GREMLIN Database
Q9HMA6 - Uncharacterized protein
UniProt: Q9HMA6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 201 (184)
Sequences: 2034 (1161)
Seq/√Len: 85.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_R195_T4.5591.00
103_F106_A3.1331.00
132_F138_V2.9071.00
176_E189_R2.8701.00
14_L139_Y2.6791.00
15_E73_V2.5891.00
95_R169_D2.5791.00
91_A135_E2.4601.00
156_S191_H2.4301.00
87_C96_V2.4001.00
33_D75_R2.3791.00
157_R196_V2.3261.00
154_G193_P2.2981.00
86_A137_T2.2371.00
88_E137_T2.2101.00
95_R131_Q2.0661.00
148_R197_W1.9941.00
168_E195_T1.9151.00
98_V140_V1.9081.00
96_V166_A1.8631.00
171_V193_P1.8531.00
43_S64_R1.8371.00
84_I104_V1.7661.00
164_V167_F1.7271.00
95_R133_T1.6921.00
52_A113_G1.6821.00
23_A64_R1.6511.00
151_L155_D1.6491.00
150_A195_T1.6481.00
98_V102_G1.6471.00
129_M167_F1.6211.00
158_V189_R1.6001.00
9_G83_E1.5981.00
96_V197_W1.5861.00
151_L193_P1.5791.00
155_D193_P1.5761.00
98_V132_F1.5711.00
111_S133_T1.5661.00
172_R191_H1.5581.00
26_A76_F1.5561.00
142_G165_V1.5531.00
171_V190_F1.5361.00
16_V24_V1.5321.00
17_T73_V1.5271.00
86_A139_Y1.5121.00
13_L32_V1.5101.00
94_G168_E1.5061.00
88_E91_A1.4970.99
182_E186_S1.4830.99
152_A193_P1.4770.99
18_L74_V1.4680.99
12_G83_E1.4550.99
17_T71_G1.4360.99
58_R160_A1.4350.99
19_D71_G1.4180.99
38_V74_V1.4110.99
113_G131_Q1.4100.99
23_A108_V1.3910.99
158_V187_V1.3630.99
181_M184_A1.3590.99
156_S189_R1.3530.99
20_A70_G1.3510.99
174_A189_R1.3490.99
83_E145_R1.3330.99
117_I121_P1.3090.99
112_V132_F1.2960.98
177_R180_A1.2660.98
84_I139_Y1.2220.98
65_V74_V1.2120.98
115_R131_Q1.2120.98
31_L160_A1.2100.98
39_R69_G1.2010.98
16_V76_F1.2000.98
85_A142_G1.1870.97
167_F173_V1.1820.97
37_D71_G1.1760.97
146_V197_W1.1610.97
37_D70_G1.1590.97
41_D64_R1.1590.97
90_G135_E1.1560.97
76_F105_A1.1540.97
164_V173_V1.1440.97
142_G146_V1.1440.97
35_T73_V1.1380.97
110_V132_F1.0960.96
89_L138_V1.0930.96
25_L106_A1.0650.95
56_R130_T1.0490.95
89_L94_G1.0490.95
178_V183_D1.0450.94
91_A94_G1.0410.94
38_V65_V1.0410.94
77_A104_V1.0400.94
34_H158_V1.0350.94
15_E75_R1.0300.94
13_L33_D1.0220.94
50_S53_N1.0140.94
37_D72_A1.0090.93
37_D69_G0.9820.92
106_A110_V0.9790.92
32_V77_A0.9720.92
26_A65_V0.9660.92
107_P137_T0.9650.92
45_A50_S0.9580.91
149_V198_V0.9570.91
14_L84_I0.9570.91
19_D22_E0.9570.91
87_C140_V0.9520.91
154_G171_V0.9480.91
151_L171_V0.9440.91
96_V138_V0.9400.91
120_A127_L0.9370.91
98_V138_V0.9320.90
89_L135_E0.9300.90
181_M185_A0.9180.90
90_G94_G0.9160.90
24_V76_F0.9070.89
27_A61_T0.9050.89
40_I178_V0.8890.88
36_G72_A0.8790.87
110_V170_R0.8790.87
35_T72_A0.8700.87
27_A141_A0.8700.87
36_G156_S0.8650.87
49_R111_S0.8620.86
97_S115_R0.8600.86
168_E171_V0.8580.86
44_R60_V0.8520.86
117_I120_A0.8390.85
51_V54_T0.8390.85
182_E185_A0.8380.85
183_D186_S0.8320.84
109_G135_E0.8240.84
152_A155_D0.8190.84
36_G70_G0.8150.83
28_A42_R0.8090.83
94_G169_D0.8050.82
151_L156_S0.8020.82
159_V198_V0.7950.82
94_G135_E0.7930.82
129_M173_V0.7870.81
40_I63_V0.7810.81
97_S167_F0.7760.80
25_L43_S0.7680.79
20_A71_G0.7580.79
25_L64_R0.7540.78
176_E179_S0.7540.78
159_V164_V0.7510.78
27_A59_E0.7460.77
85_A148_R0.7440.77
119_N174_A0.7430.77
115_R173_V0.7400.77
44_R51_V0.7400.77
149_V157_R0.7290.76
97_S129_M0.7290.76
161_A188_G0.7150.74
97_S131_Q0.7140.74
159_V190_F0.7100.74
42_R63_V0.7100.74
99_A161_A0.7080.74
125_M162_A0.7080.74
168_E197_W0.7030.73
133_T169_D0.7000.73
116_S119_N0.6900.72
41_D182_E0.6890.72
40_I110_V0.6880.72
176_E191_H0.6870.71
78_P143_R0.6770.70
99_A129_M0.6740.70
54_T183_D0.6690.69
159_V163_N0.6650.69
123_R173_V0.6650.69
131_Q169_D0.6600.68
158_V176_E0.6600.68
25_L62_P0.6570.68
190_F198_V0.6560.68
167_F190_F0.6530.68
85_A140_V0.6510.67
177_R184_A0.6470.67
38_V95_R0.6410.66
29_G124_G0.6400.66
49_R55_A0.6350.65
132_F140_V0.6290.65
49_R52_A0.6280.65
51_V60_V0.6260.64
58_R99_A0.6260.64
150_A193_P0.6240.64
87_C146_V0.6240.64
177_R181_M0.6230.64
63_V129_M0.6200.64
106_A112_V0.6200.64
16_V19_D0.6190.63
48_M51_V0.6190.63
114_A132_F0.6180.63
121_P124_G0.6180.63
18_L38_V0.6170.63
126_G194_G0.6160.63
125_M165_V0.6150.63
121_P125_M0.6130.63
72_A149_V0.6130.63
58_R161_A0.6100.62
94_G170_R0.6070.62
96_V140_V0.6060.62
107_P110_V0.6020.61
89_L95_R0.5990.61
135_E152_A0.5960.61
54_T133_T0.5960.61
99_A125_M0.5940.60
50_S54_T0.5930.60
26_A30_A0.5930.60
37_D155_D0.5920.60
78_P141_A0.5870.59
27_A42_R0.5860.59
12_G22_E0.5860.59
146_V166_A0.5850.59
95_R172_R0.5810.59
116_S126_G0.5810.59
31_L40_I0.5810.59
50_S111_S0.5810.59
24_V71_G0.5790.58
99_A130_T0.5770.58
28_A59_E0.5720.57
96_V195_T0.5700.57
120_A182_E0.5700.57
65_V76_F0.5680.57
30_A160_A0.5660.57
100_W127_L0.5630.56
58_R101_D0.5620.56
151_L154_G0.5620.56
24_V47_A0.5610.56
54_T113_G0.5610.56
42_R183_D0.5590.56
174_A191_H0.5580.56
15_E85_A0.5550.55
146_V195_T0.5540.55
57_E124_G0.5540.55
33_D157_R0.5470.54
152_A170_R0.5420.53
88_E94_G0.5420.53
9_G36_G0.5410.53
31_L187_V0.5400.53
106_A132_F0.5390.53
84_I105_A0.5380.53
164_V190_F0.5380.53
26_A63_V0.5370.53
50_S123_R0.5360.53
87_C91_A0.5360.53
32_V167_F0.5360.53
25_L112_V0.5360.53
35_T157_R0.5330.52
42_R178_V0.5330.52
27_A58_R0.5310.52
123_R162_A0.5300.52
14_L105_A0.5290.52
128_L140_V0.5290.52
164_V188_G0.5280.52
31_L104_V0.5280.52
125_M128_L0.5270.51
141_A175_V0.5270.51
27_A78_P0.5260.51
134_G192_G0.5250.51
53_N144_G0.5250.51
94_G98_V0.5250.51
31_L199_A0.5220.51
89_L96_V0.5210.51
80_Y141_A0.5200.50
25_L45_A0.5170.50
119_N145_R0.5160.50
143_R188_G0.5120.49
166_A190_F0.5100.49
84_I155_D0.5080.49
165_V197_W0.5070.49
108_V111_S0.5070.49
111_S135_E0.5060.49
44_R50_S0.5030.48
98_V130_T0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yoxA 3 0.9254 100 0.189 Contact Map
1pg6A 3 0.9453 100 0.199 Contact Map
3ww9A 1 0.7313 14.4 0.953 Contact Map
4qglA 1 0.2886 11.8 0.955 Contact Map
3wwaA 1 0.6667 7.4 0.959 Contact Map
3m0cC 1 0.9403 5.5 0.962 Contact Map
3hlkA 1 0.2736 5.1 0.962 Contact Map
2hc8A 1 0.4826 5 0.962 Contact Map
1ci3M 4 0.2985 4.9 0.963 Contact Map
4zcnA 3 0.4229 4.6 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.