Q9HM87 - HALSA - GREMLIN Contacts

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Q9HM87 - Uncharacterized protein

UniProt:	Q9HM87	Sequences: MTVWNDYQGMGEEATKTIQTRLQIASGERSWLHDARLASREIFNQTIRLKQQGYNRTEIQREVDRDDFLRNNKCAVVGKALQTWNSYQSLKDWWENQDDPDGGKPTPPSTDKSGVYPLVMAHAEGYRLTVDDDTNRVRFRISPKPYKKVKGHLRGEPDAMDELRDAITSDKIDVGQAELLYRDGVYYLHVTVTREFDVPEPDTSDTLVGVDINERNVALTALDRETMRTKGTLVLDYGRVKEERQRYHTITTRCQEHGKTSIHRKLGDDEERFTEWVLHRLSRAVVEFSEQFSNPVIVFEDMTGIRDEIKYGTYMNRRLHKLPFHKFETFVSYKATWREIPMDTVDAYYNSKTCSCCGERGSRQGRRFRCTNDECVVVQDHADRNASVNIAWRETLKLDGNESNYRTHKTQPQVRLVRLSGSGRVSRPTSSRSLAEQGVLAHG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	443 (345)
Sequences:	4157 (2710)
Seq/√Len:	145.9

ECOLI - INSQ
HALSA - Q9HM87 Q9HSW7 Q9HSW9 Q9HHJ9 Q9HHG8 Q9HHU6 Q9HSZ6 Q9HSD4 Q9HSY4 Q9HHX8
SULSO - Q7LXD9 Q97XQ0 Q97XQ8 Q97YI5 Q97YU1 Q7LXH2 Q97U51 Q97Z61 Q97V47 Q97V25 Q97XP1 Q97Y48 Q97YI2 Q97U68 Q97YW4 Q97Y44 Q97UQ8 Q97Y67 Q97WZ3 Q97YW9 Q97WY6 Q97X39 Q97XB6 Q97XA4 Q97V53 Q7LXH6 Y2105 Q97YF7 Q97U09

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
276_W	280_R	5.360	1.00
355_S	385_N	4.655	1.00
303_T	307_D	4.616	1.00
335_A	342_M	3.763	1.00
298_V	394_E	3.284	1.00
217_V	327_F	3.163	1.00
328_E	344_T	3.055	1.00
299_F	331_V	2.889	1.00
326_K	330_F	2.767	1.00
283_R	287_E	2.728	1.00
352_K	361_G	2.693	1.00
177_A	188_L	2.648	1.00
16_K	337_W	2.643	1.00
237_Y	317_R	2.567	1.00
363_R	382_A	2.553	1.00
349_Y	352_K	2.550	1.00
345_V	390_I	2.537	1.00
326_K	329_T	2.470	1.00
350_N	390_I	2.388	1.00
393_R	396_L	2.387	1.00
286_V	335_A	2.341	1.00
309_I	320_H	2.339	1.00
297_I	335_A	2.321	1.00
175_G	193_T	2.285	1.00
327_F	331_V	2.270	1.00
332_S	344_T	2.270	1.00
312_G	316_N	2.162	1.00
279_H	330_F	2.127	1.00
279_H	333_Y	2.116	1.00
362_S	365_G	2.104	1.00
48_R	52_Q	2.103	1.00
243_E	260_T	2.086	1.00
46_T	77_V	2.082	1.00
299_F	342_M	2.060	1.00
313_T	316_N	2.059	1.00
357_C	375_C	2.041	1.00
352_K	360_R	2.037	1.00
25_A	28_E	2.014	1.00
295_P	340_I	1.946	1.00
354_C	357_C	1.945	1.00
33_H	181_Y	1.945	1.00
51_Q	107_P	1.943	1.00
370_C	375_C	1.937	1.00
354_C	375_C	1.934	1.00
33_H	186_Y	1.931	1.00
34_D	67_D	1.919	1.00
217_V	277_V	1.918	1.00
369_R	379_Q	1.885	1.00
275_E	326_K	1.874	1.00
282_S	330_F	1.870	1.00
47_I	80_A	1.863	1.00
21_R	185_V	1.854	1.00
368_F	380_D	1.845	1.00
246_R	250_I	1.830	1.00
357_C	370_C	1.827	1.00
210_V	218_A	1.827	1.00
260_T	263_H	1.821	1.00
279_H	334_K	1.818	1.00
354_C	370_C	1.776	1.00
332_S	336_T	1.772	1.00
279_H	282_S	1.762	1.00
32_L	186_Y	1.716	1.00
356_C	378_V	1.715	1.00
236_D	273_F	1.662	1.00
255_Q	258_G	1.645	1.00
278_L	330_F	1.636	1.00
17_T	189_H	1.630	1.00
278_L	326_K	1.581	1.00
300_E	347_A	1.566	1.00
299_F	328_E	1.539	1.00
299_F	344_T	1.526	1.00
207_L	391_A	1.512	1.00
60_Q	63_V	1.512	1.00
182_R	268_D	1.489	1.00
220_T	224_R	1.486	1.00
301_D	344_T	1.461	1.00
282_S	333_Y	1.461	1.00
253_R	257_H	1.451	1.00
367_R	379_Q	1.430	1.00
41_E	64_D	1.429	1.00
368_F	378_V	1.424	1.00
282_S	327_F	1.409	1.00
319_L	324_F	1.403	1.00
46_T	80_A	1.403	1.00
90_L	105_P	1.395	1.00
84_W	107_P	1.394	1.00
30_S	34_D	1.379	1.00
282_S	334_K	1.374	1.00
29_R	33_H	1.373	1.00
216_N	219_L	1.364	1.00
228_R	231_G	1.352	1.00
208_V	220_T	1.350	1.00
219_L	384_R	1.349	1.00
185_V	268_D	1.341	1.00
36_R	186_Y	1.339	1.00
268_D	272_R	1.328	1.00
236_D	270_E	1.319	1.00
388_V	392_W	1.318	1.00
258_G	261_S	1.307	1.00
355_S	388_V	1.303	1.00
81_L	85_N	1.303	1.00
250_I	260_T	1.299	1.00
75_A	78_G	1.299	1.00
39_S	76_V	1.296	1.00
183_D	268_D	1.276	1.00
363_R	366_R	1.275	1.00
51_Q	55_N	1.253	1.00
366_R	382_A	1.237	1.00
243_E	266_L	1.221	1.00
384_R	388_V	1.218	1.00
85_N	89_S	1.210	1.00
71_N	122_H	1.207	1.00
221_A	387_S	1.197	1.00
303_T	347_A	1.195	1.00
282_S	331_V	1.180	1.00
355_S	380_D	1.179	1.00
350_N	393_R	1.173	1.00
283_R	338_R	1.172	1.00
71_N	124_E	1.171	1.00
43_F	76_V	1.169	1.00
18_I	192_V	1.161	1.00
330_F	333_Y	1.160	1.00
52_Q	56_R	1.153	1.00
332_S	342_M	1.152	1.00
26_S	29_R	1.150	1.00
210_V	220_T	1.149	1.00
86_S	105_P	1.136	0.99
286_V	338_R	1.128	0.99
361_G	365_G	1.127	0.99
204_S	295_P	1.127	0.99
209_G	391_A	1.125	0.99
74_C	78_G	1.124	0.99
150_K	156_E	1.123	0.99
305_I	325_H	1.122	0.99
212_I	328_E	1.122	0.99
219_L	225_E	1.117	0.99
19_Q	182_R	1.114	0.99
89_S	104_K	1.107	0.99
214_E	322_L	1.107	0.99
278_L	327_F	1.105	0.99
168_T	172_I	1.102	0.99
285_V	297_I	1.100	0.99
82_Q	86_S	1.092	0.99
87_Y	107_P	1.088	0.99
361_G	368_F	1.087	0.99
353_T	393_R	1.078	0.99
69_L	72_N	1.077	0.99
212_I	324_F	1.060	0.99
47_I	84_W	1.055	0.99
79_K	120_M	1.043	0.99
275_E	330_F	1.042	0.99
334_K	337_W	1.037	0.99
86_S	89_S	1.035	0.99
301_D	347_A	1.034	0.99
140_R	156_E	1.027	0.99
250_I	254_C	1.026	0.99
309_I	312_G	1.025	0.99
150_K	153_L	1.025	0.99
247_Y	260_T	1.021	0.99
239_R	243_E	1.017	0.99
298_V	390_I	1.016	0.99
207_L	296_V	1.015	0.99
243_E	246_R	1.015	0.99
180_L	189_H	1.007	0.99
207_L	395_T	1.004	0.99
243_E	263_H	0.995	0.99
50_K	81_L	0.989	0.99
65_R	73_K	0.988	0.99
278_L	282_S	0.986	0.98
329_T	332_S	0.986	0.98
24_I	28_E	0.984	0.98
355_S	378_V	0.983	0.98
287_E	338_R	0.983	0.98
118_L	121_A	0.981	0.98
271_E	275_E	0.973	0.98
380_D	384_R	0.969	0.98
365_G	368_F	0.968	0.98
137_V	188_L	0.966	0.98
86_S	90_L	0.965	0.98
345_V	393_R	0.964	0.98
71_N	75_A	0.963	0.98
345_V	394_E	0.960	0.98
182_R	185_V	0.955	0.98
256_E	259_K	0.953	0.98
48_R	110_T	0.952	0.98
363_R	368_F	0.948	0.98
208_V	221_A	0.945	0.98
51_Q	84_W	0.938	0.98
29_R	186_Y	0.937	0.98
355_S	386_A	0.935	0.98
286_V	297_I	0.925	0.98
353_T	389_N	0.924	0.98
207_L	298_V	0.923	0.98
312_G	315_M	0.922	0.98
24_I	32_L	0.919	0.98
75_A	79_K	0.916	0.98
233_L	236_D	0.916	0.98
355_S	392_W	0.911	0.97
41_E	45_Q	0.911	0.97
211_D	383_D	0.910	0.97
43_F	83_T	0.910	0.97
79_K	178_E	0.910	0.97
335_A	340_I	0.909	0.97
151_G	156_E	0.907	0.97
240_V	267_G	0.905	0.97
86_S	104_K	0.904	0.97
71_N	74_C	0.903	0.97
53_G	57_T	0.902	0.97
208_V	297_I	0.900	0.97
244_R	248_H	0.900	0.97
127_R	130_V	0.898	0.97
380_D	388_V	0.897	0.97
325_H	329_T	0.893	0.97
349_Y	393_R	0.893	0.97
254_C	257_H	0.891	0.97
347_A	350_N	0.887	0.97
77_V	81_L	0.885	0.97
20_T	188_L	0.880	0.97
368_F	382_A	0.880	0.97
301_D	328_E	0.879	0.97
286_V	340_I	0.872	0.97
206_T	295_P	0.872	0.97
225_E	381_H	0.870	0.97
253_R	258_G	0.864	0.97
266_L	270_E	0.854	0.96
43_F	80_A	0.850	0.96
54_Y	58_E	0.850	0.96
37_L	40_R	0.847	0.96
214_E	309_I	0.846	0.96
247_Y	263_H	0.845	0.96
54_Y	84_W	0.845	0.96
49_L	53_G	0.843	0.96
21_R	187_Y	0.841	0.96
278_L	323_P	0.837	0.96
224_R	284_A	0.835	0.96
215_R	219_L	0.831	0.96
138_R	152_H	0.830	0.96
214_E	318_R	0.830	0.96
356_C	388_V	0.829	0.96
240_V	263_H	0.829	0.96
367_R	380_D	0.827	0.96
393_R	397_K	0.826	0.96
277_V	281_L	0.823	0.95
124_E	127_R	0.820	0.95
232_T	273_F	0.820	0.95
366_R	381_H	0.820	0.95
154_R	157_P	0.819	0.95
309_I	316_N	0.818	0.95
362_S	382_A	0.817	0.95
296_V	343_D	0.816	0.95
247_Y	250_I	0.810	0.95
244_R	263_H	0.809	0.95
283_R	334_K	0.806	0.95
246_R	249_T	0.806	0.95
240_V	248_H	0.803	0.95
34_D	38_A	0.802	0.95
22_L	188_L	0.796	0.95
296_V	341_P	0.795	0.94
385_N	389_N	0.794	0.94
328_E	332_S	0.793	0.94
69_L	121_A	0.792	0.94
68_F	73_K	0.792	0.94
49_L	52_Q	0.792	0.94
262_I	265_K	0.792	0.94
225_E	384_R	0.791	0.94
185_V	272_R	0.791	0.94
241_K	244_R	0.790	0.94
45_Q	49_L	0.785	0.94
386_A	389_N	0.782	0.94
151_G	154_R	0.781	0.94
396_L	399_D	0.781	0.94
212_I	218_A	0.780	0.94
126_Y	130_V	0.778	0.94
242_E	246_R	0.778	0.94
181_Y	186_Y	0.778	0.94
87_Y	108_P	0.778	0.94
84_W	87_Y	0.777	0.94
38_A	64_D	0.772	0.94
152_H	156_E	0.772	0.94
313_T	320_H	0.769	0.93
218_A	281_L	0.767	0.93
178_E	189_H	0.765	0.93
384_R	387_S	0.761	0.93
221_A	225_E	0.761	0.93
251_T	257_H	0.759	0.93
335_A	338_R	0.757	0.93
216_N	225_E	0.754	0.93
388_V	391_A	0.752	0.93
221_A	384_R	0.749	0.93
364_Q	382_A	0.744	0.92
215_R	366_R	0.743	0.92
80_A	84_W	0.743	0.92
179_L	188_L	0.741	0.92
281_L	284_A	0.741	0.92
38_A	68_F	0.741	0.92
120_M	176_Q	0.738	0.92
287_E	296_V	0.735	0.92
361_G	382_A	0.734	0.92
269_D	273_F	0.734	0.92
305_I	324_F	0.732	0.92
343_D	394_E	0.731	0.92
122_H	126_Y	0.730	0.92
218_A	327_F	0.728	0.91
395_T	399_D	0.727	0.91
201_P	204_S	0.727	0.91
312_G	320_H	0.726	0.91
217_V	322_L	0.721	0.91
37_L	41_E	0.721	0.91
35_A	39_S	0.713	0.91
38_A	41_E	0.713	0.91
50_K	84_W	0.709	0.90
315_M	319_L	0.709	0.90
394_E	398_L	0.708	0.90
73_K	76_V	0.707	0.90
352_K	362_S	0.705	0.90
302_M	347_A	0.705	0.90
349_Y	353_T	0.704	0.90
35_A	69_L	0.703	0.90
106_T	109_S	0.702	0.90
90_L	106_T	0.701	0.90
241_K	245_Q	0.699	0.90
90_L	104_K	0.699	0.90
176_Q	191_T	0.695	0.89
307_D	347_A	0.695	0.89
35_A	68_F	0.694	0.89
84_W	88_Q	0.687	0.89
125_G	140_R	0.686	0.89
205_D	295_P	0.683	0.89
68_F	71_N	0.682	0.89
71_N	123_A	0.682	0.89
390_I	393_R	0.681	0.89
208_V	222_L	0.677	0.88
298_V	343_D	0.676	0.88
42_I	73_K	0.675	0.88
172_I	192_V	0.674	0.88
91_K	105_P	0.674	0.88
161_D	164_R	0.674	0.88
353_T	368_F	0.673	0.88
211_D	351_S	0.673	0.88
50_K	53_G	0.672	0.88
208_V	294_N	0.672	0.88
380_D	385_N	0.671	0.88
31_W	35_A	0.670	0.88
252_T	257_H	0.670	0.88
42_I	76_V	0.670	0.88
19_Q	180_L	0.669	0.88
220_T	226_T	0.666	0.87
234_V	318_R	0.661	0.87
173_D	193_T	0.658	0.87
77_V	80_A	0.657	0.87
125_G	128_L	0.657	0.87
333_Y	337_W	0.655	0.87
236_D	266_L	0.654	0.86
61_R	64_D	0.652	0.86
248_H	263_H	0.650	0.86
26_S	30_S	0.647	0.86
353_T	358_G	0.644	0.86
127_R	138_R	0.644	0.86
275_E	279_H	0.644	0.86
45_Q	64_D	0.643	0.86
217_V	282_S	0.638	0.85
152_H	157_P	0.636	0.85
34_D	68_F	0.635	0.85
32_L	36_R	0.635	0.85
267_G	274_T	0.633	0.85
274_T	321_K	0.633	0.85
74_C	77_V	0.633	0.85
150_K	157_P	0.632	0.85
196_F	336_T	0.624	0.84
330_F	334_K	0.624	0.84
368_F	371_T	0.624	0.84
347_A	393_R	0.624	0.84
203_T	206_T	0.622	0.84
270_E	321_K	0.621	0.84
220_T	285_V	0.618	0.83
206_T	222_L	0.616	0.83
19_Q	187_Y	0.616	0.83
244_R	267_G	0.615	0.83
353_T	360_R	0.615	0.83
34_D	37_L	0.615	0.83
221_A	228_R	0.613	0.83
209_G	387_S	0.613	0.83
149_V	153_L	0.612	0.83
226_T	277_V	0.612	0.83
350_N	389_N	0.609	0.82
392_W	395_T	0.607	0.82
27_G	30_S	0.607	0.82
19_Q	189_H	0.606	0.82
209_G	298_V	0.604	0.82
54_Y	57_T	0.603	0.82
278_L	281_L	0.602	0.82
24_I	29_R	0.601	0.82
320_H	351_S	0.601	0.82
280_R	283_R	0.600	0.81
17_T	191_T	0.598	0.81
298_V	391_A	0.597	0.81
38_A	65_R	0.596	0.81
213_N	216_N	0.596	0.81
72_N	121_A	0.595	0.81
220_T	225_E	0.594	0.81
78_G	82_Q	0.593	0.81
359_E	368_F	0.593	0.81
54_Y	87_Y	0.592	0.81
244_R	247_Y	0.591	0.80
211_D	300_E	0.590	0.80
217_V	278_L	0.589	0.80
362_S	366_R	0.589	0.80
76_V	80_A	0.586	0.80
250_I	262_I	0.583	0.80
294_N	340_I	0.583	0.80
308_E	319_L	0.583	0.80
390_I	395_T	0.583	0.80
127_R	132_D	0.582	0.79
241_K	249_T	0.580	0.79
250_I	253_R	0.579	0.79
72_N	119_V	0.579	0.79
243_E	262_I	0.578	0.79
369_R	378_V	0.578	0.79
316_N	320_H	0.578	0.79
216_N	227_M	0.576	0.79
75_A	122_H	0.576	0.79
395_T	398_L	0.576	0.79
350_N	353_T	0.576	0.79
367_R	381_H	0.573	0.78
272_R	276_W	0.572	0.78
392_W	397_K	0.570	0.78
233_L	237_Y	0.565	0.77
348_Y	352_K	0.565	0.77
107_P	110_T	0.564	0.77
87_Y	90_L	0.564	0.77
345_V	348_Y	0.563	0.77
223_D	226_T	0.562	0.77
257_H	260_T	0.559	0.77
165_D	168_T	0.558	0.77
78_G	81_L	0.558	0.77
298_V	393_R	0.556	0.76
297_I	331_V	0.556	0.76
241_K	246_R	0.556	0.76
236_D	269_D	0.556	0.76
305_I	320_H	0.555	0.76
346_D	349_Y	0.551	0.76
128_L	131_D	0.550	0.76
351_S	363_R	0.549	0.75
140_R	150_K	0.549	0.75
362_S	371_T	0.549	0.75
270_E	274_T	0.546	0.75
281_L	327_F	0.545	0.75
272_R	275_E	0.545	0.75
359_E	371_T	0.545	0.75
251_T	254_C	0.544	0.75
19_Q	275_E	0.544	0.75
358_G	375_C	0.544	0.75
46_T	74_C	0.543	0.75
256_E	262_I	0.541	0.74
217_V	331_V	0.541	0.74
255_Q	259_K	0.539	0.74
213_N	219_L	0.539	0.74
47_I	107_P	0.537	0.74
88_Q	91_K	0.537	0.74
20_T	166_A	0.535	0.74
48_R	51_Q	0.534	0.73
232_T	321_K	0.534	0.73
228_R	232_T	0.533	0.73
192_V	287_E	0.533	0.73
70_R	124_E	0.533	0.73
136_R	154_R	0.531	0.73
83_T	108_P	0.530	0.73
122_H	125_G	0.530	0.73
360_R	365_G	0.530	0.73
123_A	140_R	0.529	0.73
137_V	152_H	0.528	0.73
267_G	271_E	0.528	0.73
234_V	237_Y	0.528	0.73
126_Y	177_A	0.527	0.72
82_Q	85_N	0.526	0.72
234_V	317_R	0.526	0.72
216_N	381_H	0.525	0.72
62_E	65_R	0.524	0.72
214_E	320_H	0.524	0.72
50_K	54_Y	0.523	0.72
363_R	381_H	0.523	0.72
201_P	340_I	0.522	0.72
358_G	370_C	0.522	0.72
315_M	318_R	0.520	0.71
247_Y	254_C	0.519	0.71
114_G	117_P	0.518	0.71
54_Y	59_I	0.518	0.71
55_N	58_E	0.518	0.71
243_E	250_I	0.517	0.71
63_V	66_D	0.515	0.71
254_C	258_G	0.514	0.71
306_R	325_H	0.513	0.70
129_T	132_D	0.513	0.70
351_S	362_S	0.513	0.70
305_I	319_L	0.513	0.70
53_G	58_E	0.511	0.70
307_D	315_M	0.509	0.70
153_L	156_E	0.509	0.70
365_G	382_A	0.509	0.70
312_G	319_L	0.509	0.70
248_H	251_T	0.509	0.70
390_I	394_E	0.508	0.70
298_V	345_V	0.507	0.70
361_G	366_R	0.506	0.69
302_M	305_I	0.506	0.69
172_I	194_R	0.506	0.69
272_R	280_R	0.505	0.69
198_V	204_S	0.505	0.69
228_R	322_L	0.505	0.69
42_I	65_R	0.504	0.69
71_N	77_V	0.504	0.69
215_R	381_H	0.504	0.69
137_V	140_R	0.504	0.69
32_L	119_V	0.502	0.69
375_C	378_V	0.501	0.69
247_Y	257_H	0.501	0.69
381_H	386_A	0.501	0.69
126_Y	174_V	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nu0A	1	0.2935	95.6	0.931	Contact Map
1vhxA	2	0.3093	94.8	0.935	Contact Map
1iv0A	1	0.219	94.2	0.937	Contact Map
4ep4A	2	0.3679	84.5	0.949	Contact Map
1qypA	1	0.0971	80.6	0.951	Contact Map
1hjrA	2	0.3521	77.2	0.953	Contact Map
4aybP	1	0.0903	67.1	0.956	Contact Map
2k4xA	1	0.1196	60.6	0.958	Contact Map
3j20Y	1	0.1061	50.2	0.96	Contact Map
1vd4A	1	0.1196	49.1	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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