GREMLIN Database
GVPN1 - Gas vesicle protein GvpN 1
UniProt: Q9HI16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (280)
Sequences: 7525 (4412)
Seq/√Len: 263.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
276_L279_L4.4221.00
249_D252_T2.7831.00
35_I38_L2.5611.00
219_L240_L2.3721.00
18_S22_K2.3311.00
196_V208_Y2.3231.00
276_L280_R2.2491.00
25_G28_Q2.1891.00
17_S35_I2.1451.00
24_Q28_Q2.1141.00
26_R30_R2.1131.00
277_R280_R2.0501.00
199_L202_K2.0121.00
19_R23_K1.9781.00
18_S21_D1.9681.00
195_G199_L1.9671.00
280_R283_L1.9601.00
57_F60_E1.9381.00
278_E281_E1.9371.00
25_G35_I1.9261.00
20_G25_G1.8781.00
163_T166_V1.8751.00
45_R49_S1.8701.00
258_R280_R1.8641.00
101_A218_I1.8641.00
27_S31_D1.8641.00
255_E259_A1.8641.00
59_P62_Q1.8621.00
57_F61_E1.8561.00
31_D34_E1.8471.00
195_G198_E1.7431.00
55_E59_P1.7291.00
25_G29_S1.7041.00
24_Q35_I1.7041.00
38_L41_Q1.6701.00
194_E199_L1.6551.00
44_A48_E1.6401.00
194_E197_L1.6221.00
31_D35_I1.5941.00
20_G24_Q1.5381.00
279_L283_L1.5331.00
27_S30_R1.5151.00
28_Q42_N1.5021.00
59_P63_S1.4931.00
67_T70_V1.4881.00
31_D38_L1.4871.00
254_I281_E1.4851.00
39_E42_N1.4821.00
88_H240_L1.4771.00
122_T125_D1.4671.00
223_S231_E1.4631.00
21_D25_G1.4621.00
195_G201_G1.4521.00
196_V199_L1.4451.00
55_E58_V1.4351.00
255_E258_R1.4341.00
237_L242_G1.4321.00
66_E70_V1.4281.00
277_R281_E1.4271.00
38_L42_N1.4271.00
36_E40_R1.4211.00
46_G49_S1.4131.00
33_K37_R1.4131.00
278_E282_R1.4111.00
57_F64_F1.3991.00
22_K25_G1.3911.00
23_K29_S1.3871.00
28_Q35_I1.3801.00
250_L281_E1.3771.00
37_R40_R1.3701.00
166_V169_G1.3591.00
19_R36_E1.3591.00
105_A112_V1.3581.00
17_S21_D1.3511.00
35_I43_D1.3481.00
260_H263_K1.3441.00
35_I41_Q1.3391.00
23_K27_S1.3391.00
36_E43_D1.3331.00
24_Q27_S1.3171.00
165_A172_L1.3141.00
17_S24_Q1.3081.00
320_S323_A1.3001.00
27_S34_E1.3001.00
160_N164_L1.2951.00
34_E43_D1.2941.00
48_E51_T1.2881.00
30_R34_E1.2781.00
32_D35_I1.2721.00
79_R302_V1.2691.00
33_K36_E1.2681.00
21_D28_Q1.2681.00
55_E60_E1.2641.00
39_E43_D1.2561.00
28_Q38_L1.2511.00
49_S53_V1.2431.00
19_R22_K1.2381.00
305_V309_V1.2361.00
35_I39_E1.2321.00
17_S20_G1.2301.00
20_G28_Q1.2291.00
275_V279_L1.2271.00
18_S25_G1.2161.00
29_S33_K1.2141.00
28_Q32_D1.2131.00
65_I71_N1.2101.00
23_K35_I1.2101.00
22_K28_Q1.2051.00
44_A47_Q1.2031.00
194_E202_K1.2031.00
32_D36_E1.1931.00
72_R76_R1.1871.00
38_L43_D1.1841.00
37_R42_N1.1831.00
311_T315_T1.1811.00
25_G38_L1.1791.00
74_E77_M1.1751.00
176_E222_N1.1751.00
35_I42_N1.1721.00
195_G202_K1.1691.00
76_R79_R1.1651.00
88_H177_F1.1591.00
56_G60_E1.1541.00
309_V314_C1.1511.00
165_A169_G1.1471.00
49_S52_H1.1411.00
28_Q33_K1.1411.00
293_I297_E1.1351.00
163_T209_V1.1241.00
161_P165_A1.1231.00
319_A322_V1.1041.00
40_R43_D1.1001.00
34_E42_N1.1001.00
74_E79_R1.0961.00
309_V313_I1.0941.00
26_R29_S1.0931.00
29_S42_N1.0921.00
18_S29_S1.0851.00
18_S38_L1.0841.00
32_D37_R1.0841.00
30_R33_K1.0801.00
36_E41_Q1.0781.00
31_D43_D1.0761.00
22_K26_R1.0721.00
48_E52_H1.0671.00
17_S28_Q1.0641.00
36_E39_E1.0641.00
197_L201_G1.0601.00
23_K34_E1.0581.00
58_V61_E1.0561.00
270_E273_V1.0541.00
173_V220_T1.0541.00
318_L322_V1.0521.00
55_E62_Q1.0491.00
66_E69_S1.0471.00
223_S228_G1.0451.00
34_E37_R1.0401.00
71_N74_E1.0391.00
194_E201_G1.0391.00
306_D309_V1.0351.00
46_G52_H1.0341.00
20_G26_R1.0321.00
18_S24_Q1.0291.00
54_D57_F1.0281.00
73_V76_R1.0191.00
30_R38_L1.0161.00
316_D320_S1.0111.00
34_E40_R1.0101.00
25_G32_D1.0091.00
22_K40_R1.0081.00
23_K26_R1.0061.00
27_S41_Q1.0021.00
269_V272_I0.9951.00
98_T175_N0.9911.00
18_S35_I0.9891.00
21_D24_Q0.9781.00
36_E42_N0.9751.00
56_G59_P0.9721.00
29_S36_E0.9711.00
17_S25_G0.9621.00
164_L167_Q0.9591.00
28_Q34_E0.9581.00
274_R278_E0.9571.00
45_R48_E0.9521.00
44_A51_T0.9511.00
180_T188_L0.9501.00
159_D163_T0.9451.00
70_V73_V0.9441.00
299_A303_D0.9391.00
20_G23_K0.9381.00
18_S28_Q0.9351.00
76_R80_W0.9341.00
308_A312_D0.9321.00
60_E63_S0.9321.00
21_D35_I0.9231.00
74_E80_W0.9231.00
37_R43_D0.9211.00
45_R50_S0.9211.00
19_R24_Q0.9211.00
277_R283_L0.9151.00
319_A323_A0.9151.00
22_K27_S0.9121.00
24_Q31_D0.9111.00
262_D265_A0.9111.00
31_D42_N0.9091.00
196_V201_G0.9061.00
34_E38_L0.9021.00
25_G30_R0.9021.00
18_S26_R0.9011.00
52_H55_E0.8991.00
31_D36_E0.8991.00
18_S27_S0.8971.00
23_K43_D0.8961.00
306_D313_I0.8921.00
19_R25_G0.8901.00
79_R82_D0.8891.00
26_R32_D0.8881.00
23_K28_Q0.8861.00
25_G36_E0.8841.00
317_V320_S0.8751.00
27_S42_N0.8741.00
315_T319_A0.8741.00
19_R27_S0.8731.00
64_F67_T0.8681.00
17_S22_K0.8621.00
308_A315_T0.8611.00
19_R34_E0.8460.99
315_T318_L0.8420.99
65_I70_V0.8420.99
304_T307_Q0.8410.99
37_R41_Q0.8370.99
73_V79_R0.8340.99
19_R32_D0.8330.99
23_K38_L0.8270.99
275_V280_R0.8220.99
55_E64_F0.8190.99
29_S35_I0.8150.99
60_E64_F0.8130.99
34_E39_E0.8070.99
23_K36_E0.8070.99
160_N163_T0.8060.99
24_Q41_Q0.8050.99
26_R33_K0.7980.99
22_K36_E0.7980.99
73_V77_M0.7970.99
22_K43_D0.7950.99
80_W87_V0.7920.99
21_D39_E0.7910.99
32_D39_E0.7900.99
34_E41_Q0.7890.99
18_S36_E0.7850.99
24_Q38_L0.7820.99
19_R29_S0.7810.99
198_E202_K0.7780.99
21_D27_S0.7750.99
260_H293_I0.7740.99
27_S36_E0.7740.99
276_L283_L0.7730.99
160_N165_A0.7720.99
48_E55_E0.7670.99
20_G27_S0.7650.99
71_N75_S0.7640.99
26_R42_N0.7620.99
24_Q30_R0.7610.99
22_K37_R0.7580.99
25_G31_D0.7560.99
164_L168_E0.7540.99
165_A168_E0.7530.99
307_Q317_V0.7520.99
295_A299_A0.7500.99
46_G50_S0.7500.99
28_Q36_E0.7490.99
24_Q33_K0.7480.99
197_L200_P0.7440.99
71_N252_T0.7420.99
266_D269_V0.7420.99
27_S35_I0.7400.99
111_P169_G0.7360.99
159_D164_L0.7340.99
25_G33_K0.7300.99
23_K31_D0.7290.99
19_R28_Q0.7280.98
19_R33_K0.7260.98
51_T55_E0.7210.98
19_R35_I0.7210.98
60_E107_E0.7190.98
23_K30_R0.7170.98
309_V320_S0.7140.98
73_V80_W0.7140.98
252_T255_E0.7130.98
47_Q51_T0.7110.98
62_Q65_I0.7080.98
186_N189_L0.7070.98
223_S230_H0.7060.98
272_I276_L0.7060.98
18_S31_D0.7060.98
77_M80_W0.7060.98
22_K33_K0.7050.98
73_V81_L0.7040.98
47_Q50_S0.7030.98
76_R82_D0.7030.98
27_S38_L0.7010.98
22_K29_S0.7010.98
46_G53_V0.7000.98
27_S43_D0.6980.98
314_C320_S0.6980.98
103_H106_R0.6970.98
73_V78_E0.6960.98
159_D165_A0.6960.98
30_R37_R0.6960.98
21_D42_N0.6940.98
112_V171_T0.6880.98
75_S79_R0.6860.98
18_S23_K0.6830.98
194_E198_E0.6800.98
29_S32_D0.6740.98
27_S32_D0.6740.98
78_E82_D0.6710.97
29_S38_L0.6630.97
21_D32_D0.6620.97
59_P64_F0.6620.97
235_A239_R0.6610.97
19_R31_D0.6580.97
195_G200_P0.6510.97
45_R53_V0.6490.97
55_E63_S0.6450.97
20_G35_I0.6450.97
33_K43_D0.6440.97
306_D320_S0.6430.97
26_R35_I0.6420.97
45_R51_T0.6370.97
17_S41_Q0.6370.97
20_G29_S0.6360.96
313_I317_V0.6340.96
31_D39_E0.6290.96
73_V245_M0.6280.96
312_D316_D0.6260.96
61_E65_I0.6250.96
162_L165_A0.6250.96
33_K38_L0.6230.96
312_D315_T0.6220.96
19_R42_N0.6220.96
254_I258_R0.6190.96
307_Q310_L0.6140.96
57_F62_Q0.6140.96
251_D254_I0.6140.96
304_T311_T0.6130.96
21_D26_R0.6110.96
197_L202_K0.6070.95
265_A272_I0.6050.95
227_A230_H0.6030.95
311_T314_C0.6010.95
89_L245_M0.6010.95
20_G32_D0.6010.95
59_P65_I0.6000.95
163_T167_Q0.5980.95
309_V315_T0.5950.95
18_S41_Q0.5940.95
177_F219_L0.5910.95
17_S34_E0.5890.95
161_P169_G0.5870.95
25_G42_N0.5840.94
32_D40_R0.5840.94
44_A49_S0.5820.94
58_V62_Q0.5810.94
26_R36_E0.5790.94
194_E200_P0.5750.94
29_S43_D0.5740.94
75_S78_E0.5730.94
27_S37_R0.5710.94
19_R39_E0.5700.94
69_S73_V0.5680.94
30_R35_I0.5680.94
23_K33_K0.5660.93
310_L313_I0.5630.93
196_V202_K0.5630.93
78_E81_L0.5600.93
65_I69_S0.5580.93
29_S37_R0.5580.93
24_Q42_N0.5570.93
17_S38_L0.5570.93
26_R38_L0.5570.93
161_P168_E0.5560.93
90_I242_G0.5520.93
17_S29_S0.5510.92
315_T322_V0.5510.92
120_E161_P0.5480.92
23_K40_R0.5470.92
186_N233_Q0.5460.92
76_R83_V0.5460.92
21_D36_E0.5450.92
30_R41_Q0.5450.92
79_R83_V0.5450.92
63_S70_V0.5430.92
32_D43_D0.5410.92
20_G33_K0.5390.92
30_R42_N0.5380.92
129_E174_Y0.5370.92
60_E65_I0.5340.91
80_W83_V0.5330.91
53_V56_G0.5290.91
22_K32_D0.5280.91
47_Q53_V0.5270.91
267_T270_E0.5260.91
23_K37_R0.5240.91
309_V318_L0.5220.90
159_D169_G0.5200.90
25_G34_E0.5200.90
19_R40_R0.5190.90
50_S53_V0.5150.90
30_R36_E0.5130.90
22_K31_D0.5120.90
161_P164_L0.5110.89
265_A276_L0.5090.89
318_L321_K0.5090.89
22_K41_Q0.5070.89
51_T54_D0.5060.89
18_S40_R0.5050.89
268_N272_I0.5040.89
311_T319_A0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4akgA 2 0.902 100 0.314 Contact Map
3vkgA 2 0.8818 100 0.324 Contact Map
4rh7A 1 0.9337 100 0.465 Contact Map
2r44A 1 0.8127 99.9 0.615 Contact Map
1r6bX 1 0.8876 99.9 0.651 Contact Map
3ja86 1 0.7839 99.8 0.674 Contact Map
3ja87 1 0.8386 99.8 0.674 Contact Map
3pxiA 3 0.8213 99.8 0.676 Contact Map
4r7yA 3 0.8617 99.8 0.677 Contact Map
1qvrA 3 0.8213 99.8 0.678 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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