Q9HM98 - HALSA - GREMLIN Contacts

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Q9HM98 - Aminomethyltransferase

UniProt:	Q9HM98	Sequences: MTVVRAAHEAHGATFREVAGRAVPVEYGRPDRTHRAVRNAAGVTEHAFDVVVATGEDAHEVVAAGVSGGVPTEDGRGAYVVVCDDGRVRADGYVFATDDRLLALLPAGEGDGVASRWRERAGNRDAAVTLSTGEFGTFGVHGPQATEKVASVLHRASPPEERLRFVRGEMEGGVTVVRDDDLAGEEGYLVVCAAEDADDVFETLLVRGLNAVPFGRETWETLTLEAGTPLFASELAGRTLATLGLARLDGSDAAAAGEPHRRLVGLAPDALPASEAAVYADGSRVGEVTRAAESPMRGDPLAFAVVSEWHGELSVAADGDRVDAAVVEPPFVDTGERSRRRPEY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (332)
Sequences:	6565 (4204)
Seq/√Len:	230.7

ECOLI - GCST YGFZ
BACSU - GCST
HALSA - Q9HM98 GCST
SULSO - Q97ZI7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
144_Q	147_E	3.645	1.00
7_A	202_E	3.644	1.00
267_A	299_D	3.171	1.00
277_A	284_R	3.167	1.00
41_A	148_K	3.128	1.00
52_V	100_R	2.866	1.00
314_S	321_R	2.725	1.00
266_L	302_A	2.640	1.00
5_R	9_E	2.574	1.00
278_V	304_A	2.568	1.00
9_E	15_F	2.563	1.00
40_A	144_Q	2.550	1.00
136_G	197_A	2.485	1.00
35_R	39_N	2.440	1.00
57_D	60_E	2.338	1.00
312_E	323_D	2.310	1.00
269_D	325_A	2.269	1.00
42_G	214_F	2.226	1.00
37_V	42_G	2.160	1.00
54_T	100_R	2.134	1.00
316_A	321_R	2.100	1.00
161_E	164_R	2.095	1.00
267_A	325_A	2.094	1.00
10_A	202_E	2.093	1.00
65_G	117_W	2.081	1.00
294_S	297_R	2.069	1.00
275_E	287_E	2.049	1.00
279_Y	321_R	2.040	1.00
233_S	274_S	2.020	1.00
63_A	69_G	2.000	1.00
316_A	319_G	1.983	1.00
74_D	96_A	1.968	1.00
313_L	324_A	1.964	1.00
312_E	325_A	1.953	1.00
6_A	10_A	1.934	1.00
314_S	323_D	1.926	1.00
208_G	211_A	1.912	1.00
6_A	9_E	1.868	1.00
36_A	40_A	1.865	1.00
7_A	11_H	1.856	1.00
251_S	255_A	1.848	1.00
76_R	164_R	1.820	1.00
116_R	120_R	1.789	1.00
193_A	196_D	1.781	1.00
36_A	212_V	1.769	1.00
156_A	159_P	1.747	1.00
6_A	198_D	1.746	1.00
151_S	207_R	1.740	1.00
192_C	200_V	1.707	1.00
51_V	114_A	1.703	1.00
283_S	307_S	1.694	1.00
169_E	174_V	1.671	1.00
167_R	174_V	1.662	1.00
35_R	296_M	1.658	1.00
148_K	211_A	1.656	1.00
196_D	199_D	1.653	1.00
8_H	27_Y	1.641	1.00
252_D	255_A	1.640	1.00
7_A	10_A	1.640	1.00
57_D	125_D	1.611	1.00
59_H	101_L	1.594	1.00
54_T	129_T	1.589	1.00
279_Y	284_R	1.575	1.00
52_V	131_S	1.570	1.00
11_H	213_P	1.529	1.00
198_D	202_E	1.517	1.00
288_V	302_A	1.509	1.00
114_A	118_R	1.503	1.00
52_V	129_T	1.498	1.00
279_Y	316_A	1.490	1.00
54_T	127_A	1.487	1.00
59_H	96_A	1.486	1.00
266_L	304_A	1.485	1.00
56_E	125_D	1.481	1.00
160_E	164_R	1.481	1.00
203_T	206_V	1.479	1.00
34_H	221_T	1.475	1.00
277_A	316_A	1.474	1.00
171_E	203_T	1.472	1.00
264_V	306_V	1.470	1.00
242_T	261_R	1.469	1.00
315_V	324_A	1.468	1.00
51_V	105_L	1.455	1.00
66_V	94_V	1.455	1.00
43_V	205_L	1.454	1.00
77_G	93_Y	1.446	1.00
308_E	311_G	1.440	1.00
201_F	213_P	1.439	1.00
115_S	119_E	1.437	1.00
160_E	166_V	1.436	1.00
40_A	210_N	1.417	1.00
67_S	83_C	1.417	1.00
97_T	100_R	1.410	1.00
152_V	204_L	1.406	1.00
110_G	130_L	1.380	1.00
13_A	23_V	1.374	1.00
3_V	136_G	1.370	1.00
74_D	98_D	1.369	1.00
66_V	80_V	1.364	1.00
53_A	103_A	1.361	1.00
266_L	324_A	1.360	1.00
207_R	210_N	1.359	1.00
65_G	120_R	1.349	1.00
81_V	245_L	1.344	1.00
40_A	212_V	1.337	1.00
170_M	175_T	1.337	1.00
224_L	292_A	1.334	1.00
136_G	194_A	1.330	1.00
43_V	138_F	1.328	1.00
173_G	196_D	1.324	1.00
303_F	329_P	1.321	1.00
16_R	25_V	1.306	1.00
95_F	165_F	1.291	1.00
140_V	149_V	1.287	1.00
241_A	259_P	1.287	1.00
32_R	212_V	1.285	1.00
168_G	177_V	1.281	1.00
61_V	126_A	1.280	1.00
7_A	198_D	1.278	1.00
103_A	117_W	1.276	1.00
293_E	298_G	1.275	1.00
59_H	71_P	1.257	1.00
306_V	313_L	1.246	1.00
311_G	326_V	1.242	1.00
269_D	323_D	1.229	1.00
84_D	237_G	1.225	1.00
129_T	134_E	1.223	1.00
282_G	321_R	1.215	1.00
4_V	138_F	1.214	1.00
147_E	150_A	1.207	1.00
121_A	128_V	1.192	1.00
5_R	22_A	1.188	1.00
73_E	76_R	1.180	1.00
63_A	71_P	1.173	1.00
224_L	290_R	1.158	1.00
114_A	128_V	1.158	1.00
131_S	135_F	1.142	1.00
112_G	237_G	1.134	1.00
241_A	254_A	1.128	1.00
265_G	331_F	1.127	1.00
109_E	112_G	1.126	1.00
243_L	305_V	1.125	1.00
70_V	94_V	1.124	1.00
223_T	290_R	1.121	1.00
58_A	101_L	1.116	1.00
138_F	201_F	1.103	1.00
61_V	117_W	1.100	1.00
267_A	327_V	1.088	1.00
111_D	115_S	1.084	1.00
5_R	15_F	1.079	1.00
199_D	203_T	1.075	1.00
35_R	298_G	1.074	1.00
81_V	88_V	1.072	1.00
266_L	315_V	1.070	1.00
151_S	210_N	1.068	1.00
146_T	186_E	1.059	1.00
82_V	117_W	1.059	1.00
313_L	326_V	1.055	1.00
146_T	188_Y	1.051	1.00
29_R	32_R	1.049	1.00
64_A	124_R	1.046	1.00
269_D	312_E	1.043	1.00
96_A	101_L	1.041	1.00
88_V	235_L	1.039	1.00
280_A	314_S	1.037	1.00
41_A	211_A	1.035	1.00
192_C	197_A	1.031	1.00
59_H	70_V	1.028	1.00
57_D	124_R	1.020	1.00
317_A	322_V	1.012	1.00
144_Q	210_N	1.008	1.00
28_G	32_R	1.006	1.00
229_P	235_L	1.004	1.00
69_G	72_T	1.003	1.00
309_W	328_E	1.002	1.00
268_P	324_A	1.001	1.00
53_A	58_A	0.988	1.00
279_Y	314_S	0.986	1.00
279_Y	282_G	0.980	1.00
278_V	315_V	0.977	1.00
53_A	117_W	0.977	1.00
155_R	166_V	0.974	1.00
32_R	35_R	0.972	1.00
97_T	176_V	0.972	1.00
173_G	199_D	0.971	1.00
202_E	206_V	0.970	1.00
29_R	212_V	0.969	1.00
153_L	157_S	0.967	1.00
270_A	323_D	0.967	1.00
148_K	207_R	0.966	1.00
284_R	287_E	0.958	1.00
140_V	148_K	0.954	1.00
3_V	194_A	0.953	1.00
141_H	187_G	0.950	1.00
50_V	135_F	0.949	1.00
94_V	101_L	0.936	1.00
173_G	200_V	0.936	1.00
4_V	197_A	0.934	1.00
285_V	313_L	0.926	1.00
8_H	24_P	0.926	1.00
192_C	196_D	0.924	1.00
94_V	103_A	0.921	1.00
154_H	169_E	0.921	1.00
239_T	242_T	0.917	1.00
130_L	133_G	0.915	1.00
310_H	313_L	0.914	1.00
239_T	253_A	0.913	1.00
203_T	207_R	0.912	1.00
84_D	89_R	0.910	1.00
68_G	249_D	0.909	1.00
121_A	124_R	0.909	1.00
36_A	214_F	0.908	1.00
310_H	325_A	0.908	1.00
136_G	192_C	0.907	1.00
327_V	331_F	0.903	0.99
169_E	172_G	0.899	0.99
43_V	140_V	0.896	0.99
34_H	222_L	0.896	0.99
280_A	285_V	0.893	0.99
272_P	276_A	0.891	0.99
21_R	110_G	0.887	0.99
160_E	163_L	0.885	0.99
43_V	201_F	0.885	0.99
15_F	22_A	0.884	0.99
2_T	5_R	0.880	0.99
52_V	102_L	0.875	0.99
68_G	80_V	0.875	0.99
146_T	158_P	0.870	0.99
171_E	175_T	0.868	0.99
137_T	191_V	0.866	0.99
242_T	260_H	0.866	0.99
66_V	82_V	0.865	0.99
11_H	202_E	0.865	0.99
153_L	170_M	0.858	0.99
118_R	121_A	0.858	0.99
72_T	78_A	0.850	0.99
11_H	201_F	0.850	0.99
122_G	125_D	0.847	0.99
241_A	246_A	0.841	0.99
89_R	112_G	0.835	0.99
131_S	134_E	0.835	0.99
62_V	101_L	0.832	0.99
26_E	30_P	0.828	0.99
88_V	234_E	0.826	0.99
114_A	130_L	0.825	0.99
115_S	118_R	0.824	0.99
150_A	155_R	0.821	0.99
280_A	283_S	0.819	0.99
56_E	99_D	0.816	0.99
80_V	94_V	0.810	0.99
270_A	322_V	0.809	0.99
306_V	326_V	0.809	0.99
65_G	116_R	0.808	0.99
171_E	199_D	0.806	0.99
179_D	186_E	0.804	0.99
62_V	70_V	0.804	0.99
82_V	92_G	0.802	0.99
49_D	110_G	0.800	0.99
61_V	121_A	0.800	0.99
205_L	213_P	0.799	0.99
67_S	81_V	0.796	0.99
244_G	262_R	0.796	0.99
105_L	113_V	0.796	0.99
294_S	301_L	0.795	0.99
51_V	117_W	0.795	0.99
205_L	211_A	0.794	0.99
50_V	191_V	0.791	0.99
100_R	167_R	0.786	0.99
11_H	27_Y	0.782	0.99
167_R	176_V	0.782	0.99
73_E	164_R	0.778	0.98
241_A	248_L	0.778	0.98
66_V	70_V	0.774	0.98
37_V	222_L	0.774	0.98
242_T	259_P	0.771	0.98
190_V	204_L	0.770	0.98
79_Y	91_D	0.769	0.98
310_H	326_V	0.767	0.98
261_R	307_S	0.767	0.98
54_T	99_D	0.765	0.98
83_C	254_A	0.765	0.98
236_A	287_E	0.763	0.98
59_H	63_A	0.762	0.98
9_E	22_A	0.757	0.98
77_G	95_F	0.755	0.98
88_V	243_L	0.754	0.98
36_A	210_N	0.748	0.98
263_L	303_F	0.745	0.98
34_H	296_M	0.745	0.98
116_R	119_E	0.744	0.98
31_D	35_R	0.741	0.98
14_T	26_E	0.740	0.98
150_A	158_P	0.737	0.98
241_A	258_E	0.736	0.98
7_A	205_L	0.735	0.98
268_P	300_P	0.732	0.98
165_F	178_R	0.731	0.98
57_D	122_G	0.729	0.98
266_L	313_L	0.728	0.98
97_T	102_L	0.728	0.98
38_R	225_E	0.728	0.98
175_T	190_V	0.728	0.98
293_E	300_P	0.727	0.98
7_A	201_F	0.723	0.98
10_A	198_D	0.723	0.98
53_A	128_V	0.721	0.97
37_V	214_F	0.721	0.97
95_F	178_R	0.719	0.97
261_R	287_E	0.713	0.97
265_G	329_P	0.712	0.97
145_A	186_E	0.711	0.97
102_L	191_V	0.710	0.97
177_V	190_V	0.709	0.97
62_V	103_A	0.707	0.97
309_W	313_L	0.706	0.97
51_V	128_V	0.703	0.97
199_D	202_E	0.703	0.97
50_V	137_T	0.699	0.97
173_G	193_A	0.699	0.97
155_R	168_G	0.698	0.97
49_D	105_L	0.698	0.97
13_A	25_V	0.696	0.97
272_P	300_P	0.693	0.97
84_D	87_R	0.692	0.97
11_H	205_L	0.690	0.97
165_F	176_V	0.690	0.97
61_V	122_G	0.689	0.97
60_E	124_R	0.688	0.97
170_M	173_G	0.687	0.97
135_F	193_A	0.682	0.97
147_E	151_S	0.678	0.96
102_L	135_F	0.677	0.96
149_V	188_Y	0.675	0.96
85_D	238_R	0.671	0.96
277_A	287_E	0.671	0.96
207_R	211_A	0.670	0.96
183_A	187_G	0.669	0.96
272_P	324_A	0.668	0.96
117_W	128_V	0.665	0.96
263_L	305_V	0.665	0.96
160_E	165_F	0.664	0.96
179_D	188_Y	0.664	0.96
224_L	301_L	0.663	0.96
221_T	292_A	0.661	0.96
264_V	326_V	0.660	0.96
280_A	311_G	0.659	0.96
134_E	193_A	0.659	0.96
272_P	315_V	0.657	0.96
44_T	214_F	0.655	0.96
234_E	263_L	0.655	0.96
61_V	64_A	0.654	0.96
38_R	222_L	0.653	0.96
140_V	211_A	0.652	0.95
62_V	66_V	0.652	0.95
140_V	190_V	0.651	0.95
53_A	62_V	0.645	0.95
92_G	103_A	0.645	0.95
50_V	132_T	0.644	0.95
67_S	248_L	0.639	0.95
264_V	311_G	0.638	0.95
66_V	78_A	0.638	0.95
89_R	237_G	0.634	0.95
89_R	116_R	0.633	0.95
174_V	196_D	0.631	0.95
227_G	329_P	0.631	0.95
53_A	61_V	0.627	0.94
221_T	294_S	0.626	0.94
194_A	197_A	0.625	0.94
163_L	180_D	0.624	0.94
316_A	320_D	0.624	0.94
214_F	218_T	0.624	0.94
141_H	183_A	0.623	0.94
268_P	315_V	0.622	0.94
154_H	157_S	0.619	0.94
77_G	180_D	0.619	0.94
175_T	192_C	0.618	0.94
177_V	188_Y	0.616	0.94
153_L	171_E	0.616	0.94
121_A	126_A	0.615	0.94
178_R	191_V	0.614	0.94
291_A	300_P	0.610	0.94
60_E	71_P	0.608	0.94
4_V	8_H	0.607	0.93
8_H	15_F	0.607	0.93
145_A	188_Y	0.607	0.93
280_A	313_L	0.606	0.93
182_L	230_L	0.603	0.93
170_M	200_V	0.601	0.93
157_S	168_G	0.600	0.93
309_W	329_P	0.600	0.93
289_T	305_V	0.599	0.93
96_A	100_R	0.597	0.93
278_V	313_L	0.596	0.93
163_L	228_T	0.596	0.93
68_G	78_A	0.596	0.93
60_E	64_A	0.594	0.93
97_T	165_F	0.592	0.93
43_V	204_L	0.592	0.93
40_A	211_A	0.592	0.93
273_A	291_A	0.588	0.92
40_A	148_K	0.585	0.92
250_G	253_A	0.582	0.92
239_T	254_A	0.582	0.92
79_Y	180_D	0.580	0.92
226_A	333_D	0.579	0.92
105_L	114_A	0.577	0.92
150_A	154_H	0.577	0.92
52_V	97_T	0.577	0.92
85_D	237_G	0.576	0.92
57_D	126_A	0.575	0.91
38_R	296_M	0.574	0.91
162_R	228_T	0.574	0.91
272_P	302_A	0.574	0.91
229_P	234_E	0.572	0.91
13_A	16_R	0.572	0.91
53_A	94_V	0.571	0.91
294_S	299_D	0.571	0.91
119_E	122_G	0.569	0.91
285_V	307_S	0.569	0.91
278_V	324_A	0.569	0.91
65_G	82_V	0.567	0.91
77_G	178_R	0.567	0.91
112_G	116_R	0.566	0.91
160_E	188_Y	0.566	0.91
44_T	141_H	0.566	0.91
62_V	117_W	0.565	0.91
317_A	320_D	0.562	0.91
268_P	322_V	0.561	0.90
15_F	23_V	0.560	0.90
27_Y	213_P	0.559	0.90
33_T	215_G	0.557	0.90
46_H	136_G	0.555	0.90
235_L	243_L	0.554	0.90
17_E	22_A	0.553	0.90
227_G	265_G	0.552	0.90
8_H	11_H	0.552	0.90
296_M	332_V	0.552	0.90
257_G	260_H	0.551	0.90
82_V	113_V	0.549	0.90
83_C	88_V	0.549	0.90
148_K	151_S	0.545	0.89
95_F	104_L	0.544	0.89
231_F	235_L	0.544	0.89
61_V	124_R	0.543	0.89
256_A	259_P	0.543	0.89
80_V	92_G	0.541	0.89
265_G	303_F	0.540	0.89
138_F	197_A	0.538	0.89
43_V	211_A	0.538	0.89
28_G	212_V	0.538	0.89
139_G	189_L	0.534	0.88
160_E	168_G	0.534	0.88
161_E	165_F	0.534	0.88
34_H	295_P	0.533	0.88
112_G	115_S	0.531	0.88
66_V	101_L	0.527	0.88
153_L	156_A	0.527	0.88
60_E	63_A	0.526	0.87
186_E	226_A	0.526	0.87
64_A	122_G	0.525	0.87
49_D	130_L	0.524	0.87
204_L	211_A	0.523	0.87
110_G	133_G	0.523	0.87
18_V	47_A	0.522	0.87
48_F	219_W	0.521	0.87
36_A	42_G	0.520	0.87
314_S	322_V	0.520	0.87
25_V	217_E	0.519	0.87
64_A	123_N	0.518	0.87
109_E	231_F	0.518	0.87
82_V	116_R	0.517	0.87
103_A	126_A	0.517	0.87
261_R	305_V	0.517	0.87
48_F	104_L	0.517	0.87
240_L	248_L	0.516	0.86
311_G	325_A	0.516	0.86
267_A	301_L	0.515	0.86
69_G	249_D	0.514	0.86
288_V	304_A	0.511	0.86
327_V	330_P	0.511	0.86
299_D	325_A	0.511	0.86
41_A	140_V	0.511	0.86
271_L	300_P	0.511	0.86
61_V	65_G	0.510	0.86
152_V	203_T	0.508	0.86
106_P	220_E	0.507	0.86
268_P	299_D	0.507	0.86
110_G	114_A	0.506	0.85
66_V	92_G	0.506	0.85
85_D	253_A	0.506	0.85
48_F	137_T	0.505	0.85
309_W	312_E	0.504	0.85
49_D	108_G	0.503	0.85
145_A	148_K	0.502	0.85
223_T	232_A	0.501	0.85
246_A	262_R	0.501	0.85
47_A	107_A	0.500	0.85
222_L	296_M	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gagA	1	0.9913	100	0.195	Contact Map
1wosA	1	0.9797	100	0.208	Contact Map
1pj5A	3	0.9826	100	0.212	Contact Map
4pabA	1	0.9942	100	0.216	Contact Map
3girA	1	0.9622	100	0.217	Contact Map
1wsrA	2	0.9767	100	0.219	Contact Map
1v5vA	2	0.9971	100	0.221	Contact Map
1yx2A	1	0.968	100	0.221	Contact Map
1vloA	1	0.9709	100	0.236	Contact Map
3tfiA	2	0.9448	100	0.267	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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