GREMLIN Database
Q9HM88 - Homoserine dehydrogenase
UniProt: Q9HM88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (307)
Sequences: 3866 (2318)
Seq/√Len: 132.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_D230_T6.2161.00
169_R173_A4.5451.00
86_E90_G3.7811.00
177_Y198_V3.6691.00
93_E120_L3.5031.00
182_A186_E3.0041.00
117_V128_L2.9881.00
62_A65_D2.7501.00
176_E179_H2.5781.00
175_L180_V2.5561.00
195_T199_D2.5381.00
2_R35_A2.5031.00
154_A254_G2.4881.00
93_E116_G2.3911.00
183_E186_E2.3071.00
207_C251_G2.2491.00
137_A287_A2.1951.00
165_F183_E2.1731.00
14_A299_G2.1121.00
89_F93_E2.1041.00
175_L183_E2.1031.00
79_P310_V2.0931.00
64_S94_R2.0761.00
96_L126_G2.0681.00
17_D299_G2.0491.00
15_V307_L2.0241.00
119_E123_A2.0101.00
151_R285_E1.9931.00
93_E97_S1.8751.00
277_T295_Q1.8461.00
284_T287_A1.8281.00
18_Q303_A1.8271.00
153_R283_E1.8261.00
189_V276_T1.8231.00
246_T267_A1.8081.00
110_V128_L1.7951.00
182_A185_Q1.7771.00
150_D285_E1.7711.00
110_V209_I1.7681.00
245_Q264_L1.7641.00
5_V16_V1.7391.00
143_T292_L1.7301.00
227_D261_G1.6921.00
207_C258_V1.6691.00
97_S120_L1.6641.00
241_E267_A1.6501.00
16_V36_V1.6491.00
92_V109_P1.6311.00
92_V102_V1.6251.00
101_H126_G1.6231.00
120_L124_S1.6181.00
140_V282_L1.6171.00
154_A283_E1.6151.00
17_D21_S1.6111.00
87_P90_G1.6081.00
27_V33_T1.5721.00
269_G281_Q1.5641.00
97_S124_S1.5641.00
26_V44_A1.5611.00
46_A51_K1.5351.00
220_D223_G1.5351.00
113_R116_G1.5291.00
243_D264_L1.5131.00
158_V273_V1.5101.00
162_T190_A1.5061.00
283_E289_R1.4921.00
176_E180_V1.4831.00
96_L120_L1.4831.00
211_A258_V1.4811.00
196_F205_L1.4751.00
183_E187_V1.4741.00
208_A224_V1.4651.00
169_R183_E1.4501.00
148_G311_D1.4441.00
115_A218_E1.4391.00
234_P238_E1.4221.00
101_H313_I1.4161.00
254_G257_H1.4121.00
175_L179_H1.4061.00
18_Q286_H1.4031.00
16_V20_A1.3961.00
245_Q266_P1.3941.00
101_H127_S1.3811.00
94_R98_A1.3701.00
204_A226_V1.3661.00
201_T226_V1.3641.00
171_A246_T1.3551.00
204_A221_L1.3341.00
96_L128_L1.3291.00
169_R180_V1.3251.00
276_T295_Q1.3191.00
97_S123_A1.3151.00
92_V128_L1.3081.00
215_G253_V1.3071.00
42_V45_A1.2881.00
14_A300_A1.2861.00
46_A49_A1.2851.00
211_A253_V1.2811.00
169_R175_L1.2811.00
93_E117_V1.2781.00
8_A16_V1.2731.00
166_V181_L1.2721.00
282_L292_L1.2691.00
240_A264_L1.2641.00
240_A247_I1.2621.00
252_E261_G1.2591.00
277_T293_S1.2501.00
103_V310_V1.2461.00
252_E259_R1.2421.00
43_D46_A1.2371.00
163_A203_A1.2321.00
94_R97_S1.2321.00
273_V293_S1.2321.00
142_A146_R1.2281.00
287_A290_L1.2281.00
278_N297_A1.2251.00
15_V310_V1.2241.00
142_A312_H1.2091.00
177_Y181_L1.2061.00
13_Q299_G1.2030.99
156_R281_Q1.2000.99
171_A237_L1.1980.99
2_R76_E1.1950.99
26_V311_D1.1870.99
59_G62_A1.1780.99
135_G138_I1.1780.99
89_F113_R1.1740.99
156_R269_G1.1710.99
207_C253_V1.1710.99
129_R313_I1.1590.99
151_R255_P1.1510.99
235_S239_L1.1410.99
185_Q190_A1.1370.99
81_T306_V1.1320.99
115_A119_E1.1320.99
144_I152_V1.1030.99
44_A51_K1.0980.99
171_A241_E1.0890.99
15_V303_A1.0860.99
99_D124_S1.0810.99
281_Q291_N1.0810.99
108_G196_F1.0810.99
108_G205_L1.0790.99
252_E263_R1.0640.99
135_G280_V1.0620.99
174_G234_P1.0610.99
96_L117_V1.0590.99
228_G249_L1.0550.99
64_S67_L1.0540.99
159_L207_C1.0520.99
189_V275_G1.0500.99
71_Y94_R1.0390.99
48_C51_K1.0360.98
96_L102_V1.0330.98
307_L310_V1.0320.98
238_E242_T1.0320.98
2_R40_S1.0270.98
50_R54_A1.0250.98
246_T274_S1.0250.98
87_P91_H1.0230.98
181_L190_A1.0180.98
161_G297_A1.0160.98
155_V210_L1.0090.98
6_M66_A1.0040.98
225_S261_G1.0030.98
153_R285_E0.9990.98
23_G33_T0.9980.98
3_L310_V0.9980.98
112_E222_D0.9900.98
180_V183_E0.9880.98
25_T29_V0.9870.98
150_D304_S0.9800.98
6_M91_H0.9740.98
278_N296_G0.9710.98
250_I263_R0.9690.98
132_A305_A0.9640.98
120_L123_A0.9640.98
229_I249_L0.9610.98
2_R74_L0.9580.97
26_V29_V0.9570.97
219_Y258_V0.9430.97
46_A50_R0.9380.97
238_E241_E0.9340.97
30_A33_T0.9310.97
244_G267_A0.9250.97
86_E89_F0.9100.97
227_D231_G0.9090.97
99_D126_G0.9080.97
286_H300_A0.9080.97
85_A112_E0.9070.96
208_A221_L0.9050.96
273_V279_I0.9000.96
59_G66_A0.8980.96
44_A47_V0.8960.96
165_F169_R0.8920.96
161_G296_G0.8900.96
75_V100_R0.8890.96
90_G94_R0.8870.96
163_A249_L0.8870.96
8_A13_Q0.8850.96
117_V120_L0.8790.96
166_V177_Y0.8780.96
211_A224_V0.8770.96
155_V207_C0.8740.96
149_A308_A0.8740.96
43_D63_P0.8710.96
288_G295_Q0.8660.95
227_D259_R0.8660.95
77_A310_V0.8620.95
63_P95_A0.8600.95
270_T291_N0.8590.95
130_F213_V0.8570.95
225_S259_R0.8570.95
171_A274_S0.8540.95
127_S313_I0.8540.95
72_D75_V0.8530.95
225_S257_H0.8520.95
79_P103_V0.8490.95
294_G297_A0.8470.95
176_E234_P0.8340.94
196_F201_T0.8330.94
18_Q300_A0.8300.94
40_S72_D0.8260.94
17_D48_C0.8220.94
96_L124_S0.8210.94
266_P272_A0.8170.94
246_T272_A0.8150.94
42_V46_A0.8130.94
211_A219_Y0.8020.93
22_H26_V0.7980.93
155_V214_I0.7970.93
43_D51_K0.7970.93
71_Y98_A0.7960.93
41_G44_A0.7930.93
185_Q194_P0.7910.93
55_A58_I0.7830.92
177_Y230_T0.7800.92
232_V236_A0.7790.92
253_V258_V0.7790.92
284_T290_L0.7780.92
114_Y118_C0.7780.92
281_Q289_R0.7770.92
134_V141_L0.7760.92
31_D34_S0.7720.92
20_A23_G0.7660.91
63_P66_A0.7620.91
150_D287_A0.7590.91
156_R252_E0.7590.91
169_R275_G0.7510.91
164_N248_R0.7510.91
17_D300_A0.7510.91
279_I291_N0.7510.91
289_R295_Q0.7510.91
118_C128_L0.7490.91
45_A50_R0.7480.91
95_A102_V0.7460.90
3_L34_S0.7440.90
22_H285_E0.7430.90
146_R312_H0.7410.90
103_V313_I0.7390.90
275_G295_Q0.7360.90
136_G301_A0.7350.90
179_H182_A0.7330.90
121_A126_G0.7300.89
10_A299_G0.7300.89
64_S71_Y0.7290.89
45_A53_D0.7280.89
247_I264_L0.7270.89
50_R53_D0.7260.89
63_P91_H0.7250.89
133_T209_I0.7200.89
61_G65_D0.7190.89
44_A49_A0.7180.89
265_V271_L0.7150.88
278_N294_G0.7130.88
43_D91_H0.7110.88
2_R75_V0.7110.88
150_D284_T0.7090.88
73_V100_R0.7070.88
201_T205_L0.7070.88
49_A53_D0.7030.88
278_N298_G0.7020.88
21_S300_A0.7000.87
163_A207_C0.6980.87
273_V291_N0.6960.87
161_G278_N0.6930.87
161_G294_G0.6900.87
141_L145_E0.6880.86
269_G291_N0.6870.86
195_T230_T0.6770.86
269_G272_A0.6760.85
207_C211_A0.6710.85
171_A174_G0.6700.85
18_Q307_L0.6690.85
267_A272_A0.6690.85
60_T65_D0.6650.85
89_F109_P0.6640.84
201_T230_T0.6630.84
265_V269_G0.6630.84
178_E230_T0.6620.84
282_L290_L0.6590.84
43_D48_C0.6590.84
67_L94_R0.6590.84
140_V292_L0.6570.84
163_A205_L0.6560.84
227_D236_A0.6560.84
29_V47_V0.6530.83
308_A312_H0.6530.83
142_A308_A0.6520.83
51_K54_A0.6520.83
47_V61_G0.6500.83
121_A124_S0.6500.83
143_T290_L0.6480.83
95_A174_G0.6480.83
44_A50_R0.6420.82
66_A78_T0.6410.82
55_A59_G0.6390.82
239_L243_D0.6380.82
13_Q48_C0.6360.82
178_E182_A0.6340.82
161_G298_G0.6340.82
271_L279_I0.6340.82
109_P114_Y0.6320.81
45_A49_A0.6310.81
267_A270_T0.6310.81
66_A72_D0.6300.81
208_A212_N0.6280.81
4_A63_P0.6250.81
311_D315_D0.6250.81
138_I292_L0.6220.80
132_A303_A0.6190.80
208_A219_Y0.6190.80
41_G72_D0.6180.80
141_L212_N0.6170.80
20_A36_V0.6150.80
43_D60_T0.6150.80
45_A51_K0.6140.80
112_E221_L0.6140.80
85_A92_V0.6100.79
15_V19_A0.6080.79
146_R308_A0.6070.79
60_T66_A0.6060.79
48_C52_R0.6060.79
112_E201_T0.6050.79
284_T292_L0.6040.78
165_F168_S0.6040.78
201_T221_L0.6030.78
140_V280_V0.6020.78
73_V98_A0.6010.78
4_A66_A0.6000.78
270_T281_Q0.6000.78
30_A34_S0.5990.78
129_R312_H0.5980.78
192_A195_T0.5980.78
21_S285_E0.5970.78
79_P95_A0.5960.78
72_D76_E0.5950.77
96_L121_A0.5930.77
152_V155_V0.5920.77
13_Q17_D0.5900.77
152_V284_T0.5890.77
185_Q198_V0.5880.77
85_A109_P0.5880.77
45_A48_C0.5880.77
224_V258_V0.5870.77
239_L264_L0.5870.77
205_L221_L0.5850.76
41_G45_A0.5850.76
96_L100_R0.5820.76
136_G192_A0.5810.76
265_V272_A0.5810.76
72_D100_R0.5800.76
8_A53_D0.5800.76
62_A67_L0.5780.75
159_L280_V0.5770.75
140_V143_T0.5760.75
85_A113_R0.5750.75
203_A251_G0.5720.75
310_V313_I0.5700.74
93_E113_R0.5690.74
44_A59_G0.5680.74
43_D50_R0.5670.74
170_M180_V0.5650.74
105_A192_A0.5650.74
34_S77_A0.5640.74
195_T201_T0.5640.74
235_S238_E0.5630.74
42_V51_K0.5630.74
51_K55_A0.5620.73
67_L91_H0.5600.73
155_V280_V0.5590.73
150_D290_L0.5580.73
168_S274_S0.5570.73
137_A288_G0.5560.73
237_L246_T0.5560.73
189_V297_A0.5560.73
10_A14_A0.5550.72
11_V203_A0.5550.72
19_A23_G0.5530.72
137_A295_Q0.5530.72
48_C61_G0.5530.72
114_Y117_V0.5530.72
63_P67_L0.5530.72
228_G262_P0.5520.72
40_S45_A0.5510.72
136_G305_A0.5510.72
23_G27_V0.5480.72
297_A302_T0.5480.72
276_T301_A0.5480.72
296_G302_T0.5470.71
58_I62_A0.5430.71
89_F120_L0.5430.71
100_R126_G0.5420.71
189_V278_N0.5410.71
75_V78_T0.5410.71
168_S276_T0.5400.70
11_V192_A0.5400.70
81_T105_A0.5370.70
118_C130_F0.5370.70
17_D52_R0.5360.70
294_G298_G0.5320.69
81_T205_L0.5320.69
16_V29_V0.5300.69
88_G92_V0.5300.69
61_G64_S0.5280.69
107_K202_D0.5280.69
234_P237_L0.5260.68
236_A239_L0.5260.68
236_A264_L0.5250.68
40_S74_L0.5240.68
199_D226_V0.5240.68
277_T291_N0.5240.68
43_D49_A0.5240.68
98_A126_G0.5200.68
173_A183_E0.5190.67
120_L126_G0.5190.67
179_H186_E0.5180.67
27_V30_A0.5180.67
62_A66_A0.5180.67
89_F116_G0.5160.67
110_V130_F0.5150.67
4_A41_G0.5140.67
149_A304_S0.5140.67
110_V118_C0.5140.67
189_V296_G0.5120.66
135_G143_T0.5120.66
47_V51_K0.5110.66
108_G112_E0.5100.66
110_V196_F0.5100.66
33_T238_E0.5090.66
159_L258_V0.5090.66
205_L226_V0.5080.66
144_I282_L0.5080.66
92_V96_L0.5060.65
105_A132_A0.5050.65
67_L98_A0.5040.65
295_Q301_A0.5030.65
159_L210_L0.5030.65
158_V164_N0.5030.65
13_Q53_D0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ebfA 2 0.9842 100 0.284 Contact Map
3do5A 2 0.9653 100 0.287 Contact Map
4pg7A 2 0.9148 100 0.31 Contact Map
3ingA 2 0.9495 100 0.318 Contact Map
2ejwA 2 0.9243 100 0.332 Contact Map
3mtjA 3 0.9495 100 0.364 Contact Map
3c8mA 2 0.9495 100 0.388 Contact Map
4xb1A 2 0.9432 100 0.391 Contact Map
3wycA 2 0.877 99.9 0.748 Contact Map
3uplA 2 0.9369 99.9 0.751 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0107 seconds.