Q9HM72 - HALSA - GREMLIN Contacts

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Q9HM72 - Uncharacterized protein

UniProt:	Q9HM72	Sequences: MNRIAEEVGLQKASVYHHYAEKDTLLLALVDYVVEELRYRIVQPDDEDPRQQLRRFIDEVVFGHHAGPDATALSPPTDGTIRAFIQIRAQAVHDDDYREQITTIDRIQQEHIAEIIQRGVDAGEFRDVDPTQVASFISTLLTGVFTRRVTMTTDLTPVREATHAYLEAVLVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	172 (161)
Sequences:	244 (190)
Seq/√Len:	15.0

HALSA - Q9HM72

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
2_N	6_E	4.222	1.00
113_A	117_Q	3.558	0.99
119_G	125_F	3.247	0.99
8_V	14_S	2.743	0.96
21_E	28_A	2.618	0.95
52_Q	118_R	2.546	0.94
19_Y	28_A	2.415	0.92
102_T	152_T	2.344	0.91
16_Y	21_E	2.172	0.88
14_S	105_D	2.166	0.88
116_I	130_P	2.143	0.87
5_A	17_H	2.100	0.86
88_R	150_T	2.068	0.85
11_Q	14_S	2.029	0.84
120_V	126_R	2.011	0.83
116_I	128_V	1.995	0.83
8_V	93_H	1.955	0.81
115_I	125_F	1.899	0.79
137_I	162_T	1.878	0.79
52_Q	83_A	1.858	0.78
58_D	159_R	1.850	0.78
136_F	165_Y	1.799	0.75
5_A	12_K	1.730	0.72
35_E	130_P	1.699	0.71
37_L	82_R	1.692	0.71
12_K	29_L	1.605	0.67
106_R	164_A	1.586	0.66
120_V	125_F	1.581	0.65
120_V	164_A	1.548	0.64
47_E	132_Q	1.542	0.63
16_Y	104_I	1.536	0.63
95_D	121_D	1.526	0.62
36_E	57_I	1.520	0.62
15_V	54_R	1.513	0.62
15_V	141_L	1.465	0.59
33_V	118_R	1.449	0.58
105_D	147_R	1.444	0.58
117_Q	121_D	1.433	0.57
15_V	50_R	1.428	0.57
19_Y	148_R	1.427	0.57
105_D	165_Y	1.421	0.57
19_Y	88_R	1.400	0.56
24_T	159_R	1.388	0.55
83_A	92_V	1.361	0.53
31_D	100_Q	1.334	0.52
17_H	92_V	1.329	0.52
149_V	155_L	1.318	0.51
109_Q	135_S	1.295	0.50
16_Y	145_F	1.293	0.50
91_A	146_T	1.282	0.49
31_D	153_T	1.261	0.48
42_V	87_I	1.241	0.47
39_Y	120_V	1.228	0.46
119_G	123_G	1.216	0.45
31_D	141_L	1.208	0.45
5_A	8_V	1.202	0.45
28_A	52_Q	1.186	0.44
98_R	133_V	1.180	0.43
99_E	122_A	1.160	0.42
18_H	35_E	1.139	0.41
27_L	145_F	1.126	0.40
40_R	49_P	1.117	0.40
23_D	27_L	1.113	0.40
14_S	100_Q	1.107	0.39
23_D	112_I	1.107	0.39
47_E	155_L	1.094	0.39
20_A	170_L	1.086	0.38
61_V	153_T	1.082	0.38
85_I	92_V	1.081	0.38
112_I	137_I	1.080	0.38
78_D	95_D	1.080	0.38
43_Q	127_D	1.079	0.38
87_I	101_I	1.075	0.38
30_V	148_R	1.072	0.37
49_P	167_E	1.069	0.37
23_D	94_D	1.060	0.37
120_V	167_E	1.057	0.37
51_Q	73_L	1.057	0.37
117_Q	130_P	1.056	0.37
33_V	82_R	1.056	0.37
54_R	163_H	1.043	0.36
33_V	117_Q	1.043	0.36
102_T	151_M	1.030	0.35
140_L	162_T	1.008	0.34
90_Q	143_G	1.005	0.34
80_T	97_Y	0.992	0.33
15_V	41_I	0.992	0.33
133_V	165_Y	0.990	0.33
5_A	101_I	0.989	0.33
47_E	166_L	0.978	0.33
5_A	83_A	0.967	0.32
123_G	156_T	0.960	0.32
46_D	137_I	0.953	0.31
21_E	49_P	0.950	0.31
80_T	84_F	0.949	0.31
51_Q	156_T	0.944	0.31
3_R	101_I	0.937	0.31
115_I	158_V	0.937	0.31
50_R	54_R	0.935	0.31
20_A	116_I	0.928	0.30
118_R	122_A	0.924	0.30
47_E	51_Q	0.924	0.30
2_N	18_H	0.910	0.29
24_T	76_P	0.910	0.29
24_T	95_D	0.905	0.29
58_D	64_H	0.893	0.29
130_P	156_T	0.881	0.28
84_F	168_A	0.878	0.28
12_K	162_T	0.866	0.27
83_A	143_G	0.865	0.27
9_G	113_A	0.852	0.27
31_D	49_P	0.851	0.27
15_V	103_T	0.846	0.27
85_I	93_H	0.846	0.27
24_T	124_E	0.841	0.26
16_Y	23_D	0.839	0.26
124_E	162_T	0.835	0.26
25_L	120_V	0.834	0.26
34_V	162_T	0.831	0.26
60_V	148_R	0.825	0.26
15_V	101_I	0.825	0.26
8_V	88_R	0.818	0.25
97_Y	100_Q	0.812	0.25
58_D	130_P	0.812	0.25
18_H	34_V	0.801	0.25
16_Y	150_T	0.801	0.25
47_E	96_D	0.791	0.24
155_L	162_T	0.784	0.24
16_Y	28_A	0.783	0.24
20_A	115_I	0.782	0.24
51_Q	80_T	0.781	0.24
133_V	166_L	0.781	0.24
26_L	37_L	0.776	0.24
161_A	166_L	0.775	0.24
11_Q	51_Q	0.773	0.23
17_H	85_I	0.772	0.23
61_V	141_L	0.768	0.23
27_L	48_D	0.766	0.23
16_Y	85_I	0.762	0.23
27_L	100_Q	0.750	0.23
47_E	57_I	0.749	0.22
91_A	133_V	0.748	0.22
16_Y	118_R	0.745	0.22
20_A	101_I	0.742	0.22
13_A	137_I	0.740	0.22
18_H	88_R	0.737	0.22
16_Y	93_H	0.730	0.22
92_V	145_F	0.729	0.22
29_L	36_E	0.725	0.22
76_P	145_F	0.724	0.22
2_N	12_K	0.723	0.21
120_V	128_V	0.721	0.21
2_N	29_L	0.718	0.21
55_R	110_E	0.718	0.21
45_D	110_E	0.713	0.21
140_L	161_A	0.711	0.21
80_T	149_V	0.707	0.21
10_L	84_F	0.704	0.21
7_E	16_Y	0.700	0.21
23_D	151_M	0.696	0.20
56_F	115_I	0.691	0.20
51_Q	78_D	0.689	0.20
62_F	79_G	0.682	0.20
20_A	152_T	0.679	0.20
57_I	137_I	0.678	0.20
87_I	127_D	0.676	0.20
51_Q	122_A	0.675	0.20
6_E	37_L	0.668	0.19
114_E	148_R	0.667	0.19
8_V	107_I	0.661	0.19
37_L	142_T	0.658	0.19
30_V	36_E	0.652	0.19
88_R	104_I	0.651	0.19
10_L	22_K	0.646	0.19
13_A	166_L	0.639	0.18
89_A	170_L	0.638	0.18
19_Y	38_R	0.637	0.18
97_Y	163_H	0.633	0.18
6_E	116_I	0.628	0.18
7_E	128_V	0.626	0.18
73_L	166_L	0.626	0.18
5_A	14_S	0.625	0.18
10_L	14_S	0.624	0.18
48_D	124_E	0.623	0.18
49_P	53_L	0.622	0.18
37_L	61_V	0.621	0.18
10_L	159_R	0.621	0.18
113_A	131_T	0.621	0.18
16_Y	101_I	0.620	0.18
24_T	28_A	0.618	0.18
36_E	106_R	0.618	0.18
21_E	108_Q	0.616	0.18
53_L	140_L	0.614	0.18
44_P	136_F	0.613	0.18
41_I	121_D	0.611	0.18
19_Y	107_I	0.609	0.17
5_A	52_Q	0.607	0.17
41_I	84_F	0.602	0.17
10_L	19_Y	0.601	0.17
26_L	128_V	0.599	0.17
25_L	134_A	0.598	0.17
7_E	26_L	0.595	0.17
76_P	114_E	0.594	0.17
90_Q	101_I	0.590	0.17
112_I	154_D	0.587	0.17
39_Y	160_E	0.585	0.17
81_I	124_E	0.584	0.17
155_L	159_R	0.582	0.17
26_L	97_Y	0.579	0.17
75_P	95_D	0.579	0.17
13_A	117_Q	0.571	0.16
84_F	124_E	0.569	0.16
95_D	114_E	0.567	0.16
28_A	48_D	0.563	0.16
15_V	83_A	0.561	0.16
79_G	156_T	0.560	0.16
4_I	18_H	0.558	0.16
75_P	167_E	0.558	0.16
9_G	41_I	0.555	0.16
50_R	124_E	0.554	0.16
94_D	137_I	0.551	0.16
114_E	137_I	0.546	0.16
53_L	125_F	0.542	0.15
56_F	106_R	0.540	0.15
62_F	84_F	0.539	0.15
12_K	135_S	0.535	0.15
80_T	90_Q	0.532	0.15
62_F	127_D	0.531	0.15
13_A	113_A	0.530	0.15
77_T	158_V	0.526	0.15
30_V	34_V	0.524	0.15
117_Q	126_R	0.521	0.15
139_T	147_R	0.520	0.15
35_E	112_I	0.518	0.15
139_T	146_T	0.513	0.15
106_R	110_E	0.512	0.15
127_D	164_A	0.507	0.14
29_L	128_V	0.507	0.14
9_G	135_S	0.506	0.14
15_V	86_Q	0.506	0.14
14_S	165_Y	0.500	0.14
114_E	131_T	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3crjA	2	0.936	99.8	0.644	Contact Map
4kwaA	2	0.9419	99.8	0.65	Contact Map
2nx4A	2	0.9244	99.8	0.671	Contact Map
2gfnA	2	0.9186	99.8	0.673	Contact Map
4ichA	2	0.9419	99.8	0.673	Contact Map
2g3bA	2	0.936	99.8	0.676	Contact Map
4udsA	2	0.936	99.8	0.678	Contact Map
3bqzB	3	0.9244	99.8	0.68	Contact Map
2xdnA	2	0.9535	99.8	0.681	Contact Map
2i10A	2	0.936	99.8	0.681	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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