Q9HI34 - HALSA - GREMLIN Contacts

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Q9HI34 - Uncharacterized protein

UniProt:	Q9HI34	Sequences: MRRLTTLFPSEFLEEHAEELGVVERNRTLQIPVLVWALVFGFAAGESRTLAGFRRSYNATADEPISPGGFYQRLTPSLATYLRDLVERGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSEVYEGRHEEQAGARLHLLHNATEQMIERIDVTDETAHDSTLFKTGSWLHGRLILLDLAYFKYRRFALIDENDGFFVSRLKQNANPVITAELREWRGRAIPLEGKQIQDVVDDLSRQYIDVEVEAEFKRGQYEGTRSLDTKRFRVVGVRNEDADDYHLYITNLPRDEFLPSDLATLYRCRWEVETLFRELKTQYELDEFDTRNPAVVEILLYAALLSLLVSRELLDLVTEQADDEIVFPPERWAATFRSHAQLILHELGEYLGYSPPPLLERLIDDAQKIHQQRPILQETLATATQPRCEG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	424 (346)
Sequences:	965 (779)
Seq/√Len:	41.9

ECOLI - INSG INSL1 INSL2 INSL3
HALSA - Q9HI34 O54648 O52023 O51966 O51972 Q9HI01 O54644

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_G	162_D	5.162	1.00
198_F	285_N	4.701	1.00
68_G	72_Q	4.443	1.00
324_T	329_V	4.199	1.00
178_L	299_L	3.984	1.00
73_R	76_P	3.943	1.00
172_L	175_R	3.553	1.00
69_G	72_Q	3.529	1.00
111_I	145_A	3.318	1.00
199_F	266_F	3.255	1.00
140_H	183_Y	3.209	1.00
66_S	69_G	2.973	1.00
176_L	286_L	2.816	1.00
38_L	41_G	2.682	1.00
86_V	338_L	2.672	1.00
74_L	332_I	2.658	1.00
323_D	333_L	2.541	1.00
87_E	152_R	2.522	1.00
136_G	158_E	2.451	1.00
110_M	175_R	2.429	1.00
192_I	197_G	2.364	1.00
199_F	285_N	2.360	1.00
179_L	201_S	2.345	1.00
49_T	296_L	2.343	1.00
308_T	311_R	2.326	1.00
239_R	242_I	2.244	1.00
277_D	284_T	2.239	1.00
274_E	277_D	2.178	1.00
93_V	346_E	2.167	1.00
21_G	24_E	2.140	0.99
108_D	175_R	2.112	0.99
30_Q	33_V	2.106	0.99
236_D	239_R	2.042	0.99
79_A	331_E	2.042	0.99
306_V	310_F	2.031	0.99
298_T	301_R	2.005	0.99
271_V	297_A	1.987	0.99
189_F	201_S	1.938	0.99
270_G	279_Y	1.914	0.99
311_R	315_T	1.908	0.99
191_L	195_N	1.881	0.99
161_H	164_T	1.878	0.99
141_L	310_F	1.860	0.98
125_E	327_P	1.856	0.98
112_A	142_L	1.848	0.98
83_R	331_E	1.796	0.98
23_V	31_I	1.781	0.98
110_M	151_E	1.781	0.98
152_R	170_S	1.774	0.98
31_I	81_Y	1.765	0.98
311_R	316_Q	1.749	0.98
203_L	207_A	1.742	0.98
286_L	291_F	1.737	0.98
107_R	198_F	1.692	0.97
140_H	156_T	1.691	0.97
193_D	285_N	1.686	0.97
201_S	283_I	1.643	0.97
89_G	342_L	1.589	0.96
155_V	331_E	1.581	0.96
153_I	338_L	1.579	0.96
19_E	84_D	1.539	0.95
115_T	314_K	1.537	0.95
107_R	176_L	1.536	0.95
364_E	369_T	1.520	0.95
83_R	87_E	1.499	0.94
190_A	194_E	1.493	0.94
182_A	204_K	1.492	0.94
186_Y	207_A	1.478	0.94
86_V	341_L	1.465	0.94
38_L	336_A	1.452	0.93
273_N	280_H	1.431	0.93
267_R	304_W	1.428	0.93
113_D	307_E	1.426	0.93
181_L	202_R	1.422	0.92
184_F	207_A	1.420	0.92
366_W	370_F	1.397	0.92
162_D	182_A	1.393	0.92
13_L	16_H	1.382	0.91
209_P	242_I	1.379	0.91
180_D	307_E	1.379	0.91
50_L	53_F	1.379	0.91
284_T	296_L	1.377	0.91
272_R	277_D	1.359	0.91
139_L	334_L	1.347	0.90
105_R	295_D	1.333	0.90
156_T	160_A	1.330	0.90
291_F	296_L	1.312	0.89
327_P	331_E	1.309	0.89
362_P	366_W	1.304	0.89
34_L	77_S	1.286	0.88
24_E	27_R	1.284	0.88
113_D	180_D	1.280	0.88
364_E	371_R	1.279	0.88
181_L	201_S	1.274	0.88
138_R	285_N	1.271	0.87
268_V	286_L	1.264	0.87
34_L	73_R	1.263	0.87
104_D	109_V	1.259	0.87
34_L	74_L	1.258	0.87
143_H	335_Y	1.256	0.87
8_F	15_E	1.248	0.86
270_G	281_L	1.233	0.86
132_E	205_Q	1.225	0.85
116_V	138_R	1.223	0.85
34_L	37_A	1.220	0.85
77_S	332_I	1.219	0.85
332_I	336_A	1.219	0.85
128_E	132_E	1.208	0.85
39_V	336_A	1.207	0.85
120_H	333_L	1.206	0.84
345_R	348_L	1.206	0.84
367_A	371_R	1.202	0.84
29_L	37_A	1.200	0.84
176_L	200_V	1.196	0.84
120_H	330_V	1.186	0.83
311_R	317_Y	1.182	0.83
315_T	343_V	1.179	0.83
13_L	17_A	1.171	0.83
11_E	15_E	1.165	0.82
309_L	317_Y	1.163	0.82
150_I	309_L	1.155	0.82
124_S	128_E	1.147	0.81
74_L	324_T	1.147	0.81
366_W	377_I	1.140	0.81
8_F	189_F	1.139	0.81
167_K	188_R	1.139	0.81
296_L	341_L	1.138	0.81
82_L	332_I	1.137	0.81
312_E	345_R	1.133	0.81
312_E	341_L	1.131	0.80
49_T	53_F	1.131	0.80
32_P	36_W	1.129	0.80
74_L	333_L	1.128	0.80
371_R	378_L	1.126	0.80
110_M	142_L	1.114	0.79
292_L	295_D	1.110	0.79
14_E	85_L	1.110	0.79
31_I	77_S	1.106	0.79
127_Y	331_E	1.105	0.79
271_V	282_Y	1.099	0.78
27_R	77_S	1.099	0.78
169_G	341_L	1.095	0.78
135_A	333_L	1.093	0.78
377_I	380_E	1.086	0.78
23_V	27_R	1.084	0.78
361_F	366_W	1.081	0.77
153_I	215_L	1.076	0.77
77_S	82_L	1.075	0.77
8_F	89_G	1.066	0.76
180_D	314_K	1.064	0.76
376_L	379_H	1.059	0.76
10_S	14_E	1.059	0.76
79_A	328_A	1.056	0.76
141_L	150_I	1.050	0.75
214_E	217_E	1.048	0.75
74_L	77_S	1.043	0.75
68_G	118_R	1.040	0.75
10_S	32_P	1.030	0.74
162_D	342_L	1.025	0.73
142_L	151_E	1.019	0.73
193_D	199_F	1.019	0.73
34_L	134_Q	1.013	0.73
304_W	307_E	1.012	0.72
29_L	69_G	1.001	0.72
22_V	31_I	1.001	0.72
127_Y	309_L	0.991	0.71
179_L	282_Y	0.989	0.71
368_A	373_H	0.987	0.71
8_F	49_T	0.987	0.71
274_E	306_V	0.980	0.70
281_L	285_N	0.975	0.70
115_T	139_L	0.969	0.69
152_R	349_D	0.968	0.69
303_R	307_E	0.966	0.69
375_Q	380_E	0.964	0.69
180_D	300_Y	0.962	0.69
179_L	182_A	0.961	0.68
157_D	182_A	0.960	0.68
108_D	181_L	0.960	0.68
104_D	339_L	0.959	0.68
200_V	299_L	0.958	0.68
238_S	241_Y	0.958	0.68
73_R	106_F	0.957	0.68
361_F	365_R	0.957	0.68
91_D	193_D	0.955	0.68
12_F	16_H	0.954	0.68
22_V	81_Y	0.953	0.68
135_A	332_I	0.953	0.68
324_T	333_L	0.952	0.68
31_I	34_L	0.949	0.67
21_G	277_D	0.945	0.67
271_V	280_H	0.939	0.67
62_D	109_V	0.934	0.66
110_M	177_I	0.933	0.66
20_L	23_V	0.925	0.65
144_N	147_E	0.922	0.65
119_L	137_A	0.922	0.65
113_D	202_R	0.921	0.65
216_R	275_D	0.919	0.65
173_H	299_L	0.917	0.65
4_L	18_E	0.913	0.64
150_I	342_L	0.909	0.64
163_S	204_K	0.903	0.64
113_D	304_W	0.902	0.64
74_L	134_Q	0.896	0.63
14_E	35_V	0.893	0.63
363_P	367_A	0.893	0.63
204_K	334_L	0.892	0.63
252_R	258_T	0.891	0.63
155_V	208_N	0.888	0.62
369_T	372_S	0.884	0.62
113_D	303_R	0.878	0.61
282_Y	296_L	0.874	0.61
196_D	292_L	0.873	0.61
348_L	366_W	0.872	0.61
180_D	303_R	0.871	0.61
108_D	172_L	0.871	0.61
44_A	313_L	0.868	0.61
277_D	343_V	0.867	0.60
118_R	136_G	0.862	0.60
29_L	70_F	0.860	0.60
34_L	71_Y	0.859	0.60
202_R	307_E	0.858	0.60
35_V	336_A	0.856	0.59
35_V	39_V	0.854	0.59
33_V	149_M	0.853	0.59
369_T	375_Q	0.853	0.59
155_V	334_L	0.853	0.59
70_F	311_R	0.853	0.59
29_L	33_V	0.847	0.59
153_I	240_Q	0.846	0.59
151_E	330_V	0.846	0.59
180_D	304_W	0.844	0.58
312_E	316_Q	0.843	0.58
67_P	326_N	0.842	0.58
205_Q	330_V	0.841	0.58
171_W	197_G	0.840	0.58
77_S	342_L	0.840	0.58
68_G	71_Y	0.838	0.58
361_F	370_F	0.838	0.58
79_A	83_R	0.838	0.58
155_V	294_S	0.836	0.58
307_E	314_K	0.834	0.57
284_T	307_E	0.830	0.57
302_C	305_E	0.830	0.57
137_A	334_L	0.829	0.57
128_E	133_E	0.824	0.57
171_W	177_I	0.813	0.55
161_H	347_L	0.812	0.55
84_D	88_R	0.812	0.55
363_P	366_W	0.811	0.55
8_F	35_V	0.811	0.55
279_Y	285_N	0.809	0.55
80_T	194_E	0.807	0.55
66_S	73_R	0.806	0.55
144_N	181_L	0.805	0.55
117_L	139_L	0.805	0.55
156_T	165_L	0.804	0.55
373_H	378_L	0.801	0.54
76_P	269_V	0.798	0.54
122_F	135_A	0.796	0.54
166_F	188_R	0.795	0.54
375_Q	378_L	0.795	0.54
75_T	326_N	0.791	0.53
104_D	107_R	0.786	0.53
140_H	333_L	0.784	0.53
110_M	172_L	0.782	0.53
85_L	292_L	0.781	0.53
77_S	181_L	0.777	0.52
142_L	177_I	0.777	0.52
90_L	342_L	0.776	0.52
109_V	299_L	0.776	0.52
196_D	277_D	0.773	0.52
10_S	13_L	0.772	0.52
7_L	12_F	0.771	0.52
79_A	334_L	0.764	0.51
86_V	90_L	0.763	0.51
183_Y	343_V	0.762	0.51
188_R	282_Y	0.761	0.51
12_F	92_E	0.759	0.50
186_Y	258_T	0.758	0.50
173_H	196_D	0.757	0.50
202_R	304_W	0.752	0.50
21_G	338_L	0.750	0.50
108_D	144_N	0.749	0.50
73_R	77_S	0.749	0.50
15_E	18_E	0.748	0.49
187_R	338_L	0.747	0.49
358_E	381_L	0.746	0.49
110_M	162_D	0.745	0.49
162_D	180_D	0.744	0.49
52_G	55_R	0.742	0.49
138_R	161_H	0.741	0.49
194_E	265_R	0.740	0.49
89_G	150_I	0.738	0.48
284_T	304_W	0.737	0.48
166_F	177_I	0.737	0.48
103_I	306_V	0.737	0.48
130_R	158_E	0.735	0.48
41_G	70_F	0.735	0.48
5_T	36_W	0.732	0.48
142_L	171_W	0.730	0.48
367_A	370_F	0.729	0.48
16_H	37_A	0.729	0.48
211_I	240_Q	0.728	0.48
141_L	341_L	0.727	0.47
14_E	155_V	0.726	0.47
173_H	260_S	0.723	0.47
25_R	30_Q	0.723	0.47
18_E	62_D	0.721	0.47
65_I	119_L	0.719	0.47
311_R	314_K	0.719	0.47
71_Y	329_V	0.718	0.47
296_L	310_F	0.718	0.47
114_G	136_G	0.717	0.47
123_L	325_R	0.716	0.46
266_F	317_Y	0.715	0.46
369_T	378_L	0.714	0.46
39_V	296_L	0.708	0.46
362_P	365_R	0.706	0.45
86_V	169_G	0.706	0.45
134_Q	158_E	0.706	0.45
107_R	291_F	0.702	0.45
91_D	269_V	0.700	0.45
53_F	153_I	0.700	0.45
213_A	354_Q	0.698	0.45
161_H	182_A	0.697	0.45
267_R	284_T	0.696	0.45
113_D	314_K	0.691	0.44
111_I	332_I	0.691	0.44
24_E	31_I	0.690	0.44
15_E	292_L	0.689	0.44
182_A	203_L	0.685	0.44
178_L	239_R	0.684	0.43
369_T	377_I	0.680	0.43
53_F	57_Y	0.678	0.43
174_G	241_Y	0.677	0.43
295_D	345_R	0.676	0.43
39_V	299_L	0.674	0.43
70_F	367_A	0.673	0.42
22_V	34_L	0.673	0.42
174_G	269_V	0.672	0.42
139_L	155_V	0.671	0.42
20_L	81_Y	0.671	0.42
377_I	381_L	0.670	0.42
372_S	375_Q	0.670	0.42
107_R	332_I	0.670	0.42
287_P	291_F	0.663	0.42
35_V	82_L	0.661	0.41
366_W	372_S	0.660	0.41
312_E	330_V	0.660	0.41
38_L	324_T	0.658	0.41
82_L	328_A	0.658	0.41
14_E	265_R	0.657	0.41
82_L	173_H	0.655	0.41
13_L	30_Q	0.654	0.41
117_L	311_R	0.650	0.40
91_D	284_T	0.649	0.40
163_S	167_K	0.649	0.40
277_D	285_N	0.649	0.40
11_E	151_E	0.648	0.40
74_L	81_Y	0.647	0.40
127_Y	312_E	0.647	0.40
141_L	334_L	0.645	0.40
200_V	337_A	0.643	0.40
25_R	66_S	0.641	0.40
45_G	73_R	0.640	0.39
139_L	302_C	0.638	0.39
15_E	275_D	0.638	0.39
363_P	369_T	0.636	0.39
163_S	188_R	0.635	0.39
12_F	15_E	0.634	0.39
28_T	33_V	0.633	0.39
95_V	100_D	0.632	0.39
161_H	181_L	0.629	0.38
104_D	291_F	0.629	0.38
147_E	159_T	0.628	0.38
121_E	135_A	0.628	0.38
138_R	150_I	0.628	0.38
146_T	302_C	0.627	0.38
53_F	336_A	0.627	0.38
210_V	249_E	0.626	0.38
136_G	162_D	0.626	0.38
113_D	284_T	0.620	0.38
299_L	317_Y	0.617	0.37
375_Q	379_H	0.615	0.37
287_P	348_L	0.614	0.37
52_G	141_L	0.613	0.37
296_L	313_L	0.609	0.37
300_Y	307_E	0.609	0.37
16_H	84_D	0.607	0.37
21_G	193_D	0.605	0.36
111_I	203_L	0.604	0.36
25_R	166_F	0.604	0.36
378_L	381_L	0.604	0.36
65_I	334_L	0.604	0.36
203_L	206_N	0.602	0.36
240_Q	252_R	0.602	0.36
134_Q	333_L	0.601	0.36
171_W	195_N	0.601	0.36
14_E	18_E	0.601	0.36
12_F	88_R	0.601	0.36
39_V	340_S	0.601	0.36
212_T	249_E	0.599	0.36
189_F	328_A	0.597	0.36
53_F	363_P	0.596	0.36
309_L	341_L	0.595	0.35
9_P	12_F	0.593	0.35
167_K	191_L	0.593	0.35
369_T	381_L	0.592	0.35
130_R	134_Q	0.589	0.35
153_I	168_T	0.589	0.35
25_R	332_I	0.587	0.35
325_R	333_L	0.586	0.35
181_L	204_K	0.585	0.35
104_D	299_L	0.584	0.35
205_Q	283_I	0.583	0.34
112_A	179_L	0.581	0.34
278_D	283_I	0.580	0.34
119_L	322_F	0.579	0.34
73_R	329_V	0.578	0.34
143_H	152_R	0.578	0.34
81_Y	85_L	0.576	0.34
58_N	143_H	0.576	0.34
101_A	105_R	0.575	0.34
239_R	258_T	0.575	0.34
140_H	311_R	0.574	0.34
300_Y	303_R	0.573	0.34
179_L	192_I	0.573	0.34
127_Y	132_E	0.573	0.34
101_A	109_V	0.573	0.34
284_T	300_Y	0.572	0.34
57_Y	195_N	0.571	0.33
4_L	237_L	0.570	0.33
80_T	284_T	0.570	0.33
149_M	346_E	0.570	0.33
332_I	342_L	0.570	0.33
369_T	379_H	0.567	0.33
23_V	72_Q	0.567	0.33
115_T	182_A	0.566	0.33
319_L	337_A	0.565	0.33
138_R	158_E	0.564	0.33
80_T	83_R	0.564	0.33
175_R	192_I	0.563	0.33
297_A	317_Y	0.561	0.33
26_N	35_V	0.561	0.33
206_N	350_L	0.560	0.33
271_V	275_D	0.560	0.33
237_L	240_Q	0.560	0.33
269_V	282_Y	0.558	0.32
23_V	178_L	0.557	0.32
199_F	271_V	0.557	0.32
295_D	306_V	0.557	0.32
301_R	328_A	0.552	0.32
273_N	349_D	0.550	0.32
201_S	328_A	0.550	0.32
251_K	260_S	0.548	0.32
165_L	271_V	0.547	0.31
180_D	284_T	0.547	0.31
176_L	203_L	0.547	0.31
175_R	197_G	0.546	0.31
5_T	35_V	0.546	0.31
178_L	193_D	0.543	0.31
323_D	342_L	0.541	0.31
30_Q	153_I	0.541	0.31
293_P	329_V	0.541	0.31
82_L	102_D	0.539	0.31
85_L	277_D	0.539	0.31
80_T	274_E	0.538	0.31
84_D	187_R	0.537	0.31
163_S	346_E	0.536	0.31
23_V	26_N	0.536	0.31
358_E	363_P	0.536	0.31
368_A	375_Q	0.535	0.31
122_F	125_E	0.533	0.30
114_G	180_D	0.532	0.30
5_T	8_F	0.531	0.30
16_H	19_E	0.529	0.30
66_S	72_Q	0.529	0.30
290_E	294_S	0.527	0.30
39_V	55_R	0.525	0.30
86_V	271_V	0.524	0.30
86_V	333_L	0.523	0.30
155_V	266_F	0.522	0.29
140_H	162_D	0.522	0.29
143_H	309_L	0.521	0.29
169_G	250_F	0.520	0.29
18_E	272_R	0.519	0.29
82_L	335_Y	0.518	0.29
165_L	323_D	0.518	0.29
51_A	359_I	0.518	0.29
151_E	350_L	0.516	0.29
112_A	166_F	0.516	0.29
27_R	85_L	0.515	0.29
300_Y	304_W	0.514	0.29
333_L	342_L	0.514	0.29
317_Y	344_S	0.513	0.29
142_L	186_Y	0.512	0.29
139_L	186_Y	0.511	0.29
367_A	373_H	0.510	0.29
133_E	160_A	0.510	0.29
105_R	196_D	0.510	0.29
78_L	197_G	0.509	0.28
159_T	277_D	0.508	0.28
6_T	299_L	0.507	0.28
329_V	348_L	0.507	0.28
4_L	347_L	0.507	0.28
364_E	368_A	0.506	0.28
366_W	378_L	0.506	0.28
178_L	275_D	0.505	0.28
115_T	329_V	0.504	0.28
185_K	324_T	0.504	0.28
38_L	110_M	0.504	0.28
162_D	166_F	0.503	0.28
62_D	65_I	0.503	0.28
278_D	298_T	0.502	0.28
50_L	183_Y	0.502	0.28
5_T	10_S	0.501	0.28
49_T	68_G	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.8844	100	0.704	Contact Map
2kycA	1	0.2476	23	0.966	Contact Map
1rroA	1	0.2476	22	0.966	Contact Map
1w7jB	1	0.2476	18.8	0.967	Contact Map
3pm8A	2	0.2665	16.6	0.968	Contact Map
4ociA	2	0.2689	16.3	0.968	Contact Map
1m45A	1	0.2524	15.4	0.968	Contact Map
4mvfA	1	0.2618	15.4	0.969	Contact Map
1rwyA	1	0.25	13.9	0.969	Contact Map
1s1eA	1	0.3042	13.6	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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