GREMLIN Database
EF1A - Elongation factor 1-alpha
UniProt: Q9HM89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 421 (322)
Sequences: 16637 (7370)
Seq/√Len: 410.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_A286_V5.4751.00
143_A183_T4.4941.00
156_K159_E4.4221.00
251_N279_N4.2211.00
249_V279_N3.8391.00
255_N264_G3.4151.00
269_T276_E3.0611.00
181_I209_A3.0101.00
118_D149_V2.7431.00
254_D306_P2.6291.00
224_L245_I2.4731.00
225_R247_T2.4681.00
251_N254_D2.2401.00
252_T278_P2.2091.00
161_V182_A2.1991.00
257_S264_G2.1581.00
126_R167_L2.1461.00
110_N213_L2.1151.00
272_M275_E2.1041.00
80_T85_E2.0901.00
255_N266_E2.0041.00
161_V165_K1.9921.00
224_L250_M1.9781.00
219_P222_A1.9761.00
183_T206_L1.9591.00
310_P321_V1.9521.00
9_L86_F1.9311.00
272_M277_V1.9091.00
10_A108_A1.9051.00
320_Q323_V1.8671.00
249_V281_E1.8401.00
250_M267_V1.8251.00
63_A67_E1.8141.00
222_A247_T1.8091.00
281_E284_D1.7771.00
226_L243_G1.7691.00
224_L256_V1.7671.00
23_V88_I1.7611.00
25_R188_G1.7341.00
252_T276_E1.7321.00
161_V180_F1.7251.00
245_I280_A1.7171.00
329_V332_A1.7081.00
112_V143_A1.7061.00
117_A144_V1.7011.00
129_V164_V1.7001.00
313_V321_V1.6881.00
256_V267_V1.6781.00
243_G288_F1.6691.00
317_F321_V1.6661.00
78_E85_E1.6621.00
116_A119_D1.6601.00
115_V125_T1.6451.00
240_V287_G1.6401.00
228_I241_P1.6221.00
259_Q305_G1.6041.00
241_P298_I1.5981.00
159_E163_G1.5911.00
11_V23_V1.5891.00
257_S307_A1.5851.00
59_M77_Q1.5751.00
145_N185_A1.5701.00
314_A322_V1.5321.00
317_F323_V1.5051.00
143_A185_A1.4881.00
311_P315_D1.4731.00
277_V280_A1.4711.00
208_E211_N1.4691.00
314_A323_V1.4611.00
64_E72_I1.4581.00
209_A212_G1.4511.00
80_T83_E1.4511.00
162_S166_D1.4391.00
22_M114_V1.4381.00
232_Y242_V1.4371.00
147_M189_D1.4341.00
252_T270_I1.4341.00
22_M185_A1.4241.00
263_V297_D1.4241.00
314_A321_V1.4051.00
338_F347_C1.4001.00
169_G174_N1.3881.00
321_V324_M1.3771.00
169_G172_G1.3611.00
12_I132_S1.3481.00
310_P314_A1.3441.00
315_D320_Q1.3241.00
142_V180_F1.3201.00
111_A132_S1.3141.00
113_L142_V1.3121.00
245_I286_V1.3111.00
315_D321_V1.3051.00
335_T338_F1.3051.00
121_V125_T1.3051.00
144_V182_A1.3001.00
316_T321_V1.2981.00
33_V58_V1.2771.00
160_V163_G1.2771.00
313_V320_Q1.2681.00
317_F320_Q1.2601.00
314_A320_Q1.2521.00
184_S187_E1.2521.00
350_E354_K1.2481.00
317_F325_Q1.2361.00
244_R285_N1.2331.00
156_K160_V1.2211.00
89_V108_A1.2171.00
314_A317_F1.2111.00
5_R84_Y1.2011.00
158_N162_S1.1971.00
353_D359_A1.1941.00
190_N193_D1.1921.00
23_V59_M1.1901.00
265_G293_I1.1901.00
119_D122_A1.1731.00
333_G336_P1.1671.00
25_R28_Y1.1581.00
226_L245_I1.1561.00
310_P313_V1.1431.00
26_L79_F1.1431.00
102_I131_L1.1261.00
179_K209_A1.1241.00
333_G337_V1.1231.00
257_S262_D1.1231.00
59_M71_T1.1201.00
163_G166_D1.1111.00
322_V325_Q1.1111.00
250_M288_F1.1081.00
271_E276_E1.1071.00
320_Q324_M1.1051.00
132_S140_L1.0961.00
314_A318_Q1.0941.00
8_N87_T1.0891.00
318_Q324_M1.0881.00
220_T249_V1.0781.00
317_F324_M1.0771.00
261_S302_D1.0761.00
25_R191_V1.0761.00
79_F88_I1.0741.00
220_T281_E1.0641.00
315_D323_V1.0631.00
79_F86_F1.0601.00
128_H131_L1.0561.00
5_R83_E1.0521.00
270_I288_F1.0511.00
326_H330_I1.0491.00
30_T207_L1.0491.00
12_I111_A1.0411.00
310_P319_A1.0381.00
310_P320_Q1.0351.00
170_Q174_N1.0351.00
141_I181_I1.0351.00
62_L73_D1.0351.00
256_V304_C1.0311.00
264_G307_A1.0251.00
111_A137_I1.0241.00
82_D208_E1.0231.00
239_T319_A1.0201.00
318_Q321_V1.0161.00
117_A147_M1.0061.00
313_V316_T1.0021.00
314_A325_Q1.0011.00
330_I333_G1.0001.00
22_M206_L1.0001.00
183_T190_N0.9991.00
319_A323_V0.9991.00
251_N278_P0.9981.00
142_V164_V0.9981.00
141_I213_L0.9931.00
310_P323_V0.9921.00
29_E192_S0.9891.00
157_Y182_A0.9851.00
315_D324_M0.9851.00
22_M143_A0.9801.00
255_N307_A0.9751.00
81_T208_E0.9751.00
243_G286_V0.9711.00
269_T289_N0.9701.00
158_N161_V0.9691.00
318_Q322_V0.9681.00
315_D319_A0.9631.00
288_F304_C0.9561.00
30_T79_F0.9561.00
21_T185_A0.9551.00
330_I336_P0.9531.00
310_P317_F0.9491.00
327_P336_P0.9451.00
328_S331_T0.9431.00
12_I113_L0.9431.00
258_F265_G0.9431.00
25_R29_E0.9421.00
16_D94_H0.9421.00
141_I209_A0.9371.00
61_N73_D0.9371.00
112_V141_I0.9371.00
223_D306_P0.9351.00
319_A322_V0.9351.00
293_I298_I0.9331.00
313_V323_V0.9331.00
171_V174_N0.9251.00
316_T322_V0.9251.00
147_M182_A0.9201.00
312_S321_V0.9181.00
208_E212_G0.9131.00
144_V157_Y0.9121.00
64_E68_R0.9111.00
320_Q325_Q0.9081.00
337_V348_T0.9051.00
334_Y338_F0.8951.00
343_A349_I0.8941.00
147_M157_Y0.8901.00
142_V178_A0.8901.00
313_V322_V0.8891.00
280_A284_D0.8871.00
60_D65_E0.8841.00
258_F298_I0.8831.00
311_P320_Q0.8821.00
315_D318_Q0.8821.00
331_T337_V0.8811.00
306_P309_D0.8811.00
299_R302_D0.8801.00
331_T335_T0.8781.00
326_H329_V0.8741.00
327_P334_Y0.8691.00
310_P322_V0.8691.00
310_P315_D0.8681.00
59_M75_A0.8641.00
258_F304_C0.8591.00
313_V317_F0.8511.00
224_L267_V0.8501.00
226_L229_Q0.8451.00
311_P314_A0.8431.00
313_V319_A0.8411.00
331_T334_Y0.8411.00
174_N177_D0.8401.00
336_P339_H0.8351.00
148_D184_S0.8341.00
317_F322_V0.8341.00
74_I89_V0.8341.00
326_H335_T0.8331.00
126_R130_F0.8311.00
312_S323_V0.8261.00
165_K169_G0.8251.00
329_V336_P0.8231.00
316_T323_V0.8221.00
327_P338_F0.8161.00
206_L210_L0.8111.00
61_N75_A0.8101.00
10_A91_C0.8061.00
316_T320_Q0.8061.00
182_A189_D0.8021.00
233_T236_G0.8021.00
228_I298_I0.8021.00
329_V334_Y0.8011.00
11_V112_V0.8011.00
260_P302_D0.8011.00
15_V94_H0.7981.00
332_A335_T0.7981.00
16_D70_V0.7911.00
161_V173_F0.7901.00
268_K271_E0.7901.00
321_V325_Q0.7851.00
166_D169_G0.7851.00
311_P317_F0.7851.00
220_T282_P0.7841.00
330_I335_T0.7841.00
315_D322_V0.7821.00
312_S320_Q0.7741.00
334_Y339_H0.7721.00
6_H87_T0.7661.00
164_V172_G0.7661.00
243_G304_C0.7651.00
162_S165_K0.7651.00
129_V140_L0.7651.00
250_M256_V0.7641.00
327_P335_T0.7641.00
164_V168_F0.7641.00
4_N84_Y0.7631.00
329_V335_T0.7631.00
329_V333_G0.7631.00
13_G17_H0.7621.00
210_L213_L0.7601.00
311_P321_V0.7581.00
328_S333_G0.7571.00
26_L191_V0.7571.00
318_Q323_V0.7561.00
334_Y337_V0.7561.00
33_V38_I0.7501.00
113_L125_T0.7471.00
261_S299_R0.7461.00
121_V160_V0.7441.00
330_I338_F0.7421.00
78_E87_T0.7421.00
158_N182_A0.7391.00
22_M191_V0.7351.00
10_A111_A0.7341.00
63_A66_R0.7331.00
34_P38_I0.7311.00
9_L210_L0.7311.00
85_E284_D0.7241.00
157_Y160_V0.7231.00
14_H17_H0.7191.00
155_S159_E0.7181.00
330_I337_V0.7171.00
311_P318_Q0.7151.00
15_V71_T0.7131.00
324_M337_V0.7131.00
179_K212_G0.7131.00
218_P222_A0.7121.00
218_P247_T0.7111.00
110_N141_I0.7111.00
331_T336_P0.7101.00
332_A337_V0.7091.00
170_Q173_F0.7091.00
328_S332_A0.7081.00
12_I105_A0.7051.00
311_P316_T0.7051.00
327_P330_I0.7021.00
270_I280_A0.7021.00
333_G338_F0.7011.00
326_H333_G0.7011.00
234_I240_V0.7011.00
311_P319_A0.7001.00
351_S355_K0.6961.00
115_V142_V0.6941.00
85_E272_M0.6931.00
256_V265_G0.6911.00
82_D211_N0.6881.00
165_K174_N0.6871.00
311_P323_V0.6871.00
358_P361_G0.6861.00
339_H344_Q0.6841.00
163_G167_L0.6821.00
171_V178_A0.6811.00
172_G178_A0.6811.00
310_P324_M0.6791.00
220_T223_D0.6771.00
314_A319_A0.6761.00
55_F59_M0.6750.99
157_Y161_V0.6720.99
117_A155_S0.6700.99
233_T239_T0.6700.99
35_E39_E0.6660.99
226_L288_F0.6640.99
250_M280_A0.6630.99
67_E354_K0.6600.99
29_E188_G0.6550.99
316_T324_M0.6550.99
64_E67_E0.6530.99
10_A105_A0.6500.99
337_V344_Q0.6490.99
168_F172_G0.6480.99
143_A206_L0.6470.99
310_P316_T0.6470.99
114_V145_N0.6450.99
65_E69_G0.6440.99
312_S319_A0.6430.99
159_E162_S0.6420.99
252_T269_T0.6410.99
319_A324_M0.6410.99
28_Y35_E0.6400.99
183_T191_V0.6380.99
257_S305_G0.6370.99
161_V174_N0.6360.99
257_S308_D0.6320.99
332_A336_P0.6320.99
165_K170_Q0.6290.99
268_K272_M0.6290.99
329_V339_H0.6280.99
272_M284_D0.6270.99
353_D357_D0.6230.99
328_S336_P0.6230.99
314_A324_M0.6210.99
335_T339_H0.6210.99
252_T268_K0.6200.99
112_V206_L0.6200.99
311_P322_V0.6130.99
330_I334_Y0.6130.99
327_P337_V0.6110.99
340_A343_A0.6110.99
16_D69_G0.6100.99
234_I237_I0.6100.99
116_A149_V0.6090.99
311_P325_Q0.6080.99
263_V296_D0.6070.99
110_N214_P0.6060.99
175_P178_A0.6050.99
312_S317_F0.6050.99
70_V94_H0.6020.99
221_D249_V0.5950.99
27_L32_S0.5950.99
168_F171_V0.5930.99
348_T352_I0.5920.99
243_G280_A0.5890.99
316_T319_A0.5880.99
107_Q227_P0.5870.99
211_N214_P0.5860.99
328_S335_T0.5830.99
226_L230_D0.5830.99
313_V352_I0.5820.99
144_V161_V0.5820.99
232_Y287_G0.5820.99
326_H337_V0.5790.98
27_L77_Q0.5790.98
243_G250_M0.5780.98
277_V284_D0.5780.98
327_P333_G0.5770.98
27_L58_V0.5760.98
73_D100_N0.5740.98
349_I353_D0.5730.98
60_D69_G0.5720.98
14_H125_T0.5710.98
164_V167_L0.5710.98
187_E190_N0.5700.98
218_P282_P0.5700.98
26_L207_L0.5690.98
214_P217_Q0.5680.98
113_L128_H0.5670.98
182_A190_N0.5640.98
105_A135_L0.5630.98
95_R123_P0.5620.98
326_H334_Y0.5610.98
171_V180_F0.5590.98
223_D309_D0.5580.98
265_G298_I0.5580.98
312_S316_T0.5550.98
106_S246_E0.5550.98
116_A146_K0.5550.98
31_G34_P0.5530.98
326_H336_P0.5530.98
224_L306_P0.5530.98
229_Q242_V0.5520.98
115_V160_V0.5520.98
115_V164_V0.5520.98
265_G271_E0.5510.98
113_L164_V0.5500.98
112_V210_L0.5490.98
352_I355_K0.5490.98
312_S315_D0.5470.98
91_C101_M0.5460.98
357_D360_S0.5460.98
188_G191_V0.5430.98
7_Q216_P0.5430.98
333_G339_H0.5420.98
265_G268_K0.5420.98
15_V70_V0.5400.98
207_L210_L0.5370.98
241_P288_F0.5360.97
57_Y66_R0.5350.97
14_H122_A0.5340.97
99_K323_V0.5340.97
60_D66_R0.5340.97
328_S334_Y0.5330.97
26_L30_T0.5320.97
313_V324_M0.5310.97
234_I238_G0.5310.97
125_T142_V0.5310.97
206_L209_A0.5300.97
249_V282_P0.5290.97
332_A338_F0.5280.97
6_H284_D0.5250.97
165_K180_F0.5250.97
102_I128_H0.5250.97
271_E289_N0.5230.97
28_Y188_G0.5230.97
30_T80_T0.5220.97
16_D146_K0.5220.97
118_D151_D0.5200.97
250_M270_I0.5200.97
66_R69_G0.5170.97
165_K168_F0.5170.97
17_H119_D0.5160.97
331_T338_F0.5110.97
224_L249_V0.5080.97
110_N210_L0.5080.97
133_R168_F0.5080.97
74_I104_G0.5070.96
312_S322_V0.5040.96
29_E191_V0.5040.96
172_G179_K0.5040.96
326_H332_A0.5040.96
32_S79_F0.5010.96
73_D77_Q0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jnyA 1 0.9667 100 0.187 Contact Map
1f60A 1 0.9952 100 0.196 Contact Map
4crnP 1 0.9905 100 0.203 Contact Map
4d61i 1 0.9881 100 0.205 Contact Map
3wy9A 1 0.9667 100 0.209 Contact Map
1r5bA 1 0.8955 100 0.214 Contact Map
3p26A 1 0.9359 100 0.224 Contact Map
3mcaA 1 0.8266 100 0.225 Contact Map
3izq1 1 0.9952 100 0.226 Contact Map
1zunB 1 0.924 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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