GREMLIN Database
Q9HI15 - Vng6036h
UniProt: Q9HI15 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 50 (45)
Sequences: 109891 (54837)
Seq/√Len: 8174.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_P41_S4.4961.00
13_D42_T3.0721.00
10_R39_E2.9701.00
17_R46_V2.2231.00
19_S48_S2.0971.00
21_A25_V2.0471.00
15_G44_E2.0041.00
16_E45_G1.9901.00
20_E23_L1.7211.00
39_E46_V1.5321.00
25_V28_E1.4811.00
23_L26_E1.4351.00
10_R17_R1.4131.00
13_D28_E1.2411.00
19_S23_L1.2291.00
39_E44_E1.1431.00
18_I45_G1.0961.00
18_I47_V1.0841.00
40_C43_C1.0781.00
16_E47_V1.0611.00
10_R15_G1.0251.00
12_P28_E1.0081.00
9_G38_A0.9741.00
7_I34_T0.9281.00
26_E29_K0.8801.00
41_S46_V0.8681.00
20_E24_L0.8611.00
20_E26_E0.7861.00
6_S33_E0.7751.00
22_W25_V0.7701.00
14_C27_Y0.7681.00
32_G48_S0.7451.00
14_C30_D0.7351.00
11_C27_Y0.7271.00
27_Y30_D0.7201.00
22_W26_E0.7041.00
5_A19_S0.6851.00
12_P17_R0.6731.00
11_C30_D0.6661.00
35_G38_A0.6531.00
28_E42_T0.6451.00
39_E42_T0.6361.00
4_D31_D0.6241.00
21_A28_E0.6231.00
38_A43_C0.6081.00
25_V29_K0.5961.00
2_N19_S0.5961.00
3_G6_S0.5871.00
8_L17_R0.5831.00
29_K33_E0.5821.00
35_G46_V0.5681.00
9_G14_C0.5631.00
9_G27_Y0.5481.00
14_C24_L0.5471.00
34_T38_A0.5411.00
4_D8_L0.5391.00
11_C14_C0.5391.00
32_G35_G0.5371.00
24_L28_E0.5331.00
10_R13_D0.5321.00
12_P46_V0.5301.00
21_A26_E0.5281.00
29_K35_G0.5181.00
28_E41_S0.5161.00
5_A8_L0.5131.00
9_G21_A0.5071.00
31_D34_T0.5021.00
31_D35_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ej6B 7 0.78 99 0.182 Contact Map
3w5kB 1 0.92 98.7 0.255 Contact Map
2wbtA 2 0.94 98.6 0.286 Contact Map
1x6eA 1 0.96 98.6 0.286 Contact Map
2lv2A 1 0.96 98.6 0.288 Contact Map
2drpA 1 0.96 98.6 0.29 Contact Map
2i13A 1 0.96 98.5 0.291 Contact Map
2lvhA 1 0.86 98.5 0.297 Contact Map
2d9kA 1 0.94 98.5 0.298 Contact Map
2ghfA 1 0.96 98.5 0.3 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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