GREMLIN Database
Q9HMA0 - Geranylgeranyl hydrogenase
UniProt: Q9HMA0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (316)
Sequences: 29843 (22733)
Seq/√Len: 1278.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_I115_R3.9271.00
33_Q119_T3.4311.00
13_A277_G3.3131.00
4_D27_D3.2131.00
4_D146_K3.0531.00
6_V145_A2.9901.00
300_E304_R2.8821.00
136_G141_I2.8061.00
119_T135_R2.7231.00
122_D161_A2.5451.00
17_F149_A2.4371.00
31_F143_V2.4331.00
118_H136_G2.3691.00
6_V132_V2.3581.00
106_A109_D2.3361.00
122_D133_T2.3211.00
133_T142_D2.2611.00
6_V31_F2.2441.00
62_L105_E2.2431.00
20_R285_A2.2151.00
131_T144_T2.2111.00
121_T135_R2.1821.00
124_T131_T2.1571.00
24_Q289_D2.1561.00
131_T142_D2.0511.00
101_E105_E2.0231.00
118_H134_A2.0001.00
27_D113_D1.9821.00
16_R278_M1.9781.00
220_V223_R1.9701.00
13_A259_L1.9171.00
221_A225_D1.9161.00
134_A143_V1.9151.00
225_D229_A1.8981.00
124_T133_T1.8761.00
150_G158_V1.8571.00
115_R118_H1.8501.00
5_F26_Y1.8051.00
126_H129_R1.7751.00
219_D223_R1.7751.00
106_A110_A1.7561.00
287_E302_A1.7501.00
281_A285_A1.7431.00
126_H144_T1.7371.00
126_H131_T1.7251.00
55_P60_D1.7251.00
31_F134_A1.7111.00
151_S259_L1.7081.00
118_H141_I1.7041.00
150_G258_L1.6971.00
115_R141_I1.6931.00
4_D29_I1.6861.00
120_V132_V1.6821.00
250_T253_S1.6741.00
19_R106_A1.6741.00
134_A140_S1.6711.00
252_T297_A1.6611.00
223_R226_D1.6461.00
224_F228_V1.6331.00
53_F282_D1.6261.00
136_G140_S1.6261.00
26_Y289_D1.6091.00
304_R308_E1.6001.00
5_F21_A1.5911.00
135_R140_S1.5861.00
6_V143_V1.5711.00
287_E298_G1.5681.00
23_Q110_A1.5471.00
22_A112_A1.5431.00
12_P274_I1.5341.00
29_I143_V1.5301.00
152_D156_S1.5271.00
123_V148_V1.5271.00
107_A112_A1.5151.00
62_L65_N1.5151.00
62_L106_A1.4991.00
252_T257_F1.4871.00
134_A141_I1.4581.00
18_A30_A1.4411.00
50_V275_R1.4411.00
222_G226_D1.4381.00
283_A287_E1.4301.00
62_L109_D1.4211.00
19_R23_Q1.4201.00
56_D282_D1.4081.00
222_G225_D1.4031.00
125_E253_S1.4031.00
17_F281_A1.3991.00
77_A80_S1.3961.00
147_M296_L1.3961.00
224_F227_L1.3851.00
124_T142_D1.3781.00
35_D117_H1.3691.00
61_A65_N1.3641.00
257_F284_A1.3631.00
157_R161_A1.3581.00
104_A116_E1.3481.00
7_V17_F1.3461.00
279_T306_A1.3411.00
286_R302_A1.3141.00
60_D64_Q1.3141.00
105_E108_R1.3111.00
283_A302_A1.3051.00
129_R144_T1.3031.00
226_D230_D1.3021.00
280_A303_W1.2941.00
149_A259_L1.2851.00
8_V152_D1.2811.00
104_A108_R1.2801.00
20_R57_E1.2761.00
218_E223_R1.2751.00
245_I315_H1.2691.00
226_D229_A1.2651.00
250_T300_E1.2631.00
133_T140_S1.2461.00
145_A148_V1.2421.00
186_F189_V1.2351.00
225_D228_V1.2311.00
251_V307_L1.2281.00
19_R107_A1.2281.00
162_L256_G1.2281.00
251_V300_E1.2271.00
235_V238_R1.2161.00
157_R160_D1.2031.00
81_A84_F1.2011.00
74_L77_A1.1951.00
19_R110_A1.1881.00
17_F21_A1.1851.00
67_I72_F1.1841.00
115_R143_V1.1821.00
223_R228_V1.1761.00
149_A257_F1.1741.00
6_V29_I1.1681.00
4_D26_Y1.1631.00
121_T140_S1.1621.00
187_V190_H1.1601.00
264_G280_A1.1471.00
219_D222_G1.1421.00
8_V120_V1.1411.00
120_V158_V1.1391.00
165_P249_D1.1391.00
50_V278_M1.1391.00
74_L78_D1.1261.00
287_E295_T1.1051.00
176_A179_P1.0961.00
120_V123_V1.0961.00
29_I113_D1.0911.00
125_E255_R1.0851.00
121_T133_T1.0831.00
10_V15_A1.0671.00
252_T300_E1.0551.00
22_A110_A1.0501.00
219_D228_V1.0491.00
8_V158_V1.0421.00
41_A44_G1.0371.00
44_G274_I1.0371.00
23_Q106_A1.0351.00
223_R227_L1.0351.00
61_A64_Q1.0351.00
186_F190_H1.0311.00
287_E290_P1.0291.00
173_G176_A1.0231.00
130_V255_R1.0131.00
37_G116_E1.0061.00
16_R20_R1.0011.00
22_A111_G1.0001.00
31_F115_R0.9971.00
123_V161_A0.9921.00
7_V18_A0.9901.00
298_G301_R0.9861.00
31_F118_H0.9851.00
98_H101_E0.9801.00
218_E222_G0.9781.00
221_A228_V0.9721.00
67_I70_A0.9721.00
164_L248_P0.9711.00
253_S256_G0.9711.00
173_G178_D0.9661.00
28_V112_A0.9551.00
132_V145_A0.9521.00
258_L262_A0.9511.00
59_H106_A0.9511.00
104_A114_V0.9501.00
252_T293_P0.9451.00
30_A114_V0.9361.00
218_E228_V0.9351.00
95_D98_H0.9301.00
8_V148_V0.9291.00
154_P265_Q0.9261.00
293_P297_A0.9221.00
125_E130_V0.9201.00
105_E109_D0.9171.00
123_V162_L0.9161.00
17_F259_L0.9081.00
183_H187_V0.9071.00
19_R57_E0.9001.00
266_T276_Y0.8991.00
171_L175_L0.8951.00
16_R57_E0.8921.00
188_D191_L0.8891.00
169_E173_G0.8861.00
56_D286_R0.8831.00
183_H186_F0.8831.00
172_H176_A0.8821.00
171_L176_A0.8801.00
62_L102_V0.8761.00
7_V28_V0.8731.00
130_V148_V0.8711.00
125_E254_H0.8711.00
283_A286_R0.8691.00
209_E213_A0.8691.00
297_A301_R0.8671.00
180_D183_H0.8671.00
49_D279_T0.8631.00
266_T311_I0.8621.00
308_E312_T0.8491.00
290_P298_G0.8481.00
175_L178_D0.8481.00
96_R100_D0.8431.00
18_A28_V0.8421.00
120_V157_R0.8411.00
220_V224_F0.8391.00
199_W211_G0.8391.00
120_V161_A0.8321.00
184_Q187_V0.8291.00
315_H319_A0.8281.00
257_F299_Y0.8221.00
59_H102_V0.8211.00
108_R113_D0.8211.00
147_M257_F0.8201.00
102_V106_A0.8171.00
232_G235_V0.8141.00
15_A107_A0.8131.00
51_W60_D0.8111.00
156_S159_R0.8091.00
22_A107_A0.8081.00
4_D145_A0.8081.00
167_P249_D0.8011.00
52_E55_P0.7991.00
219_D224_F0.7991.00
21_A26_Y0.7981.00
187_V191_L0.7961.00
259_L299_Y0.7941.00
15_A104_A0.7941.00
218_E224_F0.7921.00
108_R111_G0.7911.00
18_A112_A0.7861.00
42_C96_R0.7851.00
218_E225_D0.7821.00
150_G256_G0.7821.00
44_G96_R0.7781.00
252_T296_L0.7781.00
132_V148_V0.7771.00
10_V32_E0.7771.00
25_G28_V0.7751.00
298_G302_A0.7741.00
51_W92_N0.7711.00
63_F102_V0.7691.00
169_E172_H0.7671.00
285_A289_D0.7661.00
248_P258_L0.7651.00
221_A224_F0.7641.00
248_P251_V0.7621.00
149_A284_A0.7621.00
107_A111_G0.7551.00
49_D272_G0.7531.00
20_R24_Q0.7521.00
102_V105_E0.7521.00
193_V196_F0.7511.00
70_A74_L0.7501.00
20_R23_Q0.7501.00
15_A100_D0.7481.00
184_Q190_H0.7471.00
29_I145_A0.7451.00
12_P278_M0.7411.00
183_H190_H0.7391.00
172_H178_D0.7391.00
220_V225_D0.7311.00
175_L179_P0.7311.00
251_V263_A0.7261.00
158_V161_A0.7251.00
251_V304_R0.7241.00
50_V53_F0.7211.00
32_E116_E0.7181.00
49_D52_E0.7181.00
22_A108_R0.7171.00
123_V158_V0.7151.00
45_H91_S0.7151.00
208_V211_G0.7131.00
31_F145_A0.7101.00
125_E129_R0.7041.00
218_E221_A0.7031.00
210_Y213_A0.7031.00
270_T314_G0.7011.00
70_A75_G0.6991.00
174_A177_F0.6991.00
37_G104_A0.6981.00
21_A288_L0.6971.00
258_L263_A0.6961.00
150_G156_S0.6931.00
282_D286_R0.6931.00
95_D204_G0.6911.00
302_A305_D0.6871.00
45_H93_A0.6861.00
54_V278_M0.6841.00
94_I99_L0.6841.00
174_A178_D0.6821.00
21_A285_A0.6791.00
265_Q280_A0.6781.00
172_H175_L0.6771.00
219_D227_L0.6761.00
22_A113_D0.6761.00
22_A28_V0.6751.00
69_G81_A0.6721.00
20_R53_F0.6721.00
247_P304_R0.6711.00
220_V227_L0.6711.00
4_D143_V0.6711.00
63_F99_L0.6691.00
266_T270_T0.6661.00
170_F173_G0.6661.00
158_V256_G0.6651.00
100_D104_A0.6641.00
123_V256_G0.6601.00
170_F176_A0.6591.00
49_D306_A0.6571.00
67_I73_H0.6571.00
71_R79_S0.6561.00
75_G78_D0.6511.00
220_V228_V0.6481.00
150_G162_L0.6481.00
266_T314_G0.6471.00
182_D185_D0.6431.00
272_G276_Y0.6431.00
171_L315_H0.6391.00
18_A107_A0.6381.00
73_H79_S0.6371.00
181_P184_Q0.6341.00
51_W55_P0.6301.00
54_V59_H0.6301.00
98_H204_G0.6281.00
173_G179_P0.6281.00
301_R305_D0.6271.00
155_R160_D0.6261.00
27_D146_K0.6251.00
31_F132_V0.6251.00
16_R103_L0.6241.00
186_F191_L0.6231.00
224_F229_A0.6191.00
185_D188_D0.6171.00
150_G157_R0.6161.00
162_L253_S0.6161.00
305_D309_R0.6151.00
184_Q188_D0.6141.00
219_D225_D0.6131.00
148_V256_G0.6131.00
60_D63_F0.6121.00
54_V99_L0.6041.00
164_L253_S0.6021.00
182_D186_F0.6011.00
36_L40_L0.5991.00
231_Y234_D0.5971.00
152_D258_L0.5961.00
210_Y214_A0.5961.00
227_L230_D0.5941.00
247_P308_E0.5941.00
168_D171_L0.5941.00
307_L311_I0.5941.00
159_R162_L0.5931.00
171_L177_F0.5921.00
15_A114_V0.5881.00
317_V320_G0.5861.00
246_G249_D0.5861.00
279_T283_A0.5841.00
119_T157_R0.5831.00
19_R22_A0.5821.00
269_F318_R0.5821.00
34_G40_L0.5811.00
36_L116_E0.5801.00
254_H293_P0.5781.00
53_F57_E0.5771.00
19_R112_A0.5751.00
167_P176_A0.5751.00
294_G298_G0.5681.00
170_F175_L0.5681.00
71_R80_S0.5681.00
222_G228_V0.5671.00
17_F288_L0.5631.00
124_T127_R0.5631.00
238_R242_L0.5621.00
159_R258_L0.5621.00
277_G281_A0.5611.00
218_E227_L0.5611.00
55_P64_Q0.5611.00
312_T316_L0.5601.00
272_G275_R0.5591.00
182_D187_V0.5591.00
180_D190_H0.5591.00
148_V255_R0.5581.00
169_E176_A0.5581.00
58_H61_A0.5581.00
184_Q189_V0.5581.00
173_G177_F0.5561.00
73_H78_D0.5561.00
15_A30_A0.5551.00
46_V50_V0.5541.00
120_V134_A0.5531.00
183_H188_D0.5531.00
234_D238_R0.5511.00
66_D70_A0.5501.00
185_D189_V0.5501.00
279_T303_W0.5501.00
76_G79_S0.5491.00
259_L277_G0.5471.00
180_D184_Q0.5471.00
24_Q285_A0.5461.00
180_D185_D0.5461.00
37_G100_D0.5461.00
225_D230_D0.5451.00
261_D273_G0.5451.00
259_L281_A0.5451.00
47_S275_R0.5441.00
20_R281_A0.5441.00
118_H135_R0.5441.00
274_I277_G0.5441.00
270_T317_V0.5431.00
17_F20_R0.5401.00
284_A288_L0.5381.00
247_P251_V0.5381.00
71_R74_L0.5381.00
28_V111_G0.5371.00
264_G303_W0.5371.00
17_F285_A0.5351.00
171_L174_A0.5331.00
274_I278_M0.5321.00
74_L80_S0.5311.00
182_D189_V0.5311.00
257_F296_L0.5301.00
246_G251_V0.5301.00
209_E214_A0.5301.00
183_H189_V0.5301.00
5_F147_M0.5281.00
20_R282_D0.5281.00
73_H76_G0.5271.00
276_Y310_E0.5261.00
297_A300_E0.5261.00
170_F174_A0.5251.00
172_H177_F0.5241.00
276_Y307_L0.5231.00
180_D189_V0.5231.00
152_D158_V0.5211.00
209_E212_L0.5211.00
199_W203_R0.5201.00
148_V158_V0.5191.00
159_R164_L0.5181.00
66_D69_G0.5171.00
45_H271_G0.5161.00
294_G297_A0.5161.00
147_M288_L0.5151.00
197_F201_I0.5141.00
149_A288_L0.5121.00
185_D191_L0.5111.00
181_P185_D0.5101.00
107_A114_V0.5101.00
28_V107_A0.5101.00
123_V130_V0.5081.00
5_F17_F0.5081.00
174_A179_P0.5071.00
169_E178_D0.5071.00
34_G38_T0.5061.00
10_V30_A0.5061.00
267_K270_T0.5041.00
17_F284_A0.5011.00
16_R54_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qa1A 2 0.9861 100 0.312 Contact Map
2qa2A 2 0.9889 100 0.316 Contact Map
4k5sA 2 0.9944 100 0.317 Contact Map
4n9xA 5 0.9278 100 0.327 Contact Map
4k2xA 2 0.975 100 0.334 Contact Map
1pn0A 3 0.9833 100 0.339 Contact Map
1k0iA 2 0.9944 100 0.35 Contact Map
2dkhA 2 0.9361 100 0.351 Contact Map
2x3nA 1 0.9028 100 0.353 Contact Map
4k22A 4 0.8833 100 0.362 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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