GREMLIN Database
Q9HM86 - Uncharacterized protein
UniProt: Q9HM86 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (125)
Sequences: 1486 (960)
Seq/√Len: 85.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D91_R4.9391.00
35_D92_Y3.1131.00
39_L84_S2.5851.00
16_Y67_C2.5601.00
40_F84_S2.5341.00
40_F80_F2.2021.00
86_K90_E2.1521.00
125_R129_Q2.0061.00
53_A128_E2.0031.00
87_H90_E1.9551.00
49_H76_I1.9231.00
120_E124_E1.8781.00
37_R41_S1.8041.00
35_D38_E1.8011.00
67_C73_P1.7861.00
35_D39_L1.7571.00
64_F127_I1.6081.00
5_R50_E1.5741.00
18_F77_A1.5531.00
47_F79_Q1.5521.00
12_S112_V1.5371.00
85_G89_L1.5171.00
21_C107_K1.4970.99
29_L105_F1.4610.99
43_T47_F1.4600.99
15_K115_T1.4510.99
6_S11_V1.4460.99
67_C76_I1.4410.99
43_T83_Y1.4410.99
44_A80_F1.4150.99
93_P96_R1.4010.99
16_Y114_T1.3990.99
5_R66_Q1.3760.99
89_L103_G1.3540.99
75_D78_R1.3390.99
50_E66_Q1.3290.99
68_D71_H1.3210.99
7_H10_S1.3160.99
124_E128_E1.2980.99
14_C67_C1.2910.98
115_T120_E1.2750.98
44_A51_I1.2520.98
73_P77_A1.2460.98
16_Y73_P1.2320.98
125_R128_E1.2310.98
18_F73_P1.2310.98
7_H12_S1.2290.98
85_G103_G1.2050.98
65_V76_I1.2000.98
48_G70_K1.1970.97
18_F65_V1.1720.97
16_Y112_V1.1650.97
33_E37_R1.1590.97
121_E124_E1.1580.97
89_L96_R1.1580.97
69_P74_A1.1360.97
14_C112_V1.1350.97
78_R108_V1.0990.96
39_L83_Y1.0930.96
29_L88_L1.0790.95
39_L87_H1.0760.95
40_F61_V1.0520.95
106_W110_Y1.0340.94
97_E102_G0.9940.93
88_L95_I0.9920.93
73_P112_V0.9860.93
41_S45_D0.9840.93
44_A49_H0.9670.92
40_F54_L0.9630.92
18_F112_V0.9580.92
37_R55_E0.9580.92
36_V88_L0.9530.91
12_S66_Q0.9450.91
65_V112_V0.9350.90
32_V94_E0.9340.90
100_F104_G0.9250.90
15_K66_Q0.9220.90
33_E54_L0.9120.89
42_E45_D0.9060.89
42_E46_H0.9020.89
72_S75_D0.9020.89
71_H76_I0.8910.88
119_S122_V0.8890.88
38_E45_D0.8890.88
37_R54_L0.8860.88
29_L36_V0.8830.88
68_D72_S0.8730.87
39_L43_T0.8600.86
82_S104_G0.8560.86
15_K52_L0.8500.86
122_V125_R0.8480.86
43_T79_Q0.8430.85
113_G119_S0.8310.84
32_V95_I0.8220.84
31_V35_D0.8180.84
64_F120_E0.8180.84
14_C73_P0.8030.82
79_Q83_Y0.7830.81
10_S14_C0.7830.81
44_A76_I0.7820.81
49_H71_H0.7800.81
40_F63_L0.7760.80
68_D74_A0.7740.80
14_C114_T0.7740.80
35_D88_L0.7710.80
13_S113_G0.7700.80
85_G104_G0.7590.79
100_F103_G0.7590.79
12_S16_Y0.7520.78
32_V88_L0.7490.78
93_P101_W0.7480.78
5_R12_S0.7460.78
26_H100_F0.7420.77
36_V40_F0.7380.77
104_G108_V0.7370.77
119_S127_I0.7370.77
78_R83_Y0.7360.77
41_S51_I0.7350.76
57_A130_T0.7350.76
74_A110_Y0.7300.76
33_E57_A0.7240.75
65_V73_P0.7180.75
31_V34_D0.7160.75
44_A82_S0.7140.74
72_S77_A0.7140.74
27_P59_D0.7080.74
20_W65_V0.7020.73
42_E87_H0.7000.73
33_E56_I0.6950.72
25_R59_D0.6880.72
5_R77_A0.6840.71
33_E55_E0.6840.71
101_W106_W0.6800.71
64_F118_V0.6750.70
55_E109_G0.6750.70
38_E91_R0.6730.70
117_E120_E0.6710.70
38_E88_L0.6690.70
38_E42_E0.6690.70
51_I65_V0.6690.70
29_L32_V0.6660.69
113_G118_V0.6580.68
13_S111_Y0.6580.68
83_Y87_H0.6510.67
7_H68_D0.6510.67
45_D48_G0.6470.67
73_P76_I0.6430.66
52_L66_Q0.6350.66
56_I61_V0.6260.64
64_F115_T0.6260.64
72_S114_T0.6250.64
127_I130_T0.6240.64
27_P58_D0.6200.64
89_L104_G0.6150.63
26_H98_S0.6070.62
95_I103_G0.6060.62
118_V122_V0.6050.62
44_A63_L0.6040.62
96_R103_G0.5920.60
43_T87_H0.5920.60
97_E101_W0.5910.60
76_I80_F0.5910.60
39_L91_R0.5890.60
111_Y118_V0.5890.60
9_H108_V0.5870.59
16_Y68_D0.5870.59
34_D95_I0.5850.59
32_V96_R0.5800.59
46_H83_Y0.5760.58
13_S66_Q0.5700.57
103_G107_K0.5680.57
71_H75_D0.5670.57
21_C55_E0.5670.57
53_A64_F0.5570.56
27_P69_P0.5550.55
38_E41_S0.5340.52
31_V94_E0.5320.52
22_P56_I0.5260.51
121_E125_R0.5230.51
88_L91_R0.5180.50
37_R56_I0.5160.50
47_F82_S0.5110.49
67_C114_T0.5100.49
9_H109_G0.5060.49
82_S89_L0.5050.49
26_H127_I0.5000.48
83_Y86_K0.5000.48
22_P100_F0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vjvA 2 0.9318 100 0.375 Contact Map
2fyxA 2 0.9621 100 0.391 Contact Map
2f5gA 2 0.947 100 0.397 Contact Map
4er8A 1 0.8939 99.9 0.521 Contact Map
3l15A 1 0.6288 14.6 0.944 Contact Map
4re1A 1 0.5909 13.1 0.945 Contact Map
1ofdA 1 0.8485 9.8 0.948 Contact Map
1q2lA 1 0.8788 9.4 0.949 Contact Map
2ga1A 2 0.7045 8.8 0.949 Contact Map
3hlxA 2 0.3864 7.2 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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