GREMLIN Database
Q9HM98 - Aminomethyltransferase
UniProt: Q9HM98 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (332)
Sequences: 6565 (4204)
Seq/√Len: 230.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_Q147_E3.6451.00
7_A202_E3.6441.00
267_A299_D3.1711.00
277_A284_R3.1671.00
41_A148_K3.1281.00
52_V100_R2.8661.00
314_S321_R2.7251.00
266_L302_A2.6401.00
5_R9_E2.5741.00
278_V304_A2.5681.00
9_E15_F2.5631.00
40_A144_Q2.5501.00
136_G197_A2.4851.00
35_R39_N2.4401.00
57_D60_E2.3381.00
312_E323_D2.3101.00
269_D325_A2.2691.00
42_G214_F2.2261.00
37_V42_G2.1601.00
54_T100_R2.1341.00
316_A321_R2.1001.00
161_E164_R2.0951.00
267_A325_A2.0941.00
10_A202_E2.0931.00
65_G117_W2.0811.00
294_S297_R2.0691.00
275_E287_E2.0491.00
279_Y321_R2.0401.00
233_S274_S2.0201.00
63_A69_G2.0001.00
316_A319_G1.9831.00
74_D96_A1.9681.00
313_L324_A1.9641.00
312_E325_A1.9531.00
6_A10_A1.9341.00
314_S323_D1.9261.00
208_G211_A1.9121.00
6_A9_E1.8681.00
36_A40_A1.8651.00
7_A11_H1.8561.00
251_S255_A1.8481.00
76_R164_R1.8201.00
116_R120_R1.7891.00
193_A196_D1.7811.00
36_A212_V1.7691.00
156_A159_P1.7471.00
6_A198_D1.7461.00
151_S207_R1.7401.00
192_C200_V1.7071.00
51_V114_A1.7031.00
283_S307_S1.6941.00
169_E174_V1.6711.00
167_R174_V1.6621.00
35_R296_M1.6581.00
148_K211_A1.6561.00
196_D199_D1.6531.00
8_H27_Y1.6411.00
252_D255_A1.6401.00
7_A10_A1.6401.00
57_D125_D1.6111.00
59_H101_L1.5941.00
54_T129_T1.5891.00
279_Y284_R1.5751.00
52_V131_S1.5701.00
11_H213_P1.5291.00
198_D202_E1.5171.00
288_V302_A1.5091.00
114_A118_R1.5031.00
52_V129_T1.4981.00
279_Y316_A1.4901.00
54_T127_A1.4871.00
59_H96_A1.4861.00
266_L304_A1.4851.00
56_E125_D1.4811.00
160_E164_R1.4811.00
203_T206_V1.4791.00
34_H221_T1.4751.00
277_A316_A1.4741.00
171_E203_T1.4721.00
264_V306_V1.4701.00
242_T261_R1.4691.00
315_V324_A1.4681.00
51_V105_L1.4551.00
66_V94_V1.4551.00
43_V205_L1.4541.00
77_G93_Y1.4461.00
308_E311_G1.4401.00
201_F213_P1.4391.00
115_S119_E1.4371.00
160_E166_V1.4361.00
40_A210_N1.4171.00
67_S83_C1.4171.00
97_T100_R1.4101.00
152_V204_L1.4061.00
110_G130_L1.3801.00
13_A23_V1.3741.00
3_V136_G1.3701.00
74_D98_D1.3691.00
66_V80_V1.3641.00
53_A103_A1.3611.00
266_L324_A1.3601.00
207_R210_N1.3591.00
65_G120_R1.3491.00
81_V245_L1.3441.00
40_A212_V1.3371.00
170_M175_T1.3371.00
224_L292_A1.3341.00
136_G194_A1.3301.00
43_V138_F1.3281.00
173_G196_D1.3241.00
303_F329_P1.3211.00
16_R25_V1.3061.00
95_F165_F1.2911.00
140_V149_V1.2871.00
241_A259_P1.2871.00
32_R212_V1.2851.00
168_G177_V1.2811.00
61_V126_A1.2801.00
7_A198_D1.2781.00
103_A117_W1.2761.00
293_E298_G1.2751.00
59_H71_P1.2571.00
306_V313_L1.2461.00
311_G326_V1.2421.00
269_D323_D1.2291.00
84_D237_G1.2251.00
129_T134_E1.2231.00
282_G321_R1.2151.00
4_V138_F1.2141.00
147_E150_A1.2071.00
121_A128_V1.1921.00
5_R22_A1.1881.00
73_E76_R1.1801.00
63_A71_P1.1731.00
224_L290_R1.1581.00
114_A128_V1.1581.00
131_S135_F1.1421.00
112_G237_G1.1341.00
241_A254_A1.1281.00
265_G331_F1.1271.00
109_E112_G1.1261.00
243_L305_V1.1251.00
70_V94_V1.1241.00
223_T290_R1.1211.00
58_A101_L1.1161.00
138_F201_F1.1031.00
61_V117_W1.1001.00
267_A327_V1.0881.00
111_D115_S1.0841.00
5_R15_F1.0791.00
199_D203_T1.0751.00
35_R298_G1.0741.00
81_V88_V1.0721.00
266_L315_V1.0701.00
151_S210_N1.0681.00
146_T186_E1.0591.00
82_V117_W1.0591.00
313_L326_V1.0551.00
146_T188_Y1.0511.00
29_R32_R1.0491.00
64_A124_R1.0461.00
269_D312_E1.0431.00
96_A101_L1.0411.00
88_V235_L1.0391.00
280_A314_S1.0371.00
41_A211_A1.0351.00
192_C197_A1.0311.00
59_H70_V1.0281.00
57_D124_R1.0201.00
317_A322_V1.0121.00
144_Q210_N1.0081.00
28_G32_R1.0061.00
229_P235_L1.0041.00
69_G72_T1.0031.00
309_W328_E1.0021.00
268_P324_A1.0011.00
53_A58_A0.9881.00
279_Y314_S0.9861.00
279_Y282_G0.9801.00
278_V315_V0.9771.00
53_A117_W0.9771.00
155_R166_V0.9741.00
32_R35_R0.9721.00
97_T176_V0.9721.00
173_G199_D0.9711.00
202_E206_V0.9701.00
29_R212_V0.9691.00
153_L157_S0.9671.00
270_A323_D0.9671.00
148_K207_R0.9661.00
284_R287_E0.9581.00
140_V148_K0.9541.00
3_V194_A0.9531.00
141_H187_G0.9501.00
50_V135_F0.9491.00
94_V101_L0.9361.00
173_G200_V0.9361.00
4_V197_A0.9341.00
285_V313_L0.9261.00
8_H24_P0.9261.00
192_C196_D0.9241.00
94_V103_A0.9211.00
154_H169_E0.9211.00
239_T242_T0.9171.00
130_L133_G0.9151.00
310_H313_L0.9141.00
239_T253_A0.9131.00
203_T207_R0.9121.00
84_D89_R0.9101.00
68_G249_D0.9091.00
121_A124_R0.9091.00
36_A214_F0.9081.00
310_H325_A0.9081.00
136_G192_C0.9071.00
327_V331_F0.9030.99
169_E172_G0.8990.99
43_V140_V0.8960.99
34_H222_L0.8960.99
280_A285_V0.8930.99
272_P276_A0.8910.99
21_R110_G0.8870.99
160_E163_L0.8850.99
43_V201_F0.8850.99
15_F22_A0.8840.99
2_T5_R0.8800.99
52_V102_L0.8750.99
68_G80_V0.8750.99
146_T158_P0.8700.99
171_E175_T0.8680.99
137_T191_V0.8660.99
242_T260_H0.8660.99
66_V82_V0.8650.99
11_H202_E0.8650.99
153_L170_M0.8580.99
118_R121_A0.8580.99
72_T78_A0.8500.99
11_H201_F0.8500.99
122_G125_D0.8470.99
241_A246_A0.8410.99
89_R112_G0.8350.99
131_S134_E0.8350.99
62_V101_L0.8320.99
26_E30_P0.8280.99
88_V234_E0.8260.99
114_A130_L0.8250.99
115_S118_R0.8240.99
150_A155_R0.8210.99
280_A283_S0.8190.99
56_E99_D0.8160.99
80_V94_V0.8100.99
270_A322_V0.8090.99
306_V326_V0.8090.99
65_G116_R0.8080.99
171_E199_D0.8060.99
179_D186_E0.8040.99
62_V70_V0.8040.99
82_V92_G0.8020.99
49_D110_G0.8000.99
61_V121_A0.8000.99
205_L213_P0.7990.99
67_S81_V0.7960.99
244_G262_R0.7960.99
105_L113_V0.7960.99
294_S301_L0.7950.99
51_V117_W0.7950.99
205_L211_A0.7940.99
50_V191_V0.7910.99
100_R167_R0.7860.99
11_H27_Y0.7820.99
167_R176_V0.7820.99
73_E164_R0.7780.98
241_A248_L0.7780.98
66_V70_V0.7740.98
37_V222_L0.7740.98
242_T259_P0.7710.98
190_V204_L0.7700.98
79_Y91_D0.7690.98
310_H326_V0.7670.98
261_R307_S0.7670.98
54_T99_D0.7650.98
83_C254_A0.7650.98
236_A287_E0.7630.98
59_H63_A0.7620.98
9_E22_A0.7570.98
77_G95_F0.7550.98
88_V243_L0.7540.98
36_A210_N0.7480.98
263_L303_F0.7450.98
34_H296_M0.7450.98
116_R119_E0.7440.98
31_D35_R0.7410.98
14_T26_E0.7400.98
150_A158_P0.7370.98
241_A258_E0.7360.98
7_A205_L0.7350.98
268_P300_P0.7320.98
165_F178_R0.7310.98
57_D122_G0.7290.98
266_L313_L0.7280.98
97_T102_L0.7280.98
38_R225_E0.7280.98
175_T190_V0.7280.98
293_E300_P0.7270.98
7_A201_F0.7230.98
10_A198_D0.7230.98
53_A128_V0.7210.97
37_V214_F0.7210.97
95_F178_R0.7190.97
261_R287_E0.7130.97
265_G329_P0.7120.97
145_A186_E0.7110.97
102_L191_V0.7100.97
177_V190_V0.7090.97
62_V103_A0.7070.97
309_W313_L0.7060.97
51_V128_V0.7030.97
199_D202_E0.7030.97
50_V137_T0.6990.97
173_G193_A0.6990.97
155_R168_G0.6980.97
49_D105_L0.6980.97
13_A25_V0.6960.97
272_P300_P0.6930.97
84_D87_R0.6920.97
11_H205_L0.6900.97
165_F176_V0.6900.97
61_V122_G0.6890.97
60_E124_R0.6880.97
170_M173_G0.6870.97
135_F193_A0.6820.97
147_E151_S0.6780.96
102_L135_F0.6770.96
149_V188_Y0.6750.96
85_D238_R0.6710.96
277_A287_E0.6710.96
207_R211_A0.6700.96
183_A187_G0.6690.96
272_P324_A0.6680.96
117_W128_V0.6650.96
263_L305_V0.6650.96
160_E165_F0.6640.96
179_D188_Y0.6640.96
224_L301_L0.6630.96
221_T292_A0.6610.96
264_V326_V0.6600.96
280_A311_G0.6590.96
134_E193_A0.6590.96
272_P315_V0.6570.96
44_T214_F0.6550.96
234_E263_L0.6550.96
61_V64_A0.6540.96
38_R222_L0.6530.96
140_V211_A0.6520.95
62_V66_V0.6520.95
140_V190_V0.6510.95
53_A62_V0.6450.95
92_G103_A0.6450.95
50_V132_T0.6440.95
67_S248_L0.6390.95
264_V311_G0.6380.95
66_V78_A0.6380.95
89_R237_G0.6340.95
89_R116_R0.6330.95
174_V196_D0.6310.95
227_G329_P0.6310.95
53_A61_V0.6270.94
221_T294_S0.6260.94
194_A197_A0.6250.94
163_L180_D0.6240.94
316_A320_D0.6240.94
214_F218_T0.6240.94
141_H183_A0.6230.94
268_P315_V0.6220.94
154_H157_S0.6190.94
77_G180_D0.6190.94
175_T192_C0.6180.94
177_V188_Y0.6160.94
153_L171_E0.6160.94
121_A126_A0.6150.94
178_R191_V0.6140.94
291_A300_P0.6100.94
60_E71_P0.6080.94
4_V8_H0.6070.93
8_H15_F0.6070.93
145_A188_Y0.6070.93
280_A313_L0.6060.93
182_L230_L0.6030.93
170_M200_V0.6010.93
157_S168_G0.6000.93
309_W329_P0.6000.93
289_T305_V0.5990.93
96_A100_R0.5970.93
278_V313_L0.5960.93
163_L228_T0.5960.93
68_G78_A0.5960.93
60_E64_A0.5940.93
97_T165_F0.5920.93
43_V204_L0.5920.93
40_A211_A0.5920.93
273_A291_A0.5880.92
40_A148_K0.5850.92
250_G253_A0.5820.92
239_T254_A0.5820.92
79_Y180_D0.5800.92
226_A333_D0.5790.92
105_L114_A0.5770.92
150_A154_H0.5770.92
52_V97_T0.5770.92
85_D237_G0.5760.92
57_D126_A0.5750.91
38_R296_M0.5740.91
162_R228_T0.5740.91
272_P302_A0.5740.91
229_P234_E0.5720.91
13_A16_R0.5720.91
53_A94_V0.5710.91
294_S299_D0.5710.91
119_E122_G0.5690.91
285_V307_S0.5690.91
278_V324_A0.5690.91
65_G82_V0.5670.91
77_G178_R0.5670.91
112_G116_R0.5660.91
160_E188_Y0.5660.91
44_T141_H0.5660.91
62_V117_W0.5650.91
317_A320_D0.5620.91
268_P322_V0.5610.90
15_F23_V0.5600.90
27_Y213_P0.5590.90
33_T215_G0.5570.90
46_H136_G0.5550.90
235_L243_L0.5540.90
17_E22_A0.5530.90
227_G265_G0.5520.90
8_H11_H0.5520.90
296_M332_V0.5520.90
257_G260_H0.5510.90
82_V113_V0.5490.90
83_C88_V0.5490.90
148_K151_S0.5450.89
95_F104_L0.5440.89
231_F235_L0.5440.89
61_V124_R0.5430.89
256_A259_P0.5430.89
80_V92_G0.5410.89
265_G303_F0.5400.89
138_F197_A0.5380.89
43_V211_A0.5380.89
28_G212_V0.5380.89
139_G189_L0.5340.88
160_E168_G0.5340.88
161_E165_F0.5340.88
34_H295_P0.5330.88
112_G115_S0.5310.88
66_V101_L0.5270.88
153_L156_A0.5270.88
60_E63_A0.5260.87
186_E226_A0.5260.87
64_A122_G0.5250.87
49_D130_L0.5240.87
204_L211_A0.5230.87
110_G133_G0.5230.87
18_V47_A0.5220.87
48_F219_W0.5210.87
36_A42_G0.5200.87
314_S322_V0.5200.87
25_V217_E0.5190.87
64_A123_N0.5180.87
109_E231_F0.5180.87
82_V116_R0.5170.87
103_A126_A0.5170.87
261_R305_V0.5170.87
48_F104_L0.5170.87
240_L248_L0.5160.86
311_G325_A0.5160.86
267_A301_L0.5150.86
69_G249_D0.5140.86
288_V304_A0.5110.86
327_V330_P0.5110.86
299_D325_A0.5110.86
41_A140_V0.5110.86
271_L300_P0.5110.86
61_V65_G0.5100.86
152_V203_T0.5080.86
106_P220_E0.5070.86
268_P299_D0.5070.86
110_G114_A0.5060.85
66_V92_G0.5060.85
85_D253_A0.5060.85
48_F137_T0.5050.85
309_W312_E0.5040.85
49_D108_G0.5030.85
145_A148_K0.5020.85
223_T232_A0.5010.85
246_A262_R0.5010.85
47_A107_A0.5000.85
222_L296_M0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gagA 1 0.9913 100 0.195 Contact Map
1wosA 1 0.9797 100 0.208 Contact Map
1pj5A 3 0.9826 100 0.212 Contact Map
4pabA 1 0.9942 100 0.216 Contact Map
3girA 1 0.9622 100 0.217 Contact Map
1wsrA 2 0.9767 100 0.219 Contact Map
1v5vA 2 0.9971 100 0.221 Contact Map
1yx2A 1 0.968 100 0.221 Contact Map
1vloA 1 0.9709 100 0.236 Contact Map
3tfiA 2 0.9448 100 0.267 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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