GREMLIN Database
Q9HI34 - Uncharacterized protein
UniProt: Q9HI34 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (346)
Sequences: 965 (779)
Seq/√Len: 41.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_G162_D5.1621.00
198_F285_N4.7011.00
68_G72_Q4.4431.00
324_T329_V4.1991.00
178_L299_L3.9841.00
73_R76_P3.9431.00
172_L175_R3.5531.00
69_G72_Q3.5291.00
111_I145_A3.3181.00
199_F266_F3.2551.00
140_H183_Y3.2091.00
66_S69_G2.9731.00
176_L286_L2.8161.00
38_L41_G2.6821.00
86_V338_L2.6721.00
74_L332_I2.6581.00
323_D333_L2.5411.00
87_E152_R2.5221.00
136_G158_E2.4511.00
110_M175_R2.4291.00
192_I197_G2.3641.00
199_F285_N2.3601.00
179_L201_S2.3451.00
49_T296_L2.3431.00
308_T311_R2.3261.00
239_R242_I2.2441.00
277_D284_T2.2391.00
274_E277_D2.1781.00
93_V346_E2.1671.00
21_G24_E2.1400.99
108_D175_R2.1120.99
30_Q33_V2.1060.99
236_D239_R2.0420.99
79_A331_E2.0420.99
306_V310_F2.0310.99
298_T301_R2.0050.99
271_V297_A1.9870.99
189_F201_S1.9380.99
270_G279_Y1.9140.99
311_R315_T1.9080.99
191_L195_N1.8810.99
161_H164_T1.8780.99
141_L310_F1.8600.98
125_E327_P1.8560.98
112_A142_L1.8480.98
83_R331_E1.7960.98
23_V31_I1.7810.98
110_M151_E1.7810.98
152_R170_S1.7740.98
31_I81_Y1.7650.98
311_R316_Q1.7490.98
203_L207_A1.7420.98
286_L291_F1.7370.98
107_R198_F1.6920.97
140_H156_T1.6910.97
193_D285_N1.6860.97
201_S283_I1.6430.97
89_G342_L1.5890.96
155_V331_E1.5810.96
153_I338_L1.5790.96
19_E84_D1.5390.95
115_T314_K1.5370.95
107_R176_L1.5360.95
364_E369_T1.5200.95
83_R87_E1.4990.94
190_A194_E1.4930.94
182_A204_K1.4920.94
186_Y207_A1.4780.94
86_V341_L1.4650.94
38_L336_A1.4520.93
273_N280_H1.4310.93
267_R304_W1.4280.93
113_D307_E1.4260.93
181_L202_R1.4220.92
184_F207_A1.4200.92
366_W370_F1.3970.92
162_D182_A1.3930.92
13_L16_H1.3820.91
209_P242_I1.3790.91
180_D307_E1.3790.91
50_L53_F1.3790.91
284_T296_L1.3770.91
272_R277_D1.3590.91
139_L334_L1.3470.90
105_R295_D1.3330.90
156_T160_A1.3300.90
291_F296_L1.3120.89
327_P331_E1.3090.89
362_P366_W1.3040.89
34_L77_S1.2860.88
24_E27_R1.2840.88
113_D180_D1.2800.88
364_E371_R1.2790.88
181_L201_S1.2740.88
138_R285_N1.2710.87
268_V286_L1.2640.87
34_L73_R1.2630.87
104_D109_V1.2590.87
34_L74_L1.2580.87
143_H335_Y1.2560.87
8_F15_E1.2480.86
270_G281_L1.2330.86
132_E205_Q1.2250.85
116_V138_R1.2230.85
34_L37_A1.2200.85
77_S332_I1.2190.85
332_I336_A1.2190.85
128_E132_E1.2080.85
39_V336_A1.2070.85
120_H333_L1.2060.84
345_R348_L1.2060.84
367_A371_R1.2020.84
29_L37_A1.2000.84
176_L200_V1.1960.84
120_H330_V1.1860.83
311_R317_Y1.1820.83
315_T343_V1.1790.83
13_L17_A1.1710.83
11_E15_E1.1650.82
309_L317_Y1.1630.82
150_I309_L1.1550.82
124_S128_E1.1470.81
74_L324_T1.1470.81
366_W377_I1.1400.81
8_F189_F1.1390.81
167_K188_R1.1390.81
296_L341_L1.1380.81
82_L332_I1.1370.81
312_E345_R1.1330.81
312_E341_L1.1310.80
49_T53_F1.1310.80
32_P36_W1.1290.80
74_L333_L1.1280.80
371_R378_L1.1260.80
110_M142_L1.1140.79
292_L295_D1.1100.79
14_E85_L1.1100.79
31_I77_S1.1060.79
127_Y331_E1.1050.79
271_V282_Y1.0990.78
27_R77_S1.0990.78
169_G341_L1.0950.78
135_A333_L1.0930.78
377_I380_E1.0860.78
23_V27_R1.0840.78
361_F366_W1.0810.77
153_I215_L1.0760.77
77_S82_L1.0750.77
8_F89_G1.0660.76
180_D314_K1.0640.76
376_L379_H1.0590.76
10_S14_E1.0590.76
79_A328_A1.0560.76
141_L150_I1.0500.75
214_E217_E1.0480.75
74_L77_S1.0430.75
68_G118_R1.0400.75
10_S32_P1.0300.74
162_D342_L1.0250.73
142_L151_E1.0190.73
193_D199_F1.0190.73
34_L134_Q1.0130.73
304_W307_E1.0120.72
29_L69_G1.0010.72
22_V31_I1.0010.72
127_Y309_L0.9910.71
179_L282_Y0.9890.71
368_A373_H0.9870.71
8_F49_T0.9870.71
274_E306_V0.9800.70
281_L285_N0.9750.70
115_T139_L0.9690.69
152_R349_D0.9680.69
303_R307_E0.9660.69
375_Q380_E0.9640.69
180_D300_Y0.9620.69
179_L182_A0.9610.68
157_D182_A0.9600.68
108_D181_L0.9600.68
104_D339_L0.9590.68
200_V299_L0.9580.68
238_S241_Y0.9580.68
73_R106_F0.9570.68
361_F365_R0.9570.68
91_D193_D0.9550.68
12_F16_H0.9540.68
22_V81_Y0.9530.68
135_A332_I0.9530.68
324_T333_L0.9520.68
31_I34_L0.9490.67
21_G277_D0.9450.67
271_V280_H0.9390.67
62_D109_V0.9340.66
110_M177_I0.9330.66
20_L23_V0.9250.65
144_N147_E0.9220.65
119_L137_A0.9220.65
113_D202_R0.9210.65
216_R275_D0.9190.65
173_H299_L0.9170.65
4_L18_E0.9130.64
150_I342_L0.9090.64
163_S204_K0.9030.64
113_D304_W0.9020.64
74_L134_Q0.8960.63
14_E35_V0.8930.63
363_P367_A0.8930.63
204_K334_L0.8920.63
252_R258_T0.8910.63
155_V208_N0.8880.62
369_T372_S0.8840.62
113_D303_R0.8780.61
282_Y296_L0.8740.61
196_D292_L0.8730.61
348_L366_W0.8720.61
180_D303_R0.8710.61
108_D172_L0.8710.61
44_A313_L0.8680.61
277_D343_V0.8670.60
118_R136_G0.8620.60
29_L70_F0.8600.60
34_L71_Y0.8590.60
202_R307_E0.8580.60
35_V336_A0.8560.59
35_V39_V0.8540.59
33_V149_M0.8530.59
369_T375_Q0.8530.59
155_V334_L0.8530.59
70_F311_R0.8530.59
29_L33_V0.8470.59
153_I240_Q0.8460.59
151_E330_V0.8460.59
180_D304_W0.8440.58
312_E316_Q0.8430.58
67_P326_N0.8420.58
205_Q330_V0.8410.58
171_W197_G0.8400.58
77_S342_L0.8400.58
68_G71_Y0.8380.58
361_F370_F0.8380.58
79_A83_R0.8380.58
155_V294_S0.8360.58
307_E314_K0.8340.57
284_T307_E0.8300.57
302_C305_E0.8300.57
137_A334_L0.8290.57
128_E133_E0.8240.57
171_W177_I0.8130.55
161_H347_L0.8120.55
84_D88_R0.8120.55
363_P366_W0.8110.55
8_F35_V0.8110.55
279_Y285_N0.8090.55
80_T194_E0.8070.55
66_S73_R0.8060.55
144_N181_L0.8050.55
117_L139_L0.8050.55
156_T165_L0.8040.55
373_H378_L0.8010.54
76_P269_V0.7980.54
122_F135_A0.7960.54
166_F188_R0.7950.54
375_Q378_L0.7950.54
75_T326_N0.7910.53
104_D107_R0.7860.53
140_H333_L0.7840.53
110_M172_L0.7820.53
85_L292_L0.7810.53
77_S181_L0.7770.52
142_L177_I0.7770.52
90_L342_L0.7760.52
109_V299_L0.7760.52
196_D277_D0.7730.52
10_S13_L0.7720.52
7_L12_F0.7710.52
79_A334_L0.7640.51
86_V90_L0.7630.51
183_Y343_V0.7620.51
188_R282_Y0.7610.51
12_F92_E0.7590.50
186_Y258_T0.7580.50
173_H196_D0.7570.50
202_R304_W0.7520.50
21_G338_L0.7500.50
108_D144_N0.7490.50
73_R77_S0.7490.50
15_E18_E0.7480.49
187_R338_L0.7470.49
358_E381_L0.7460.49
110_M162_D0.7450.49
162_D180_D0.7440.49
52_G55_R0.7420.49
138_R161_H0.7410.49
194_E265_R0.7400.49
89_G150_I0.7380.48
284_T304_W0.7370.48
166_F177_I0.7370.48
103_I306_V0.7370.48
130_R158_E0.7350.48
41_G70_F0.7350.48
5_T36_W0.7320.48
142_L171_W0.7300.48
367_A370_F0.7290.48
16_H37_A0.7290.48
211_I240_Q0.7280.48
141_L341_L0.7270.47
14_E155_V0.7260.47
173_H260_S0.7230.47
25_R30_Q0.7230.47
18_E62_D0.7210.47
65_I119_L0.7190.47
311_R314_K0.7190.47
71_Y329_V0.7180.47
296_L310_F0.7180.47
114_G136_G0.7170.47
123_L325_R0.7160.46
266_F317_Y0.7150.46
369_T378_L0.7140.46
39_V296_L0.7080.46
362_P365_R0.7060.45
86_V169_G0.7060.45
134_Q158_E0.7060.45
107_R291_F0.7020.45
91_D269_V0.7000.45
53_F153_I0.7000.45
213_A354_Q0.6980.45
161_H182_A0.6970.45
267_R284_T0.6960.45
113_D314_K0.6910.44
111_I332_I0.6910.44
24_E31_I0.6900.44
15_E292_L0.6890.44
182_A203_L0.6850.44
178_L239_R0.6840.43
369_T377_I0.6800.43
53_F57_Y0.6780.43
174_G241_Y0.6770.43
295_D345_R0.6760.43
39_V299_L0.6740.43
70_F367_A0.6730.42
22_V34_L0.6730.42
174_G269_V0.6720.42
139_L155_V0.6710.42
20_L81_Y0.6710.42
377_I381_L0.6700.42
372_S375_Q0.6700.42
107_R332_I0.6700.42
287_P291_F0.6630.42
35_V82_L0.6610.41
366_W372_S0.6600.41
312_E330_V0.6600.41
38_L324_T0.6580.41
82_L328_A0.6580.41
14_E265_R0.6570.41
82_L173_H0.6550.41
13_L30_Q0.6540.41
117_L311_R0.6500.40
91_D284_T0.6490.40
163_S167_K0.6490.40
277_D285_N0.6490.40
11_E151_E0.6480.40
74_L81_Y0.6470.40
127_Y312_E0.6470.40
141_L334_L0.6450.40
200_V337_A0.6430.40
25_R66_S0.6410.40
45_G73_R0.6400.39
139_L302_C0.6380.39
15_E275_D0.6380.39
363_P369_T0.6360.39
163_S188_R0.6350.39
12_F15_E0.6340.39
28_T33_V0.6330.39
95_V100_D0.6320.39
161_H181_L0.6290.38
104_D291_F0.6290.38
147_E159_T0.6280.38
121_E135_A0.6280.38
138_R150_I0.6280.38
146_T302_C0.6270.38
53_F336_A0.6270.38
210_V249_E0.6260.38
136_G162_D0.6260.38
113_D284_T0.6200.38
299_L317_Y0.6170.37
375_Q379_H0.6150.37
287_P348_L0.6140.37
52_G141_L0.6130.37
296_L313_L0.6090.37
300_Y307_E0.6090.37
16_H84_D0.6070.37
21_G193_D0.6050.36
111_I203_L0.6040.36
25_R166_F0.6040.36
378_L381_L0.6040.36
65_I334_L0.6040.36
203_L206_N0.6020.36
240_Q252_R0.6020.36
134_Q333_L0.6010.36
171_W195_N0.6010.36
14_E18_E0.6010.36
12_F88_R0.6010.36
39_V340_S0.6010.36
212_T249_E0.5990.36
189_F328_A0.5970.36
53_F363_P0.5960.36
309_L341_L0.5950.35
9_P12_F0.5930.35
167_K191_L0.5930.35
369_T381_L0.5920.35
130_R134_Q0.5890.35
153_I168_T0.5890.35
25_R332_I0.5870.35
325_R333_L0.5860.35
181_L204_K0.5850.35
104_D299_L0.5840.35
205_Q283_I0.5830.34
112_A179_L0.5810.34
278_D283_I0.5800.34
119_L322_F0.5790.34
73_R329_V0.5780.34
143_H152_R0.5780.34
81_Y85_L0.5760.34
58_N143_H0.5760.34
101_A105_R0.5750.34
239_R258_T0.5750.34
140_H311_R0.5740.34
300_Y303_R0.5730.34
179_L192_I0.5730.34
127_Y132_E0.5730.34
101_A109_V0.5730.34
284_T300_Y0.5720.34
57_Y195_N0.5710.33
4_L237_L0.5700.33
80_T284_T0.5700.33
149_M346_E0.5700.33
332_I342_L0.5700.33
369_T379_H0.5670.33
23_V72_Q0.5670.33
115_T182_A0.5660.33
319_L337_A0.5650.33
138_R158_E0.5640.33
80_T83_R0.5640.33
175_R192_I0.5630.33
297_A317_Y0.5610.33
26_N35_V0.5610.33
206_N350_L0.5600.33
271_V275_D0.5600.33
237_L240_Q0.5600.33
269_V282_Y0.5580.32
23_V178_L0.5570.32
199_F271_V0.5570.32
295_D306_V0.5570.32
301_R328_A0.5520.32
273_N349_D0.5500.32
201_S328_A0.5500.32
251_K260_S0.5480.32
165_L271_V0.5470.31
180_D284_T0.5470.31
176_L203_L0.5470.31
175_R197_G0.5460.31
5_T35_V0.5460.31
178_L193_D0.5430.31
323_D342_L0.5410.31
30_Q153_I0.5410.31
293_P329_V0.5410.31
82_L102_D0.5390.31
85_L277_D0.5390.31
80_T274_E0.5380.31
84_D187_R0.5370.31
163_S346_E0.5360.31
23_V26_N0.5360.31
358_E363_P0.5360.31
368_A375_Q0.5350.31
122_F125_E0.5330.30
114_G180_D0.5320.30
5_T8_F0.5310.30
16_H19_E0.5290.30
66_S72_Q0.5290.30
290_E294_S0.5270.30
39_V55_R0.5250.30
86_V271_V0.5240.30
86_V333_L0.5230.30
155_V266_F0.5220.29
140_H162_D0.5220.29
143_H309_L0.5210.29
169_G250_F0.5200.29
18_E272_R0.5190.29
82_L335_Y0.5180.29
165_L323_D0.5180.29
51_A359_I0.5180.29
151_E350_L0.5160.29
112_A166_F0.5160.29
27_R85_L0.5150.29
300_Y304_W0.5140.29
333_L342_L0.5140.29
317_Y344_S0.5130.29
142_L186_Y0.5120.29
139_L186_Y0.5110.29
367_A373_H0.5100.29
133_E160_A0.5100.29
105_R196_D0.5100.29
78_L197_G0.5090.28
159_T277_D0.5080.28
6_T299_L0.5070.28
329_V348_L0.5070.28
4_L347_L0.5070.28
364_E368_A0.5060.28
366_W378_L0.5060.28
178_L275_D0.5050.28
115_T329_V0.5040.28
185_K324_T0.5040.28
38_L110_M0.5040.28
162_D166_F0.5030.28
62_D65_I0.5030.28
278_D298_T0.5020.28
50_L183_Y0.5020.28
5_T10_S0.5010.28
49_T68_G0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8844 100 0.704 Contact Map
2kycA 1 0.2476 23 0.966 Contact Map
1rroA 1 0.2476 22 0.966 Contact Map
1w7jB 1 0.2476 18.8 0.967 Contact Map
3pm8A 2 0.2665 16.6 0.968 Contact Map
4ociA 2 0.2689 16.3 0.968 Contact Map
1m45A 1 0.2524 15.4 0.968 Contact Map
4mvfA 1 0.2618 15.4 0.969 Contact Map
1rwyA 1 0.25 13.9 0.969 Contact Map
1s1eA 1 0.3042 13.6 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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