GREMLIN Database
Q9HMA3 - Uncharacterized protein
UniProt: Q9HMA3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (171)
Sequences: 245 (172)
Seq/√Len: 13.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_N42_Q3.9161.00
68_G74_G3.8060.99
52_P60_P2.9060.96
118_R140_D2.8840.96
42_Q49_E2.3380.88
150_G177_V2.3230.88
160_D185_D2.2390.85
50_Q63_T2.2000.84
20_Q27_Y2.1400.83
91_D102_T2.0870.81
50_Q65_A2.0440.80
92_E188_E2.0260.79
51_F64_V2.0070.78
66_A74_G1.9820.77
67_G77_T1.8660.73
129_I135_V1.8470.72
37_V70_L1.8390.72
31_D35_E1.7350.67
129_I132_V1.7150.66
42_Q48_K1.7050.66
21_A57_D1.6850.65
63_T81_D1.6710.64
100_N188_E1.6560.63
111_A163_T1.6550.63
21_A28_D1.6530.63
42_Q187_L1.6110.61
97_F186_A1.5790.60
57_D172_I1.5740.59
35_E87_V1.5640.59
27_Y160_D1.5600.59
123_S127_H1.5570.58
53_F113_A1.5560.58
60_P81_D1.5240.57
125_L158_V1.4700.54
50_Q60_P1.4670.54
119_S124_A1.4440.53
20_Q160_D1.4370.52
21_A164_V1.4100.51
95_S117_S1.4050.50
88_V117_S1.4030.50
29_V176_G1.3990.50
82_T128_L1.3940.50
162_Y185_D1.3720.49
20_Q162_Y1.3600.48
129_I134_L1.3400.47
75_T91_D1.3310.47
98_A120_T1.3260.46
68_G75_T1.3030.45
110_D145_E1.3000.45
48_K66_A1.3000.45
31_D78_I1.2710.43
34_G149_V1.2680.43
95_S123_S1.2660.43
78_I101_W1.2550.43
136_P156_F1.2450.42
19_R136_P1.2420.42
43_K65_A1.2420.42
16_F21_A1.2370.42
63_T134_L1.2340.42
35_E103_I1.2280.41
90_L167_D1.2260.41
157_S160_D1.2120.40
16_F125_L1.2100.40
42_Q66_A1.1920.39
23_V45_F1.1730.39
78_I123_S1.1710.38
20_Q186_A1.1670.38
134_L149_V1.1660.38
88_V173_P1.1590.38
48_K71_D1.1560.38
63_T149_V1.1550.38
63_T129_I1.1530.38
160_D186_A1.1500.37
20_Q25_N1.1420.37
39_K92_E1.1390.37
53_F62_F1.1330.37
87_V161_T1.1250.36
55_T58_G1.1180.36
20_Q185_D1.1150.36
90_L115_I1.0850.34
117_S123_S1.0770.34
137_N157_S1.0710.34
101_W179_A1.0650.33
46_K49_E1.0590.33
97_F126_R1.0580.33
27_Y185_D1.0560.33
42_Q76_Y1.0500.33
124_A153_E1.0490.33
86_D164_V1.0450.32
76_Y187_L1.0420.32
59_D147_R1.0390.32
53_F150_G1.0350.32
78_I176_G1.0310.32
95_S98_A1.0260.32
78_I127_H1.0200.31
18_V37_V1.0120.31
73_G158_V1.0050.31
15_S32_A1.0040.31
103_I180_A0.9860.30
93_D102_T0.9820.30
96_L107_D0.9720.29
47_L70_L0.9630.29
114_T145_E0.9600.29
137_N154_G0.9510.28
77_T127_H0.9480.28
26_K41_K0.9460.28
80_D171_T0.9430.28
103_I112_L0.9420.28
78_I175_E0.9420.28
53_F142_Y0.9340.27
76_Y95_S0.9330.27
106_P164_V0.9330.27
125_L128_L0.9300.27
99_E187_L0.9290.27
134_L156_F0.9270.27
105_D174_K0.9220.27
130_G171_T0.9120.27
76_Y179_A0.8980.26
46_K69_I0.8950.26
119_S123_S0.8900.26
116_E125_L0.8830.25
31_D97_F0.8830.25
54_V60_P0.8790.25
86_D130_G0.8780.25
29_V152_I0.8770.25
45_F71_D0.8730.25
123_S139_Y0.8720.25
73_G132_V0.8690.25
127_H176_G0.8690.25
22_L156_F0.8690.25
85_E116_E0.8590.24
126_R186_A0.8570.24
48_K76_Y0.8550.24
35_E114_T0.8530.24
85_E91_D0.8510.24
124_A128_L0.8450.24
16_F113_A0.8270.23
29_V79_V0.8210.23
42_Q46_K0.8190.23
58_G168_D0.8170.23
67_G74_G0.8140.23
94_Y177_V0.8120.23
90_L101_W0.8080.23
23_V53_F0.8060.22
18_V155_Q0.8050.22
66_A71_D0.7990.22
28_D57_D0.7980.22
100_N116_E0.7940.22
95_S100_N0.7860.22
150_G160_D0.7850.22
60_P63_T0.7750.21
104_R113_A0.7700.21
103_I125_L0.7620.21
27_Y162_Y0.7570.21
16_F84_G0.7550.21
144_P147_R0.7520.21
34_G69_I0.7520.21
54_V179_A0.7510.21
162_Y186_A0.7480.20
124_A131_V0.7440.20
99_E123_S0.7420.20
24_R117_S0.7410.20
73_G76_Y0.7290.20
65_A147_R0.7250.20
87_V124_A0.7240.20
85_E147_R0.7200.19
51_F94_Y0.7190.19
49_E117_S0.7160.19
140_D160_D0.7030.19
105_D157_S0.7020.19
31_D121_V0.7010.19
124_A178_V0.7010.19
135_V156_F0.7010.19
142_Y146_E0.6990.19
18_V146_E0.6970.19
54_V88_V0.6820.18
136_P157_S0.6810.18
89_V177_V0.6780.18
141_I183_V0.6750.18
91_D177_V0.6720.18
36_V111_A0.6720.18
41_K86_D0.6720.18
155_Q163_T0.6710.18
29_V131_V0.6620.18
46_K92_E0.6610.18
77_T175_E0.6560.17
100_N123_S0.6520.17
88_V176_G0.6500.17
22_L110_D0.6440.17
73_G92_E0.6430.17
59_D87_V0.6430.17
119_S154_G0.6410.17
101_W149_V0.6330.17
82_T87_V0.6320.17
41_K44_L0.6320.17
135_V149_V0.6320.17
96_L119_S0.6290.17
134_L165_T0.6240.17
33_D110_D0.6220.16
117_S173_P0.6210.16
101_W137_N0.6180.16
48_K65_A0.6180.16
58_G128_L0.6180.16
144_P161_T0.6180.16
36_V84_G0.6140.16
123_S184_I0.6120.16
93_D103_I0.6120.16
70_L145_E0.6100.16
22_L178_V0.6040.16
82_T125_L0.6010.16
32_A171_T0.5980.16
70_L152_I0.5960.16
136_P174_K0.5960.16
22_L32_A0.5950.16
128_L132_V0.5900.16
96_L116_E0.5860.15
68_G73_G0.5850.15
97_F120_T0.5780.15
38_L51_F0.5740.15
75_T119_S0.5730.15
33_D163_T0.5700.15
15_S37_V0.5690.15
155_Q171_T0.5680.15
98_A117_S0.5670.15
92_E187_L0.5670.15
137_N152_I0.5580.15
103_I128_L0.5580.15
60_P180_A0.5550.15
61_A124_A0.5550.15
27_Y186_A0.5500.14
42_Q71_D0.5490.14
21_A87_V0.5480.14
131_V135_V0.5460.14
131_V188_E0.5440.14
133_N136_P0.5430.14
104_R110_D0.5430.14
164_V177_V0.5420.14
141_I185_D0.5410.14
102_T148_A0.5400.14
57_D129_I0.5400.14
111_A164_V0.5320.14
127_H175_E0.5280.14
28_D36_V0.5260.14
116_E161_T0.5260.14
127_H177_V0.5240.14
36_V56_D0.5230.14
137_N162_Y0.5220.14
92_E183_V0.5210.14
68_G94_Y0.5210.14
121_V125_L0.5180.14
89_V150_G0.5170.14
100_N181_A0.5140.14
17_E53_F0.5130.14
37_V125_L0.5070.13
66_A187_L0.5040.13
61_A69_I0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zxuA 1 0.8053 99.8 0.727 Contact Map
3ltiA 1 0.8789 20 0.957 Contact Map
1b5fB 1 0.2263 16.6 0.958 Contact Map
3m4aA 1 0.4842 7.7 0.964 Contact Map
3d6rB 4 0.1737 7 0.965 Contact Map
2i7rA 2 0.2105 6.1 0.966 Contact Map
3zc7A 1 0.8474 5.6 0.966 Contact Map
3rvcA 1 0.1421 5.1 0.967 Contact Map
2pjsA 2 0.2105 3.7 0.969 Contact Map
4yxpA 2 0.5737 3.6 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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