GREMLIN Database
Q9HM72 - Uncharacterized protein
UniProt: Q9HM72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (161)
Sequences: 244 (190)
Seq/√Len: 15.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_N6_E4.2221.00
113_A117_Q3.5580.99
119_G125_F3.2470.99
8_V14_S2.7430.96
21_E28_A2.6180.95
52_Q118_R2.5460.94
19_Y28_A2.4150.92
102_T152_T2.3440.91
16_Y21_E2.1720.88
14_S105_D2.1660.88
116_I130_P2.1430.87
5_A17_H2.1000.86
88_R150_T2.0680.85
11_Q14_S2.0290.84
120_V126_R2.0110.83
116_I128_V1.9950.83
8_V93_H1.9550.81
115_I125_F1.8990.79
137_I162_T1.8780.79
52_Q83_A1.8580.78
58_D159_R1.8500.78
136_F165_Y1.7990.75
5_A12_K1.7300.72
35_E130_P1.6990.71
37_L82_R1.6920.71
12_K29_L1.6050.67
106_R164_A1.5860.66
120_V125_F1.5810.65
120_V164_A1.5480.64
47_E132_Q1.5420.63
16_Y104_I1.5360.63
95_D121_D1.5260.62
36_E57_I1.5200.62
15_V54_R1.5130.62
15_V141_L1.4650.59
33_V118_R1.4490.58
105_D147_R1.4440.58
117_Q121_D1.4330.57
15_V50_R1.4280.57
19_Y148_R1.4270.57
105_D165_Y1.4210.57
19_Y88_R1.4000.56
24_T159_R1.3880.55
83_A92_V1.3610.53
31_D100_Q1.3340.52
17_H92_V1.3290.52
149_V155_L1.3180.51
109_Q135_S1.2950.50
16_Y145_F1.2930.50
91_A146_T1.2820.49
31_D153_T1.2610.48
42_V87_I1.2410.47
39_Y120_V1.2280.46
119_G123_G1.2160.45
31_D141_L1.2080.45
5_A8_V1.2020.45
28_A52_Q1.1860.44
98_R133_V1.1800.43
99_E122_A1.1600.42
18_H35_E1.1390.41
27_L145_F1.1260.40
40_R49_P1.1170.40
23_D27_L1.1130.40
14_S100_Q1.1070.39
23_D112_I1.1070.39
47_E155_L1.0940.39
20_A170_L1.0860.38
61_V153_T1.0820.38
85_I92_V1.0810.38
112_I137_I1.0800.38
78_D95_D1.0800.38
43_Q127_D1.0790.38
87_I101_I1.0750.38
30_V148_R1.0720.37
49_P167_E1.0690.37
23_D94_D1.0600.37
120_V167_E1.0570.37
51_Q73_L1.0570.37
117_Q130_P1.0560.37
33_V82_R1.0560.37
54_R163_H1.0430.36
33_V117_Q1.0430.36
102_T151_M1.0300.35
140_L162_T1.0080.34
90_Q143_G1.0050.34
80_T97_Y0.9920.33
15_V41_I0.9920.33
133_V165_Y0.9900.33
5_A101_I0.9890.33
47_E166_L0.9780.33
5_A83_A0.9670.32
123_G156_T0.9600.32
46_D137_I0.9530.31
21_E49_P0.9500.31
80_T84_F0.9490.31
51_Q156_T0.9440.31
3_R101_I0.9370.31
115_I158_V0.9370.31
50_R54_R0.9350.31
20_A116_I0.9280.30
118_R122_A0.9240.30
47_E51_Q0.9240.30
2_N18_H0.9100.29
24_T76_P0.9100.29
24_T95_D0.9050.29
58_D64_H0.8930.29
130_P156_T0.8810.28
84_F168_A0.8780.28
12_K162_T0.8660.27
83_A143_G0.8650.27
9_G113_A0.8520.27
31_D49_P0.8510.27
15_V103_T0.8460.27
85_I93_H0.8460.27
24_T124_E0.8410.26
16_Y23_D0.8390.26
124_E162_T0.8350.26
25_L120_V0.8340.26
34_V162_T0.8310.26
60_V148_R0.8250.26
15_V101_I0.8250.26
8_V88_R0.8180.25
97_Y100_Q0.8120.25
58_D130_P0.8120.25
18_H34_V0.8010.25
16_Y150_T0.8010.25
47_E96_D0.7910.24
155_L162_T0.7840.24
16_Y28_A0.7830.24
20_A115_I0.7820.24
51_Q80_T0.7810.24
133_V166_L0.7810.24
26_L37_L0.7760.24
161_A166_L0.7750.24
11_Q51_Q0.7730.23
17_H85_I0.7720.23
61_V141_L0.7680.23
27_L48_D0.7660.23
16_Y85_I0.7620.23
27_L100_Q0.7500.23
47_E57_I0.7490.22
91_A133_V0.7480.22
16_Y118_R0.7450.22
20_A101_I0.7420.22
13_A137_I0.7400.22
18_H88_R0.7370.22
16_Y93_H0.7300.22
92_V145_F0.7290.22
29_L36_E0.7250.22
76_P145_F0.7240.22
2_N12_K0.7230.21
120_V128_V0.7210.21
2_N29_L0.7180.21
55_R110_E0.7180.21
45_D110_E0.7130.21
140_L161_A0.7110.21
80_T149_V0.7070.21
10_L84_F0.7040.21
7_E16_Y0.7000.21
23_D151_M0.6960.20
56_F115_I0.6910.20
51_Q78_D0.6890.20
62_F79_G0.6820.20
20_A152_T0.6790.20
57_I137_I0.6780.20
87_I127_D0.6760.20
51_Q122_A0.6750.20
6_E37_L0.6680.19
114_E148_R0.6670.19
8_V107_I0.6610.19
37_L142_T0.6580.19
30_V36_E0.6520.19
88_R104_I0.6510.19
10_L22_K0.6460.19
13_A166_L0.6390.18
89_A170_L0.6380.18
19_Y38_R0.6370.18
97_Y163_H0.6330.18
6_E116_I0.6280.18
7_E128_V0.6260.18
73_L166_L0.6260.18
5_A14_S0.6250.18
10_L14_S0.6240.18
48_D124_E0.6230.18
49_P53_L0.6220.18
37_L61_V0.6210.18
10_L159_R0.6210.18
113_A131_T0.6210.18
16_Y101_I0.6200.18
24_T28_A0.6180.18
36_E106_R0.6180.18
21_E108_Q0.6160.18
53_L140_L0.6140.18
44_P136_F0.6130.18
41_I121_D0.6110.18
19_Y107_I0.6090.17
5_A52_Q0.6070.17
41_I84_F0.6020.17
10_L19_Y0.6010.17
26_L128_V0.5990.17
25_L134_A0.5980.17
7_E26_L0.5950.17
76_P114_E0.5940.17
90_Q101_I0.5900.17
112_I154_D0.5870.17
39_Y160_E0.5850.17
81_I124_E0.5840.17
155_L159_R0.5820.17
26_L97_Y0.5790.17
75_P95_D0.5790.17
13_A117_Q0.5710.16
84_F124_E0.5690.16
95_D114_E0.5670.16
28_A48_D0.5630.16
15_V83_A0.5610.16
79_G156_T0.5600.16
4_I18_H0.5580.16
75_P167_E0.5580.16
9_G41_I0.5550.16
50_R124_E0.5540.16
94_D137_I0.5510.16
114_E137_I0.5460.16
53_L125_F0.5420.15
56_F106_R0.5400.15
62_F84_F0.5390.15
12_K135_S0.5350.15
80_T90_Q0.5320.15
62_F127_D0.5310.15
13_A113_A0.5300.15
77_T158_V0.5260.15
30_V34_V0.5240.15
117_Q126_R0.5210.15
139_T147_R0.5200.15
35_E112_I0.5180.15
139_T146_T0.5130.15
106_R110_E0.5120.15
127_D164_A0.5070.14
29_L128_V0.5070.14
9_G135_S0.5060.14
15_V86_Q0.5060.14
14_S165_Y0.5000.14
114_E131_T0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3crjA 2 0.936 99.8 0.644 Contact Map
4kwaA 2 0.9419 99.8 0.65 Contact Map
2nx4A 2 0.9244 99.8 0.671 Contact Map
2gfnA 2 0.9186 99.8 0.673 Contact Map
4ichA 2 0.9419 99.8 0.673 Contact Map
2g3bA 2 0.936 99.8 0.676 Contact Map
4udsA 2 0.936 99.8 0.678 Contact Map
3bqzB 3 0.9244 99.8 0.68 Contact Map
2xdnA 2 0.9535 99.8 0.681 Contact Map
2i10A 2 0.936 99.8 0.681 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0072 seconds.