GREMLIN Database
GVPL1 - Protein GvpL 1
UniProt: Q9HI27 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (235)
Sequences: 877 (702)
Seq/√Len: 45.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
245_D248_A6.3981.00
62_V92_A5.4251.00
239_V249_L4.4551.00
136_V242_D3.7711.00
136_V211_N3.4111.00
122_H125_G3.0251.00
58_G123_Y2.9531.00
25_R112_D2.9041.00
137_W243_E2.6561.00
113_A116_E2.6091.00
29_C89_V2.5381.00
57_D123_Y2.4991.00
203_K239_V2.4041.00
216_Q238_A2.3991.00
143_L264_I2.3851.00
98_T133_F2.3401.00
61_A115_I2.3141.00
52_Y65_D2.2561.00
181_K184_D2.2181.00
142_N236_R2.1871.00
24_G68_T2.1681.00
233_Q236_R2.1361.00
141_I264_I2.1161.00
140_R270_W2.1111.00
32_D131_A2.0931.00
32_D134_A2.0550.99
28_Y64_H2.0310.99
216_Q274_T1.9940.99
132_S212_D1.9720.99
49_N64_H1.9670.99
211_N242_D1.9620.99
26_Y85_H1.8260.99
25_R65_D1.8220.99
52_Y112_D1.8050.99
53_V60_G1.7980.99
100_L129_E1.7350.98
77_Q81_W1.6950.98
250_G266_F1.6750.98
56_A123_Y1.6560.98
140_R274_T1.6100.97
123_Y127_R1.6090.97
135_G244_D1.5860.97
128_D132_S1.5530.96
31_V62_V1.5520.96
29_C62_V1.5460.96
242_D245_D1.5250.96
267_T270_W1.5170.96
46_V84_T1.5070.96
47_D130_L1.4650.95
210_V253_L1.4620.95
174_G178_L1.4420.94
28_Y103_R1.4390.94
65_D112_D1.4150.94
33_T58_G1.4020.94
82_L104_F1.3920.93
140_R236_R1.3910.93
203_K267_T1.3900.93
161_L186_R1.3870.93
33_T60_G1.3740.93
112_D116_E1.3620.93
143_L235_V1.3360.92
104_F271_P1.3310.92
155_A161_L1.3140.91
61_A135_G1.3030.91
139_Y246_E1.2870.90
138_E270_W1.2840.90
100_L104_F1.2750.90
29_C92_A1.2590.89
137_W246_E1.2380.88
103_R107_V1.2340.88
247_T251_D1.2340.88
79_K83_V1.2230.88
51_V92_A1.2190.88
79_K82_L1.2070.87
81_W104_F1.1990.87
34_T99_P1.1970.87
163_E167_R1.1960.87
47_D64_H1.1940.87
54_V130_L1.1870.86
178_L181_K1.1810.86
27_L102_M1.1720.86
145_W234_I1.1700.85
186_R190_L1.1680.85
90_D271_P1.1660.85
159_D162_R1.1640.85
202_L256_I1.1610.85
26_Y273_Y1.1600.85
26_Y271_P1.1510.84
178_L270_W1.1420.84
134_A248_A1.1330.84
141_I242_D1.1220.83
86_Q274_T1.1120.82
120_E251_D1.1110.82
128_D148_A1.1050.82
246_E250_G1.0630.79
254_D257_V1.0610.79
78_V106_T1.0590.79
182_Q186_R1.0460.78
146_D263_E1.0460.78
148_A170_Q1.0440.78
75_L103_R1.0420.78
64_H81_W1.0360.78
55_E58_G1.0310.77
196_T200_D1.0270.77
236_R274_T1.0210.77
144_L233_Q1.0210.77
206_I264_I1.0180.76
29_C82_L1.0080.76
254_D258_E1.0030.75
86_Q90_D1.0020.75
200_D204_E0.9970.75
206_I249_L0.9840.74
100_L212_D0.9800.74
241_A249_L0.9780.73
51_V88_V0.9780.73
203_K235_V0.9770.73
129_E132_S0.9760.73
161_L183_S0.9680.73
204_E207_T0.9660.72
30_V109_E0.9590.72
138_E271_P0.9580.72
54_V119_L0.9570.72
201_Q204_E0.9550.72
203_K215_E0.9530.71
202_L243_E0.9480.71
141_I262_V0.9430.71
115_I135_G0.9340.70
233_Q271_P0.9300.70
140_R267_T0.9280.69
29_C51_V0.9180.69
45_G51_V0.9130.68
84_T142_N0.9090.68
61_A130_L0.9090.68
253_L266_F0.9010.67
66_C77_Q0.8990.67
42_S251_D0.8960.67
203_K207_T0.8920.66
43_T92_A0.8840.66
31_V60_G0.8830.66
27_L42_S0.8810.65
215_E237_F0.8750.65
209_V256_I0.8730.65
179_L182_Q0.8710.64
210_V239_V0.8670.64
85_H142_N0.8650.64
108_L142_N0.8600.63
151_E155_A0.8590.63
61_A119_L0.8570.63
26_Y100_L0.8570.63
134_A243_E0.8530.63
165_R169_Q0.8520.63
30_V59_V0.8460.62
135_G243_E0.8450.62
206_I256_I0.8380.61
77_Q139_Y0.8330.61
158_D161_L0.8280.60
92_A97_G0.8240.60
57_D133_F0.8210.60
56_A120_E0.8050.58
139_Y266_F0.8050.58
87_Q201_Q0.8020.58
104_F154_I0.7970.58
98_T207_T0.7950.57
145_W195_R0.7920.57
77_Q144_L0.7840.56
78_V139_Y0.7820.56
188_Q201_Q0.7800.56
82_L265_R0.7770.56
38_S55_E0.7720.55
160_R163_E0.7710.55
58_G127_R0.7690.55
106_T230_E0.7690.55
37_E40_T0.7680.55
27_L61_A0.7680.55
97_G238_A0.7670.55
140_R234_I0.7660.55
203_K237_F0.7610.54
249_L253_L0.7600.54
93_S274_T0.7590.54
30_V158_D0.7580.54
81_W181_K0.7540.53
181_K261_G0.7520.53
28_Y100_L0.7490.53
97_G271_P0.7470.53
54_V121_D0.7470.53
241_A266_F0.7470.53
98_T216_Q0.7370.52
174_G274_T0.7350.52
144_L265_R0.7330.51
53_V214_T0.7320.51
29_C196_T0.7320.51
110_G260_E0.7310.51
108_L118_W0.7280.51
78_V81_W0.7260.51
102_M106_T0.7260.51
176_K179_L0.7250.51
203_K213_L0.7220.50
247_T252_R0.7180.50
68_T175_K0.7170.50
67_E142_N0.7150.50
152_E258_E0.7130.49
91_A94_D0.7130.49
167_R179_L0.7120.49
56_A119_L0.7120.49
30_V126_F0.7090.49
79_K185_Q0.7090.49
197_E204_E0.7080.49
54_V116_E0.7070.49
119_L137_W0.7060.49
200_D215_E0.7060.49
79_K86_Q0.7050.49
100_L238_A0.7020.48
174_G181_K0.7000.48
59_V214_T0.6980.48
86_Q93_S0.6950.48
94_D193_E0.6940.47
54_V134_A0.6850.47
125_G204_E0.6830.46
197_E209_V0.6810.46
54_V63_V0.6810.46
79_K104_F0.6800.46
89_V162_R0.6780.46
200_D218_T0.6780.46
261_G270_W0.6770.46
202_L218_T0.6770.46
113_A120_E0.6740.46
92_A235_V0.6730.45
133_F271_P0.6720.45
66_C265_R0.6710.45
177_F181_K0.6700.45
185_Q189_E0.6700.45
30_V100_L0.6680.45
167_R196_T0.6670.45
82_L217_D0.6640.45
106_T177_F0.6620.44
103_R106_T0.6600.44
203_K208_P0.6580.44
100_L233_Q0.6580.44
134_A242_D0.6460.43
157_R194_R0.6460.43
257_V272_P0.6450.43
34_T127_R0.6410.42
58_G245_D0.6400.42
78_V82_L0.6390.42
108_L265_R0.6380.42
242_D251_D0.6350.42
117_R200_D0.6340.42
155_A193_E0.6330.42
207_T211_N0.6310.41
32_D218_T0.6300.41
25_R272_P0.6300.41
141_I255_T0.6300.41
142_N233_Q0.6290.41
58_G143_L0.6290.41
29_C241_A0.6240.41
47_D126_F0.6220.41
119_L130_L0.6210.40
64_H105_D0.6210.40
184_D270_W0.6170.40
38_S247_T0.6160.40
66_C178_L0.6150.40
139_Y241_A0.6140.40
74_D77_Q0.6110.40
75_L142_N0.6100.39
102_M263_E0.6090.39
68_T196_T0.6090.39
238_A271_P0.6070.39
108_L114_S0.6030.39
76_E79_K0.5990.38
195_R250_G0.5980.38
205_A256_I0.5970.38
77_Q181_K0.5960.38
114_S117_R0.5900.38
59_V192_R0.5890.37
198_L250_G0.5870.37
165_R179_L0.5860.37
25_R99_P0.5860.37
25_R86_Q0.5860.37
77_Q137_W0.5860.37
206_I235_V0.5840.37
238_A274_T0.5830.37
81_W140_R0.5830.37
113_A117_R0.5820.37
145_W262_V0.5770.36
51_V258_E0.5750.36
61_A102_M0.5720.36
101_P275_F0.5720.36
55_E65_D0.5690.36
51_V64_H0.5680.36
205_A255_T0.5670.35
174_G177_F0.5660.35
42_S195_R0.5640.35
164_L186_R0.5630.35
140_R216_Q0.5630.35
30_V39_A0.5590.35
129_E277_P0.5590.35
198_L261_G0.5570.35
115_I118_W0.5570.35
59_V130_L0.5540.34
58_G201_Q0.5540.34
113_A202_L0.5530.34
151_E188_Q0.5530.34
33_T55_E0.5520.34
59_V190_L0.5510.34
92_A141_I0.5500.34
82_L270_W0.5500.34
29_C187_L0.5430.33
101_P138_E0.5420.33
62_V235_V0.5410.33
110_G130_L0.5390.33
209_V245_D0.5390.33
154_I169_Q0.5380.33
141_I239_V0.5380.33
113_A160_R0.5370.33
30_V67_E0.5360.33
75_L274_T0.5360.33
45_G88_V0.5340.33
194_R205_A0.5330.32
81_W184_D0.5320.32
81_W105_D0.5310.32
82_L86_Q0.5310.32
177_F270_W0.5300.32
218_T232_E0.5290.32
29_C99_P0.5290.32
148_A193_E0.5280.32
192_R196_T0.5280.32
32_D177_F0.5240.32
101_P240_L0.5220.32
33_T143_L0.5200.31
92_A128_D0.5200.31
102_M179_L0.5190.31
81_W274_T0.5180.31
85_H236_R0.5170.31
45_G112_D0.5170.31
78_V236_R0.5170.31
64_H118_W0.5170.31
57_D159_D0.5130.31
102_M110_G0.5130.31
57_D98_T0.5120.31
26_Y142_N0.5110.31
56_A258_E0.5110.31
257_V260_E0.5100.31
41_L169_Q0.5090.30
74_D181_K0.5080.30
150_F246_E0.5070.30
209_V248_A0.5060.30
188_Q207_T0.5030.30
114_S176_K0.5030.30
94_D129_E0.5030.30
166_Q247_T0.5020.30
133_F231_K0.5020.30
28_Y45_G0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qsgA 1 0.847 100 0.217 Contact Map
2jpkA 1 0.0498 34.5 0.954 Contact Map
1pb7A 1 0.1815 27.4 0.956 Contact Map
2pvuA 1 0.089 25.5 0.957 Contact Map
2ylnA 1 0.1246 16.5 0.961 Contact Map
4q0cA 2 0.1815 15.8 0.961 Contact Map
1xt8A 1 0.1246 13.4 0.962 Contact Map
2yjpA 1 0.1139 13.2 0.962 Contact Map
2q9rA 2 0.3274 10.8 0.964 Contact Map
3f7cA 2 0.3381 8.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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