GREMLIN Database
GVPF1 - Protein GvpF 1
UniProt: Q9HI21 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (195)
Sequences: 949 (756)
Seq/√Len: 54.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_K171_A5.3601.00
40_V66_V4.6481.00
162_Y172_F3.9421.00
111_T165_D3.2701.00
111_T144_I3.1411.00
5_L87_A2.9711.00
97_A100_A2.5991.00
9_G63_L2.4491.00
117_K159_N2.4221.00
30_Y87_A2.4181.00
136_T162_Y2.3231.00
112_V166_F2.2761.00
39_A90_L2.2721.00
36_T98_R2.2251.00
30_Y43_D2.2161.00
88_R91_K2.0761.00
115_G194_W2.0401.00
12_E106_N1.9641.00
107_D145_N1.9351.00
149_N198_N1.8940.99
149_N161_S1.8830.99
118_I188_I1.8670.99
191_T194_W1.8460.99
4_N46_T1.8450.99
35_K98_R1.8340.99
8_Y42_S1.7450.99
144_I165_D1.7420.99
43_D87_A1.7310.99
156_L159_N1.7160.99
6_Y59_H1.7110.99
173_D190_Y1.6840.99
31_T38_S1.6800.99
34_Y98_R1.6150.98
76_V104_T1.6090.98
103_S107_D1.5640.98
27_E42_S1.4940.97
98_R102_R1.4900.97
23_V58_A1.4770.97
24_A42_S1.4730.97
5_L43_D1.4690.97
115_G198_N1.4560.97
116_V188_I1.4510.97
112_V169_R1.4500.97
53_D56_V1.4440.97
90_L110_G1.4440.97
136_T148_E1.4280.96
44_I49_P1.4140.96
143_S176_I1.4050.96
12_E109_E1.3840.96
13_Q38_S1.3840.96
60_N64_Q1.3470.95
165_D168_K1.3400.95
114_L169_R1.3070.94
74_T108_I1.2920.94
8_Y79_S1.2780.93
115_G159_N1.2740.93
53_D57_E1.2640.93
7_T78_M1.2540.93
110_G167_E1.2390.92
55_D80_F1.2320.92
87_A91_K1.2240.92
170_D174_S1.2210.92
49_P81_G1.2130.91
104_T107_D1.2060.91
9_G40_V1.1820.90
6_Y195_P1.1710.90
80_F195_P1.1550.89
136_T140_A1.1500.89
56_V80_F1.1490.89
32_V105_L1.1470.89
9_G66_V1.1350.88
118_I158_I1.1270.88
134_N182_E1.1230.88
138_Q182_E1.1200.88
90_L93_V1.1190.88
29_V62_V1.1170.88
29_V66_V1.1060.87
134_N137_D1.1050.87
169_R173_D1.0990.87
136_T191_T1.0950.87
14_E75_V1.0920.86
24_A105_L1.0910.86
177_D181_A1.0860.86
113_E194_W1.0780.86
11_I40_V1.0730.85
115_G191_T1.0650.85
120_G157_I1.0560.85
119_L156_L1.0490.84
10_I37_L1.0450.84
64_Q195_P1.0320.83
13_Q36_T1.0310.83
59_H117_K1.0270.83
126_V130_E1.0250.83
31_T40_V1.0210.82
89_T92_G1.0100.82
42_S55_D1.0050.81
56_V60_N1.0040.81
127_P181_A1.0020.81
32_V94_L0.9970.81
152_F156_L0.9940.81
78_M82_M0.9940.81
60_N198_N0.9920.81
117_K152_F0.9900.80
136_T146_E0.9800.80
61_N134_N0.9780.80
20_V66_V0.9770.80
185_E194_W0.9620.79
53_D60_N0.9620.79
133_E137_D0.9620.79
76_V80_F0.9500.78
39_A110_G0.9390.77
95_R174_S0.9390.77
121_P187_T0.9380.77
110_G166_F0.9320.76
32_V91_K0.9150.75
32_V41_V0.9140.75
139_L172_F0.9140.75
156_L195_P0.9120.75
5_L196_P0.8970.73
115_G157_I0.8960.73
133_E138_Q0.8950.73
116_V186_L0.8920.73
10_I85_K0.8890.73
177_D180_E0.8840.72
159_N198_N0.8720.71
39_A105_L0.8700.71
136_T141_D0.8690.71
7_T19_D0.8670.71
36_T168_K0.8670.71
127_P131_I0.8630.71
58_A117_K0.8610.70
6_Y197_Y0.8560.70
47_T130_E0.8560.70
176_I190_Y0.8500.69
5_L75_V0.8390.68
41_V90_L0.8390.68
64_Q67_L0.8350.68
109_E165_D0.8310.68
84_F117_K0.8220.67
25_G28_Q0.8130.66
123_D130_E0.8110.66
131_I167_E0.8050.65
119_L189_Q0.8030.65
7_T90_L0.8030.65
84_F93_V0.7980.64
19_D174_S0.7970.64
11_I38_S0.7900.64
116_V165_D0.7860.63
183_Y195_P0.7860.63
103_S123_D0.7820.63
94_L105_L0.7810.63
164_V172_F0.7810.63
149_N152_F0.7810.63
9_G29_V0.7800.63
148_E160_K0.7790.63
39_A94_L0.7770.62
100_A137_D0.7750.62
136_T158_I0.7600.61
80_F129_E0.7560.60
136_T160_K0.7550.60
142_L179_V0.7540.60
84_F189_Q0.7540.60
109_E171_A0.7540.60
116_V140_A0.7540.60
34_Y95_R0.7510.60
114_L190_Y0.7460.59
51_R84_F0.7430.59
53_D80_F0.7420.59
135_V177_D0.7390.59
90_L121_P0.7370.58
40_V158_I0.7360.58
161_S198_N0.7320.58
66_V158_I0.7300.58
8_Y23_V0.7300.58
114_L164_V0.7280.57
9_G75_V0.7130.56
66_V73_R0.7130.56
35_K108_I0.7120.56
32_V109_E0.7100.55
51_R81_G0.7060.55
143_S162_Y0.7010.55
138_Q178_D0.7010.55
104_T108_I0.6970.54
98_R171_A0.6940.54
56_V189_Q0.6940.54
63_L81_G0.6930.54
25_G54_E0.6890.53
33_D36_T0.6840.53
120_G186_L0.6840.53
73_R195_P0.6820.53
76_V79_S0.6800.52
85_K89_T0.6790.52
63_L82_M0.6790.52
73_R161_S0.6790.52
67_L198_N0.6770.52
10_I101_L0.6770.52
12_E154_D0.6760.52
117_K156_L0.6690.51
32_V63_L0.6690.51
4_N51_R0.6670.51
9_G56_V0.6670.51
116_V157_I0.6660.51
36_T102_R0.6640.51
79_S82_M0.6640.51
76_V156_L0.6600.50
171_A174_S0.6560.50
113_E195_P0.6530.49
32_V96_G0.6480.49
178_D182_E0.6480.49
168_K181_A0.6460.49
79_S83_A0.6410.48
138_Q145_N0.6390.48
162_Y194_W0.6390.48
29_V185_E0.6350.48
78_M187_T0.6350.48
74_T106_N0.6330.47
175_A178_D0.6250.46
95_R129_E0.6240.46
114_L173_D0.6220.46
113_E198_N0.6220.46
36_T118_I0.6220.46
8_Y22_G0.6200.46
37_L105_L0.6180.46
55_D81_G0.6170.46
166_F186_L0.6150.45
172_F176_I0.6150.45
78_M86_S0.6150.45
39_A78_M0.6110.45
56_V194_W0.6100.45
51_R56_V0.6080.45
29_V42_S0.6050.44
138_Q175_A0.6040.44
74_T166_F0.6030.44
79_S86_S0.6010.44
116_V177_D0.6000.44
28_Q164_V0.5990.44
22_G29_V0.5980.44
63_L194_W0.5970.43
24_A143_S0.5940.43
114_L172_F0.5940.43
62_V196_P0.5900.43
5_L30_Y0.5880.43
118_I186_L0.5860.42
42_S81_G0.5850.42
101_L106_N0.5840.42
97_A121_P0.5830.42
67_L195_P0.5810.42
76_V145_N0.5750.41
130_E141_D0.5730.41
114_L152_F0.5720.41
180_E184_D0.5710.41
138_Q179_V0.5680.40
98_R138_Q0.5660.40
60_N149_N0.5650.40
115_G162_Y0.5610.40
123_D127_P0.5600.40
24_A55_D0.5560.39
140_A169_R0.5540.39
86_S184_D0.5500.39
6_Y76_V0.5490.39
74_T109_E0.5430.38
25_G107_D0.5430.38
14_E88_R0.5410.38
60_N67_L0.5370.37
44_I189_Q0.5350.37
97_A133_E0.5340.37
118_I194_W0.5330.37
77_P199_F0.5320.37
5_L60_N0.5310.37
183_Y186_L0.5300.37
94_L112_V0.5290.37
60_N84_F0.5280.36
145_N170_D0.5280.36
95_R132_Q0.5280.36
99_R175_A0.5260.36
182_E202_I0.5240.36
5_L90_L0.5230.36
137_D140_A0.5190.36
143_S197_Y0.5190.36
10_I76_V0.5120.35
109_E166_F0.5110.35
10_I16_L0.5080.34
146_E162_Y0.5070.34
11_I15_D0.5070.34
116_V190_Y0.5070.34
101_L195_P0.5030.34
28_Q131_I0.5030.34
189_Q194_W0.5030.34
38_S200_V0.5020.34
142_L168_K0.5010.34
55_D115_G0.5000.34
17_E72_E0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qsgA 1 0.9249 100 0.131 Contact Map
4atyA 2 0.8263 11.5 0.955 Contact Map
1svvA 4 0.7653 10.4 0.956 Contact Map
3u0kA 1 0.3709 10.4 0.956 Contact Map
3v4gA 5 0.4178 9.9 0.956 Contact Map
4chmA 1 0.4507 9.1 0.957 Contact Map
3k40A 2 0.7512 7 0.959 Contact Map
1x9aA 2 0.2488 6.3 0.96 Contact Map
3nojA 5 0.4413 6.1 0.961 Contact Map
2v25A 1 0.1831 5.7 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.