GREMLIN Database
Q9HM91 - Ribonuclease II family protein
UniProt: Q9HM91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (405)
Sequences: 4197 (2591)
Seq/√Len: 128.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_D186_H4.2711.00
71_A179_E4.1611.00
74_R158_D4.0891.00
169_D174_S3.9361.00
51_E120_E3.9191.00
84_V194_K3.3171.00
96_L103_V3.1641.00
197_E201_D3.0411.00
76_L96_L2.7951.00
46_P50_A2.7921.00
107_H163_T2.7201.00
249_L348_F2.7141.00
165_E181_Y2.6561.00
101_E167_H2.6461.00
45_P48_V2.6151.00
71_A181_Y2.5971.00
352_G366_N2.5121.00
161_A185_I2.4991.00
103_V165_E2.4881.00
182_K371_Y2.4361.00
129_A389_K2.3781.00
99_D167_H2.3631.00
268_V383_C2.3531.00
105_W165_E2.2761.00
197_E238_D2.2571.00
161_A183_S2.2341.00
78_T185_I2.2151.00
167_H177_T2.2111.00
103_V167_H2.2011.00
53_E145_V2.1931.00
126_I382_L2.1711.00
19_I36_E2.1511.00
93_I244_I2.1431.00
271_V336_M2.1401.00
112_T364_L2.1241.00
154_V157_E2.1191.00
78_T188_D2.0791.00
253_K348_F2.0711.00
51_E119_S2.0451.00
412_D415_N2.0381.00
163_T183_S2.0371.00
116_H119_S2.0051.00
223_E227_A1.9851.00
89_F190_R1.9681.00
86_A89_F1.9411.00
97_E216_D1.9351.00
273_P340_F1.9121.00
98_R103_V1.9011.00
60_Q66_E1.8981.00
77_P188_D1.8771.00
130_N389_K1.8711.00
215_F219_D1.8441.00
168_L250_K1.8101.00
98_R101_E1.8001.00
384_D388_D1.7971.00
135_P400_Y1.7681.00
73_M183_S1.7661.00
81_V243_I1.7401.00
66_E69_D1.7281.00
192_T195_D1.7281.00
102_Y213_L1.7231.00
162_H371_Y1.7181.00
362_S386_A1.7041.00
73_M165_E1.6781.00
222_H246_E1.6711.00
273_P334_R1.6701.00
77_P210_D1.6631.00
389_K392_A1.6591.00
107_H183_S1.6591.00
268_V365_V1.6381.00
132_V393_G1.6341.00
174_S224_Q1.6331.00
171_D174_S1.6111.00
222_H242_T1.5991.00
178_I254_A1.5961.00
126_I385_R1.5871.00
144_P148_E1.5841.00
168_L175_Y1.5731.00
79_W210_D1.5721.00
163_T181_Y1.5721.00
283_A326_V1.5631.00
97_E213_L1.5631.00
287_I322_I1.5631.00
155_P187_S1.5591.00
94_S107_H1.5571.00
48_V124_E1.5421.00
45_P124_E1.5401.00
404_L407_V1.5391.00
106_V166_M1.5321.00
122_W368_W1.5211.00
130_N362_S1.5191.00
98_R167_H1.5191.00
316_E319_L1.5121.00
67_I74_R1.4981.00
57_E145_V1.4931.00
271_V340_F1.4891.00
156_G186_H1.4711.00
219_D239_R1.4691.00
93_I214_V1.4581.00
268_V386_A1.4491.00
208_H212_S1.4461.00
178_I258_E1.4461.00
94_S105_W1.4451.00
95_V213_L1.4371.00
78_T107_H1.4281.00
332_R391_Q1.4161.00
238_D241_H1.4141.00
55_R150_V1.3941.00
166_M254_A1.3881.00
122_W361_M1.3771.00
37_K399_E1.3741.00
259_L267_A1.3731.00
132_V396_A1.3711.00
224_Q227_A1.3701.00
166_M175_Y1.3701.00
105_W163_T1.3621.00
164_V180_I1.3591.00
215_F218_A1.3491.00
102_Y220_Q1.3471.00
222_H226_K1.3451.00
78_T163_T1.3381.00
52_A145_V1.3361.00
73_M181_Y1.3291.00
213_L216_D1.3261.00
104_L247_S1.3221.00
385_R389_K1.3191.00
101_E176_Q1.3191.00
101_E170_K1.3041.00
38_F399_E1.3041.00
354_F366_N1.3021.00
199_R208_H1.2991.00
129_A386_A1.2931.00
258_E263_R1.2911.00
361_M368_W1.2851.00
95_V214_V1.2701.00
158_D184_V1.2671.00
214_V247_S1.2651.00
49_V53_E1.2571.00
78_T161_A1.2521.00
71_A165_E1.2441.00
215_F239_R1.2441.00
162_H182_K1.2200.99
124_E127_D1.2150.99
23_L26_Q1.2090.99
74_R184_V1.2020.99
276_S331_P1.1970.99
306_A309_A1.1950.99
225_R246_E1.1910.99
124_E128_R1.1900.99
97_E170_K1.1890.99
167_H176_Q1.1830.99
200_L215_F1.1810.99
293_V318_Q1.1760.99
312_E315_P1.1750.99
130_N393_G1.1680.99
95_V210_D1.1670.99
44_F48_V1.1660.99
40_L396_A1.1520.99
197_E241_H1.1510.99
112_T371_Y1.1510.99
34_L403_F1.1450.99
175_Y254_A1.1440.99
166_M250_K1.1420.99
119_S123_A1.1370.99
339_P342_G1.1340.99
180_I254_A1.1300.99
76_L105_W1.1270.99
131_T138_T1.1200.99
191_L207_L1.1190.99
149_T154_V1.1180.99
199_R211_L1.1150.99
35_F139_M1.1090.99
160_L184_V1.1090.99
64_Q67_I1.1080.99
337_N383_C1.1080.99
80_T89_F1.1060.99
352_G369_I1.1050.99
218_A246_E1.1050.99
94_S163_T1.1020.99
89_F154_V1.0950.99
73_M78_T1.0940.99
50_A54_A1.0940.99
31_R400_Y1.0900.99
50_A53_E1.0880.99
41_H392_A1.0870.99
378_T382_L1.0840.99
162_H370_V1.0830.99
287_I310_T1.0730.99
319_L323_Q1.0700.99
257_H262_N1.0690.99
380_I384_D1.0690.99
84_V192_T1.0590.99
200_L212_S1.0550.99
169_D176_Q1.0430.98
256_T366_N1.0420.98
30_K404_L1.0350.98
257_H350_I1.0350.98
259_L366_N1.0270.98
82_D91_D1.0170.98
34_L400_Y1.0100.98
164_V254_A1.0090.98
283_A287_I1.0060.98
51_E116_H1.0040.98
354_F367_H1.0020.98
155_P189_E1.0010.98
172_D220_Q0.9990.98
198_Q204_T0.9970.98
80_T187_S0.9970.98
104_L217_L0.9970.98
78_T105_W0.9970.98
94_S188_D0.9930.98
78_T94_S0.9910.98
149_T157_E0.9870.98
73_M163_T0.9830.98
130_N386_A0.9800.98
228_E348_F0.9800.98
82_D359_R0.9760.98
60_Q65_A0.9750.98
286_E325_A0.9750.98
239_R243_I0.9660.97
79_W211_L0.9650.97
309_A313_Q0.9630.97
76_L94_S0.9570.97
335_Y353_H0.9540.97
67_I184_V0.9490.97
216_D220_Q0.9480.97
145_V150_V0.9450.97
237_R241_H0.9430.97
121_M125_A0.9390.97
83_P192_T0.9380.97
381_S385_R0.9380.97
315_P319_L0.9350.97
220_Q223_E0.9340.97
84_V195_D0.9310.97
40_L392_A0.9310.97
83_P196_A0.9300.97
201_D238_D0.9280.97
79_W191_L0.9150.96
180_I258_E0.9150.96
41_H127_D0.9130.96
189_E195_D0.9130.96
82_D133_Y0.9120.96
100_D170_K0.9110.96
198_Q202_D0.9100.96
196_A200_L0.9080.96
66_E113_H0.9060.96
156_G187_S0.9050.96
259_L370_V0.9040.96
32_D36_E0.9010.96
207_L211_L0.9000.96
162_H367_H0.8940.96
256_T352_G0.8940.96
117_P374_D0.8890.96
113_H182_K0.8870.96
305_K309_A0.8810.96
197_E239_R0.8800.95
239_R242_T0.8770.95
165_E179_E0.8760.95
118_D123_A0.8760.95
120_E123_A0.8670.95
314_A322_I0.8660.95
210_D213_L0.8630.95
228_E253_K0.8620.95
164_V255_V0.8620.95
25_R30_K0.8540.95
217_L247_S0.8530.95
100_D167_H0.8530.95
48_V52_A0.8510.95
40_L139_M0.8500.95
175_Y250_K0.8500.95
133_Y359_R0.8490.95
91_D356_S0.8460.94
304_R308_N0.8440.94
191_L211_L0.8430.94
105_W181_Y0.8420.94
386_A389_K0.8400.94
298_D302_D0.8390.94
134_L396_A0.8350.94
212_S215_F0.8340.94
29_N33_D0.8330.94
225_R230_S0.8310.94
48_V121_M0.8270.94
310_T314_A0.8260.94
35_F137_Y0.8260.94
94_S165_E0.8230.94
202_D205_A0.8180.93
307_V329_V0.8170.93
99_D176_Q0.8130.93
34_L396_A0.8130.93
375_V378_T0.8120.93
237_R242_T0.8080.93
88_D358_I0.8060.93
49_V52_A0.8060.93
85_D190_R0.8060.93
248_M356_S0.8050.93
311_L314_A0.8040.93
101_E169_D0.8020.93
381_S384_D0.8020.93
145_V149_T0.7990.93
60_Q64_Q0.7980.93
30_K403_F0.7980.93
60_Q113_H0.7970.92
408_G412_D0.7960.92
402_D423_D0.7950.92
107_H165_E0.7940.92
82_D90_D0.7940.92
117_P378_T0.7860.92
314_A323_Q0.7860.92
91_D248_M0.7850.92
200_L211_L0.7840.92
47_D50_A0.7810.92
396_A400_Y0.7810.92
98_R176_Q0.7800.92
180_I370_V0.7790.92
281_D285_Q0.7760.91
383_C386_A0.7760.91
113_H371_Y0.7760.91
272_H345_A0.7740.91
259_L369_I0.7720.91
104_L168_L0.7670.91
76_L165_E0.7660.91
90_D359_R0.7660.91
269_Y339_P0.7650.91
230_S235_P0.7590.91
89_F144_P0.7570.90
91_D359_R0.7560.90
180_I255_V0.7560.90
199_R212_S0.7550.90
47_D120_E0.7550.90
196_A240_A0.7540.90
200_L239_R0.7460.90
73_M185_I0.7460.90
118_D126_I0.7440.90
217_L220_Q0.7440.90
91_D193_Y0.7420.90
168_L221_M0.7400.89
52_A119_S0.7350.89
90_D133_Y0.7350.89
83_P241_H0.7340.89
281_D284_L0.7320.89
221_M224_Q0.7310.89
258_E370_V0.7290.89
129_A385_R0.7290.89
178_I257_H0.7280.89
52_A55_R0.7280.89
242_T246_E0.7280.89
96_L105_W0.7280.89
115_V119_S0.7270.89
198_Q203_E0.7270.89
172_D217_L0.7240.88
255_V352_G0.7240.88
287_I293_V0.7240.88
97_E209_D0.7230.88
82_D248_M0.7220.88
56_T59_V0.7200.88
202_D206_P0.7200.88
78_T93_I0.7170.88
51_E54_A0.7150.88
308_N311_L0.7140.88
218_A239_R0.7090.87
209_D213_L0.7080.87
114_Y151_C0.7080.87
223_E226_K0.7070.87
203_E206_P0.7070.87
83_P86_A0.7060.87
271_V334_R0.7040.87
213_L220_Q0.7020.87
88_D245_E0.7000.87
191_L195_D0.6990.87
284_L295_I0.6990.87
134_L139_M0.6970.86
83_P190_R0.6950.86
104_L214_V0.6940.86
57_E60_Q0.6920.86
26_Q29_N0.6890.86
55_R145_V0.6880.86
330_M344_H0.6870.86
251_A354_F0.6860.86
189_E207_L0.6860.86
270_R360_R0.6860.86
296_P303_P0.6860.86
194_K238_D0.6840.85
95_V217_L0.6820.85
111_V353_H0.6820.85
94_S183_S0.6800.85
48_V51_E0.6790.85
82_D193_Y0.6780.85
90_D248_M0.6740.85
123_A126_I0.6740.85
399_E402_D0.6740.85
336_M340_F0.6730.84
59_V67_I0.6710.84
65_A68_E0.6700.84
91_D133_Y0.6690.84
220_Q224_Q0.6690.84
57_E150_V0.6680.84
156_G189_E0.6680.84
91_D141_M0.6660.84
302_D305_K0.6650.84
28_E32_D0.6650.84
374_D378_T0.6640.84
191_L199_R0.6630.84
152_S358_I0.6630.84
60_Q67_I0.6600.83
80_T92_A0.6590.83
34_L399_E0.6590.83
339_P350_I0.6560.83
90_D193_Y0.6560.83
306_A311_L0.6550.83
194_K198_Q0.6550.83
112_T367_H0.6530.83
197_E240_A0.6530.83
27_L30_K0.6520.83
67_I158_D0.6520.83
193_Y359_R0.6520.83
127_D212_S0.6500.82
305_K308_N0.6490.82
277_P281_D0.6490.82
115_V146_L0.6490.82
85_D138_T0.6480.82
82_D153_L0.6460.82
267_A352_G0.6460.82
207_L210_D0.6430.82
73_M105_W0.6420.82
171_D220_Q0.6390.81
49_V145_V0.6360.81
67_I160_L0.6360.81
107_H161_A0.6330.81
77_P189_E0.6320.81
86_A190_R0.6310.80
79_W196_A0.6300.80
22_E30_K0.6290.80
203_E212_S0.6280.80
108_I152_S0.6280.80
89_F155_P0.6260.80
70_R160_L0.6250.80
310_T313_Q0.6250.80
88_D133_Y0.6250.80
201_D239_R0.6230.80
77_P94_S0.6230.80
45_P127_D0.6230.80
111_V115_V0.6220.80
87_Q190_R0.6200.79
126_I378_T0.6200.79
168_L220_Q0.6160.79
299_A302_D0.6160.79
97_E102_Y0.6160.79
76_L188_D0.6150.79
254_A257_H0.6150.79
90_D109_A0.6140.79
296_P302_D0.6140.79
79_W93_I0.6140.79
64_Q68_E0.6130.79
268_V379_L0.6130.79
229_G347_N0.6110.78
66_E160_L0.6110.78
209_D212_S0.6100.78
46_P49_V0.6100.78
91_D244_I0.6080.78
75_P188_D0.6080.78
224_Q228_E0.6060.78
219_D223_E0.6050.78
48_V120_E0.6040.78
307_V326_V0.6020.77
282_D285_Q0.5990.77
211_L215_F0.5980.77
109_A355_T0.5970.77
281_D297_G0.5960.77
78_T92_A0.5960.77
31_R34_L0.5950.76
20_S23_L0.5950.76
103_V163_T0.5950.76
43_E46_P0.5950.76
387_S391_Q0.5950.76
257_H349_E0.5920.76
80_T190_R0.5920.76
304_R310_T0.5890.76
387_S390_Q0.5890.76
255_V370_V0.5890.76
82_D88_D0.5890.76
309_A326_V0.5880.76
365_V382_L0.5870.76
385_R388_D0.5860.75
22_E29_N0.5850.75
353_H360_R0.5830.75
56_T150_V0.5830.75
164_V178_I0.5830.75
155_P332_R0.5800.75
197_E202_D0.5790.75
13_D21_P0.5790.75
195_D205_A0.5780.74
21_P36_E0.5780.74
327_M390_Q0.5780.74
284_L288_Q0.5770.74
131_T140_H0.5760.74
86_A140_H0.5730.74
87_Q148_E0.5730.74
218_A222_H0.5720.74
218_A247_S0.5710.74
28_E31_R0.5700.73
402_D406_E0.5690.73
204_T208_H0.5680.73
126_I381_S0.5680.73
133_Y193_Y0.5670.73
80_T155_P0.5660.73
108_I358_I0.5650.73
101_E177_T0.5640.73
36_E40_L0.5640.73
157_E187_S0.5640.73
221_M253_K0.5630.72
187_S191_L0.5620.72
306_A310_T0.5600.72
230_S246_E0.5600.72
295_I299_A0.5580.72
102_Y216_D0.5580.72
402_D405_E0.5580.72
314_A319_L0.5580.72
89_F192_T0.5570.72
241_H348_F0.5570.72
14_Q17_V0.5570.72
73_M76_L0.5550.71
126_I365_V0.5550.71
38_F395_T0.5550.71
296_P299_A0.5540.71
77_P207_L0.5520.71
270_R333_A0.5520.71
391_Q395_T0.5510.71
355_T359_R0.5500.71
56_T145_V0.5490.71
106_V248_M0.5480.70
293_V297_G0.5480.70
244_I248_M0.5470.70
155_P190_R0.5470.70
159_R187_S0.5470.70
202_D212_S0.5460.70
304_R307_V0.5460.70
17_V20_S0.5450.70
275_P344_H0.5450.70
245_E272_H0.5440.70
83_P193_Y0.5430.70
83_P89_F0.5430.70
51_E121_M0.5410.69
195_D198_Q0.5410.69
83_P244_I0.5400.69
280_W307_V0.5390.69
31_R137_Y0.5390.69
75_P186_H0.5380.69
303_P306_A0.5380.69
270_R359_R0.5380.69
108_I193_Y0.5370.69
295_I298_D0.5370.69
303_P307_V0.5360.69
189_E211_L0.5350.69
87_Q358_I0.5350.69
403_F407_V0.5350.69
377_E381_S0.5340.69
245_E333_A0.5340.69
40_L331_P0.5330.68
30_K407_V0.5320.68
193_Y248_M0.5320.68
234_N242_T0.5310.68
56_T66_E0.5310.68
36_E42_D0.5310.68
309_A312_E0.5310.68
150_V157_E0.5290.68
200_L243_I0.5280.68
366_N369_I0.5280.68
81_V91_D0.5270.68
19_I32_D0.5270.68
60_Q69_D0.5250.67
91_D358_I0.5240.67
168_L217_L0.5220.67
314_A317_R0.5200.66
24_A39_D0.5190.66
293_V317_R0.5190.66
52_A56_T0.5190.66
23_L144_P0.5180.66
177_T377_E0.5170.66
94_S103_V0.5170.66
212_S216_D0.5170.66
133_Y248_M0.5160.66
276_S279_E0.5160.66
87_Q138_T0.5160.66
103_V181_Y0.5160.66
48_V127_D0.5140.66
332_R394_E0.5130.65
295_I301_D0.5130.65
91_D367_H0.5110.65
115_V142_L0.5100.65
140_H172_D0.5090.65
154_V159_R0.5090.65
34_L210_D0.5090.65
88_D152_S0.5080.65
39_D389_K0.5080.65
35_F42_D0.5070.65
28_E33_D0.5060.64
272_H333_A0.5050.64
168_L172_D0.5050.64
108_I248_M0.5040.64
86_A147_A0.5020.64
151_C333_A0.5020.64
196_A211_L0.5010.64
272_H367_H0.5010.64
102_Y172_D0.5010.64
41_H389_K0.5010.64
270_R335_Y0.5000.63
44_F49_V0.5000.63
134_L241_H0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ro1A 1 0.986 100 0.096 Contact Map
4pmwA 1 0.986 100 0.1 Contact Map
2vnuD 1 0.9907 100 0.102 Contact Map
4ifdJ 1 0.9907 100 0.102 Contact Map
2id0A 1 0.9627 100 0.134 Contact Map
2r7dA 1 0.8788 100 0.253 Contact Map
3bzcA 1 0.8252 96.8 0.94 Contact Map
1go3E 1 0.2075 89.2 0.957 Contact Map
1e3pA 3 0.6993 83.7 0.961 Contact Map
4qjfA 1 0.2075 45.7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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