GREMLIN Database
Q9HM87 - Uncharacterized protein
UniProt: Q9HM87 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 443 (345)
Sequences: 4157 (2710)
Seq/√Len: 145.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
276_W280_R5.3601.00
355_S385_N4.6551.00
303_T307_D4.6161.00
335_A342_M3.7631.00
298_V394_E3.2841.00
217_V327_F3.1631.00
328_E344_T3.0551.00
299_F331_V2.8891.00
326_K330_F2.7671.00
283_R287_E2.7281.00
352_K361_G2.6931.00
177_A188_L2.6481.00
16_K337_W2.6431.00
237_Y317_R2.5671.00
363_R382_A2.5531.00
349_Y352_K2.5501.00
345_V390_I2.5371.00
326_K329_T2.4701.00
350_N390_I2.3881.00
393_R396_L2.3871.00
286_V335_A2.3411.00
309_I320_H2.3391.00
297_I335_A2.3211.00
175_G193_T2.2851.00
327_F331_V2.2701.00
332_S344_T2.2701.00
312_G316_N2.1621.00
279_H330_F2.1271.00
279_H333_Y2.1161.00
362_S365_G2.1041.00
48_R52_Q2.1031.00
243_E260_T2.0861.00
46_T77_V2.0821.00
299_F342_M2.0601.00
313_T316_N2.0591.00
357_C375_C2.0411.00
352_K360_R2.0371.00
25_A28_E2.0141.00
295_P340_I1.9461.00
354_C357_C1.9451.00
33_H181_Y1.9451.00
51_Q107_P1.9431.00
370_C375_C1.9371.00
354_C375_C1.9341.00
33_H186_Y1.9311.00
34_D67_D1.9191.00
217_V277_V1.9181.00
369_R379_Q1.8851.00
275_E326_K1.8741.00
282_S330_F1.8701.00
47_I80_A1.8631.00
21_R185_V1.8541.00
368_F380_D1.8451.00
246_R250_I1.8301.00
357_C370_C1.8271.00
210_V218_A1.8271.00
260_T263_H1.8211.00
279_H334_K1.8181.00
354_C370_C1.7761.00
332_S336_T1.7721.00
279_H282_S1.7621.00
32_L186_Y1.7161.00
356_C378_V1.7151.00
236_D273_F1.6621.00
255_Q258_G1.6451.00
278_L330_F1.6361.00
17_T189_H1.6301.00
278_L326_K1.5811.00
300_E347_A1.5661.00
299_F328_E1.5391.00
299_F344_T1.5261.00
207_L391_A1.5121.00
60_Q63_V1.5121.00
182_R268_D1.4891.00
220_T224_R1.4861.00
301_D344_T1.4611.00
282_S333_Y1.4611.00
253_R257_H1.4511.00
367_R379_Q1.4301.00
41_E64_D1.4291.00
368_F378_V1.4241.00
282_S327_F1.4091.00
319_L324_F1.4031.00
46_T80_A1.4031.00
90_L105_P1.3951.00
84_W107_P1.3941.00
30_S34_D1.3791.00
282_S334_K1.3741.00
29_R33_H1.3731.00
216_N219_L1.3641.00
228_R231_G1.3521.00
208_V220_T1.3501.00
219_L384_R1.3491.00
185_V268_D1.3411.00
36_R186_Y1.3391.00
268_D272_R1.3281.00
236_D270_E1.3191.00
388_V392_W1.3181.00
258_G261_S1.3071.00
355_S388_V1.3031.00
81_L85_N1.3031.00
250_I260_T1.2991.00
75_A78_G1.2991.00
39_S76_V1.2961.00
183_D268_D1.2761.00
363_R366_R1.2751.00
51_Q55_N1.2531.00
366_R382_A1.2371.00
243_E266_L1.2211.00
384_R388_V1.2181.00
85_N89_S1.2101.00
71_N122_H1.2071.00
221_A387_S1.1971.00
303_T347_A1.1951.00
282_S331_V1.1801.00
355_S380_D1.1791.00
350_N393_R1.1731.00
283_R338_R1.1721.00
71_N124_E1.1711.00
43_F76_V1.1691.00
18_I192_V1.1611.00
330_F333_Y1.1601.00
52_Q56_R1.1531.00
332_S342_M1.1521.00
26_S29_R1.1501.00
210_V220_T1.1491.00
86_S105_P1.1360.99
286_V338_R1.1280.99
361_G365_G1.1270.99
204_S295_P1.1270.99
209_G391_A1.1250.99
74_C78_G1.1240.99
150_K156_E1.1230.99
305_I325_H1.1220.99
212_I328_E1.1220.99
219_L225_E1.1170.99
19_Q182_R1.1140.99
89_S104_K1.1070.99
214_E322_L1.1070.99
278_L327_F1.1050.99
168_T172_I1.1020.99
285_V297_I1.1000.99
82_Q86_S1.0920.99
87_Y107_P1.0880.99
361_G368_F1.0870.99
353_T393_R1.0780.99
69_L72_N1.0770.99
212_I324_F1.0600.99
47_I84_W1.0550.99
79_K120_M1.0430.99
275_E330_F1.0420.99
334_K337_W1.0370.99
86_S89_S1.0350.99
301_D347_A1.0340.99
140_R156_E1.0270.99
250_I254_C1.0260.99
309_I312_G1.0250.99
150_K153_L1.0250.99
247_Y260_T1.0210.99
239_R243_E1.0170.99
298_V390_I1.0160.99
207_L296_V1.0150.99
243_E246_R1.0150.99
180_L189_H1.0070.99
207_L395_T1.0040.99
243_E263_H0.9950.99
50_K81_L0.9890.99
65_R73_K0.9880.99
278_L282_S0.9860.98
329_T332_S0.9860.98
24_I28_E0.9840.98
355_S378_V0.9830.98
287_E338_R0.9830.98
118_L121_A0.9810.98
271_E275_E0.9730.98
380_D384_R0.9690.98
365_G368_F0.9680.98
137_V188_L0.9660.98
86_S90_L0.9650.98
345_V393_R0.9640.98
71_N75_A0.9630.98
345_V394_E0.9600.98
182_R185_V0.9550.98
256_E259_K0.9530.98
48_R110_T0.9520.98
363_R368_F0.9480.98
208_V221_A0.9450.98
51_Q84_W0.9380.98
29_R186_Y0.9370.98
355_S386_A0.9350.98
286_V297_I0.9250.98
353_T389_N0.9240.98
207_L298_V0.9230.98
312_G315_M0.9220.98
24_I32_L0.9190.98
75_A79_K0.9160.98
233_L236_D0.9160.98
355_S392_W0.9110.97
41_E45_Q0.9110.97
211_D383_D0.9100.97
43_F83_T0.9100.97
79_K178_E0.9100.97
335_A340_I0.9090.97
151_G156_E0.9070.97
240_V267_G0.9050.97
86_S104_K0.9040.97
71_N74_C0.9030.97
53_G57_T0.9020.97
208_V297_I0.9000.97
244_R248_H0.9000.97
127_R130_V0.8980.97
380_D388_V0.8970.97
325_H329_T0.8930.97
349_Y393_R0.8930.97
254_C257_H0.8910.97
347_A350_N0.8870.97
77_V81_L0.8850.97
20_T188_L0.8800.97
368_F382_A0.8800.97
301_D328_E0.8790.97
286_V340_I0.8720.97
206_T295_P0.8720.97
225_E381_H0.8700.97
253_R258_G0.8640.97
266_L270_E0.8540.96
43_F80_A0.8500.96
54_Y58_E0.8500.96
37_L40_R0.8470.96
214_E309_I0.8460.96
247_Y263_H0.8450.96
54_Y84_W0.8450.96
49_L53_G0.8430.96
21_R187_Y0.8410.96
278_L323_P0.8370.96
224_R284_A0.8350.96
215_R219_L0.8310.96
138_R152_H0.8300.96
214_E318_R0.8300.96
356_C388_V0.8290.96
240_V263_H0.8290.96
367_R380_D0.8270.96
393_R397_K0.8260.96
277_V281_L0.8230.95
124_E127_R0.8200.95
232_T273_F0.8200.95
366_R381_H0.8200.95
154_R157_P0.8190.95
309_I316_N0.8180.95
362_S382_A0.8170.95
296_V343_D0.8160.95
247_Y250_I0.8100.95
244_R263_H0.8090.95
283_R334_K0.8060.95
246_R249_T0.8060.95
240_V248_H0.8030.95
34_D38_A0.8020.95
22_L188_L0.7960.95
296_V341_P0.7950.94
385_N389_N0.7940.94
328_E332_S0.7930.94
69_L121_A0.7920.94
68_F73_K0.7920.94
49_L52_Q0.7920.94
262_I265_K0.7920.94
225_E384_R0.7910.94
185_V272_R0.7910.94
241_K244_R0.7900.94
45_Q49_L0.7850.94
386_A389_N0.7820.94
151_G154_R0.7810.94
396_L399_D0.7810.94
212_I218_A0.7800.94
126_Y130_V0.7780.94
242_E246_R0.7780.94
181_Y186_Y0.7780.94
87_Y108_P0.7780.94
84_W87_Y0.7770.94
38_A64_D0.7720.94
152_H156_E0.7720.94
313_T320_H0.7690.93
218_A281_L0.7670.93
178_E189_H0.7650.93
384_R387_S0.7610.93
221_A225_E0.7610.93
251_T257_H0.7590.93
335_A338_R0.7570.93
216_N225_E0.7540.93
388_V391_A0.7520.93
221_A384_R0.7490.93
364_Q382_A0.7440.92
215_R366_R0.7430.92
80_A84_W0.7430.92
179_L188_L0.7410.92
281_L284_A0.7410.92
38_A68_F0.7410.92
120_M176_Q0.7380.92
287_E296_V0.7350.92
361_G382_A0.7340.92
269_D273_F0.7340.92
305_I324_F0.7320.92
343_D394_E0.7310.92
122_H126_Y0.7300.92
218_A327_F0.7280.91
395_T399_D0.7270.91
201_P204_S0.7270.91
312_G320_H0.7260.91
217_V322_L0.7210.91
37_L41_E0.7210.91
35_A39_S0.7130.91
38_A41_E0.7130.91
50_K84_W0.7090.90
315_M319_L0.7090.90
394_E398_L0.7080.90
73_K76_V0.7070.90
352_K362_S0.7050.90
302_M347_A0.7050.90
349_Y353_T0.7040.90
35_A69_L0.7030.90
106_T109_S0.7020.90
90_L106_T0.7010.90
241_K245_Q0.6990.90
90_L104_K0.6990.90
176_Q191_T0.6950.89
307_D347_A0.6950.89
35_A68_F0.6940.89
84_W88_Q0.6870.89
125_G140_R0.6860.89
205_D295_P0.6830.89
68_F71_N0.6820.89
71_N123_A0.6820.89
390_I393_R0.6810.89
208_V222_L0.6770.88
298_V343_D0.6760.88
42_I73_K0.6750.88
172_I192_V0.6740.88
91_K105_P0.6740.88
161_D164_R0.6740.88
353_T368_F0.6730.88
211_D351_S0.6730.88
50_K53_G0.6720.88
208_V294_N0.6720.88
380_D385_N0.6710.88
31_W35_A0.6700.88
252_T257_H0.6700.88
42_I76_V0.6700.88
19_Q180_L0.6690.88
220_T226_T0.6660.87
234_V318_R0.6610.87
173_D193_T0.6580.87
77_V80_A0.6570.87
125_G128_L0.6570.87
333_Y337_W0.6550.87
236_D266_L0.6540.86
61_R64_D0.6520.86
248_H263_H0.6500.86
26_S30_S0.6470.86
353_T358_G0.6440.86
127_R138_R0.6440.86
275_E279_H0.6440.86
45_Q64_D0.6430.86
217_V282_S0.6380.85
152_H157_P0.6360.85
34_D68_F0.6350.85
32_L36_R0.6350.85
267_G274_T0.6330.85
274_T321_K0.6330.85
74_C77_V0.6330.85
150_K157_P0.6320.85
196_F336_T0.6240.84
330_F334_K0.6240.84
368_F371_T0.6240.84
347_A393_R0.6240.84
203_T206_T0.6220.84
270_E321_K0.6210.84
220_T285_V0.6180.83
206_T222_L0.6160.83
19_Q187_Y0.6160.83
244_R267_G0.6150.83
353_T360_R0.6150.83
34_D37_L0.6150.83
221_A228_R0.6130.83
209_G387_S0.6130.83
149_V153_L0.6120.83
226_T277_V0.6120.83
350_N389_N0.6090.82
392_W395_T0.6070.82
27_G30_S0.6070.82
19_Q189_H0.6060.82
209_G298_V0.6040.82
54_Y57_T0.6030.82
278_L281_L0.6020.82
24_I29_R0.6010.82
320_H351_S0.6010.82
280_R283_R0.6000.81
17_T191_T0.5980.81
298_V391_A0.5970.81
38_A65_R0.5960.81
213_N216_N0.5960.81
72_N121_A0.5950.81
220_T225_E0.5940.81
78_G82_Q0.5930.81
359_E368_F0.5930.81
54_Y87_Y0.5920.81
244_R247_Y0.5910.80
211_D300_E0.5900.80
217_V278_L0.5890.80
362_S366_R0.5890.80
76_V80_A0.5860.80
250_I262_I0.5830.80
294_N340_I0.5830.80
308_E319_L0.5830.80
390_I395_T0.5830.80
127_R132_D0.5820.79
241_K249_T0.5800.79
250_I253_R0.5790.79
72_N119_V0.5790.79
243_E262_I0.5780.79
369_R378_V0.5780.79
316_N320_H0.5780.79
216_N227_M0.5760.79
75_A122_H0.5760.79
395_T398_L0.5760.79
350_N353_T0.5760.79
367_R381_H0.5730.78
272_R276_W0.5720.78
392_W397_K0.5700.78
233_L237_Y0.5650.77
348_Y352_K0.5650.77
107_P110_T0.5640.77
87_Y90_L0.5640.77
345_V348_Y0.5630.77
223_D226_T0.5620.77
257_H260_T0.5590.77
165_D168_T0.5580.77
78_G81_L0.5580.77
298_V393_R0.5560.76
297_I331_V0.5560.76
241_K246_R0.5560.76
236_D269_D0.5560.76
305_I320_H0.5550.76
346_D349_Y0.5510.76
128_L131_D0.5500.76
351_S363_R0.5490.75
140_R150_K0.5490.75
362_S371_T0.5490.75
270_E274_T0.5460.75
281_L327_F0.5450.75
272_R275_E0.5450.75
359_E371_T0.5450.75
251_T254_C0.5440.75
19_Q275_E0.5440.75
358_G375_C0.5440.75
46_T74_C0.5430.75
256_E262_I0.5410.74
217_V331_V0.5410.74
255_Q259_K0.5390.74
213_N219_L0.5390.74
47_I107_P0.5370.74
88_Q91_K0.5370.74
20_T166_A0.5350.74
48_R51_Q0.5340.73
232_T321_K0.5340.73
228_R232_T0.5330.73
192_V287_E0.5330.73
70_R124_E0.5330.73
136_R154_R0.5310.73
83_T108_P0.5300.73
122_H125_G0.5300.73
360_R365_G0.5300.73
123_A140_R0.5290.73
137_V152_H0.5280.73
267_G271_E0.5280.73
234_V237_Y0.5280.73
126_Y177_A0.5270.72
82_Q85_N0.5260.72
234_V317_R0.5260.72
216_N381_H0.5250.72
62_E65_R0.5240.72
214_E320_H0.5240.72
50_K54_Y0.5230.72
363_R381_H0.5230.72
201_P340_I0.5220.72
358_G370_C0.5220.72
315_M318_R0.5200.71
247_Y254_C0.5190.71
114_G117_P0.5180.71
54_Y59_I0.5180.71
55_N58_E0.5180.71
243_E250_I0.5170.71
63_V66_D0.5150.71
254_C258_G0.5140.71
306_R325_H0.5130.70
129_T132_D0.5130.70
351_S362_S0.5130.70
305_I319_L0.5130.70
53_G58_E0.5110.70
307_D315_M0.5090.70
153_L156_E0.5090.70
365_G382_A0.5090.70
312_G319_L0.5090.70
248_H251_T0.5090.70
390_I394_E0.5080.70
298_V345_V0.5070.70
361_G366_R0.5060.69
302_M305_I0.5060.69
172_I194_R0.5060.69
272_R280_R0.5050.69
198_V204_S0.5050.69
228_R322_L0.5050.69
42_I65_R0.5040.69
71_N77_V0.5040.69
215_R381_H0.5040.69
137_V140_R0.5040.69
32_L119_V0.5020.69
375_C378_V0.5010.69
247_Y257_H0.5010.69
381_H386_A0.5010.69
126_Y174_V0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.2935 95.6 0.931 Contact Map
1vhxA 2 0.3093 94.8 0.935 Contact Map
1iv0A 1 0.219 94.2 0.937 Contact Map
4ep4A 2 0.3679 84.5 0.949 Contact Map
1qypA 1 0.0971 80.6 0.951 Contact Map
1hjrA 2 0.3521 77.2 0.953 Contact Map
4aybP 1 0.0903 67.1 0.956 Contact Map
2k4xA 1 0.1196 60.6 0.958 Contact Map
3j20Y 1 0.1061 50.2 0.96 Contact Map
1vd4A 1 0.1196 49.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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