GREMLIN Database
Q9HM93 - Uncharacterized protein
UniProt: Q9HM93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (155)
Sequences: 773 (541)
Seq/√Len: 43.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_V62_P3.3591.00
94_D142_K2.9381.00
78_V116_Q2.8371.00
52_D71_R2.8151.00
132_D135_E2.8091.00
69_A114_V2.7631.00
11_S15_D2.7381.00
97_R143_V2.6551.00
127_G144_V2.5101.00
130_L145_S2.4871.00
109_A135_E2.3751.00
129_A136_M2.3351.00
107_I129_A2.3151.00
45_E57_Y2.2781.00
20_A23_T2.2711.00
134_T137_D2.1841.00
82_D85_A2.1511.00
89_V95_V2.1271.00
79_V144_V2.1110.99
70_N123_T2.0020.99
6_R36_R1.9900.99
108_T132_D1.9480.99
109_A130_L1.8480.99
33_A50_D1.7270.98
9_L15_D1.7180.98
110_G129_A1.7170.98
79_V107_I1.7090.98
93_A141_G1.6780.97
17_I47_V1.6550.97
28_E68_G1.6450.97
69_A76_T1.6210.97
83_A117_E1.5860.96
97_R139_E1.5530.96
15_D45_E1.4820.94
108_T111_D1.4740.94
37_V45_E1.4740.94
63_F147_L1.4470.94
107_I133_G1.4410.94
96_M99_G1.4380.94
92_G99_G1.3950.92
80_T116_Q1.3770.92
13_D16_E1.3610.91
103_A133_G1.3240.90
115_I125_A1.3180.90
86_V117_E1.3180.90
9_L110_G1.2720.88
63_F112_L1.2690.88
38_T48_L1.2490.88
116_Q123_T1.2190.86
129_A133_G1.2170.86
89_V125_A1.2040.86
85_A88_F1.1850.85
98_P140_S1.1830.84
88_F91_D1.1830.84
18_G22_R1.1800.84
61_E128_R1.1750.84
128_R145_S1.1710.84
7_H143_V1.1660.84
79_V113_V1.1630.83
125_A148_H1.1500.83
19_D23_T1.1280.82
32_D39_F1.1250.81
46_I53_P1.1180.81
89_V146_S1.1110.81
112_L128_R1.0820.79
25_L63_F1.0730.78
8_H36_R1.0570.77
88_F96_M1.0430.76
51_G79_V1.0410.76
81_V124_L1.0220.75
81_V95_V1.0190.74
11_S24_G0.9830.72
12_D15_D0.9770.71
26_G48_L0.9730.71
76_T112_L0.9590.70
111_D136_M0.9560.70
106_E134_T0.9540.69
33_A126_V0.9510.69
21_L93_A0.9460.69
18_G29_L0.9410.68
61_E112_L0.9370.68
81_V85_A0.9360.68
76_T114_V0.9300.67
108_T134_T0.9250.67
80_T104_S0.9220.67
85_A95_V0.9130.66
120_H150_V0.9100.66
112_L147_L0.9050.65
26_G30_D0.8980.65
141_G148_H0.8930.64
82_D118_A0.8900.64
69_A75_S0.8820.63
95_V144_V0.8800.63
97_R131_V0.8790.63
114_V154_L0.8740.63
26_G153_E0.8660.62
81_V88_F0.8660.62
12_D30_D0.8610.61
95_V125_A0.8610.61
87_S155_F0.8500.60
97_R138_G0.8490.60
62_P76_T0.8420.60
54_L68_G0.8410.60
59_D145_S0.8380.59
79_V129_A0.8360.59
82_D88_F0.8360.59
88_F93_A0.8270.58
82_D102_A0.8190.58
47_V151_G0.8150.57
27_V51_G0.8140.57
31_G113_V0.8120.57
140_S155_F0.8110.57
47_V95_V0.8110.57
94_D125_A0.8090.57
148_H152_D0.8080.56
55_V64_V0.7880.55
39_F56_W0.7820.54
10_R124_L0.7740.53
113_V144_V0.7720.53
67_A155_F0.7630.52
117_E120_H0.7580.52
86_V90_S0.7550.51
111_D128_R0.7550.51
93_A99_G0.7510.51
93_A96_M0.7500.51
65_T126_V0.7410.50
48_L109_A0.7410.50
41_D87_S0.7400.50
110_G128_R0.7370.50
86_V113_V0.7360.50
110_G137_D0.7330.49
66_V83_A0.7320.49
131_V143_V0.7300.49
13_D19_D0.7260.49
111_D129_A0.7250.49
92_G96_M0.7220.48
20_A24_G0.7210.48
84_G149_H0.7190.48
47_V83_A0.7130.47
30_D76_T0.7120.47
16_E115_I0.7080.47
94_D145_S0.7050.47
28_E74_P0.7030.46
63_F128_R0.6980.46
3_V134_T0.6950.46
50_D106_E0.6900.45
129_A144_V0.6900.45
40_A44_F0.6860.45
63_F141_G0.6860.45
57_Y60_G0.6850.45
149_H153_E0.6810.44
100_I142_K0.6800.44
7_H11_S0.6780.44
14_I140_S0.6770.44
80_T101_T0.6770.44
42_E57_Y0.6760.44
101_T139_E0.6750.44
54_L157_F0.6610.43
33_A36_R0.6600.42
67_A70_N0.6570.42
38_T58_P0.6540.42
29_L129_A0.6540.42
77_G104_S0.6530.42
29_L148_H0.6520.42
123_T155_F0.6460.41
126_V147_L0.6460.41
23_T26_G0.6440.41
131_V136_M0.6430.41
6_R75_S0.6420.41
103_A107_I0.6380.40
35_E155_F0.6370.40
100_I129_A0.6370.40
66_V150_V0.6340.40
34_Y60_G0.6340.40
20_A126_V0.6340.40
30_D73_D0.6330.40
4_S43_E0.6320.40
25_L126_V0.6310.40
18_G119_A0.6250.39
103_A138_G0.6230.39
29_L50_D0.6220.39
93_A112_L0.6210.39
50_D130_L0.6150.38
94_D98_P0.6140.38
53_P65_T0.6110.38
99_G141_G0.6060.37
82_D101_T0.6020.37
82_D97_R0.5980.37
84_G88_F0.5980.37
70_N150_V0.5960.37
47_V91_D0.5890.36
15_D59_D0.5880.36
97_R100_I0.5870.36
83_A86_V0.5870.36
140_S149_H0.5830.35
25_L30_D0.5820.35
25_L106_E0.5790.35
50_D156_E0.5780.35
81_V84_G0.5760.35
19_D22_R0.5730.35
53_P146_S0.5720.34
66_V138_G0.5680.34
52_D147_L0.5680.34
11_S91_D0.5620.34
135_E138_G0.5620.34
56_W64_V0.5610.34
141_G152_D0.5580.33
70_N82_D0.5580.33
100_I103_A0.5560.33
10_R13_D0.5520.33
109_A138_G0.5520.33
89_V101_T0.5490.33
125_A146_S0.5480.32
52_D67_A0.5480.32
15_D89_V0.5440.32
31_G34_Y0.5430.32
8_H111_D0.5350.31
3_V71_R0.5300.31
84_G87_S0.5210.30
118_A130_L0.5130.30
67_A145_S0.5110.29
82_D86_V0.5100.29
40_A46_I0.5090.29
51_G65_T0.5080.29
15_D57_Y0.5070.29
104_S143_V0.5060.29
103_A136_M0.5050.29
75_S114_V0.5040.29
56_W101_T0.5030.29
28_E32_D0.5010.29
46_I66_V0.5010.29
8_H12_D0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d79A 1 0.9748 100 0.252 Contact Map
3r90A 5 1 100 0.273 Contact Map
1q7hA 2 0.9434 100 0.297 Contact Map
2cx0A 1 0.9937 100 0.368 Contact Map
1iq8A 2 0.9308 99.9 0.528 Contact Map
2q07A 1 0.8679 99.9 0.529 Contact Map
2p38A 4 0.8365 99.9 0.594 Contact Map
3zv0C 2 0.805 99.8 0.615 Contact Map
2ausC 1 0.8994 98.6 0.802 Contact Map
3u28A 1 0.9182 98.5 0.806 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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