6101.00
124_E301_L0.6061.00
115_N143_G0.6041.00
195_I225_V0.6031.00
308_K311_I0.6001.00
124_E300_T0.5991.00
170_V189_Y0.5991.00
281_I285_I0.5991.00
180_C184_G0.5951.00
143_G187_E0.5941.00
162_A259_A0.5931.00
139_T306_V0.5921.00
153_T316_T0.5921.00
102_N105_G0.5921.00
182_R185_H0.5901.00
158_W259_A0.5901.00
116_D145_G0.5891.00
9_G268_A0.5891.00
283_A286_Q0.5881.00
190_C243_L0.5861.00
97_V111_V0.5851.00
13_V30_R0.5841.00
243_L277_V0.5841.00
244_G277_V0.5811.00
14_R307_L0.5811.00
65_A107_D0.5801.00
178_C188_A0.5761.00
169_V174_G0.5761.00
138_L146_A0.5741.00
312_A316_T0.5720.99
218_G224_D0.5710.99
17_V63_I0.5700.99
171_D246_W0.5700.99
187_E191_S0.5690.99
196_P222_A0.5690.99
52_A56_A0.5690.99
149_A154_V0.5670.99
194_N198_Y0.5640.99
294_P298_L0.5560.99
192_G269_V0.5560.99
138_L254_L0.5550.99
181_G185_H0.5540.99
74_L81_I0.5510.99
100_L104_L0.5470.99
125_R315_L0.5470.99
272_H276_Q0.5430.99
275_E278_L0.5430.99
91_V94_I0.5410.99
198_Y246_W0.5410.99
122_I313_S0.5380.99
3_Y20_E0.5380.99
143_G164_E0.5360.99
53_A56_A0.5350.99
65_A106_V0.5330.99
173_R245_V0.5320.99
88_P92_E0.5320.99
304_D308_K0.5320.99
13_V45_V0.5310.99
3_Y18_S0.5290.99
174_G189_Y0.5290.99
120_G266_G0.5280.99
79_G98_G0.5280.99
260_P263_V0.5280.99
158_W260_P0.5270.99
175_R201_L0.5250.99
266_G299_T0.5250.99
232_G237_A0.5240.99
197_E201_L0.5210.99
71_I86_N0.5200.99
79_G95_P0.5200.99
84_P87_M0.5200.99
128_A131_T0.5160.99
14_R304_D0.5160.99
115_N118_V0.5140.99
76_L156_G0.5140.99
49_M104_L0.5130.99
38_G91_V0.5100.99
123_G312_A0.5090.99
115_N145_G0.5080.99
127_Y297_R0.5080.99
147_G154_V0.5050.99
28_D52_A0.5040.99
4_A17_V0.5040.99
65_A112_F0.5040.99
165_L257_A0.5030.99
67_G313_S0.5020.99
245_V280_P0.5020.99
120_G139_T0.5020.99
127_Y301_L0.5010.99
188_A197_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z05A 2 0.9632 100 0.199 Contact Map
1z6rA 3 0.9632 100 0.201 Contact Map
3vovA 3 0.9049 100 0.215 Contact Map
2qm1A 2 0.9601 100 0.218 Contact Map
3vglA 3 0.9294 100 0.226 Contact Map
2yhwA 2 0.9233 100 0.232 Contact Map
2aa4A 2 0.8834 100 0.234 Contact Map
2ap1A 2 0.8926 100 0.236 Contact Map
2hoeA 2 0.8957 100 0.242 Contact Map
3htvA 2 0.8252 100 0.246 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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