Q9HMA6 - HALSA - GREMLIN Contacts

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Q9HMA6 - Uncharacterized protein

UniProt:	Q9HMA6	Sequences: MMEASVGDGMGGLLEVTLDAEEAVLAAAGALVDHTGDVRIDRSRAGAMRSVANTAREREVTPVRVRAVGGGAVVRFAPDYPGEIAACELGAAGGRVSVAWDGFVAAPVGVSVGARSIGNAPTRGMGLLMTQFTGERTVYVAGRGRVERVALAEGDSRVVAAANVVAFEDRVRVAVERVSAMEDAASVGRFHGPGTVWVATR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	201 (184)
Sequences:	2034 (1161)
Seq/√Len:	85.6

HALSA - Q9HMA6 Q9HPJ4 Q9HRV1
SULSO - Q97XI4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
148_R	195_T	4.559	1.00
103_F	106_A	3.133	1.00
132_F	138_V	2.907	1.00
176_E	189_R	2.870	1.00
14_L	139_Y	2.679	1.00
15_E	73_V	2.589	1.00
95_R	169_D	2.579	1.00
91_A	135_E	2.460	1.00
156_S	191_H	2.430	1.00
87_C	96_V	2.400	1.00
33_D	75_R	2.379	1.00
157_R	196_V	2.326	1.00
154_G	193_P	2.298	1.00
86_A	137_T	2.237	1.00
88_E	137_T	2.210	1.00
95_R	131_Q	2.066	1.00
148_R	197_W	1.994	1.00
168_E	195_T	1.915	1.00
98_V	140_V	1.908	1.00
96_V	166_A	1.863	1.00
171_V	193_P	1.853	1.00
43_S	64_R	1.837	1.00
84_I	104_V	1.766	1.00
164_V	167_F	1.727	1.00
95_R	133_T	1.692	1.00
52_A	113_G	1.682	1.00
23_A	64_R	1.651	1.00
151_L	155_D	1.649	1.00
150_A	195_T	1.648	1.00
98_V	102_G	1.647	1.00
129_M	167_F	1.621	1.00
158_V	189_R	1.600	1.00
9_G	83_E	1.598	1.00
96_V	197_W	1.586	1.00
151_L	193_P	1.579	1.00
155_D	193_P	1.576	1.00
98_V	132_F	1.571	1.00
111_S	133_T	1.566	1.00
172_R	191_H	1.558	1.00
26_A	76_F	1.556	1.00
142_G	165_V	1.553	1.00
171_V	190_F	1.536	1.00
16_V	24_V	1.532	1.00
17_T	73_V	1.527	1.00
86_A	139_Y	1.512	1.00
13_L	32_V	1.510	1.00
94_G	168_E	1.506	1.00
88_E	91_A	1.497	0.99
182_E	186_S	1.483	0.99
152_A	193_P	1.477	0.99
18_L	74_V	1.468	0.99
12_G	83_E	1.455	0.99
17_T	71_G	1.436	0.99
58_R	160_A	1.435	0.99
19_D	71_G	1.418	0.99
38_V	74_V	1.411	0.99
113_G	131_Q	1.410	0.99
23_A	108_V	1.391	0.99
158_V	187_V	1.363	0.99
181_M	184_A	1.359	0.99
156_S	189_R	1.353	0.99
20_A	70_G	1.351	0.99
174_A	189_R	1.349	0.99
83_E	145_R	1.333	0.99
117_I	121_P	1.309	0.99
112_V	132_F	1.296	0.98
177_R	180_A	1.266	0.98
84_I	139_Y	1.222	0.98
65_V	74_V	1.212	0.98
115_R	131_Q	1.212	0.98
31_L	160_A	1.210	0.98
39_R	69_G	1.201	0.98
16_V	76_F	1.200	0.98
85_A	142_G	1.187	0.97
167_F	173_V	1.182	0.97
37_D	71_G	1.176	0.97
146_V	197_W	1.161	0.97
37_D	70_G	1.159	0.97
41_D	64_R	1.159	0.97
90_G	135_E	1.156	0.97
76_F	105_A	1.154	0.97
164_V	173_V	1.144	0.97
142_G	146_V	1.144	0.97
35_T	73_V	1.138	0.97
110_V	132_F	1.096	0.96
89_L	138_V	1.093	0.96
25_L	106_A	1.065	0.95
56_R	130_T	1.049	0.95
89_L	94_G	1.049	0.95
178_V	183_D	1.045	0.94
91_A	94_G	1.041	0.94
38_V	65_V	1.041	0.94
77_A	104_V	1.040	0.94
34_H	158_V	1.035	0.94
15_E	75_R	1.030	0.94
13_L	33_D	1.022	0.94
50_S	53_N	1.014	0.94
37_D	72_A	1.009	0.93
37_D	69_G	0.982	0.92
106_A	110_V	0.979	0.92
32_V	77_A	0.972	0.92
26_A	65_V	0.966	0.92
107_P	137_T	0.965	0.92
45_A	50_S	0.958	0.91
149_V	198_V	0.957	0.91
14_L	84_I	0.957	0.91
19_D	22_E	0.957	0.91
87_C	140_V	0.952	0.91
154_G	171_V	0.948	0.91
151_L	171_V	0.944	0.91
96_V	138_V	0.940	0.91
120_A	127_L	0.937	0.91
98_V	138_V	0.932	0.90
89_L	135_E	0.930	0.90
181_M	185_A	0.918	0.90
90_G	94_G	0.916	0.90
24_V	76_F	0.907	0.89
27_A	61_T	0.905	0.89
40_I	178_V	0.889	0.88
36_G	72_A	0.879	0.87
110_V	170_R	0.879	0.87
35_T	72_A	0.870	0.87
27_A	141_A	0.870	0.87
36_G	156_S	0.865	0.87
49_R	111_S	0.862	0.86
97_S	115_R	0.860	0.86
168_E	171_V	0.858	0.86
44_R	60_V	0.852	0.86
117_I	120_A	0.839	0.85
51_V	54_T	0.839	0.85
182_E	185_A	0.838	0.85
183_D	186_S	0.832	0.84
109_G	135_E	0.824	0.84
152_A	155_D	0.819	0.84
36_G	70_G	0.815	0.83
28_A	42_R	0.809	0.83
94_G	169_D	0.805	0.82
151_L	156_S	0.802	0.82
159_V	198_V	0.795	0.82
94_G	135_E	0.793	0.82
129_M	173_V	0.787	0.81
40_I	63_V	0.781	0.81
97_S	167_F	0.776	0.80
25_L	43_S	0.768	0.79
20_A	71_G	0.758	0.79
25_L	64_R	0.754	0.78
176_E	179_S	0.754	0.78
159_V	164_V	0.751	0.78
27_A	59_E	0.746	0.77
85_A	148_R	0.744	0.77
119_N	174_A	0.743	0.77
115_R	173_V	0.740	0.77
44_R	51_V	0.740	0.77
149_V	157_R	0.729	0.76
97_S	129_M	0.729	0.76
161_A	188_G	0.715	0.74
97_S	131_Q	0.714	0.74
159_V	190_F	0.710	0.74
42_R	63_V	0.710	0.74
99_A	161_A	0.708	0.74
125_M	162_A	0.708	0.74
168_E	197_W	0.703	0.73
133_T	169_D	0.700	0.73
116_S	119_N	0.690	0.72
41_D	182_E	0.689	0.72
40_I	110_V	0.688	0.72
176_E	191_H	0.687	0.71
78_P	143_R	0.677	0.70
99_A	129_M	0.674	0.70
54_T	183_D	0.669	0.69
159_V	163_N	0.665	0.69
123_R	173_V	0.665	0.69
131_Q	169_D	0.660	0.68
158_V	176_E	0.660	0.68
25_L	62_P	0.657	0.68
190_F	198_V	0.656	0.68
167_F	190_F	0.653	0.68
85_A	140_V	0.651	0.67
177_R	184_A	0.647	0.67
38_V	95_R	0.641	0.66
29_G	124_G	0.640	0.66
49_R	55_A	0.635	0.65
132_F	140_V	0.629	0.65
49_R	52_A	0.628	0.65
51_V	60_V	0.626	0.64
58_R	99_A	0.626	0.64
150_A	193_P	0.624	0.64
87_C	146_V	0.624	0.64
177_R	181_M	0.623	0.64
63_V	129_M	0.620	0.64
106_A	112_V	0.620	0.64
16_V	19_D	0.619	0.63
48_M	51_V	0.619	0.63
114_A	132_F	0.618	0.63
121_P	124_G	0.618	0.63
18_L	38_V	0.617	0.63
126_G	194_G	0.616	0.63
125_M	165_V	0.615	0.63
121_P	125_M	0.613	0.63
72_A	149_V	0.613	0.63
58_R	161_A	0.610	0.62
94_G	170_R	0.607	0.62
96_V	140_V	0.606	0.62
107_P	110_V	0.602	0.61
89_L	95_R	0.599	0.61
135_E	152_A	0.596	0.61
54_T	133_T	0.596	0.61
99_A	125_M	0.594	0.60
50_S	54_T	0.593	0.60
26_A	30_A	0.593	0.60
37_D	155_D	0.592	0.60
78_P	141_A	0.587	0.59
27_A	42_R	0.586	0.59
12_G	22_E	0.586	0.59
146_V	166_A	0.585	0.59
95_R	172_R	0.581	0.59
116_S	126_G	0.581	0.59
31_L	40_I	0.581	0.59
50_S	111_S	0.581	0.59
24_V	71_G	0.579	0.58
99_A	130_T	0.577	0.58
28_A	59_E	0.572	0.57
96_V	195_T	0.570	0.57
120_A	182_E	0.570	0.57
65_V	76_F	0.568	0.57
30_A	160_A	0.566	0.57
100_W	127_L	0.563	0.56
58_R	101_D	0.562	0.56
151_L	154_G	0.562	0.56
24_V	47_A	0.561	0.56
54_T	113_G	0.561	0.56
42_R	183_D	0.559	0.56
174_A	191_H	0.558	0.56
15_E	85_A	0.555	0.55
146_V	195_T	0.554	0.55
57_E	124_G	0.554	0.55
33_D	157_R	0.547	0.54
152_A	170_R	0.542	0.53
88_E	94_G	0.542	0.53
9_G	36_G	0.541	0.53
31_L	187_V	0.540	0.53
106_A	132_F	0.539	0.53
84_I	105_A	0.538	0.53
164_V	190_F	0.538	0.53
26_A	63_V	0.537	0.53
50_S	123_R	0.536	0.53
87_C	91_A	0.536	0.53
32_V	167_F	0.536	0.53
25_L	112_V	0.536	0.53
35_T	157_R	0.533	0.52
42_R	178_V	0.533	0.52
27_A	58_R	0.531	0.52
123_R	162_A	0.530	0.52
14_L	105_A	0.529	0.52
128_L	140_V	0.529	0.52
164_V	188_G	0.528	0.52
31_L	104_V	0.528	0.52
125_M	128_L	0.527	0.51
141_A	175_V	0.527	0.51
27_A	78_P	0.526	0.51
134_G	192_G	0.525	0.51
53_N	144_G	0.525	0.51
94_G	98_V	0.525	0.51
31_L	199_A	0.522	0.51
89_L	96_V	0.521	0.51
80_Y	141_A	0.520	0.50
25_L	45_A	0.517	0.50
119_N	145_R	0.516	0.50
143_R	188_G	0.512	0.49
166_A	190_F	0.510	0.49
84_I	155_D	0.508	0.49
165_V	197_W	0.507	0.49
108_V	111_S	0.507	0.49
111_S	135_E	0.506	0.49
44_R	50_S	0.503	0.48
98_V	130_T	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1yoxA	3	0.9254	100	0.189	Contact Map
1pg6A	3	0.9453	100	0.199	Contact Map
3ww9A	1	0.7313	14.4	0.953	Contact Map
4qglA	1	0.2886	11.8	0.955	Contact Map
3wwaA	1	0.6667	7.4	0.959	Contact Map
3m0cC	1	0.9403	5.5	0.962	Contact Map
3hlkA	1	0.2736	5.1	0.962	Contact Map
2hc8A	1	0.4826	5	0.962	Contact Map
1ci3M	4	0.2985	4.9	0.963	Contact Map
4zcnA	3	0.4229	4.6	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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