Q9HM88 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HM88 - Homoserine dehydrogenase

UniProt:	Q9HM88	Sequences: MRLAVMGAGAVGQAVVDQAASHGHTVVAVADSTSAVVDGSGVDAAAVCARKRDAASEIGTGAPSDALAADYDVLVEATPTTLGDAEPGFGHVERALSADRHVVLANKGPVAERYAGVCELAAASAGSLRFEATVGGAIPVLATIERIGADRVRAVRGVLNGTANFVLSRMAAAGLEYEHVLAEAQEVGVAEADPTFDVDGTDAALKCAILANVIGDREYDLDGVSVDGITGVAPSALELAETDGQTIRLIGEVGPDHVRVGPRLVPANGTLAVSGTTNIVQLETEHAGRLNLSGQGAGGAATASAVLADVDHIADQQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (307)
Sequences:	3866 (2318)
Seq/√Len:	132.3

ECOLI - AK1H AK2H
BACSU - DHOM
HALSA - Q9HM88
SULSO - Q7LXP8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_D	230_T	6.216	1.00
169_R	173_A	4.545	1.00
86_E	90_G	3.781	1.00
177_Y	198_V	3.669	1.00
93_E	120_L	3.503	1.00
182_A	186_E	3.004	1.00
117_V	128_L	2.988	1.00
62_A	65_D	2.750	1.00
176_E	179_H	2.578	1.00
175_L	180_V	2.556	1.00
195_T	199_D	2.538	1.00
2_R	35_A	2.503	1.00
154_A	254_G	2.488	1.00
93_E	116_G	2.391	1.00
183_E	186_E	2.307	1.00
207_C	251_G	2.249	1.00
137_A	287_A	2.195	1.00
165_F	183_E	2.173	1.00
14_A	299_G	2.112	1.00
89_F	93_E	2.104	1.00
175_L	183_E	2.103	1.00
79_P	310_V	2.093	1.00
64_S	94_R	2.076	1.00
96_L	126_G	2.068	1.00
17_D	299_G	2.049	1.00
15_V	307_L	2.024	1.00
119_E	123_A	2.010	1.00
151_R	285_E	1.993	1.00
93_E	97_S	1.875	1.00
277_T	295_Q	1.846	1.00
284_T	287_A	1.828	1.00
18_Q	303_A	1.827	1.00
153_R	283_E	1.826	1.00
189_V	276_T	1.823	1.00
246_T	267_A	1.808	1.00
110_V	128_L	1.795	1.00
182_A	185_Q	1.777	1.00
150_D	285_E	1.771	1.00
110_V	209_I	1.768	1.00
245_Q	264_L	1.764	1.00
5_V	16_V	1.739	1.00
143_T	292_L	1.730	1.00
227_D	261_G	1.692	1.00
207_C	258_V	1.669	1.00
97_S	120_L	1.664	1.00
241_E	267_A	1.650	1.00
16_V	36_V	1.649	1.00
92_V	109_P	1.631	1.00
92_V	102_V	1.625	1.00
101_H	126_G	1.623	1.00
120_L	124_S	1.618	1.00
140_V	282_L	1.617	1.00
154_A	283_E	1.615	1.00
17_D	21_S	1.611	1.00
87_P	90_G	1.608	1.00
27_V	33_T	1.572	1.00
269_G	281_Q	1.564	1.00
97_S	124_S	1.564	1.00
26_V	44_A	1.561	1.00
46_A	51_K	1.535	1.00
220_D	223_G	1.535	1.00
113_R	116_G	1.529	1.00
243_D	264_L	1.513	1.00
158_V	273_V	1.510	1.00
162_T	190_A	1.506	1.00
283_E	289_R	1.492	1.00
176_E	180_V	1.483	1.00
96_L	120_L	1.483	1.00
211_A	258_V	1.481	1.00
196_F	205_L	1.475	1.00
183_E	187_V	1.474	1.00
208_A	224_V	1.465	1.00
169_R	183_E	1.450	1.00
148_G	311_D	1.444	1.00
115_A	218_E	1.439	1.00
234_P	238_E	1.422	1.00
101_H	313_I	1.416	1.00
254_G	257_H	1.412	1.00
175_L	179_H	1.406	1.00
18_Q	286_H	1.403	1.00
16_V	20_A	1.396	1.00
245_Q	266_P	1.394	1.00
101_H	127_S	1.381	1.00
94_R	98_A	1.370	1.00
204_A	226_V	1.366	1.00
201_T	226_V	1.364	1.00
171_A	246_T	1.355	1.00
204_A	221_L	1.334	1.00
96_L	128_L	1.329	1.00
169_R	180_V	1.325	1.00
276_T	295_Q	1.319	1.00
97_S	123_A	1.315	1.00
92_V	128_L	1.308	1.00
215_G	253_V	1.307	1.00
42_V	45_A	1.288	1.00
14_A	300_A	1.286	1.00
46_A	49_A	1.285	1.00
211_A	253_V	1.281	1.00
169_R	175_L	1.281	1.00
93_E	117_V	1.278	1.00
8_A	16_V	1.273	1.00
166_V	181_L	1.272	1.00
282_L	292_L	1.269	1.00
240_A	264_L	1.264	1.00
240_A	247_I	1.262	1.00
252_E	261_G	1.259	1.00
277_T	293_S	1.250	1.00
103_V	310_V	1.246	1.00
252_E	259_R	1.242	1.00
43_D	46_A	1.237	1.00
163_A	203_A	1.232	1.00
94_R	97_S	1.232	1.00
273_V	293_S	1.232	1.00
142_A	146_R	1.228	1.00
287_A	290_L	1.228	1.00
278_N	297_A	1.225	1.00
15_V	310_V	1.224	1.00
142_A	312_H	1.209	1.00
177_Y	181_L	1.206	1.00
13_Q	299_G	1.203	0.99
156_R	281_Q	1.200	0.99
171_A	237_L	1.198	0.99
2_R	76_E	1.195	0.99
26_V	311_D	1.187	0.99
59_G	62_A	1.178	0.99
135_G	138_I	1.178	0.99
89_F	113_R	1.174	0.99
156_R	269_G	1.171	0.99
207_C	253_V	1.171	0.99
129_R	313_I	1.159	0.99
151_R	255_P	1.151	0.99
235_S	239_L	1.141	0.99
185_Q	190_A	1.137	0.99
81_T	306_V	1.132	0.99
115_A	119_E	1.132	0.99
144_I	152_V	1.103	0.99
44_A	51_K	1.098	0.99
171_A	241_E	1.089	0.99
15_V	303_A	1.086	0.99
99_D	124_S	1.081	0.99
281_Q	291_N	1.081	0.99
108_G	196_F	1.081	0.99
108_G	205_L	1.079	0.99
252_E	263_R	1.064	0.99
135_G	280_V	1.062	0.99
174_G	234_P	1.061	0.99
96_L	117_V	1.059	0.99
228_G	249_L	1.055	0.99
64_S	67_L	1.054	0.99
159_L	207_C	1.052	0.99
189_V	275_G	1.050	0.99
71_Y	94_R	1.039	0.99
48_C	51_K	1.036	0.98
96_L	102_V	1.033	0.98
307_L	310_V	1.032	0.98
238_E	242_T	1.032	0.98
2_R	40_S	1.027	0.98
50_R	54_A	1.025	0.98
246_T	274_S	1.025	0.98
87_P	91_H	1.023	0.98
181_L	190_A	1.018	0.98
161_G	297_A	1.016	0.98
155_V	210_L	1.009	0.98
6_M	66_A	1.004	0.98
225_S	261_G	1.003	0.98
153_R	285_E	0.999	0.98
23_G	33_T	0.998	0.98
3_L	310_V	0.998	0.98
112_E	222_D	0.990	0.98
180_V	183_E	0.988	0.98
25_T	29_V	0.987	0.98
150_D	304_S	0.980	0.98
6_M	91_H	0.974	0.98
278_N	296_G	0.971	0.98
250_I	263_R	0.969	0.98
132_A	305_A	0.964	0.98
120_L	123_A	0.964	0.98
229_I	249_L	0.961	0.98
2_R	74_L	0.958	0.97
26_V	29_V	0.957	0.97
219_Y	258_V	0.943	0.97
46_A	50_R	0.938	0.97
238_E	241_E	0.934	0.97
30_A	33_T	0.931	0.97
244_G	267_A	0.925	0.97
86_E	89_F	0.910	0.97
227_D	231_G	0.909	0.97
99_D	126_G	0.908	0.97
286_H	300_A	0.908	0.97
85_A	112_E	0.907	0.96
208_A	221_L	0.905	0.96
273_V	279_I	0.900	0.96
59_G	66_A	0.898	0.96
44_A	47_V	0.896	0.96
165_F	169_R	0.892	0.96
161_G	296_G	0.890	0.96
75_V	100_R	0.889	0.96
90_G	94_R	0.887	0.96
163_A	249_L	0.887	0.96
8_A	13_Q	0.885	0.96
117_V	120_L	0.879	0.96
166_V	177_Y	0.878	0.96
211_A	224_V	0.877	0.96
155_V	207_C	0.874	0.96
149_A	308_A	0.874	0.96
43_D	63_P	0.871	0.96
288_G	295_Q	0.866	0.95
227_D	259_R	0.866	0.95
77_A	310_V	0.862	0.95
63_P	95_A	0.860	0.95
270_T	291_N	0.859	0.95
130_F	213_V	0.857	0.95
225_S	259_R	0.857	0.95
171_A	274_S	0.854	0.95
127_S	313_I	0.854	0.95
72_D	75_V	0.853	0.95
225_S	257_H	0.852	0.95
79_P	103_V	0.849	0.95
294_G	297_A	0.847	0.95
176_E	234_P	0.834	0.94
196_F	201_T	0.833	0.94
18_Q	300_A	0.830	0.94
40_S	72_D	0.826	0.94
17_D	48_C	0.822	0.94
96_L	124_S	0.821	0.94
266_P	272_A	0.817	0.94
246_T	272_A	0.815	0.94
42_V	46_A	0.813	0.94
211_A	219_Y	0.802	0.93
22_H	26_V	0.798	0.93
155_V	214_I	0.797	0.93
43_D	51_K	0.797	0.93
71_Y	98_A	0.796	0.93
41_G	44_A	0.793	0.93
185_Q	194_P	0.791	0.93
55_A	58_I	0.783	0.92
177_Y	230_T	0.780	0.92
232_V	236_A	0.779	0.92
253_V	258_V	0.779	0.92
284_T	290_L	0.778	0.92
114_Y	118_C	0.778	0.92
281_Q	289_R	0.777	0.92
134_V	141_L	0.776	0.92
31_D	34_S	0.772	0.92
20_A	23_G	0.766	0.91
63_P	66_A	0.762	0.91
150_D	287_A	0.759	0.91
156_R	252_E	0.759	0.91
169_R	275_G	0.751	0.91
164_N	248_R	0.751	0.91
17_D	300_A	0.751	0.91
279_I	291_N	0.751	0.91
289_R	295_Q	0.751	0.91
118_C	128_L	0.749	0.91
45_A	50_R	0.748	0.91
95_A	102_V	0.746	0.90
3_L	34_S	0.744	0.90
22_H	285_E	0.743	0.90
146_R	312_H	0.741	0.90
103_V	313_I	0.739	0.90
275_G	295_Q	0.736	0.90
136_G	301_A	0.735	0.90
179_H	182_A	0.733	0.90
121_A	126_G	0.730	0.89
10_A	299_G	0.730	0.89
64_S	71_Y	0.729	0.89
45_A	53_D	0.728	0.89
247_I	264_L	0.727	0.89
50_R	53_D	0.726	0.89
63_P	91_H	0.725	0.89
133_T	209_I	0.720	0.89
61_G	65_D	0.719	0.89
44_A	49_A	0.718	0.89
265_V	271_L	0.715	0.88
278_N	294_G	0.713	0.88
43_D	91_H	0.711	0.88
2_R	75_V	0.711	0.88
150_D	284_T	0.709	0.88
73_V	100_R	0.707	0.88
201_T	205_L	0.707	0.88
49_A	53_D	0.703	0.88
278_N	298_G	0.702	0.88
21_S	300_A	0.700	0.87
163_A	207_C	0.698	0.87
273_V	291_N	0.696	0.87
161_G	278_N	0.693	0.87
161_G	294_G	0.690	0.87
141_L	145_E	0.688	0.86
269_G	291_N	0.687	0.86
195_T	230_T	0.677	0.86
269_G	272_A	0.676	0.85
207_C	211_A	0.671	0.85
171_A	174_G	0.670	0.85
18_Q	307_L	0.669	0.85
267_A	272_A	0.669	0.85
60_T	65_D	0.665	0.85
89_F	109_P	0.664	0.84
201_T	230_T	0.663	0.84
265_V	269_G	0.663	0.84
178_E	230_T	0.662	0.84
282_L	290_L	0.659	0.84
43_D	48_C	0.659	0.84
67_L	94_R	0.659	0.84
140_V	292_L	0.657	0.84
163_A	205_L	0.656	0.84
227_D	236_A	0.656	0.84
29_V	47_V	0.653	0.83
308_A	312_H	0.653	0.83
142_A	308_A	0.652	0.83
51_K	54_A	0.652	0.83
47_V	61_G	0.650	0.83
121_A	124_S	0.650	0.83
143_T	290_L	0.648	0.83
95_A	174_G	0.648	0.83
44_A	50_R	0.642	0.82
66_A	78_T	0.641	0.82
55_A	59_G	0.639	0.82
239_L	243_D	0.638	0.82
13_Q	48_C	0.636	0.82
178_E	182_A	0.634	0.82
161_G	298_G	0.634	0.82
271_L	279_I	0.634	0.82
109_P	114_Y	0.632	0.81
45_A	49_A	0.631	0.81
267_A	270_T	0.631	0.81
66_A	72_D	0.630	0.81
208_A	212_N	0.628	0.81
4_A	63_P	0.625	0.81
311_D	315_D	0.625	0.81
138_I	292_L	0.622	0.80
132_A	303_A	0.619	0.80
208_A	219_Y	0.619	0.80
41_G	72_D	0.618	0.80
141_L	212_N	0.617	0.80
20_A	36_V	0.615	0.80
43_D	60_T	0.615	0.80
45_A	51_K	0.614	0.80
112_E	221_L	0.614	0.80
85_A	92_V	0.610	0.79
15_V	19_A	0.608	0.79
146_R	308_A	0.607	0.79
60_T	66_A	0.606	0.79
48_C	52_R	0.606	0.79
112_E	201_T	0.605	0.79
284_T	292_L	0.604	0.78
165_F	168_S	0.604	0.78
201_T	221_L	0.603	0.78
140_V	280_V	0.602	0.78
73_V	98_A	0.601	0.78
4_A	66_A	0.600	0.78
270_T	281_Q	0.600	0.78
30_A	34_S	0.599	0.78
129_R	312_H	0.598	0.78
192_A	195_T	0.598	0.78
21_S	285_E	0.597	0.78
79_P	95_A	0.596	0.78
72_D	76_E	0.595	0.77
96_L	121_A	0.593	0.77
152_V	155_V	0.592	0.77
13_Q	17_D	0.590	0.77
152_V	284_T	0.589	0.77
185_Q	198_V	0.588	0.77
85_A	109_P	0.588	0.77
45_A	48_C	0.588	0.77
224_V	258_V	0.587	0.77
239_L	264_L	0.587	0.77
205_L	221_L	0.585	0.76
41_G	45_A	0.585	0.76
96_L	100_R	0.582	0.76
136_G	192_A	0.581	0.76
265_V	272_A	0.581	0.76
72_D	100_R	0.580	0.76
8_A	53_D	0.580	0.76
62_A	67_L	0.578	0.75
159_L	280_V	0.577	0.75
140_V	143_T	0.576	0.75
85_A	113_R	0.575	0.75
203_A	251_G	0.572	0.75
310_V	313_I	0.570	0.74
93_E	113_R	0.569	0.74
44_A	59_G	0.568	0.74
43_D	50_R	0.567	0.74
170_M	180_V	0.565	0.74
105_A	192_A	0.565	0.74
34_S	77_A	0.564	0.74
195_T	201_T	0.564	0.74
235_S	238_E	0.563	0.74
42_V	51_K	0.563	0.74
51_K	55_A	0.562	0.73
67_L	91_H	0.560	0.73
155_V	280_V	0.559	0.73
150_D	290_L	0.558	0.73
168_S	274_S	0.557	0.73
137_A	288_G	0.556	0.73
237_L	246_T	0.556	0.73
189_V	297_A	0.556	0.73
10_A	14_A	0.555	0.72
11_V	203_A	0.555	0.72
19_A	23_G	0.553	0.72
137_A	295_Q	0.553	0.72
48_C	61_G	0.553	0.72
114_Y	117_V	0.553	0.72
63_P	67_L	0.553	0.72
228_G	262_P	0.552	0.72
40_S	45_A	0.551	0.72
136_G	305_A	0.551	0.72
23_G	27_V	0.548	0.72
297_A	302_T	0.548	0.72
276_T	301_A	0.548	0.72
296_G	302_T	0.547	0.71
58_I	62_A	0.543	0.71
89_F	120_L	0.543	0.71
100_R	126_G	0.542	0.71
189_V	278_N	0.541	0.71
75_V	78_T	0.541	0.71
168_S	276_T	0.540	0.70
11_V	192_A	0.540	0.70
81_T	105_A	0.537	0.70
118_C	130_F	0.537	0.70
17_D	52_R	0.536	0.70
294_G	298_G	0.532	0.69
81_T	205_L	0.532	0.69
16_V	29_V	0.530	0.69
88_G	92_V	0.530	0.69
61_G	64_S	0.528	0.69
107_K	202_D	0.528	0.69
234_P	237_L	0.526	0.68
236_A	239_L	0.526	0.68
236_A	264_L	0.525	0.68
40_S	74_L	0.524	0.68
199_D	226_V	0.524	0.68
277_T	291_N	0.524	0.68
43_D	49_A	0.524	0.68
98_A	126_G	0.520	0.68
173_A	183_E	0.519	0.67
120_L	126_G	0.519	0.67
179_H	186_E	0.518	0.67
27_V	30_A	0.518	0.67
62_A	66_A	0.518	0.67
89_F	116_G	0.516	0.67
110_V	130_F	0.515	0.67
4_A	41_G	0.514	0.67
149_A	304_S	0.514	0.67
110_V	118_C	0.514	0.67
189_V	296_G	0.512	0.66
135_G	143_T	0.512	0.66
47_V	51_K	0.511	0.66
108_G	112_E	0.510	0.66
110_V	196_F	0.510	0.66
33_T	238_E	0.509	0.66
159_L	258_V	0.509	0.66
205_L	226_V	0.508	0.66
144_I	282_L	0.508	0.66
92_V	96_L	0.506	0.65
105_A	132_A	0.505	0.65
67_L	98_A	0.504	0.65
295_Q	301_A	0.503	0.65
159_L	210_L	0.503	0.65
158_V	164_N	0.503	0.65
13_Q	53_D	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ebfA	2	0.9842	100	0.284	Contact Map
3do5A	2	0.9653	100	0.287	Contact Map
4pg7A	2	0.9148	100	0.31	Contact Map
3ingA	2	0.9495	100	0.318	Contact Map
2ejwA	2	0.9243	100	0.332	Contact Map
3mtjA	3	0.9495	100	0.364	Contact Map
3c8mA	2	0.9495	100	0.388	Contact Map
4xb1A	2	0.9432	100	0.391	Contact Map
3wycA	2	0.877	99.9	0.748	Contact Map
3uplA	2	0.9369	99.9	0.751	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.